Germ granules and gene regulation in the Caenorhabditis elegans germline.

The transparency of Caenorhabditis elegans provides a unique window to observe and study the function of germ granules. Germ granules are specialized ribonucleoprotein (RNP) assemblies specific to the germline cytoplasm, and they are largely conserved across Metazoa. Within the germline cytoplasm, they are positioned to regulate mRNA abundance, translation, small RNA production, and cytoplasmic inheritance to help specify and maintain germline identity across generations. Here we provide an overview of germ granules and focus on the significance of more recent observations that describe how they further demix into sub-granules, each with unique compositions and functions.

• Publication year

  2022

• Venue

  Genetics

• Publication date

  2022-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/genetics/iyab195PMID 35239965PMCID PMC8893257
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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