A role for guanylate cyclase C in acid-stimulated duodenal mucosal bicarbonate secretion.

No abstract is available for this paper.

• Publication year

  2004

• Venue

  American Journal of Physiology - Gastrointestinal and Liver Physiology

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1152/AJPGI.00087.2003PMID 12881226
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Angiotensin II Stimulation of Renal Epithelial Cell Na/HCO3 Cotransport Activity: A Central Role for Src Family Kinase/Classic MAPK Pathway Coupling

  2002cited by this paper
• ERK mediates inhibition of Na(+)/H(+) exchange and HCO(3)(-) absorption by nerve growth factor in MTAL.

  2002cited by this paper
• A Novel PDZ Protein Regulates the Activity of Guanylyl Cyclase C, the Heat-stable Enterotoxin Receptor*

  2002cited by this paper
• Protein Kinase G Activates the JNK1 Pathway via Phosphorylation of MEKK1*

  2001cited by this paper
• Effect of E. coli heat-stable enterotoxin on colonic transport in guanylyl cyclase C receptor-deficient mice.

  2001influential reference
• Evidence of calcium influx across the plasma membrane depends upon the initial rise of cytosolic calcium with activation of IP(3) in rat enterocytes by heat-stable enterotoxin of Vibrio cholerae non-O1.

  2001cited by this paper
• Identification of transport abnormalities in duodenal mucosa and duodenal enterocytes from patients with cystic fibrosis.

  2000cited by this paper
• Cyclic GMP mediates apoptosis induced by sulindac derivatives via activation of c-Jun NH2-terminal kinase 1.

  2000cited by this paper
• Protein Kinase-mediated Regulation of the Na+/H+ Exchanger in the Rat Myocardium by Mitogen-activated Protein Kinase-dependent Pathways*

  1999cited by this paper
• Guanylin regulatory peptides: structures, biological activities mediated by cyclic GMP and pathobiology.

  1999cited by this paper
• An Apical PDZ Protein Anchors the Cystic Fibrosis Transmembrane Conductance Regulator to the Cytoskeleton*

  1998cited by this paper
• Guanylin mRNA expression in human intestine and colorectal adenocarcinoma.

  1998cited by this paper
• Regulation of intestinal Cl- and[Formula: see text] secretion by uroguanylin.

  1998cited by this paper
• Carbachol stimulates transactivation of epidermal growth factor receptor and mitogen-activated protein kinase in T84 cells. Implications for carbachol-stimulated chloride secretion.

  1998influential reference
• Regulation of intestinal Cl 2 and HCO 3 2 secretion by uroguanylin

  1998cited by this paper
• Coexpression of inducible NO synthase and soluble guanylyl cyclase in colonic enterocytes: a pathophysiologic signaling pathway for the initiation of diarrhea by gram‐negative bacteria?

  1998cited by this paper
• Acid-induced duodenal mucosal nitric oxide output parallels bicarbonate secretion in the anaesthetized pig.

  1998cited by this paper
• Signaling pathways for guanylin and uroguanylin in the digestive, renal, central nervous, reproductive, and lymphoid systems.

  1997cited by this paper
• Acid-stimulated duodenal bicarbonate secretion involves a CFTR-mediated transport pathway in mice.

  1997influential reference
• A functional CFTR protein is required for mouse intestinal cAMP‐, cGMP‐ and Ca2+‐dependent HCO3− secretion

  1997influential reference
• Mice lacking the guanylyl cyclase C receptor are resistant to STa-induced intestinal secretion.

  1997cited by this paper
• Acid-induced increase in duodenal mucosal alkaline secretion in the rat involves the L-arginine/NO pathway.

  1997cited by this paper
• Guanylin strongly stimulates rat duodenal HCO3- secretion: proposed mechanism and comparison with other secretagogues.

  1996cited by this paper
• Cruising the villus-to-crypt axis: the role of cyclic 3',5'-guanosine monophosphate in duodenal bicarbonate secretion.

  1996cited by this paper
• Intestinal Secretory Defects and Dwarfism in Mice Lacking cGMP-Dependent Protein Kinase II

  1996cited by this paper
• The guanylin/STa receptor is expressed in crypts and apical epithelium throughout the mouse intestine.

  1996cited by this paper
• Textbook of Gastroenterology

  1995cited by this paper
• Immunohistochemical localization of guanylin in the rat small intestine and colon.

  1995cited by this paper
• Endogenous expression of type II cGMP-dependent protein kinase mRNA and protein in rat intestine. Implications for cystic fibrosis transmembrane conductance regulator.

  1995cited by this paper
• Evidence for stimulation of the inositol triphosphate-Ca2+ signalling system in rat enterocytes by heat stable enterotoxin of Escherichia coli.

  1995cited by this paper
• Review article: gastroduodenal bicarbonate secretion

  1994cited by this paper
• Effect of cyclic GMP on intestinal transport.

  1994influential reference
• Distribution of heat-stable enterotoxin/guanylin receptors in the intestinal tract of man and other mammals.

  1994cited by this paper
• Proximal duodenal enterocyte transport: evidence for Na(+)-H+ and Cl(-)-HCO3- exchange and NaHCO3 cotransport.

  1993cited by this paper
• Gastroduodenal mucosal protection.

  1993cited by this paper
• Atriopeptins and Escherichia coli enterotoxin STa have different sites of action in mammalian intestine.

  1992cited by this paper
• Cholinergic regulation of human proximal duodenal mucosal bicarbonate secretion.

  1991cited by this paper
• Guanylyl cyclase is a heat-stable enterotoxin receptor.

  1990cited by this paper
• Proximal duodenal prostaglandin E2 release and mucosal bicarbonate secretion are altered in patients with duodenal ulcer.

  1990cited by this paper
• Stimulation of duodenal mucosal bicarbonate secretion in the rat by brain peptides.

  1989cited by this paper
• Mechanism of action of Escherichia coli heat stable enterotoxin in a human colonic cell line.

  1988cited by this paper

• Congenital diarrhea and enteropathies caused by a heterozygous mutation in the GUCY2C gene: a rare case report

  2026cites this paper
• DRA involvement in linaclotide-stimulated bicarbonate secretion during loss of CFTR function

  2024cites this paper
• Key role of down-regulated in adenoma (SLC26A3) chloride/bicarbonate exchanger in linaclotide-stimulated intestinal bicarbonate secretion upon loss of CFTR function

  2023cites this paper
• Guanylin and uroguanylin mRNA expression is increased following Roux‐en‐Y gastric bypass, but guanylins do not play a significant role in body weight regulation and glycemic control

  2018cites this paper
• Cystic fibrosis defects in intestinal bile acid and guanylin signaling : Signaal transductie door galzouten en guanylines in cystic fibrosis darmepitheel

  2017influential citation
• Plecanatide-mediated activation of guanylate cyclase-C suppresses inflammation-induced colorectal carcinogenesis in Apc+/Min-FCCC mice

  2017cites this paper
• Guanylin and uroguanylin are produced by mouse intestinal epithelial cells of columnar and secretory lineage

  2016cites this paper
• The rat kidney contains high levels of prouroguanylin (the uroguanylin precursor) but does not express GC-C (the enteric uroguanylin receptor).

  2011cites this paper
• Polar Effects on Ion Transport and Cell Proliferation Induced by GC-C Ligands in Intestinal Epithelial Cells

  2011cites this paper
• Linaclotide is a potent and selective guanylate cyclase C agonist that elicits pharmacological effects locally in the gastrointestinal tract.

  2010cites this paper
• Linaclotide, through activation of guanylate cyclase C, acts locally in the gastrointestinal tract to elicit enhanced intestinal secretion and transit.

  2010cites this paper
• Defining a role for the cystic fibrosis transmembrane conductance regulator in the heart

  2010cites this paper
• Effects of orexins, guanylins and feeding on duodenal bicarbonate secretion and enterocyte intracellular signaling.

  2008cites this paper
• Heat‐stable enterotoxin of Escherichia coli (STa) can stimulate duodenal HCO3− secretion via a novel GC‐C‐ and CFTR‐independent pathway

  2008cites this paper
• Phosphodiesterase Isozymes Involved in Regulation of \batchmode \documentclass[fleqn,10pt,legalpaper]{article} \usepackage{amssymb} \usepackage{amsfonts} \usepackage{amsmath} \pagestyle{empty} \begin{document} \(\mathrm{HCO}_{3}^{-}\) \end{document} Secretion in Isolated Mouse Stomach in Vitro

  2008cites this paper
• Phosphodiesterase Isozymes Involved in Regulation of HCO 3 Secretion in Isolated Mouse Stomach in Vitro

  2008cites this paper
• Duodenal bicarbonate secretion in rats: stimulation by intra‐arterial and luminal guanylin and uroguanylin

  2007cites this paper
• Regulation of Ion Transport in Eel Intestine by the Homologous Guanylin Family of Peptides

  2007cites this paper
• Guanylyl cyclase receptor C

  2006cites this paper
• Gastroduodenal mucus bicarbonate barrier: protection against acid and pepsin.

  2005cites this paper
• Lack of guanylyl cyclase C, the receptor for Escherichia coli heat‐stable enterotoxin, results in reduced polyp formation and increased apoptosis in the multiple intestinal neoplasia (Min) mouse model

  2005cites this paper
• Heat-stable enterotoxin of Escherichia coli stimulates a non-CFTR-mediated duodenal bicarbonate secretory pathway.

  2005cites this paper
• Epithelial cells and their neighbors. II. New perspectives on efferent signaling between brain, neuroendocrine cells, and gut epithelial cells.

  2005cites this paper