Srg3, a mouse homolog of BAF155, is a novel p53 target and acts as a tumor suppressor by modulating p21WAF1/CIP1 expression

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Oncogene

• Publication date

  2011-01-27

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/onc.2010.424PMID 20935679
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Characterization of mammary tumors from Brg1 heterozygous mice

  2008cited by this paper
• Targeted knockout of BRG1 potentiates lung cancer development.

  2008cited by this paper
• BAF60a Interacts with p53 to Recruit the SWI/SNF Complex*

  2008cited by this paper
• Loss of the Epigenetic Tumor Suppressor SNF5 Leads to Cancer without Genomic Instability

  2008cited by this paper
• SRG3, a core component of mouse SWI/SNF complex, is essential for extra-embryonic vascular development.

  2008cited by this paper
• SRG3 Interacts Directly with the Major Components of the SWI/SNF Chromatin Remodeling Complex and Protects Them from Proteasomal Degradation*

  2007cited by this paper
• Swi3p controls SWI/SNF assembly and ATP-dependent H2A-H2B displacement

  2007cited by this paper
• Mammalian SWI/SNF complexes facilitate DNA double‐strand break repair by promoting γ‐H2AX induction

  2006cited by this paper
• Chromatin remodelling in mammalian differentiation: lessons from ATP-dependent remodellers

  2006cited by this paper
• Tumorigenic activity of p21Waf1/Cip1 in thymic lymphoma

  2006cited by this paper
• Increased DNA Damage Sensitivity and Apoptosis in Cells Lacking the Snf5/Ini1 Subunit of the SWI/SNF Chromatin Remodeling Complex

  2006influential reference
• Functional Differentiation of SWI/SNF Remodelers in Transcription and Cell Cycle Control

  2006cited by this paper
• Outcomes of p53 activation - spoilt for choice

  2006cited by this paper
• Cancer-associated mutations in chromatin remodeler hSNF5 promote chromosomal instability by compromising the mitotic checkpoint.

  2005cited by this paper
• Regulating SWI/SNF Subunit Levels via Protein-Protein Interactions and Proteasomal Degradation: BAF155 and BAF170 Limit Expression of BAF57

  2005cited by this paper
• Inactivation of the Snf5 tumor suppressor stimulates cell cycle progression and cooperates with p53 loss in oncogenic transformation.

  2005influential reference
• Distinct roles for the RSC and Swi/Snf ATP-dependent chromatin remodelers in DNA double-strand break repair.

  2005cited by this paper
• Siah-1b is a direct transcriptional target of p53: identification of the functional p53 responsive element in the siah-1b promoter.

  2004cited by this paper
• The SWI/SNF complex — chromatin and cancer

  2004influential reference
• Loss of the INI1 tumor suppressor does not impair the expression of multiple BRG1-dependent genes or the assembly of SWI/SNF enzymes

  2004influential reference
• Role for BRG1 in Cell Cycle Control and Tumor Suppression

  2004cited by this paper
• Integral role of Noxa in p53-mediated apoptotic response.

  2003cited by this paper
• Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses

  2003cited by this paper
• Live or let die: the cell's response to p53

  2002cited by this paper
• Dissecting p53 tumor suppressor functions in vivo.

  2002cited by this paper
• The role of the cyclin-dependent kinase inhibitor p21 in apoptosis.

  2002cited by this paper
• Re-expression of hSNF5/INI1/BAF47 in pediatric tumor cells leads to G1arrest associated with induction of p16ink4a and activation of RB

  2002cited by this paper
• Cell Cycle Arrest and Repression of Cyclin D1 Transcription by INI1/hSNF5

  2002cited by this paper
• Highly penetrant, rapid tumorigenesis through conditional inversion of the tumor suppressor gene Snf5.

  2002cited by this paper
• Siah-1 mediates a novel beta-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein.

  2001cited by this paper
• Peripheral T Cells Become Sensitive to Glucocorticoid- and Stress-Induced Apoptosis in Transgenic Mice Overexpressing SRG31

  2001cited by this paper
• Disruption of Ini1 Leads to Peri-Implantation Lethality and Tumorigenesis in Mice

  2001cited by this paper
• Tumor susceptibility of p21(Waf1/Cip1)-deficient mice.

  2001cited by this paper
• Characterization of SWI/SNF protein expression in human breast cancer cell lines and other malignancies

  2001cited by this paper
• Cooperative effects of genes controlling the G(2)/M checkpoint.

  2000cited by this paper
• Haploinsufficiency of Snf5 (integrase interactor 1) predisposes to malignant rhabdoid tumors in mice.

  2000cited by this paper
• BRG1, a component of the SWI-SNF complex, is mutated in multiple human tumor cell lines.

  2000cited by this paper
• A Brg1 null mutation in the mouse reveals functional differences among mammalian SWI/SNF complexes.

  2000cited by this paper
• The murine SNF5/INI1 chromatin remodeling factor is essential for embryonic development and tumor suppression

  2000cited by this paper
• BRG-1 is required for RB-mediated cell cycle arrest.

  2000cited by this paper
• Siah-1 N-Terminal RING Domain Is Required for Proteolysis Function, and C-Terminal Sequences Regulate Oligomerization and Binding to Target Proteins

  1999cited by this paper
• Germ-line and acquired mutations of INI1 in atypical teratoid and rhabdoid tumors.

  1999cited by this paper
• Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits.

  1999cited by this paper
• Induction of apoptosis by the p53‐273L (Arg→Leu) mutant in HSC3 cells without transactivation of p21Waf1/Cip1/Sdi1 and bax

  1999cited by this paper
• Truncating mutations of hSNF5/INI1 in aggressive paediatric cancer

  1998cited by this paper
• DNA Double-stranded Breaks Induce Histone H2AX Phosphorylation on Serine 139*

  1998cited by this paper
• Five SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin (SMARC) genes are dispersed in the human genome.

  1998cited by this paper
• Requirement for p53 and p21 to sustain G2 arrest after DNA damage.

  1998cited by this paper
• RB and hbrm cooperate to repress the activation functions of E2F1.

  1997cited by this paper
• Loss of p21 increases sensitivity to ionizing radiation and delays the onset of lymphoma in atm-deficient mice.

  1997cited by this paper
• Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21

  1996influential reference
• Genetic determinants of p53-induced apoptosis and growth arrest.

  1996cited by this paper
• The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest.

  1994cited by this paper
• p53-dependent apoptosis suppresses tumor growth and progression in vivo.

  1994cited by this paper

• Case report: Extraskeletal Ewing sarcoma with a germline pathogenic variant of SMARCA4

  2024cites this paper
• SWI/SNF complexes and cancers.

  2023cites this paper
• GBAF, a small BAF sub-complex with big implications: a systematic review

  2020cites this paper
• RBM15 Modulates the Function of Chromatin Remodeling Factor BAF155 Through RNA Methylation in Developing Cortex

  2019cites this paper
• Tumor suppressor SMARCB1 suppresses super-enhancers to govern hESC lineage determination

  2019cites this paper
• SWI/SNF Chromatin Remodelling and Human Cancer

  2016cites this paper
• The Roles of Chromatin Remodeling Proteins in Cancer.

  2016cites this paper
• Transposon mutagenesis identifies genes and evolutionary forces driving gastrointestinal tract tumor progression

  2015cites this paper
• Wwp2 targets SRG3, a scaffold protein of the SWI/SNF-like BAF complex, for ubiquitination and degradation.

  2014cites this paper
• SWI/SNF chromatin remodeling complexes and cancer

  2014cites this paper
• miR-320c regulates gemcitabine-resistance in pancreatic cancer via SMARCC1

  2013cites this paper
• Diverse functions of ATP-dependent chromatin remodeling complexes in development and cancer.

  2012cites this paper
• The dynamic interplay in chromatin remodeling factors polycomb and trithorax proteins in response to DNA damage

  2012cites this paper
• Antiproliferative and cytotoxic effects of different type cytostatics on mouse pluripotent stem and teratocarcinoma cells

  2012cites this paper
• SRG3/mBAF155 stabilizes the SWI/SNF-like BAF complex by blocking CHFR mediated ubiquitination and degradation of its major components.

  2012cites this paper
• The BRG1 Chromatin Remodeler Protects Against Ovarian Cysts, Uterine Tumors, and Mammary Tumors in a Lineage-Specific Manner

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