The bizarre pharmacology of the ATP release channel pannexin1.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Neuropharmacology

• Publication date

  2013-12-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.neuropharm.2013.02.019PMID 23499662PMCID PMC3711969
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Pannexin: from discovery to bedside in 11±4 years?

  2012cited by this paper
• Neurons respond directly to mechanical deformation with pannexin‐mediated ATP release and autostimulation of P2X7 receptors

  2012cited by this paper
• ATP signaling is deficient in cultured pannexin1‐null mouse astrocytes

  2012cited by this paper
• p53 opens the mitochondrial permeability transition pore to trigger necrosis.

  2012cited by this paper
• Nature of plasmalemmal functional "hemichannels".

  2012cited by this paper
• Mitochondrial adenine nucleotide transport and cardioprotection.

  2012cited by this paper
• Activation of neuronal P2X7 receptor-Pannexin-1 mediates death of enteric neurons during colitis

  2012cited by this paper
• Intrarenal localization of the plasma membrane ATP channel pannexin1.

  2012influential reference
• Pannexin 1 forms an anion-selective channel

  2012influential reference
• Cardiomyocyte ATP release through pannexin 1 aids in early fibroblast activation.

  2012cited by this paper
• Targeting Pannexin1 Improves Seizure Outcome

  2011cited by this paper
• Alanine substitution scanning of pannexin1 reveals amino acid residues mediating ATP sensitivity

  2011cited by this paper
• Mitochondrial calcium handling during ischemia-induced cell death in neurons.

  2011cited by this paper
• Extracellular ATP acts on P2Y2 purinergic receptors to facilitate HIV-1 infection

  2011cited by this paper
• Two non‐vesicular ATP release pathways in the mouse erythrocyte membrane

  2011cited by this paper
• Pannexin channels are not gap junction hemichannels

  2011cited by this paper
• Pannexin 1 is the conduit for low oxygen tension-induced ATP release from human erythrocytes.

  2010cited by this paper
• Pannexin 1 channels mediate ‘find-me’ signal release and membrane permeability during apoptosis

  2010influential reference
• The inflammasomes: mechanisms of activation and function.

  2010cited by this paper
• The NLRP3 Inflammasome: A Sensor for Metabolic Danger?

  2010cited by this paper
• SCAM analysis of Panx1 suggests a peculiar pore structure

  2010cited by this paper
• Purinergic Signaling: A Fundamental Mechanism in Neutrophil Activation

  2010cited by this paper
• Mefloquine Blockade of Pannexin1 Currents: Resolution of a Conflict

  2010cited by this paper
• Pannexin 1 Constitutes the Large Conductance Cation Channel of Cardiac Myocytes

  2010cited by this paper
• Intracellular Cysteine 346 Is Essentially Involved in Regulating Panx1 Channel Activity*

  2010influential reference
• Title : Pannexin 1 is the Conduit for Low Oxygen Tension-Induced ATP Release 3 from Human Erythrocytes 4 5 6 7

  2010cited by this paper
• Pannexin 1: The Molecular Substrate of Astrocyte “Hemichannels”

  2009cited by this paper
• Glyburide inhibits the Cryopyrin/Nalp3 inflammasome

  2009cited by this paper
• Regulation and pharmacology of the mitochondrial permeability transition pore.

  2009cited by this paper
• THE MOLECULAR SUBSTRATE OF ASTROCYTE "HEMICHANNELS"

  2009cited by this paper
• The potassium channel subunit Kvβ3 interacts with pannexin 1 and attenuates its sensitivity to changes in redox potentials

  2009cited by this paper
• A permeant regulating its permeation pore: inhibition of pannexin 1 channels by ATP.

  2009cited by this paper
• The P2X7 receptor–pannexin connection to dye uptake and IL-1β release

  2009cited by this paper
• The Pannexin 1 Channel Activates the Inflammasome in Neurons and Astrocytes*

  2009cited by this paper
• Glycosylation regulates pannexin intermixing and cellular localization.

  2009cited by this paper
• Pharmacological Characterization of Pannexin-1 Currents Expressed in Mammalian Cells

  2009cited by this paper
• Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence

  2009cited by this paper
• Pannexin 1 contributes to ATP release in airway epithelia.

  2009cited by this paper
• Activation of Pannexin-1 Hemichannels Augments Aberrant Bursting in the Hippocampus

  2008cited by this paper
• Probenecid, a gout remedy, inhibits pannexin 1 channels.

  2008cited by this paper
• Pannexin-1-Mediated Intracellular Delivery of Muramyl Dipeptide Induces Caspase-1 Activation via Cryopyrin/NLRP3 Independently of Nod21

  2008influential reference
• Trafficking Dynamics of Glycosylated Pannexin1 Proteins

  2008cited by this paper
• Pannexins are new molecular candidates for assembling gap junctions in the cochlea

  2008cited by this paper
• Colchicine: Its mechanism of action and efficacy in crystal-induced inflammation

  2008cited by this paper
• Purinergic Control of T Cell Activation by ATP Released Through Pannexin-1 Hemichannels

  2008cited by this paper
• The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response

  2008cited by this paper
• Tumor-suppressive effects of pannexin 1 in C6 glioma cells.

  2007cited by this paper
• Pannexin 1 and pannexin 3 are glycoproteins that exhibit many distinct characteristics from the connexin family of gap junction proteins

  2007influential reference
• Functional expression of connexin30 and connexin31 in the polarized human airway epithelium.

  2007cited by this paper
• Pannexin1 is expressed by neurons and glia but does not form functional gap junctions

  2007cited by this paper
• Modulation of membrane channel currents by gap junction protein mimetic peptides: size matters.

  2007cited by this paper
• Gap Junction–Mimetic Peptides do Work, but in Unexpected Ways

  2007cited by this paper
• Pannexin1 is part of the pore forming unit of the P2X7 receptor death complex

  2007cited by this paper
• Pannexin1 Channels Contain a Glycosylation Site That Targets the Hexamer to the Plasma Membrane*

  2007cited by this paper
• Glutamate acts at NMDA receptors on fresh bovine and on cultured human retinal pigment epithelial cells to trigger release of ATP

  2006influential reference
• Expanding insights of mitochondrial dysfunction in Parkinson's disease

  2006cited by this paper
• The inflammatory process of gout and its treatment

  2006cited by this paper
• Pannexin: To gap or not to gap, is that a question?

  2006cited by this paper
• Activation of pannexin 1 channels by ATP through P2Y receptors and by cytoplasmic calcium

  2006cited by this paper
• Stimulation of rat erythrocyte P2X7 receptor induces the release of epoxyeicosatrienoic acids

  2006cited by this paper
• Functional implications of calcium permeability of the channel formed by pannexin 1

  2006cited by this paper
• Intracellular calcium changes trigger connexin 32 hemichannel opening

  2006cited by this paper
• Pannexin 1 in erythrocytes: Function without a gap

  2006cited by this paper
• Ischemia Opens Neuronal Gap Junction Hemichannels

  2006influential reference
• Pannexin‐1 mediates large pore formation and interleukin‐1β release by the ATP‐gated P2X7 receptor

  2006influential reference
• Bongkrekic acid ameliorates ischemic neuronal death in the cortex by preventing cytochrome c release and inhibiting astrocyte activation.

  2005cited by this paper
• Pharmacological properties of homomeric and heteromeric pannexin hemichannels expressed in Xenopus oocytes

  2005cited by this paper
• ATP binding cassette transporter ABC1 is required for the release of interleukin‐1β by P2X7‐stimulated and lipopolysaccharide‐primed mouse Schwann cells

  2005cited by this paper
• Pannexin membrane channels are mechanosensitive conduits for ATP

  2004cited by this paper
• Potent block of Cx36 and Cx50 gap junction channels by mefloquine.

  2004cited by this paper
• Photoliberating inositol-1,4,5-trisphosphate triggers ATP release that is blocked by the connexin mimetic peptide gap 26.

  2003cited by this paper
• Inhibition of lipopolysaccharide/ATP-induced release of interleukin-18 by KN-62 and glyburide.

  2003cited by this paper
• Pannexins, a family of gap junction proteins expressed in brain

  2003cited by this paper
• ATP released from astrocytes during swelling activates chloride channels.

  2003cited by this paper
• Glial cells express multiple ATP binding cassette proteins which are involved in ATP release

  2002influential reference
• The permeability transition pore complex: another view.

  2002cited by this paper
• Inhibition of Gap Junction Hemichannels by Chloride Channel Blockers

  2002cited by this paper
• Molecular structure of the glibenclamide binding site of the beta-cell K(ATP) channel.

  2001cited by this paper
• Molecular structure of the glibenclamide binding site of the β‐cell KATP channel

  2001cited by this paper
• Fenamates: a novel class of reversible gap junction blockers.

  2001cited by this paper
• Volume-Dependent Atp-Conductive Large-Conductance Anion Channel as a Pathway for Swelling-Induced Atp Release

  2001influential reference
• A ubiquitous family of putative gap junction molecules.

  2000cited by this paper
• The mitochondrial permeability transition pore and its role in cell death.

  1999cited by this paper
• A release mechanism for stored ATP in ocular ciliary epithelial cells.

  1998influential reference
• Artesunate/mefloquine treatment of multi-drug resistant falciparum malaria.

  1997cited by this paper
• Interleukin-1beta secretion is impaired by inhibitors of the Atp binding cassette transporter, ABC1.

  1997cited by this paper
• Specific motifs in the external loops of connexin proteins can determine gap junction formation between chick heart myocytes.

  1995cited by this paper
• Attempts to define functional domains of gap junction proteins with synthetic peptides.

  1994cited by this paper
• Multiple conductance states of newly formed single gap junction channels between insect cells

  1993cited by this paper
• Multisubunit assembly of an integral plasma membrane channel protein, gap junction connexin43, occurs after exit from the ER.

  1993cited by this paper
• Mutational analysis of gap junction formation.

  1992cited by this paper
• Reversible inhibition of intercellular junctional communication by glycyrrhetinic acid.

  1986cited by this paper
• The sulphonylurea receptor may be an ATP-sensitive potassium channel.

  1985cited by this paper
• Interaction of anaesthetics with electrical synapses

  1980cited by this paper
• Inhibitors of the adenine nucleotide translocase.

  1979cited by this paper
• Letter: District community physicians.

  1974cited by this paper

• Panx1 and drug discovery: from non-specific inhibitors to tailored drug compounds

  2026cites this paper
• Pannexins in the heart: cell-specific expression and contributions to disease

  2026cites this paper
• Pannexin1: A potential therapeutic target for multi-organ ischemic diseases

  2025cites this paper
• Effect of Gap-Junctıon Inhıbıtıon on High-Frequency Oscillations Under Hyperexcitability: An In Vitro Electrophysiological Study

  2025cites this paper
• Dual Regulatory Roles of Pannexin 1 in the Pathogenesis and Recovery of Sepsis-Induced Acute Lung Injury

  2025cites this paper
• Silybin, silychristin and silydianin are potential novel plant-based Pannexin1 channel inhibitors.

  2025cites this paper
• Activation of Pannexin-1 channels causes cell dysfunction and damage in mesangial cells derived from angiotensin II-exposed mice

  2024cites this paper
• NMDAR-mediated activation of pannexin1 channels contributes to the detonator properties of hippocampal mossy fiber synapses

  2024cites this paper
• Targeting Pannexin-1 Channels: Addressing the ‘Gap’ in Chronic Pain

  2024cites this paper
• The Pannexin-1 N-terminal Helix Gates a Switch between Ion Conductance and Anandamide Transport

  2024cites this paper
• Modulation of the allosteric and vasoregulatory arms of erythrocytic oxygen transport

  2024cites this paper
• ATP and Formyl Peptides Facilitate Chemoattractant Leukotriene-B4 Synthesis and Drive Calcium Fluxes, Which May Contribute to Neutrophil Swarming at Sites of Cell Damage and Pathogens Invasion

  2024cites this paper
• Counteracting TGM2 by a Fibroin peptide ameliorated Adriamycin-induced nephropathy via regulation of lipid metabolism through PANX1-PPAR α/PANK1 pathway.

  2024cites this paper
• Pannexins in the musculoskeletal system: new targets for development and disease progression

  2024cites this paper
• Neuronal Panx1 drives peripheral sensitization in experimental plantar inflammatory pain

  2024cites this paper
• Pharmacology of pannexin channels.

  2023cites this paper
• Meningeal P2X7 signaling mediates migraine-related intracranial mechanical hypersensitivity

  2023cites this paper
• Vascular Endothelial Barrier Protection Prevents Atrial Fibrillation by Preserving Cardiac Nanostructure

  2023cites this paper
• Structure-Based Design and Synthesis of Stapled 10Panx1 Analogues for Use in Cardiovascular Inflammatory Diseases

  2023cites this paper
• Pannexin1: insight into inflammatory conditions and its potential involvement in multiple organ dysfunction syndrome

  2023cites this paper
• Structural and functional analysis of human pannexin 2 channel

  2023cites this paper
• Probenecid affects muscle Ca2+ homeostasis and contraction independently from pannexin channel block

  2023cites this paper
• Exercise Training Lowers Arterial Blood Pressure Independently of Pannexin 1 in Men with Essential Hypertension

  2022cites this paper
• The homolog of human ecto-nucleoside triphosphate diphosphohydrolase MIG-23 is involved in sperm migration by modulating extracellular ATP levels in Ascaris suum.

  2022cites this paper
• Structure-based discovery and in vitro validation of inhibitors of chloride intracellular channel 4 protein

  2022cites this paper
• Hypertensive Nephropathy: Unveiling the Possible Involvement of Hemichannels and Pannexons

  2022cites this paper
• Mechanosensitive piezo1 calcium channel activates connexin 43 hemichannels through PI3K signaling pathway in bone

  2022cites this paper
• Pannexin1 channels—a potential therapeutic target in inflammation

  2022influential citation
• SARS-CoV-2 E and 3a Proteins Are Inducers of Pannexin Currents

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• The Role of Neuro-Immune Interactions in Chronic Pain: Implications for Clinical Practice

  2022cites this paper
• Direct cell extraction of membrane proteins for structure–function analysis

  2022cites this paper
• Peripheral mechanisms of chronic pain

  2022cites this paper
• Pannexin1 channels regulate mechanically stimulated but not spontaneous adenosine release

  2022cites this paper
• Neural versus alternative integrative systems: molecular insights into origins of neurotransmitters

  2021cites this paper
• iPSC-Derived Trabecular Meshwork Cells Stimulate Endogenous TM Cell Division Through Gap Junction in a Mouse Model of Glaucoma

  2021cites this paper
• Design and synthesis of the first indole-based blockers of Panx-1 channel.

  2021cites this paper
• Protective effect of genetic deletion of pannexinl in experimental mouse models of acute and chronic liver disease

  2021cites this paper
• Anti-parasitics drugs that modulates non-selective channels formed by connexins or pannexins.

  2021cites this paper
• Panx1 channels promote both anti- and pro-seizure-like activities in the zebrafish via p2rx7 receptors and ATP signaling

  2021cites this paper
• Pannexins and Connexins: Their Relevance for Oocyte Developmental Competence

  2021cites this paper
• Extracellular vesicles regulate purinergic signaling and epithelial sodium channel expression in renal collecting duct cells

  2021cites this paper
• Purinergic signaling in nervous system health and disease: Focus on pannexin 1.

  2021cites this paper
• Inhibition of astrocyte hemichannel improves recovery from spinal cord injury

  2021cites this paper
• Capillaries communicate with the arteriolar microvascular network by a pannexin/purinergic dependent pathway in hamster skeletal muscle.

  2021cites this paper
• Impact of Spinal Cord Injury

  2020cites this paper
• PANNEXIN 1 CHANNELS AS A THERAPEUTIC TARGET: STRUCTURE, INHIBITION, AND OUTLOOK.

  2020influential citation
• Adaptive thermogenesis in brown adipose tissue involves activation of pannexin-1 channels

  2020cites this paper
• ATP-mediated Increase in H+ Flux from Retinal Müller Cells: a Role for Na+/H+ Exchange.

  2020cites this paper
• Spinal neuron-glia-immune interaction in cross-organ sensitization.

  2020cites this paper
• Organ-on-chip model shows that ATP release through connexin hemichannels drives spontaneous Ca2+ signaling in non-sensory cells of the greater epithelial ridge in the developing cochlea.

  2020cites this paper
• Emerging importance of satellite glia in nervous system function and dysfunction

  2020cites this paper
• Role of an Aromatic–Aromatic Interaction in the Assembly and Trafficking of the Zebrafish Panx1a Membrane Channel

  2020cites this paper
• Pannexin-1 in the CNS: emerging concepts in health and disease.

  2020cites this paper
• Glial connexins and pannexins in the healthy and diseased brain.

  2020cites this paper
• A "noisy" electrical stimulation protocol favors muscle regeneration in vitro through release of endogenous ATP.

  2019cites this paper
• Inhibition of Pannexin 1 Reduces the Tumorigenic Properties of Human Melanoma Cells

  2019cites this paper
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• The Role of Purinergic Signaling in the Pathophysiology of Perinatal Hypoxic-Ischemic Encephalopathy

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• On the effects of Streptococcal NAD+-glycohydrolase and Streptolysin O on macrophages

  2019cites this paper
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  2018cites this paper
• Pannexin1: a multifunction and multiconductance and/or permeability membrane channel.

  2018cites this paper
• ATP Release Channels

  2018cites this paper
• Search for characteristics of the enigmatic retinal relaxing factor

  2018cites this paper
• Interactions of Pannexin1 channels with purinergic and NMDA receptor channels.

  2018cites this paper
• Angiotensin II-Induced Mesangial Cell Damage Is Preceded by Cell Membrane Permeabilization Due to Upregulation of Non-Selective Channels

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  2018cites this paper
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  2018cites this paper
• Human erythrocytes release ATP by a novel pathway involving VDAC oligomerization independent of pannexin-1

  2018cites this paper
• Reversal of loss of bone mass in old mice treated with mefloquine.

  2018cites this paper
• Protective effect of genetic deletion of pannexin1 in experimental mouse models of acute and chronic liver disease.

  2018cites this paper
• Mechanisms of pannexin1 channel gating and regulation.

  2018cites this paper
• A Potential Compensatory Role of Panx3 in the VNO of a Panx1 Knock Out Mouse Model

  2018cites this paper
• Calcium Homeostasis Modulator 1-Like Currents in Rat Fungiform Taste Cells Expressing Amiloride-Sensitive Sodium Currents

  2017cites this paper
• Inhibition of Pannexin 1 reduces tumorigenic properties of human melanoma

  2017cites this paper
• Exciting and not so exciting roles of pannexins.

  2017cites this paper
• Purinergic signalling links mechanical breath profile and alveolar mechanics with the pro-inflammatory innate immune response causing ventilation-induced lung injury

  2017cites this paper
• Involvement of Gap Junction Proteins in Infectious Diseases Caused by Parasites

  2017influential citation
• P2X7 Receptor Primes IL-1β and the NLRP3 Inflammasome in Astrocytes Subjected to Mechanical Strain

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• Pannexin- and Connexin-Mediated Intercellular Communication in Platelet Function

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• ATP release during cell swelling activates a Ca2+-dependent Cl− current by autocrine mechanism in mouse hippocampal microglia

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• Differential distribution of probenecid as detected by on-tissue mass spectrometry

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• Emerging concepts regarding pannexin 1 in the vasculature.

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