Tumor susceptibility of p21(Waf1/Cip1)-deficient mice.

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Cancer Research

• Publication date

  2001-08-15

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 11507077
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Targeted Inactivation of the p21WAF1/cip1 Gene Enhances Apc-initiated Tumor Formation and the Tumor-promoting Activity of a Western-Style High-Risk Diet by Altering Cell Maturation in the Intestinal Mucosa

  2001cited by this paper
• Targeted inactivation of the p21(WAF1/cip1) gene enhances Apc-initiated tumor formation and the tumor-promoting activity of a Western-style high-risk diet by altering cell maturation in the intestinal mucosal.

  2001cited by this paper
• Tumorigenic effect of nonfunctional p53 or p21 in mice mutant in the Werner syndrome helicase.

  2001cited by this paper
• Bax accelerates tumorigenesis in p53-deficient mice.

  2001cited by this paper
• The cell cycle inhibitor p21 controls T-cell proliferation and sex-linked lupus development

  2000cited by this paper
• Different impact of p53 and p21 on the radiation response of mouse tissues

  2000cited by this paper
• Tissue and cell-specific expression of the p53-target genes: bax, fas, mdm2 and waf1/p21, before and following ionising irradiation in mice

  2000cited by this paper
• NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription.

  2000cited by this paper
• Analysis of p53-regulated gene expression patterns using oligonucleotide arrays.

  2000cited by this paper
• Loss of p21WAF1/CIP1 accelerates Ras oncogenesis in a transgenic/knockout mammary cancer model

  2000cited by this paper
• Functional Collaboration between Different Cyclin-Dependent Kinase Inhibitors Suppresses Tumor Growth with Distinct Tissue Specificity

  2000cited by this paper
• p53: death star.

  2000cited by this paper
• The ARF/p53 pathway.

  2000cited by this paper
• Surfing the p53 network

  2000cited by this paper
• p21(WAF1/Cip1) functions as a suppressor of malignant skin tumor formation and a determinant of keratinocyte stem-cell potential.

  1999cited by this paper
• Genomic instability in Gadd45a-deficient mice

  1999cited by this paper
• Tumor spectrum in ARF-deficient mice.

  1999cited by this paper
• Identification and classification of p53-regulated genes.

  1999cited by this paper
• Genetic deletion of p21WAF1 enhances papilloma formation but not malignant conversion in experimental mouse skin carcinogenesis.

  1999cited by this paper
• Inhibition of cyclin-dependent kinase 2 by p21 is necessary for retinoblastoma protein-mediated G1 arrest after gamma-irradiation.

  1999cited by this paper
• CDK inhibitors: positive and negative regulators of G1-phase progression.

  1999cited by this paper
• p21 Is a Critical CDK2 Regulator Essential for Proliferation Control in Rb-deficient Cells

  1998cited by this paper
• Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF.

  1997cited by this paper
• Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame

  1997cited by this paper
• High-intensity Raf signal causes cell cycle arrest mediated by p21Cip1

  1997cited by this paper
• p21WAF1 mutations and human malignancies.

  1997cited by this paper
• Loss of p21 increases sensitivity to ionizing radiation and delays the onset of lymphoma in atm-deficient mice.

  1997influential reference
• Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1

  1997cited by this paper
• Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma.

  1996cited by this paper
• Pleiotropic defects in ataxia-telangiectasia protein-deficient mice.

  1996cited by this paper
• TGF-beta mediated G1 arrest in a human melanoma cell line lacking p15INK4B: evidence for cooperation between p21Cip1/WAF1 and p27Kip1.

  1996cited by this paper
• Atm-deficient mice: a paradigm of ataxia telangiectasia.

  1996cited by this paper
• Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism.

  1995cited by this paper
• Inhibitors of mammalian G1 cyclin-dependent kinases.

  1995cited by this paper
• Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD

  1995cited by this paper
• p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage.

  1995cited by this paper
• Potential Role of WAF1/Cip1/p21 as a Mediator of TGF-β Cytoinhibitory Effect (*)

  1995cited by this paper
• Radiation-induced cell cycle arrest compromised by p21 deficiency

  1995cited by this paper
• Induction of WAF1/CIP1 by a p53-independent pathway.

  1994cited by this paper
• Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen.

  1994cited by this paper
• p53-deficient mice are extremely susceptible to radiation-induced tumorigenesis

  1994cited by this paper
• Tumor spectrum analysis in p53-mutant mice.

  1994cited by this paper
• Cell cycle expression and p53 regulation of the cyclin-dependent kinase inhibitor p21.

  1994cited by this paper
• DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.

  1994cited by this paper
• WAF1, a potential mediator of p53 tumor suppression.

  1993cited by this paper
• p53 is required for radiation-induced apoptosis in mouse thymocytes

  1993cited by this paper
• Spontaneous and carcinogen–induced tumorigenesis in p53–deficient mice

  1993cited by this paper
• Thymocyte apoptosis induced by p53-dependent and independent pathways

  1993cited by this paper
• p21 is a universal inhibitor of cyclin kinases

  1993cited by this paper
• The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.

  1993cited by this paper
• Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

  1992cited by this paper
• Radiation therapy of spontaneous autoimmunity: a review of mouse models.

  1988cited by this paper
• Total lymphoid irradiation in alloimmunity and autoimmunity.

  1987cited by this paper

• Senescence-inhibitory Δ133p53α counteracts accelerated ageing and mortality

  2026cites this paper
• AMH induces a reversible quiescence-associated secretory phenotype in preantral follicles†.

  2025cites this paper
• Targeting PIK3CB/YAP1 improves the sensitivity of paclitaxel by suppressing aging in head and neck squamous tumor cells

  2025cites this paper
• Interactions between key genes and pathways in prostate cancer progression and therapy resistance

  2025cites this paper
• Targeted Nanodelivery of Myristicin Loaded Hyaluronic Acid Functionalized PLGA-PEG Nanoparticles Enhanced Apoptosis and Cell Cycle Arrest Via Intracellular ROS Generation and p53/Cyclin B Pathways in MCF-7 Human Breast Cancer Cells

  2025cites this paper
• Intermittent clearance of p21-highly-expressing cells extends lifespan and confers sustained benefits to health and physical function.

  2024cites this paper
• Transcriptome analysis of polyploid giant cancer cells and their progeny reveals a functional role for p21 in polyploidization and depolyploidization

  2024cites this paper
• Pro-survival roles for p21(Cip1/Waf1) in non-small cell lung cancer

  2024cites this paper
• Elucidating the chain of command: our current understanding of critical target genes for p53-mediated tumor suppression

  2024cites this paper
• Mechanisms of endocrine resistance in hormone receptor-positive breast cancer

  2024cites this paper
• Sustained ERK signaling promotes G2 cell cycle exit and primes cells for whole-genome duplication.

  2024cites this paper
• Therapeutic strategies targeting cellular senescence for cancer and other diseases

  2024cites this paper
• CIP/KIP and INK4 families as hostages of oncogenic signaling

  2024cites this paper
• Targeting Cell Senescence and Senolytics: Novel Interventions for Age-Related Endocrine Dysfunction

  2024cites this paper
• CREB3L1/OASIS: cell cycle regulator and tumor suppressor

  2024cites this paper
• Network of extracellular vesicles surrounding senescent cells.

  2024cites this paper
• Primary cilia as a targetable node between biliary injury, senescence and regeneration in liver transplantation.

  2024cites this paper
• SATB1, senescence and senescence‐related diseases

  2024cites this paper
• Decreased mitochondrial transcription factor A and mitochondrial DNA copy number promote cyclin-dependent kinase inhibitor 1A expression and reduce tumorigenic properties of colorectal cancer cells

  2024cites this paper
• Senescent Cells: A Therapeutic Target in Cardiovascular Diseases

  2023cites this paper
• Pancreatic β-cell senescence in diabetes: mechanisms, markers and therapies

  2023cites this paper
• SOCS1 Deficiency Promotes Hepatocellular Carcinoma via SOCS3-Dependent CDKN1A Induction and NRF2 Activation

  2023cites this paper
• Different impacts of TP53 mutations on cell cycle-related gene expression among cancer types

  2023cites this paper
• Disrupted Binding of Cystathionine γ-Lyase to p53 Promotes Endothelial Senescence

  2023cites this paper
• Effective‐by‐method for the preparation of folic acid‐coated TiO2 nanoparticles with high targeting potential for apoptosis induction against bladder cancer cells (T24)

  2023cites this paper
• Clinical value of Cyclin D1 and P21 in the differential diagnosis of papillary thyroid carcinoma

  2023cites this paper
• Smp24, a Scorpion-Venom Peptide, Exhibits Potent Antitumor Effects against Hepatoma HepG2 Cells via Multi-Mechanisms In Vivo and In Vitro

  2022cites this paper
• A Unique Spectrum of Spontaneous Tumors in Dino Knockout Mice Identifies Tissue-Specific Requirements for Tumor Suppression

  2022cites this paper
• Mechanistic Contributions of lncRNAs to Cellular Signaling Pathways Crucial to the Lifecycle of Human Papillomaviruses

  2022cites this paper
• An Unanticipated Modulation of Cyclin-Dependent Kinase Inhibitors: The Role of Long Non-Coding RNAs

  2022cites this paper
• The Pt(S-pr-thiosal)2 and BCL1 Leukemia Lymphoma: Antitumor Activity In Vitro and In Vivo

  2022cites this paper
• Zinc finger protein 277 is an intestinal transit-amplifying cell marker and colon cancer oncogene

  2022cites this paper
• Senescence and cancer — role and therapeutic opportunities

  2022cites this paper
• Poly(rC)-binding proteins as pleiotropic regulators in hematopoiesis and hematological malignancy

  2022cites this paper
• Should mutant TP53 be targeted for cancer therapy?

  2022cites this paper
• Suffruticosol C-Mediated Autophagy and Cell Cycle Arrest via Inhibition of mTORC1 Signaling

  2022cites this paper
• Senolytic treatment preserves biliary regenerative capacity lost through cellular senescence during cold storage

  2022cites this paper
• Circulating Extracellular Vesicles and Particles Derived From Adipocytes: The Potential Role in Spreading MicroRNAs Associated With Cellular Senescence

  2022cites this paper
• Cyclin-dependent kinase inhibitors in malignant hematopoiesis

  2022cites this paper
• The potential roles of p53 signaling reactivation in pancreatic cancer therapy.

  2021cites this paper
• Hub Gene Identi cation and Prognostic Model Establishment for Patients with HBV-related Hepatocellular Carcinoma

  2021cites this paper
• Mouse Hematolymphoid Neoplasms

  2021cites this paper
• The Significant Influence of a Second Metal on the Antiproliferative Properties of the Complex [Ru(η6−C10H14)(Cl2)(dmoPTA)]

  2021cites this paper
• GFI-1 overexpression promotes cell proliferation and apoptosis resistance in mycosis fungoides by repressing Bax and P21

  2021cites this paper
• Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity.

  2021cites this paper
• Tomentosin a Sesquiterpene Lactone Induces Antiproliferative and Proapoptotic Effects in Human Burkitt Lymphoma by Deregulation of Anti- and Pro-Apoptotic Genes

  2021cites this paper
• Developmental Acquisition of p53 Functions

  2021cites this paper
• MI-773, a breaker of the MDM2/p53 axis, exhibits anticancer effects in neuroblastoma via downregulation of INSM1.

  2021cites this paper
• Cellular senescence or stemness: hypoxia flips the coin

  2021cites this paper
• Multifaceted effect of chlorpromazine in cancer: implications for cancer treatment

  2021cites this paper
• Cdkn1a deletion or suppression by cyclic stretch enhance the osteogenic potential of bone marrow mesenchymal stem cell-derived cultures.

  2021cites this paper
• The role of p53/p21/p16 in DNA damage signaling and DNA repair

  2021cites this paper
• Induction of mitochondria mediated apoptosis in human ovarian cancer cells by folic acid coated tin oxide nanoparticles

  2021cites this paper
• An inducible p21-Cre mouse model to monitor and manipulate p21-highly-expressing senescent cells in vivo

  2021cites this paper
• Mechanisms of TP53 Pathway Inactivation in Embryonic and Somatic Cells—Relevance for Understanding (Germ Cell) Tumorigenesis

  2021cites this paper
• The Role of Intrinsic Signaling Pathways in Cell Proliferation

  2021cites this paper
• PSMD9 ribosomal protein network maintains nucleolar architecture and WT p53 levels.

  2021cites this paper
• AHNAK controls 53BP1-mediated p53 response by restraining 53BP1 oligomerization and phase separation

  2021cites this paper
• Simultaneous expression of MMB-FOXM1 complex components enables efficient bypass of senescence

  2021cites this paper
• Senescence under appraisal: hopes and challenges revisited

  2021cites this paper
• Platinum drugs and taxanes: can we overcome resistance?

  2021cites this paper
• Long-Term Effects of Very Low Dose Particle Radiation on Gene Expression in the Heart: Degenerative Disease Risks

  2021cites this paper
• Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype

  2021cites this paper
• Research models and mesenchymal/epithelial plasticity of osteosarcoma

  2021cites this paper
• Endothelial sprouting, proliferation, or senescence: tipping the balance from physiology to pathology

  2020cites this paper
• Senescence-associated extracellular vesicle (SA-EV) release plays a role in senescence-associated secretory phenotype (SASP) in age-associated diseases.

  2020cites this paper
• Functional Versatility of the CDK Inhibitor p57Kip2

  2020cites this paper
• The Role of Cell Cycle Regulators in Cell Survival—Dual Functions of Cyclin-Dependent Kinase 20 and p21Cip1/Waf1

  2020influential citation
• Irisin, an exercise myokine, potently suppresses tumor proliferation, invasion, and growth in glioma

  2020cites this paper
• Cellular Senescence and Senotherapies in the Kidney: Current Evidence and Future Directions

  2020cites this paper
• Cellular Senescence: Mechanisms, Morphology, and Mouse Models

  2020influential citation
• Garcinol inhibits the proliferation of endometrial cancer cells by inducing cell cycle arrest

  2020cites this paper
• Sensitive and selective monitoring of the DNA damage-induced intracellular p21 protein and unraveling the role of the p21 protein in DNA repair and cell apoptosis by surface plasmon resonance.

  2020cites this paper
• Less-well known functions of cyclin/CDK complexes.

  2020cites this paper
• MAGE-A inhibit apoptosis and promote proliferation in multiple myeloma through regulation of BIM and p21Cip1

  2020cites this paper
• Bone Tissue Engineering

  2020cites this paper
• Nuclear myosin 1 activates p21 gene transcription in response to DNA damage through a chromatin-based mechanism

  2020cites this paper
• Identification of a novel regulatory mechanism involved in inhibition of transcription of suvivin mRNA in breast cancer cells via p21cip–mediated regulation

  2019cites this paper
• Cytotoxic activity of caffeic acid and gallic acid against MCF-7 human breast cancer cells: An in silico and in vitro study

  2019cites this paper
• Cellular Senescence and the Kidney: Potential Therapeutic Targets and Tools

  2019cites this paper
• Suppression of colorectal cancer cell growth by combined treatment of 6-gingerol and γ-tocotrienol via alteration of multiple signalling pathways

  2019cites this paper
• p21cip1/waf1 Coordinates Autophagy, Proliferation and Apoptosis in Response to Metabolic Stress

  2019cites this paper
• The Role of Apoptosis in the Pathogenic Mechanism of Critical States (Review)

  2019cites this paper
• Dysregulated microRNAs in colorectal carcinogenesis: New insight to cell survival and apoptosis regulation

  2019cites this paper
• p21 in Cancer Research

  2019cites this paper
• Absence of cyclin-dependent kinase inhibitor p27 or p18 increases efficiency of iPSC generation without induction of iPSC genomic instability

  2019cites this paper
• p27 allosterically activates cyclin-dependent kinase 4 and antagonizes palbociclib inhibition

  2019cites this paper
• Integrated analysis of 34 microarray datasets reveals CBX3 as a diagnostic and prognostic biomarker in glioblastoma

  2019cites this paper
• STAT5 deficiency in hepatocytes reduces diethylnitrosamine-induced liver tumorigenesis in mice.

  2019cites this paper
• A potential role of cyclin-dependent kinase inhibitor 1 (p21/WAF1) in the pathogenesis of endometriosis: Directions for future research.

  2019cites this paper
• Identification of differentially expressed transcription factors and dissecting the role of DREAM complex associated components in cellular senescence

  2019cites this paper
• Molecular links between COPD and lung cancer: new targets for drug discovery?

  2019cites this paper
• Human Colorectal Cancer from the Perspective of Mouse Models

  2019cites this paper
• The Multifaceted p21 (Cip1/Waf1/CDKN1A) in Cell Differentiation, Migration and Cancer Therapy

  2019cites this paper
• Loss of parkin reduces lung tumor development by blocking p21 degradation

  2019cites this paper
• Senolytic treatment targets aberrant p21-expression to restore liver regeneration in adult mice

  2019cites this paper
• Cellular Senescence in the Kidney.

  2019cites this paper
• A comprehensive model for the proliferation–quiescence decision in response to endogenous DNA damage in human cells

  2018cites this paper
• Chapter 10 p 21 CDKN 1 A and DNA Repair Systems : Recent Findings and Future Perspectives

  2018cites this paper
• Telomere length-dependent transcription and epigenetic modifications in promoters remote from telomere ends

  2018cites this paper