Glucose increases intracellular free Ca2+ in tanycytes via ATP released through connexin 43 hemichannels

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Glia

• Publication date

  2012-01-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/glia.21246PMID 21987367PMCID PMC3417330
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2011influential reference
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  2010cited by this paper
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  2001cited by this paper
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  2001influential reference
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  2001cited by this paper
• Glucose sensing in pancreatic beta-cells: a model for the study of other glucose-regulated cells in gut, pancreas, and hypothalamus.

  2001influential reference
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  1996cited by this paper
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  1996cited by this paper
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  1995cited by this paper
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  1985cited by this paper
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  1977cited by this paper
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