DNA testing for sickle cell anemia in Africa: Implementation choices for the Democratic Republic of Congo

Hemoglobin‐based tests form the reference diagnostic test for SCA. In limited resource countries, these tests face limitations including cost, low sensitivity due to recurrent transfusions in endemic malaria region, and interference from fetal hemoglobin in neonatal diagnostic. This study aimed at adapting DNA‐based SCA tests to limited resource countries and evaluating the economic benefit.

• Publication year

  2022

• Venue

  Journal of clinical laboratory analysis (Print)

• Publication date

  2022-04-11

• Fields of study

  Medicine

• Identifiers
  DOI 10.1002/jcla.24398PMID 35405024PMCID 9102645
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• DNA testing for sickle cell anemia in Africa: Implementation choices for the Democratic Republic of Congo

  2022cited by this paper
• Best practices for the analytical validation of clinical whole-genome sequencing intended for the diagnosis of germline disease

  2020cited by this paper
• The importance of forensic storage support: DNA quality from 11-year-old saliva on FTA cards

  2019cited by this paper
• Newborn Screening for SCD in the USA and Canada

  2018cited by this paper
• Diagnostic tools and follow-up of sickle-cell anemia in Central Africa.

  2018cited by this paper
• Clinical phenotypes and the biological parameters of Congolese patients suffering from sickle cell anemia: A first report from Central Africa

  2017cited by this paper
• An evaluation of clinical performance of FTA cards for HPV 16/18 detection using cobas 4800 HPV Test compared to dry swab and liquid medium.

  2017cited by this paper
• Evaluation and comparison of FTA card and CTAB DNA extraction methods for non-agricultural taxa1

  2017cited by this paper
• Long-term storage and safe retrieval of human papillomavirus DNA using FTA elute cards.

  2016cited by this paper
• Use of FTA cards for the storage of breast carcinoma nucleic acid on fine‐needle aspiration samples

  2015cited by this paper
• Performance of Four Transport and Storage Systems for Molecular Detection of Multidrug-Resistant Tuberculosis

  2015cited by this paper
• Optimising sample collection for placental research.

  2014cited by this paper
• Drépanocytose chez l'enfant lushois de 6 à 59 mois en phase stationnaire: épidémiologie et clinique

  2014cited by this paper
• Variation of a test’s sensitivity and specificity with disease prevalence

  2013cited by this paper
• Comparison of genomic DNA extraction techniques from whole blood samples: a time, cost and quality evaluation study

  2012cited by this paper
• Saliva samples are a viable alternative to blood samples as a source of DNA for high throughput genotyping

  2012cited by this paper
• Sickle Cell Disease in Africa A Neglected Cause of Early Childhood Mortality

  2011cited by this paper
• Sickle Cell Disease in Africa

  2011cited by this paper
• The use of FTA® filter papers for diagnosis of avian influenza virus.

  2011cited by this paper
• Prevalence of sickle cell disease in a northeastern region of the Democratic Republic of Congo: what impact on transfusion policy?

  2010cited by this paper
• Do we need to test blood donors for sickle cell anaemia?

  2010cited by this paper
• Whatman Paper (FTA Cards) for Storing and Transferring Leishmania DNA for PCR Examination

  2009cited by this paper
• Sickle cell disease and dental treatment.

  2008cited by this paper
• Neonatal screening for sickle cell anaemia in the Democratic Republic of the Congo: experience from a pioneer project on 31 204 newborns

  2008cited by this paper
• DNA cards: determinants of DNA yield and quality in collecting genetic samples for pharmacogenetic studies.

  2007cited by this paper
• Long-term storage and safe retrieval of DNA from microorganisms for molecular analysis using FTA matrix cards.

  2006cited by this paper
• [Good practices for the study of hemoglobin].

  2003cited by this paper
• [Sickle cell anemia in the south of Zaire. Study of two series of 251 and 340 patients followed-up 1988-1992].

  1996cited by this paper
• A simple salting out procedure for extracting DNA from human nucleated cells.

  1988cited by this paper
• [HEMOGLOBINOSES IN THE CONGO (L'EOPOLDVILLE) AND IN RUANDA-URUNDI].

  1963cited by this paper

• First Insights Into the Phenotype and Genotype of Inherited Retinal Disorders in the Democratic Republic of Congo (DRC)

  2025cites this paper
• Genetic Modulators of Diversity in the Biological Expression of Sickle Cell Anemia in Patients from Democratic Republic of Congo: Role of βs-globin Haplotypes

  2024cites this paper
• Current challenges and new approaches to implementing optimal management of sickle cell disease in sub-Saharan Africa.

  2023cites this paper
• DNA testing for sickle cell anemia in Africa: Implementation choices for the Democratic Republic of Congo

  2022cites this paper
• Genetic Polymorphisms of AQP1 rs10244884 Associated with Genetic Polymorphisms of AQP1 rs10244884 Associated with Iron Deficiency Anemia in Baghdad City Iron Deficiency Anemia in Baghdad City

  year unknowncites this paper