Aromatase, 17 beta-hydroxysteroid dehydrogenase and intratissular sex hormone concentrations in cancerous and normal glandular breast tissue in postmenopausal women.

No abstract is available for this paper.

• Publication year

  1986

• Venue

  European Journal of Cancer and Clinical Oncology

• Publication date

  1986-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/0277-5379(86)90121-5PMID 3015631
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Endogenous concentration and subcellular distribution of androgens in normal and malignant human breast tissue.

  1985cited by this paper
• Endogenous concentration and subcellular distribution of estrogens in normal and malignant human breast tissue.

  1985cited by this paper
• Effects of aging and obesity on aromatase activity of human adipose cells.

  1985cited by this paper
• [Evaluation of 17-beta-hydroxysteroid dehydrogenase activity as a marker of the hormone dependence of breast cancers].

  1985cited by this paper
• Differential permeability of uterine and liver vascular beds to estrogens and estrogen conjugates.

  1984cited by this paper
• Androgens regulate brain aromatase activity in adult male rats through a receptor mechanism.

  1984cited by this paper
• Do hormones cause breast cancer?

  1984cited by this paper
• In situ estrogen production via the estrone sulfatase pathway in breast tumors: relative importance versus the aromatase pathway.

  1984cited by this paper
• Tracer kinetic model of blood-brain barrier transport of plasma protein-bound ligands. Empiric testing of the free hormone hypothesis.

  1984cited by this paper
• 17β-Hydroxysteroid Dehydrogenase Activity in Human Breast Epithelial Cell and Fibroblast Cultures

  1984cited by this paper
• The endogenous concentration of estradiol and estrone in normal human postmenopausal endometrium.

  1984cited by this paper
• Adrenal androgen concentrations in breast tumours and in normal breast tissue. The relationship to oestradiol metabolism.

  1984cited by this paper
• Biological significance of aromatase activity in human breast tumors.

  1983cited by this paper
• THE RELATIONSHIP BETWEEN 17β‐HYDROXYSTEROID DEHYDROGENASE ACTIVITY AND OESTROGEN CONCENTRATIONS IN HUMAN BREAST TUMOURS AND IN NORMAL BREAST TISSUE

  1983cited by this paper
• Androgen and precursor levels in serum and testes of adult rats under basal conditions and after hCG stimulation.

  1983cited by this paper
• Estradiol and progesterone receptor levels in human breast cancer in relation to cytosol and plasma estrogen level.

  1983cited by this paper
• Plasma levels of estrone, estrone sulfate, and estradiol and the percentage of unbound estradiol in postmenopausal women with and without breast disease.

  1983cited by this paper
• Inhibition of 17 beta-hydroxysteroid dehydrogenase activity in human endometrium by adrenal androgens.

  1983cited by this paper
• In vivo uptake and subcellular distribution of tritium-labeled estrogens in human endometrium, myometrium, and vagina.

  1983cited by this paper
• Estradiol 17 beta-hydroxysteroid dehydrogenase activity in human breast fibroadenomas.

  1982cited by this paper
• A reassessment of the role of breast tumor aromatization.

  1982cited by this paper
• Studies on the activity of 17 beta-hydroxysteroid dehydrogenase in human adipose tissue.

  1982cited by this paper
• Significance of aromatase activity in human breast cancer.

  1982cited by this paper
• [Steroid hormone content of the breast tissue in breast tumors].

  1982cited by this paper
• Maternal stress decreases steroid aromatase activity in brains of male and female rat fetuses.

  1982cited by this paper
• A reassessment of the role of breast tumor aromatization.

  1982cited by this paper
• Plasma concentration gradient of steroid hormones across human mammary tumours in vivo.

  1981cited by this paper
• Comparison of levels of cytosol estrogen receptors with "arterial" and "venous" concentrations of gonadic steroids in mammary tumors.

  1981cited by this paper
• Aromatization of testosterone and oestrogen receptor levels in human breast cancer.

  1981cited by this paper
• Endogenous oestradiol-17beta concentration in breast tumours determined by mass fragmentography and by radioimmunoassay: relationship to receptor content.

  1981cited by this paper
• Changes in plasma concentrations of oestrogens and progesterone in women during anaesthesia and gynaecological operations.

  1981cited by this paper
• In vivo uptake of estrone sulfate by rabbit uterus.

  1980cited by this paper
• Serum androgens and estrogens in postmenopausal women with and without endometrial cancer.

  1980cited by this paper
• Effects of plasma estrogen sulfates in mammary cancer cells.

  1980cited by this paper
• Oestrogen receptors and metabolism of oestrone sulphate in human mammary carcinoma.

  1980cited by this paper
• Sex Hormone Binding Globulin as a Reliable Indicator of Hormone Dependence in Human Breast Cancer

  1979cited by this paper
• Estradiol 17β-dehydrogenase and estradiol binding in human mammary tumors

  1979cited by this paper
• Estradiol formation from testosterone by continuously cultured human breast cancer cells.

  1979cited by this paper
• Aromatization of androgens by human breast cancer.

  1979cited by this paper
• Estradiol 17 beta-dehydrogenase and estradiol binding in human mammary tumors.

  1979cited by this paper
• Sex hormone-binding globulin and recurrence after mastectomy.

  1979cited by this paper
• Factors affecting sex hormone levels in postmenopausal women.

  1979cited by this paper
• Factors affecting testosterone metabolism by human breast tissues.

  1978cited by this paper
• Estrogen synthesis and estradiol binding by human mammary tumors.

  1978cited by this paper
• Sex hormone-binding globulin and estrogen receptor in breast cancer: technique and preliminary clinical results.

  1978cited by this paper
• Oestradiol levels in fractions of human breast tumours [proceedings].

  1978cited by this paper
• Failure of breast cancer cells in long-term culture to aromatize androstenedione.

  1978cited by this paper
• Comparison of the in vitro conversion of estradiol-17 beta to estrone of normal and neoplastic human breast tissue.

  1977cited by this paper
• ESTRADIOL RECEPTOR AND 17β‐DEHYDROGENASE IN NORMAL AND ABNORMAL HUMAN ENDOMETRIUM *

  1977cited by this paper
• Estrone and estradiol content in human breast tumors: relationship to estradiol receptors.

  1977cited by this paper
• Radioimmunoassay of 17beta-hydroxy-5alpha-androstan-3-one, 4-androstene-3,17-dione, dehydroepiandrosterone, 17-hydroxyprogesterone and progesterone and its application to the human male plasma.

  1976cited by this paper
• Biogenesis of steroid hormones by human mammary gland in vivo and in vitro.

  1976cited by this paper
• Radioimmunoassay of 17β-hydroxy-5α-androstan-3-one, 4-androstene-3,17-dione, dehydroepiandrosterone, 17-hydroxyprogesterone and progesterone and its application to human male plasma

  1976cited by this paper
• Metabolism of dehydroepiandrosterone by hormone dependent and hormone independent human breast carcinoma.

  1975cited by this paper
• Determination of hormonal steroid concentrations in biological extracts by high resolution mass fragmentography.

  1975cited by this paper
• Estrogen-induced uterine responses and growth: relationship to receptor estrogen binding by uterine nuclei.

  1975cited by this paper
• Letter: Blood, plasma, or serum?

  1975cited by this paper
• Utilization of oxygen and reduced nicotinamide adenine dinucleotide phosphate by human placental microsomes during aromatization of androstenedione.

  1974cited by this paper
• Oestradiol synthesis by a human breast carcinoma.

  1974cited by this paper
• ŒSTRADIOL SYNTHESIS BY A HUMAN BREAST CARCINOMA

  1974cited by this paper
• Estimation of oestrone sulphate, oestradiol-17beta and oestrone in peripheral plasma: concentrations during the menstrual cycle and in men.

  1974cited by this paper
• Utilization of oxygen and reduced nicotinamide adenine dinucleotide phosphate by human placental microsomes during aromatization of androstenedione.

  1974cited by this paper
• Comparison of quick methods of the estimation of estradiol in plasma by radioimmunoassay.

  1974cited by this paper
• Estrone interaction with the rat uterus: in vitro response and nuclear uptake.

  1973cited by this paper
• Letter: The new N.H.S. consultant contract.

  1973cited by this paper
• DETERMINATION OF ANDROGENS IN PLASMA

  1973cited by this paper
• The apparent free testosterone concentration, an index of androgenicity.

  1971cited by this paper
• Metabolism and tissue uptake of estrogen in women with advanced carcinoma of the breast.

  1969cited by this paper
• STUDIES WITH TRITIUM-LABELLED HEXŒSTROL IN ADVANCED BREAST CANCER

  1961cited by this paper
• Studies with tritium-labelled hexoestrol in advanced breast cancer. Comparison of tissue accumulation of hexoestrol with response to bilateral adrenalectomy and oophorectomy.

  1961cited by this paper
• Hydrolysis of ketosteroid hydrogen sulfates by solvolysis procedures.

  1958cited by this paper
• The Determination of Enzyme Dissociation Constants

  1934cited by this paper

• 17β-Estradiol Does Not Designate Non-Sex-Specific Early Ventricular Arrhythmia in Acute Myocardial Infarction, in Contrast to C-Reactive Protein

  2026cites this paper
• Dehydroepiandrosterone impact on smooth muscle contractile activity by a nongenomic action.

  2025cites this paper
• Oestrogen changes at menopause: insights into obesity-associated breast risk and outcomes

  2025cites this paper
• Plasma Aromatase Activity Index, Gonadotropins and Estrone Are Associated with Frailty Syndrome in Post-Menopausal Women with Breast Cancer

  2022cites this paper
• Effect of estradiol as a continuous variable on breast cancer survival by menopausal status: a cohort study in China

  2021cites this paper
• Endocrine, paracrine and intracrine mechanisms of growth regulation in normal and malignant breast epithelium

  2020cites this paper
• Low-dose environmental endocrine disruptors, increase aromatase activity, estradiol biosynthesis and cell proliferation in human breast cells.

  2019cites this paper
• Pre-diagnostic sex hormone levels and survival among breast cancer patients

  2019cites this paper
• Therapeutic potential of omega fatty acids in breast cancer. Review

  2019cites this paper
• Androgen excess in breast cancer development: implications for prevention and treatment.

  2019cites this paper
• Breast Hormone Concentrations in Random Fine-Needle Aspirates of Healthy Women Associate with Cytological Atypia and Gene Methylation

  2018cites this paper
• Influence of age on radiomic features in 18F-FDG PET in normal breast tissue and in breast cancer tumors

  2018cites this paper
• The Emerging Roles of Steroid Hormone Receptors in Ductal Carcinoma in Situ (DCIS) of the Breast

  2018cites this paper
• SLCO1B1 polymorphisms and plasma estrone conjugates in postmenopausal women with ER+ breast cancer: genome-wide association studies of the estrone pathway

  2017cites this paper
• Clinical implications of estrone sulfate measurement in laboratory medicine

  2017cites this paper
• Improved detectability of sex steroids from frozen sections of breast cancer tissue using GC-triple quadrupole-MS.

  2017cites this paper
• Evaluation of Local CYP17A1 and CYP19A1 Expression Levels as Prognostic Factors in Postmenopausal Invasive Ductal Breast Cancer Cases

  2016cites this paper
• Dense breast tissue in postmenopausal women is associated with a pro-inflammatory microenvironment in vivo

  2016cites this paper
• Relationships of sex steroid hormone levels in benign and cancerous breast tissue and blood: A critical appraisal of current science.

  2015cites this paper
• The serum estradiol concentration is the main determinant of the estradiol concentration in normal breast tissue.

  2015cites this paper
• The unique transcriptional response produced by concurrent estrogen and progesterone treatment in breast cancer cells results in upregulation of growth factor pathways and switching from a Luminal A to a Basal-like subtype

  2015cites this paper
• Ineffective Inhibition of Aromatase: A Cause for AI Resistance?

  2015cites this paper
• Breast cancer treatment and sulfotransferase

  2015cites this paper
• Breast adipose tissue estrogen metabolism in postmenopausal women with or without breast cancer.

  2014cites this paper
• Breast Cancer Cells: Regulation of Expression by a Progestin -Hydroxysteroid Dehydrogenase Gene Expression in Human β 17

  2013cites this paper
• Progesterone – promoter or inhibitor of breast cancer

  2013cites this paper
• A comparison of the third-generation aromatase inhibitors and their effects on postmenopausal women with early hormone sensitive breast cancer

  2012cites this paper
• Role of androgen excess in the development of estrogen receptor-positive and estrogen receptor-negative breast cancer.

  2012cites this paper
• Androgen receptors and serum testosterone levels identify different subsets of postmenopausal breast cancers

  2012influential citation
• Estrogen Receptor Alpha Interacts with Mitochondrial Protein HADHB and Affects Beta-Oxidation Activity*

  2012cites this paper
• Estrogen Receptor Alpha Interacts with Mitochondrial Protein HADHB and Affects Beta-Oxidation Activity*□S

  2012cites this paper
• Hormonal enzymatic systems in normal and cancerous human breast: control, prognostic factors, and clinical applications

  2012cites this paper
• Mammographic breast density and subsequent risk of breast cancer in postmenopausal women according to tumor characteristics.

  2011cites this paper
• Recent data on intratumor estrogens in breast cancer.

  2011cites this paper
• Estrogen sulfotransferase (sult1e1) expression and function in mcf10a-series breast epithelial cells: role as a modifier of breast carcinogenesis and regulation by proliferation state

  2011influential citation
• Inhibition of Tumor Growth by Grape Seed Extract (GSE).

  2011cites this paper
• Sex steroid hormone levels in breast adipose tissue and serum in postmenopausal women

  2011cites this paper
• Estrogen-induced reactive oxygen species-mediated signalings contribute to breast cancer.

  2011cites this paper
• Exploring Breast Cancer Estrogen Disposition: The Basis for Endocrine Manipulation

  2011cites this paper
• Angiogenesis regulation in hormone dependent breast- and ovarian cancer

  2011cites this paper
• Estrogens in the breast tissue: a systematic review

  2011cites this paper
• 4-hydroxy estradiol-induced oxidant-mediated signaling is involved in the development of breast cancer

  2011cites this paper
• Nomegestrol acetate is an anti-aromatase agent in human MCF-7aro breast cancer cells

  2010cites this paper
• The potency and clinical efficacy of aromatase inhibitors across the breast cancer continuum

  2010cites this paper
• Growth factor activation of ErbB2/ErbB3 signaling pathways regulate the activity of Estrogen Receptors (ER)

  2010cites this paper
• Aromatase inhibition in male breast cancer patients: biological and clinical implications.

  2010cites this paper
• Aromatase inhibition in male breast cancer patients: Biological and clinical implications.

  2009cites this paper
• Plasma sex steroids and SHBG in patients with breast cancer and their relation to tumor oestrogen-dependency.

  2009cites this paper
• Phytochemicals for breast cancer prevention by targeting aromatase.

  2009cites this paper
• Design, chemical synthesis, and in vitro biological evaluation of simplified estradiol–adenosine hybrids as inhibitors of 17β-hydroxysteroid dehydrogenase type 1

  2009cites this paper
• Measurement of Sex Steroid Hormones in Breast Adipocytes: Methods and Implications

  2008cites this paper
• Development of a high sensitivity, nested Q-PCR assay for mouse and human aromatase

  2008cites this paper
• A significant proportion of elderly patients develop hormone-dependant "luminal-B" tumours associated with aggressive characteristics.

  2008cites this paper
• Clinical studies with anastrozole

  2008cites this paper
• The Enzymatic Systems in the Formation and Transformation of Estrogens in Normal and Cancerous Human Breast: Control and Potential Clinical Applications

  2008cites this paper
• Clinical importance of estrogen receptor-beta evaluation in breast cancer patients treated with adjuvant tamoxifen therapy.

  2008cites this paper
• Estrogen-induced breast oncogenesis: modulation by an Aurora kinase inhibitor.

  2008cites this paper
• Deciphering the Conundrum of Estrogen-driven Breast Cancer: Aurora Kinase Deregulation

  2008influential citation
• Aromatase inhibitors: assessment of biochemical efficacy measured by total body aromatase inhibition and tissue estrogen suppression.

  2008cites this paper
• Endogenous hormone levels and risk of breast, endometrial and ovarian cancers: prospective studies.

  2008cites this paper
• In vivo measurement of tumor estradiol and Vascular Endothelial Growth Factor in breast cancer patients

  2008cites this paper
• Inhibitors of 17beta-hydroxysteroid dehydrogenase type 1.

  2008cites this paper
• Étude des effets endocriniens produits par les organochlorés en lien avec la carcinogenèse mammaire

  2008cites this paper
• Effects of sex steroids and tamoxifen on matrix metalloproteinase activity and generation of endostatin in the breast

  2007cites this paper
• A new polymorphism in the coding region of exon four in HSD17B2 in relation to risk of sporadic and hereditary breast cancer

  2007cites this paper
• Targeted functional imaging in breast cancer

  2007cites this paper
• Inhibition of steroid sulfatase activity and cell proliferation in ZR-75-1 and BT-474 human breast cancer cells by KW-2581 in vitro and in vivo

  2007influential citation
• A novel steroidal selective steroid sulfatase inhibitor KW-2581 inhibits sulfated-estrogen dependent growth of breast cancer cells in vitro and in animal models

  2007cites this paper
• Endogenous estrogen, testosterone and progesterone levels in relation to breast cancer risk.

  2007cites this paper
• The discovery and mechanism of action of letrozole

  2007cites this paper
• Progestins and breast cancer

  2007cites this paper
• New experimental models for aromatase inhibitor resistance.

  2007cites this paper
• Drug Insight: breast cancer prevention and tissue-targeted hormone replacement therapy

  2007cites this paper
• Estrogen controls PKCepsilon-dependent mechanical hyperalgesia through direct action on nociceptive neurons

  2007cites this paper
• Expression of aromatase and estrogen sulfotransferase in preinvasive and invasive breast cancer

  2007cites this paper
• Genistein stimulates growth of human breast cancer cells in a novel, postmenopausal animal model, with low plasma estradiol concentrations.

  2006cites this paper
• Mutational Analysis of 17β-hydroxysteroid dehydrogenase type 2 gene in Breast Cancers

  2006cites this paper
• Control of cell proliferation by steroids: the role of 17HSDs.

  2006cites this paper
• Estrogen controls PKCε‐dependent mechanical hyperalgesia through direct action on nociceptive neurons

  2006cites this paper
• Grape seed extract is an aromatase inhibitor and a suppressor of aromatase expression.

  2006cites this paper
• Aromatase Inhibitors

  2006cites this paper
• What do we know about the mechanisms of aromatase inhibitor resistance?

  2006cites this paper
• Endogenous hormone levels, mammographic density, and subsequent risk of breast cancer in postmenopausal women.

  2006cites this paper
• Effects of sex steroids and tamoxifen on VEGF in the breast

  2006cites this paper
• Endocrine effects of aromatase inhibitors and inactivators in vivo: review of data and method limitations.

  2005cites this paper
• Estradiol-adenosine hybrid compounds designed to inhibit type 1 17beta-hydroxysteroid dehydrogenase.

  2005cites this paper
• Serum lipids, lipid-lowering drugs, and the risk of breast cancer.

  2005cites this paper
• Recent insight on the control of enzymes involved in estrogen formation and transformation in human breast cancer.

  2005cites this paper
• Increased extracellular local levels of estradiol in normal breast in vivo during the luteal phase of the menstrual cycle.

  2005cites this paper
• Enzymes as modulators in malignant transformation.

  2005cites this paper
• Treatment with high-dose estrogen (diethylstilbestrol) significantly decreases plasma estrogen and androgen levels but does not influence in vivo aromatization in postmenopausal breast cancer patients.

  2005cites this paper
• Endogenous Sex Hormone Levels and Mammographic Density among Postmenopausal Women

  2005cites this paper
• Estrogen Sulfotransferase in Breast Cancer

  2005cites this paper
• Aromatase in breast cancer tissue — localization and relationship with reproductive status of patients

  2005cites this paper
• Effects of oestradiol and tamoxifen on VEGF, soluble VEGFR-1, and VEGFR-2 in breast cancer and endothelial cells

  2005cites this paper
• Aromatase inhibitors in the treatment of early and advanced breast cancer

  2005cites this paper
• Aromatase inhibitors — mechanisms for non-steroidal inhibitors

  2004cites this paper
• The selective estrogen enzyme modulators in breast cancer: a review.

  2004influential citation
• 17β-Hydroxysteroid dehydrogenases—their role in pathophysiology

  2004cites this paper
• Correlates of obesity in postmenopausal women with breast cancer: comparison of genetic, demographic, disease-related, life history and dietary factors

  2004cites this paper