Lysine-targeting specificity in ubiquitin and ubiquitin-like modification pathways

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Nature Structural &Molecular Biology

• Publication date

  2014-04-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1038/nsmb.2792PMID 24699079
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• RBR E3‐ligases at work

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  2013cited by this paper
• Structure of Parkin Reveals Mechanisms for Ubiquitin Ligase Activation

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• Structure of a ubiquitin-loaded HECT ligase reveals the molecular basis for catalytic priming

  2013cited by this paper
• The Ubiquitin-conjugating Enzyme (E2) Ube2w Ubiquitinates the N Terminus of Substrates*

  2013cited by this paper
• Regulation of NF-κB by ubiquitination.

  2013cited by this paper
• Structure of the human Parkin ligase domain in an autoinhibited state

  2013cited by this paper
• OTU Deubiquitinases Reveal Mechanisms of Linkage Specificity and Enable Ubiquitin Chain Restriction Analysis

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• Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization

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• 53BP1 is a reader of the DNA damage-induced H2A Lys15 ubiquitin mark

  2013cited by this paper
• Target Specificity of the E3 Ligase LUBAC for Ubiquitin and NEMO Relies on Different Minimal Requirements

  2013cited by this paper
• TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexes

  2013cited by this paper
• Structural basis for ligase-specific conjugation of linear ubiquitin chains by HOIP

  2013cited by this paper
• Structure of the HHARI Catalytic Domain Shows Glimpses of a HECT E3 Ligase

  2013cited by this paper
• Ubiquitination site preferences in anaphase promoting complex/cyclosome (APC/C) substrates

  2013cited by this paper
• Essentiality of a non-RING element in priming donor ubiquitin for catalysis by a monomeric E3

  2013cited by this paper
• Mechanism of ubiquitin ligation and lysine prioritization by a HECT E3

  2013cited by this paper
• OTULIN Antagonizes LUBAC Signaling by Specifically Hydrolyzing Met1-Linked Polyubiquitin

  2013cited by this paper
• Ube2W conjugates ubiquitin to α-amino groups of protein N-termini

  2013cited by this paper
• Ubiquitin - omics reveals novel networks and associations with human disease.

  2013cited by this paper
• Recognition of SUMO-modified PCNA requires tandem receptor motifs in Srs2

  2012cited by this paper
• The RanBP2/RanGAP1*SUMO1/Ubc9 complex is a multisubunit SUMO E3 ligase.

  2012cited by this paper
• Inhibition of homologous recombination by the PCNA-interacting protein PARI.

  2012cited by this paper
• Following Ariadne's thread: a new perspective on RBR ubiquitin ligases

  2012cited by this paper
• Protein group modification and synergy in the SUMO pathway as exemplified in DNA repair.

  2012cited by this paper
• The E3 ligase HOIP specifies linear ubiquitin chain assembly through its RING-IBR-RING domain and the unique LDD extension

  2012cited by this paper
• Function and regulation of SUMO proteases

  2012cited by this paper
• The HARP-like domain-containing protein AH2/ZRANB3 binds to PCNA and participates in cellular response to replication stress.

  2012cited by this paper
• More Than a Protease

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• BIRC7–E2 ubiquitin conjugate structure reveals the mechanism of ubiquitin transfer by a RING dimer

  2012cited by this paper
• Structure of a RING E3 ligase and ubiquitin-loaded E2 primed for catalysis

  2012cited by this paper
• Polyubiquitinated PCNA recruits the ZRANB3 translocase to maintain genomic integrity after replication stress.

  2012cited by this paper
• Ubiquitin‐specific protease‐like 1 (USPL1) is a SUMO isopeptidase with essential, non‐catalytic functions

  2012cited by this paper
• Structure of an E3:E2~Ub complex reveals an allosteric mechanism shared among RING/U-box ligases.

  2012cited by this paper
• RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA damage signaling.

  2012cited by this paper
• LUBAC synthesizes linear ubiquitin chains via a thioester intermediate

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• Intrinsic Flexibility of Ubiquitin on Proliferating Cell Nuclear Antigen (PCNA) in Translesion Synthesis

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• A novel ubiquitin mark at the N-terminal tail of histone H2As targeted by RNF168 ubiquitin ligase

  2012cited by this paper
• The ubiquitin code.

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• ZRANB3 is a structure-specific ATP-dependent endonuclease involved in replication stress response.

  2012cited by this paper
• A Novel SUMO1-specific Interacting Motif in Dipeptidyl Peptidase 9 (DPP9) That Is Important for Enzymatic Regulation*

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• The mechanism of linkage-specific ubiquitin chain elongation by a single-subunit E2.

  2011cited by this paper
• Comparative Proteomic Analysis Identifies a Role for SUMO in Protein Quality Control

  2011cited by this paper
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• RNF20–RNF40: A ubiquitin‐driven link between gene expression and the DNA damage response

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• The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activation.

  2011cited by this paper
• Constructing and decoding unconventional ubiquitin chains

  2011cited by this paper
• A Proteome-wide, Quantitative Survey of In Vivo Ubiquitylation Sites Reveals Widespread Regulatory Roles*

  2011cited by this paper
• Structural regulation of cullin-RING ubiquitin ligase complexes.

  2011cited by this paper
• Ubiquitylation and the Fanconi anemia pathway

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• The Molecular Basis of Crl4(Ddb2/Csa) Ubiquitin Ligase Architecture, Targeting, and Activation.

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• E3 ligase Rad18 promotes monoubiquitination rather than ubiquitin chain formation by E2 enzyme Rad6

  2011cited by this paper
• The differential modulation of USP activity by internal regulatory domains, interactors and eight ubiquitin chain types.

  2011cited by this paper
• The multiple levels of regulation by p53 ubiquitination

  2010cited by this paper
• Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne

  2010cited by this paper
• FAN1 Acts with FANCI-FANCD2 to Promote DNA Interstrand Cross-Link Repair

  2010cited by this paper
• Deficiency of FANCD2-associated nuclease KIAA1018/FAN1 sensitizes cells to interstrand crosslinking agents.

  2010cited by this paper
• A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair.

  2010cited by this paper
• A dual E3 mechanism for Rub1 ligation to Cdc53.

  2010cited by this paper
• Mass Spectrometric Analysis of Lysine Ubiquitylation Reveals Promiscuity at Site Level*

  2010cited by this paper
• Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2.

  2010cited by this paper
• The structure of FANCL, the catalytic subunit of the Fanconi Anemia core complex

  2010cited by this paper
• Transcriptional activation of polycomb-repressed genes by ZRF1

  2010cited by this paper
• Global analysis of lysine ubiquitination by ubiquitin remnant immunoaffinity profiling

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• Molecular Basis for Lysine Specificity in the Yeast Ubiquitin-Conjugating Enzyme Cdc34

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• K63‐specific deubiquitination by two JAMM/MPN+ complexes: BRISC‐associated Brcc36 and proteasomal Poh1

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• Ubiquitin-binding domains — from structures to functions

  2009cited by this paper
• Origin and function of ubiquitin-like proteins

  2009cited by this paper
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• Structure of the Siz/PIAS SUMO E3 ligase Siz1 and determinants required for SUMO modification of PCNA.

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• FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination.

  2009cited by this paper
• RING domain E3 ubiquitin ligases.

  2009cited by this paper
• Linkage-specific avidity defines the lysine 63-linked polyubiquitin-binding preference of rap80.

  2009cited by this paper
• Identification of a physiological E2 module for the human anaphase-promoting complex

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• Polyubiquitination by HECT E3s and the Determinants of Chain Type Specificity

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• Dcn1 functions as a scaffold-type E3 ligase for cullin neddylation.

  2008cited by this paper
• The COP9 signalosome: more than a protease.

  2008cited by this paper
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  2008cited by this paper
• FANCI is a second monoubiquitinated member of the Fanconi anemia pathway

  2007cited by this paper
• Suprafacial orientation of the SCFCdc4 dimer accommodates multiple geometries for substrate ubiquitination.

  2007cited by this paper
• Identification of the Fanconi Anemia Complementation Group I Gene, FANCI

  2007cited by this paper
• Targeting of Sna3p to the Endosomal Pathway Depends on Its Interaction with Rsp5p and Multivesicular Body Sorting on Its Ubiquitylation

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• A/T mutagenesis in hypermutated immunoglobulin genes strongly depends on PCNAK164 modification

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• PCNA, the maestro of the replication fork.

  2007cited by this paper
• Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair.

  2007cited by this paper
• Multiple domains in Siz SUMO ligases contribute to substrate selectivity

  2006cited by this paper
• Determinants of the Ubiquitin-mediated Degradation of the Met4 Transcription Factor*

  2006cited by this paper
• Structure and E3‐ligase activity of the Ring–Ring complex of Polycomb proteins Bmi1 and Ring1b

  2006cited by this paper
• A ubiquitin-interacting motif protects polyubiquitinated Met4 from degradation by the 26S proteasome

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• A recurrent phospho-sumoyl switch in transcriptional repression and beyond.

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• Mms2–Ubc13 covalently bound to ubiquitin reveals the structural basis of linkage-specific polyubiquitin chain formation

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• Specification of SUMO1- and SUMO2-interacting Motifs*

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• PDSM, a motif for phosphorylation-dependent SUMO modification.

  2006cited by this paper
• Crosstalk between SUMO and ubiquitin on PCNA is mediated by recruitment of the helicase Srs2p.

  2005cited by this paper

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