Reduction of mtDNA heteroplasmy in mitochondrial replacement therapy by inducing forced mitophagy

No abstract is available for this paper.

• Publication year

  2022

• Venue

  Nature Biomedical Engineering

• Publication date

  2022-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/s41551-022-00881-7PMID 35437313
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mitochondrial replacement in macaque monkey offspring by first polar body transfer

  2020cited by this paper
• A bacterial cytidine deaminase toxin enables CRISPR-free mitochondrial base editing

  2020cited by this paper
• Observation of two separate bipolar spindles in the human zygote

  2019cited by this paper
• Mitochondrial fragmentation drives selective removal of deleterious mtDNA in the germline

  2019cited by this paper
• Reversion after replacement of mitochondrial DNA

  2019cited by this paper
• Dual-spindle formation in zygotes keeps parental genomes apart in early mammalian embryos

  2018cited by this paper
• Mitochondrial genetic medicine

  2018cited by this paper
• MitoTALEN reduces mutant mtDNA load and restores tRNAAla levels in a mouse model of heteroplasmic mtDNA mutation

  2018cited by this paper
• Genome editing in mitochondria corrects a pathogenic mtDNA mutation in vivo

  2018cited by this paper
• Mitophagy and Alzheimer's Disease: Cellular and Molecular Mechanisms.

  2017cited by this paper
• Mitochondrial replacement techniques or therapies (MRTs) to improve embryo development and to prevent mitochondrial disease transmission.

  2017cited by this paper
• Polar bodies are efficient donors for reconstruction of human embryos for potential mitochondrial replacement therapy

  2017cited by this paper
• Assisted reproductive technologies to prevent human mitochondrial disease transmission

  2017cited by this paper
• Functional Human Oocytes Generated by Transfer of Polar Body Genomes.

  2017cited by this paper
• Novel reproductive technologies to prevent mitochondrial disease

  2017cited by this paper
• Live birth derived from oocyte spindle transfer to prevent mitochondrial disease.

  2017cited by this paper
• Mitochondrial Replacement Techniques: Remaining Ethical Challenges.

  2017cited by this paper
• Mitochondrial replacement by pre-pronuclear transfer in human embryos

  2017cited by this paper
• Towards clinical application of pronuclear transfer to prevent mitochondrial DNA disease

  2016cited by this paper
• Genetic Drift Can Compromise Mitochondrial Replacement by Nuclear Transfer in Human Oocytes.

  2016cited by this paper
• Mitochondrial replacement in human oocytes carrying pathogenic mitochondrial DNA mutations

  2016cited by this paper
• The dynamics of mitochondrial DNA heteroplasmy: implications for human health and disease

  2015cited by this paper
• Prevalence of nuclear and mitochondrial DNA mutations related to adult mitochondrial disease

  2015cited by this paper
• Mutations causing mitochondrial disease: What is new and what challenges remain?

  2015cited by this paper
• Polar body genome transfer for preventing the transmission of inherited mitochondrial diseases.

  2014cited by this paper
• The LIR motif – crucial for selective autophagy

  2013cited by this paper
• Sperm mitochondria in reproduction: good or bad and where do they go?

  2013cited by this paper
• Unique insights into maternal mitochondrial inheritance in mice

  2013cited by this paper
• Functional Analysis of Lysosomes During Mouse Preimplantation Embryo Development

  2012cited by this paper
• Nuclear genome transfer in human oocytes eliminates mitochondrial DNA variants

  2012cited by this paper
• Barriers to male transmission of mitochondrial DNA in sperm development.

  2012cited by this paper
• Towards germline gene therapy of inherited mitochondrial diseases

  2012cited by this paper
• Rapid three-dimensional isotropic imaging of living cells using Bessel beam plane illumination

  2011cited by this paper
• The Role of Mitochondrial DNA Copy Number in Mammalian Fertility1

  2010cited by this paper
• Pronuclear transfer in human embryos to prevent transmission of mitochondrial DNA disease

  2010cited by this paper
• Mechanisms of mitophagy

  2010cited by this paper
• Mitochondrial Gene Replacement in Primate Offspring and Embryonic Stem Cells

  2009cited by this paper
• Oocyte aging: cellular and molecular changes, developmental potential and reversal possibility.

  2009cited by this paper
• Pathogenic Mitochondrial DNA Mutations Are Common in the General Population

  2008cited by this paper
• Essential role for Nix in autophagic maturation of erythroid cells

  2008cited by this paper
• Two ways to make an mtDNA bottleneck

  2008cited by this paper
• A reduction of mitochondrial DNA molecules during embryogenesis explains the rapid segregation of genotypes

  2008cited by this paper
• The mitochondrial DNA genetic bottleneck results from replication of a subpopulation of genomes

  2008cited by this paper
• Behavioural phenotyping of transgenic mice.

  2007cited by this paper
• The mitochondrial bottleneck occurs without reduction of mtDNA content in female mouse germ cells

  2007cited by this paper
• Animal Models of Cognitive Impairment

  2006cited by this paper
• Phenotype of Cloned Mice: Development, Behavior, and Physiology

  2003cited by this paper
• Kinetic characterisation of primer mismatches in allele-specific PCR: a quantitative assessment.

  2002cited by this paper
• Cytoplasmic transfer in assisted reproduction.

  2001cited by this paper
• Mitochondrial distribution and function in oocytes and early embryos.

  2000cited by this paper

• Mitochondrial Heterogeneity in a Patient with Preeclampsia.

  2026cites this paper
• Mitochondrial replacement techniques to resolve mitochondrial dysfunction and ooplasmic deficiencies: where are we now?

  2025cites this paper
• β‐Diketone Functionalized Microspheres Chelate Reactive Iron via Metal Coordination for Cartilage Repair

  2025cites this paper
• Endocrine and regenerative mechanisms of adipose-derived stem cells in female infertility

  2025cites this paper
• Causes of and Solutions to Mitochondrial Disorders: A Literature Review

  2025cites this paper
• The Complexities of Interspecies Somatic Cell Nuclear Transfer: From Biological and Molecular Insights to Future Perspectives

  2025influential citation
• Modifying metabolic and immune hallmarks of cancer by a copper complex

  2025cites this paper
• Mitochondrial diseases: from molecular mechanisms to therapeutic advances

  2025cites this paper
• Therapeutic implications of mitochondrial transfer on stem cell fate in regenerative medicine

  2025cites this paper
• Genetic and reproductive strategies to prevent mitochondrial diseases.

  2025cites this paper
• Unraveling mitochondrial influence on mammalian pluripotency via enforced mitophagy.

  2025cites this paper
• Harnessing a triphenylphosphine-based AIE nano-platform for triggering incomplete mitophagy to continuously augment anti-tumor immune response in hepatocellular carcinoma

  2024cites this paper
• Nanoengineered mitochondria enable ocular mitochondrial disease therapy via the replacement of dysfunctional mitochondria

  2024cites this paper
• Emerging Multi-omic Approaches to the Molecular Diagnosis of Mitochondrial Disease and Available Strategies for Treatment and Prevention

  2024cites this paper
• Analysis of Mutational Burden of Mitochondrial Genome in Cells of Different Human Organs and Tissues.

  2024cites this paper
• The Activation of cGAS-STING in Acute Kidney Injury

  2023cites this paper
• Understanding the genetics of human infertility

  2023cites this paper
• Assisted reproductive technologies at the nexus of fertility treatment and disease prevention

  2023cites this paper
• Earlier second polar body transfer and further mitochondrial carryover removal for potential mitochondrial replacement therapy

  2023cites this paper
• Bioorthogonally Activatable Autophagy-Tethering Compounds for Aptamer-Guided Mitochondrial Degradation.

  2023cites this paper
• Therapeutic potential of engineering the mitochondrial genome.

  2023cites this paper
• Nuclear transfer improves the developmental potential of embryos derived from cytoplasmic deficient oocytes

  2023cites this paper
• Propionic acid induces alterations in mitochondrial morphology and dynamics in SH-SY5Y cells

  2023cites this paper
• Spatiotemporal Distribution and Function of Mitochondria in Oocytes

  2023cites this paper
• Targeting mitochondrial degradation by chimeric autophagy-tethering compounds

  2023cites this paper
• Polyamine metabolite spermidine rejuvenates oocyte quality by enhancing mitophagy during female reproductive aging

  2023cites this paper
• Aggregated chromosomes/chromatin transfer: a novel approach for mitochondrial replacement with minimal mitochondrial carryover-the implications of mouse experiments for human aggregated chromosome transfer.

  2023cites this paper
• A clinical approach to diagnosis and management of mitochondrial myopathies

  2023cites this paper
• SQSTM1 and its MAP1LC3B-binding domain induce forced mitophagy to degrade mitochondrial carryover during mitochondrial replacement therapy

  2022cites this paper
• The Therapeutic Strategies Targeting Mitochondrial Metabolism in Cardiovascular Disease

  2022cites this paper
• Roles of Mitochondrial DNA Damage in Kidney Diseases: A New Biomarker

  2022cites this paper
• The mitochondrial challenge: Disorders and prevention strategies

  2022cites this paper
• Manipulating autophagic degradation in human diseases: from mechanisms to interventions

  2022cites this paper
• Modulating Mitochondrial DNA Mutations: Factors Shaping Heteroplasmy in the Germ Line and Somatic Cells.

  2022cites this paper
• Operation “mitochondrial wipeout” — clearing recipient mitochondria DNA during the cytoplasmic replacement therapy

  2022cites this paper
• Aging-associated accumulation of mitochondrial DNA mutations in tumor origin

  2022cites this paper
• Unlocking the mitochondrial genome for autism research

  2022cites this paper