Siah-1b is a direct transcriptional target of p53: identification of the functional p53 responsive element in the siah-1b promoter.

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  2004-03-09

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1073/PNAS.0400177101PMID 14985507PMCID PMC373493
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase

  2003cited by this paper
• Siah-1 Facilitates Ubiquitination and Degradation of Synphilin-1*

  2003cited by this paper
• Structural Analysis of Siah1 and Its Interactions with Siah-interacting Protein (SIP)*

  2003cited by this paper
• Differential Transactivation by the p53 Transcription Factor Is Highly Dependent on p53 Level and Promoter Target Sequence

  2002cited by this paper
• Regulation of Synaptophysin Degradation by Mammalian Homologues of Seven in Absentia *

  2002cited by this paper
• The characterization of the human Siah‐1 promoter 1

  2002cited by this paper
• Modulation of Transforming Growth Factor β (TGFβ)/Smad Transcriptional Responses through Targeted Degradation of TGFβ-inducible Early Gene-1 by Human Seven in Absentia Homologue*

  2002cited by this paper
• Biological models and genes of tumor reversion: Cellular reprogramming through tpt1/TCTP and SIAH-1

  2002cited by this paper
• Normal p53 Function in Primary Cells Deficient for Siah Genes

  2002cited by this paper
• The p53MH algorithm and its application in detecting p53-responsive genes

  2002cited by this paper
• Gene expression profiling of isogenic cells with different TP53 gene dosage reveals numerous genes that are affected by TP53 dosage and identifies CSPG2 as a direct target of p53

  2002cited by this paper
• The Ubiquitin Ligase Component Siah1a Is Required for Completion of Meiosis I in Male Mice

  2002cited by this paper
• Stress‐induced decrease in TRAF2 stability is mediated by Siah2

  2002cited by this paper
• Efficient Specific DNA Binding by p53 Requires both Its Central and C-Terminal Domains as Revealed by Studies with High-Mobility Group 1 Protein

  2002cited by this paper
• PUMA induces the rapid apoptosis of colorectal cancer cells.

  2001cited by this paper
• The RING finger protein Siah‐1 regulates the level of the transcriptional coactivator OBF‐1

  2001cited by this paper
• Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses.

  2001cited by this paper
• Identification of a Mouse Thiamine Transporter Gene as a Direct Transcriptional Target for p53*

  2001cited by this paper
• Siah-1 binds and regulates the function of Numb

  2001cited by this paper
• Siah-1 mediates a novel beta-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein.

  2001cited by this paper
• Kinetics of p53 Binding to Promoter Sites In Vivo

  2001cited by this paper
• Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis.

  2000cited by this paper
• Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis.

  2000cited by this paper
• SIAH-1 interacts with α-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis

  2000cited by this paper
• RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination.

  1999cited by this paper
• SIAH-1 inhibits cell growth by altering the mitotic process

  1999cited by this paper
• SIAH-1 promotes apoptosis and tumor suppression through a network involving the regulation of protein folding, unfolding, and trafficking: identification of common effectors with p53 and p21(Waf1).

  1999cited by this paper
• p21WAF-1 reorganizes the nucleus in tumor suppression.

  1998cited by this paper
• p53‐inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: suppression by BAG‐1

  1998cited by this paper
• Myb proteins in life, death and differentiation.

  1998cited by this paper
• High-affinity binding of the Drosophila Numb phosphotyrosine-binding domain to peptides containing a Gly-Pro-(p)Tyr motif.

  1997cited by this paper
• de la Chapelle, A.

  1997cited by this paper
• Transcription Abnormalities Potentiate Apoptosis of Normal Human Fibroblasts

  1997cited by this paper
• Architectural Accommodation in the Complex of Four p53 DNA Binding Domain Peptides with the p21/waf1/cip1 DNA Response Element*

  1997cited by this paper
• PHYL acts to down-regulate TTK88, a transcriptional repressor of neuronal cell fates, by a SINA-dependent mechanism.

  1997cited by this paper
• Characterization of human homologs of the Drosophila seven in absentia (sina) gene.

  1997cited by this paper
• Activation of the human homologue of the Drosophila sina gene in apoptosis and tumor suppression.

  1996cited by this paper
• Functional interactions between p53 and the TFIIH complex are affected by tumour‐associated mutations.

  1996cited by this paper
• Isolation of 10 differentially expressed cDNAs in p53-induced apoptosis: activation of the vertebrate homologue of the drosophila seven in absentia gene.

  1996cited by this paper
• Xenopus laevis p53 protein: sequence-specific DNA binding, transcriptional regulation and oligomerization are evolutionarily conserved.

  1995cited by this paper
• The dihedral symmetry of the p53 tetramerization domain mandates a conformational switch upon DNA binding.

  1995cited by this paper
• p53 tagged sites from human genomic DNA.

  1994cited by this paper
• Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo.

  1994cited by this paper
• Cyclin G is a transcriptional target of the p53 tumor suppressor protein.

  1994cited by this paper
• WAF1, a potential mediator of p53 tumor suppression.

  1993cited by this paper
• Isolation and characterisation of murine homologues of the Drosophila seven in absentia gene (sina).

  1993cited by this paper
• The p53-mdm-2 autoregulatory feedback loop.

  1993cited by this paper
• Wild‐type p53 adopts a ‘mutant’‐like conformation when bound to DNA.

  1993cited by this paper
• A transcriptionally active DNA-binding site for human p53 protein complexes

  1992cited by this paper
• Regulation of the specific DNA binding function of p53.

  1992cited by this paper
• Definition of a consensus binding site for p53

  1992cited by this paper
• Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

  1991cited by this paper
• seven in absentia, a gene required for specification of R7 cell fate in the Drosophila eye.

  1990cited by this paper

• All-trans retinoic acid downregulates HBx levels via E6-associated protein-mediated proteasomal degradation to suppress hepatitis B virus replication

  2024cites this paper
• A non-invasive iRFP713 p53 reporter reveals dynamic p53 activity in response to irradiation and liver regeneration in vivo†

  2022cites this paper
• Isolation and identification of kurthia gibsonii from paneer and study its antibacterial activity against intestinal pathogens

  2022cites this paper
• Mutant p53 Gain-of-Function: Role in Cancer Development, Progression, and Therapeutic Approaches

  2021cites this paper
• E3 ubiquitin ligase-mediated regulation of vertebrate ocular development; new insights into the function of SIAH enzymes

  2021cites this paper
• Host cell factors stimulate HIV-1 transcription by antagonizing substrate-binding function of Siah1 ubiquitin ligase to stabilize transcription elongation factor ELL2

  2020cites this paper
• Reactive Oxygen Species, Metabolic Plasticity, and Drug Resistance in Cancer

  2020cites this paper
• An investigation of the correlation between the S-glutathionylated GAPDH levels in blood and Alzheimer’s disease progression

  2020cites this paper
• S-Nitrosylation: An Emerging Paradigm of Redox Signaling

  2019cites this paper
• HBx natural variants containing Ser-101 instead of Pro-101 evade ubiquitin-dependent proteasomal degradation by activating proteasomal activator 28 gamma expression.

  2019cites this paper
• Plakoglobin restores tumor suppressor activity of p53R175H mutant by sequestering the oncogenic potential of β‐catenin

  2018cites this paper
• Protein Promiscuity in H2O2 Signaling

  2018influential citation
• Tumor Reversion: Mesenchymal-Epithelial Transition as a Critical Step in Managing the Tumor-Microenvironment Cross-Talk.

  2017cites this paper
• Role of TCTP for Cellular Differentiation and Cancer Therapy.

  2017cites this paper
• Census and evaluation of p53 target genes

  2017cites this paper
• Seven in Absentia E3 Ubiquitin Ligases: Central Regulators of Neural Cell Fate and Neuronal Polarity

  2017cites this paper
• Signaling and Chromatin Networks in Cancer Biology

  2016cites this paper
• Inhibiting DX2-p14/ARF Interaction Exerts Antitumor Effects in Lung Cancer and Delays Tumor Progression.

  2016cites this paper
• Multi-scale modeling of cell survival and death mediated by the p53 network: a systems pharmacology framework.

  2015cites this paper
• Role of the RING domain in MDM2-mediated ubiquitination of p53

  2015cites this paper
• The inducible E3 ubiquitin ligases SIAH1 and SIAH2 perform critical roles in breast and prostate cancers.

  2015cites this paper
• Cellular reprogramming in skin cancer.

  2015cites this paper
• ESTUDIO DE LOS MECANISMOS DE REGULACIÓN DEL FACTOR HIF-1 POR N-ACIL DOPAMINAS. IMPLICACIONES EN NEUROPROTECCIÓN

  2015cites this paper
• Protein Recognition in Drug-Induced DNA Alkylation: When the Moonlight Protein GAPDH Meets S23906-1/DNA Minor Groove Adducts

  2015cites this paper
• Critical protein GAPDH and its regulatory mechanisms in cancer cells

  2015cites this paper
• Biological roles of cellular glyceraldehyde-3-phosphate dehydrogenase in the hepatitis C virus life cycle

  2015cites this paper
• Genomic DNA Hypomethylation Is Associated with Neural Tube Defects Induced by Methotrexate Inhibition of Folate Metabolism

  2015cites this paper
• Hypoximimetic activity of N-acyl-dopamines. N-arachidonoyl-dopamine stabilizes HIF-1α protein through a SIAH2-dependent pathway.

  2014cites this paper
• The transcription factor p53: Not a repressor, solely an activator

  2014cites this paper
• The ubiquitin ligase Siah is a novel regulator of Zeb1 in breast cancer

  2014cites this paper
• Histone deacetylase 2 controls p53 and is a critical factor in tumorigenesis.

  2014cites this paper
• SIAH2 antagonizes TYK2-STAT3 signaling in lung carcinoma cells

  2014influential citation
• Regulators and Effectors of Siah Ubiquitin Ligases

  2013cites this paper
• Lessons from tumor reversion for cancer treatment

  2013cites this paper
• p53 Represses Transcription of RING Finger LIM Domain-Binding Protein RLIM through Sp1

  2013cites this paper
• Roles of p53 in Herpes Simplex Virus 1 Replication

  2013cites this paper
• L'activation des récepteurs activés par les proliférateurs de peroxysomes β/δ, stimule l'expression de Siah-1L et entraîne la prolifération et la migration de cellules de glioblastomes

  2013cites this paper
• Human Papilloma Virus-Induced Head and Neck Cancer

  2012cites this paper
• Etude des cellules souches et progénitrices mammaires et de leur contribution à la tumorigenèse : rôle des facteurs de transcription Myc et p53

  2012cites this paper
• The Facilitation of Protein-DNA Search and Recognition by Multiple Modes of Binding

  2012cites this paper
• Srg3, a mouse homolog of BAF155, is a novel p53 target and acts as a tumor suppressor by modulating p21WAF1/CIP1 expression

  2011cites this paper
• Nuclear GAPDH: changing the fate of Müller cells in diabetes

  2011cites this paper
• Reciprocal repression between P53 and TCTP

  2011cites this paper
• p53, Stem Cells, and Reprogramming: Tumor Suppression beyond Guarding the Genome.

  2011cites this paper
• Siah1/SIP regulates p27kip1 stability and cell migration under metabolic stress

  2011cites this paper
• Eukaryotic translation elongation factor 1 delta inhibits the ubiquitin ligase activity of SIAH-1

  2011cites this paper
• Hypoxia suppresses chemotherapeutic drug-induced p53 Serine 46 phosphorylation by triggering HIPK2 degradation.

  2010cites this paper
• The origins and evolution of the p53 family of genes.

  2010cites this paper
• Oxidatively Modified Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) and Alzheimer's Disease: Many Pathways to Neurodegeneration

  2010cites this paper
• Charakterisierung von Interaktionspartnern des Kernrezeptors CAR ("Constitutive Androstane Receptor") mittels MALDI-TOF Massenspektrometrie

  2010cites this paper
• Wnt signalling and the control of cellular metabolism.

  2010cites this paper
• Activation of Wnt Signaling Pathway by Human Papillomavirus E6 and E7 Oncogenes in HPV16-Positive Oropharyngeal Squamous Carcinoma Cells

  2010cites this paper
• Nuclear translocation of glyceraldehyde-3-phosphate dehydrogenase is regulated by acetylation.

  2010cites this paper
• What we learn from transformation suppressor genes: lessons from RECK.

  2010cites this paper
• Mitotic Regulation of the Stability of Microtubule Plus-end Tracking Protein EB3 by Ubiquitin Ligase SIAH-1 and Aurora Mitotic Kinases*

  2009cites this paper
• How cells switch HIPK2 on and off

  2009cites this paper
• Alterations of ubiquitin ligases in human cancer and their association with the natural history of the tumor

  2009cites this paper
• Novel roles for GAPDH in cell death and carcinogenesis

  2009cites this paper
• siah-1 Protein Is Necessary for High Glucose-induced Glyceraldehyde-3-phosphate Dehydrogenase Nuclear Accumulation and Cell Death in Müller Cells*

  2009cites this paper
• The molecular programme of tumour reversion: the steps beyond malignant transformation

  2009cites this paper
• A genomewide study identifies the Wnt signaling pathway as a major target of p53 in murine embryonic stem cells

  2009cites this paper
• Hexachlorophene suppresses β-catenin expression by up-regulation of Siah-1 in EBV-infected B lymphoma cells

  2008cites this paper
• Control of HIPK2 stability by ubiquitin ligase Siah-1 and checkpoint kinases ATM and ATR

  2008cites this paper
• Genome-wide analysis of SINA family in plants and their phylogenetic relationships†

  2008cites this paper
• Etudes moléculaires et fonctionnelles des gènes TSAP6 et TCTP

  2008cites this paper
• The Role of Siah 1-Induced Degradation of β-Catenin in Androgen Receptor Signaling

  2007cites this paper
• NGF-mediated transcriptional targets of p53 in PC12 neuronal differentiation

  2007cites this paper
• Hepatitis B virus X protein differentially affects the ubiquitin-mediated proteasomal degradation of beta-catenin depending on the status of cellular p53.

  2007cites this paper
• SIAH-1 Interacts with the Kaposi's Sarcoma-Associated Herpesvirus-Encoded ORF45 Protein and Promotes Its Ubiquitylation and Proteasomal Degradation

  2007influential citation
• The effect of p53‐RNAi and p53 knockout on human 8‐oxoguanine DNA glycosylase (hOgg1) activity

  2006cites this paper
• p53 Protein and Nonmelanoma Skin Cancer

  2006cites this paper
• Critical function for SIP, a ubiquitin E3 ligase component of the beta-catenin degradation pathway, for thymocyte development and G1 checkpoint.

  2006cites this paper
• GAPDH as a sensor of NO stress.

  2006cites this paper
• Genetic and Expression Aberrations of E3 Ubiquitin Ligases in Human Breast Cancer

  2006cites this paper
• Nitric Oxide–GAPDH–Siah: A Novel Cell Death Cascade

  2006cites this paper
• Funktionelle Analyse des Regulatorproteins ICP0 von Herpes Simplex Virus Typ 2

  2006cites this paper
• AWARD NUMBER: W81XWH-05-1-0007 TITLE: The Role of Siah1-Induced Degradation of β-Catenin in Androgen Receptor Signaling

  2006cites this paper
• The p53 pathway: positive and negative feedback loops

  2005influential citation
• Up-regulation of beta-catenin by a viral oncogene correlates with inhibition of the seven in absentia homolog 1 in B lymphoma cells.

  2005cites this paper
• Up-regulation of β-catenin by a viral oncogene correlates with inhibition of the seven in absentia homolog 1 in B lymphoma cells

  2005cites this paper
• GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE ,A POPTOSIS, AND NEURODEGENERATIVE DISEASES ∗

  2005cites this paper
• S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding

  2005cites this paper
• Chromatin Immunoprecipitation-Based Screen To Identify Functional Genomic Binding Sites for Sequence-Specific Transactivators

  2005cites this paper
• Estrogen down-regulation of the corepressor N-CoR: mechanism and implications for estrogen derepression of N-CoR-regulated genes.

  2005cites this paper
• Glyceraldehyde-3-phosphate dehydrogenase, apoptosis, and neurodegenerative diseases.

  2005cites this paper
• The modular structure of SIP facilitates its role in stabilizing multiprotein assemblies.

  2005cites this paper
• Siah-1L, a novel transcript variant belonging to the human Siah family of proteins, regulates β-catenin activity in a p53-dependent manner

  2004cites this paper
• A P53 target gene, PIG11, contributes to chemosensitivity of cells to arsenic trioxide

  2004cites this paper
• Inactivating mutations of the Siah-1 gene in gastric cancer

  2004cites this paper
• p51/p63 Controls Subunit α3 of the Major Epidermis Integrin Anchoring the Stem Cells to the Niche*

  2004cites this paper
• Aromatase and breast cancer.

  1998cites this paper