Identification of transport abnormalities in duodenal mucosa and duodenal enterocytes from patients with cystic fibrosis.

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Gastroenterology

• Publication date

  2000-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S0016-5085(00)70358-1PMID 10833480
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1998cited by this paper
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  1997cited by this paper
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  1997cited by this paper
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  1997cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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  1994cited by this paper
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  1994cited by this paper
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  1994cited by this paper
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  1994cited by this paper
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  1994cited by this paper
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  1994cited by this paper
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  1993cited by this paper
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  1993cited by this paper
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  1992cited by this paper
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  1992cited by this paper
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  1992cited by this paper
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  1991cited by this paper
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  1991cited by this paper
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  1991cited by this paper
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  1990cited by this paper
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  1990cited by this paper
• Intracellular pH dependence of buffer capacity and anion exchange in the parietal cell.

  1989cited by this paper
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  1988cited by this paper
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  1988cited by this paper
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  1988cited by this paper
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  1987cited by this paper
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  1987cited by this paper

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  2024cites this paper
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  2023cites this paper
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  2023cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2017cites this paper
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  2017cites this paper
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  2015cites this paper
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  2014cites this paper
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  2014cites this paper
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  2002cites this paper
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  2002cites this paper
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  2001cites this paper
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