The LIR motif – crucial for selective autophagy

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Journal of Cell Science

• Publication date

  2013-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1242/jcs.126128PMID 23908376
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The scaffold protein EPG-7 links cargo–receptor complexes with the autophagic assembly machinery

  2013cited by this paper
• Up-to-date membrane biogenesis in the autophagosome formation.

  2013cited by this paper
• Autolysosomal β‐catenin degradation regulates Wnt‐autophagy‐p62 crosstalk

  2013cited by this paper
• Ubiquitin-independent function of optineurin in autophagic clearance of protein aggregates

  2013cited by this paper
• NBR1 acts as an autophagy receptor for peroxisomes

  2013cited by this paper
• TBK1 Kinase Addiction in Lung Cancer Cells Is Mediated via Autophagy of Tax1bp1/Ndp52 and Non-Canonical NF-κB Signalling

  2012cited by this paper
• ATG8 Family Proteins Act as Scaffolds for Assembly of the ULK Complex

  2012influential reference
• Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells

  2012cited by this paper
• Seq2Logo: a method for construction and visualization of amino acid binding motifs and sequence profiles including sequence weighting, pseudo counts and two-sided representation of amino acid enrichment and depletion

  2012influential reference
• Autophagy as an innate immunity paradigm: expanding the scope and repertoire of pattern recognition receptors.

  2012influential reference
• Selective autophagy degrades DICER and AGO2 and regulates miRNA activity

  2012cited by this paper
• Structural characterization and inhibition of the Plasmodium Atg8-Atg3 interaction.

  2012cited by this paper
• LC3C, Bound Selectively by a Noncanonical LIR Motif in NDP52, Is Required for Antibacterial Autophagy

  2012cited by this paper
• Microtubule-associated Protein 1 Light Chain 3 (LC3) Interacts with Bnip3 Protein to Selectively Remove Endoplasmic Reticulum and Mitochondria via Autophagy*

  2012cited by this paper
• MAPK15/ERK8 stimulates autophagy by interacting with LC3 and GABARAP proteins

  2012influential reference
• The pathways of mitophagy for quality control and clearance of mitochondria

  2012cited by this paper
• Bacterial autophagy: restriction or promotion of bacterial replication?

  2012cited by this paper
• Autophagy-related Protein 32 Acts as Autophagic Degron and Directly Initiates Mitophagy*

  2012cited by this paper
• Keap1 degradation by autophagy for the maintenance of redox homeostasis

  2012cited by this paper
• TP53INP1, a tumor suppressor, interacts with LC3 and ATG8-family proteins through the LC3-interacting region (LIR) and promotes autophagy-dependent cell death

  2012cited by this paper
• Binding of the Atg1/ULK1 kinase to the ubiquitin‐like protein Atg8 regulates autophagy

  2012influential reference
• Modulation of Serines 17 and 24 in the LC3-interacting Region of Bnip3 Determines Pro-survival Mitophagy versus Apoptosis*

  2012cited by this paper
• DOR/Tp53inp2 and Tp53inp1 Constitute a Metazoan Gene Family Encoding Dual Regulators of Autophagy and Transcription

  2012influential reference
• Calreticulin signaling in health and disease.

  2012cited by this paper
• The Autophagy-related Protein Kinase Atg1 Interacts with the Ubiquitin-like Protein Atg8 via the Atg8 Family Interacting Motif to Facilitate Autophagosome Formation*

  2012influential reference
• Rab GTPase-Activating Proteins in Autophagy: Regulation of Endocytic and Autophagy Pathways by Direct Binding to Human ATG8 Modifiers

  2012influential reference
• Phosphorylation of the Autophagy Receptor Optineurin Restricts Salmonella Growth

  2011influential reference
• Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells

  2011cited by this paper
• OATL1, a novel autophagosome-resident Rab33B-GAP, regulates autophagosomal maturation

  2011influential reference
• The ubiquitin-binding adaptor proteins p62/SQSTM1 and NDP52 are recruited independently to bacteria-associated microdomains to target Salmonella to the autophagy pathway

  2011cited by this paper
• Autophagy in immunity and inflammation

  2011cited by this paper
• Microautophagy in mammalian cells: Revisiting a 40-year-old conundrum

  2011cited by this paper
• GABARAPL1 Negatively Regulates Wnt/β-catenin Signaling by Mediating Dvl2 Degradation through the Autophagy Pathway

  2011influential reference
• Midbody accumulation through evasion of autophagy contributes to cellular reprogramming and tumorigenicity

  2011cited by this paper
• Autophagic targeting of Src promotes cancer cell survival following reduced FAK signalling

  2011influential reference
• Galectin-8 targets damaged vesicles for autophagy to defend cells against bacterial invasion

  2011cited by this paper
• Characterization of the interaction of GABARAPL-1 with the LIR motif of NBR1.

  2011cited by this paper
• Atg8: an autophagy-related ubiquitin-like protein family

  2011cited by this paper
• Dissecting the involvement of LC3B and GATE-16 in p62 recruitment into autophagosomes

  2011cited by this paper
• The ATG1/ATG13 Protein Kinase Complex Is Both a Regulator and a Target of Autophagic Recycling in Arabidopsis[C][W]

  2011cited by this paper
• p62 targeting to the autophagosome formation site requires self-oligomerization but not LC3 binding

  2011cited by this paper
• Chaperone-mediated autophagy in protein quality control.

  2011cited by this paper
• The role of Atg proteins in autophagosome formation.

  2011influential reference
• Plant NBR1 is a selective autophagy substrate and a functional hybrid of the mammalian autophagic adapters NBR1 and p62/SQSTM1

  2011cited by this paper
• Selective autophagy mediated by autophagic adapter proteins

  2011influential reference
• Biogenesis and cargo selectivity of autophagosomes.

  2011cited by this paper
• p62 and NDP52 Proteins Target Intracytosolic Shigella and Listeria to Different Autophagy Pathways

  2011cited by this paper
• Autophagy: Renovation of Cells and Tissues

  2011cited by this paper
• Starch-binding domain-containing protein 1 (Stbd1) and glycogen metabolism: Identification of the Atg8 family interacting motif (AIM) in Stbd1 required for interaction with GABARAPL1.

  2011cited by this paper
• Atg8‐family interacting motif crucial for selective autophagy

  2010cited by this paper
• FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end–directed vesicle transport

  2010influential reference
• Selective autophagy: ubiquitin-mediated recognition and beyond

  2010cited by this paper
• The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy.

  2010cited by this paper
• Selective Transport of α-Mannosidase by Autophagic Pathways

  2010cited by this paper
• Regulation of the autophagy protein LC3 by phosphorylation

  2010cited by this paper
• Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation

  2010influential reference
• Coupling between clathrin-dependent endocytic budding and F-BAR-dependent tubulation in a cell-free system

  2010cited by this paper
• Delivery of cytosolic components by autophagic adaptor protein p62 endows autophagosomes with unique antimicrobial properties.

  2010cited by this paper
• Nix is a selective autophagy receptor for mitochondrial clearance

  2010influential reference
• p62/SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ALIS and their degradation by autophagy

  2010cited by this paper
• Kinetics Comparisons of Mammalian Atg4 Homologues Indicate Selective Preferences toward Diverse Atg8 Substrates*

  2010cited by this paper
• Autophagy-related Protein 8 (Atg8) Family Interacting Motif in Atg3 Mediates the Atg3-Atg8 Interaction and Is Crucial for the Cytoplasm-to-Vacuole Targeting Pathway*

  2010cited by this paper
• The Cvt pathway as a model for selective autophagy

  2010cited by this paper
• The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

  2010cited by this paper
• The nuclear cofactor DOR regulates autophagy in mammalian and Drosophila cells

  2010cited by this paper
• Network organization of the human autophagy system

  2010influential reference
• p62/SQSTM1 Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription*

  2010influential reference
• Autophagy protects against Sindbis virus infection of the central nervous system.

  2010cited by this paper
• Mitochondria-anchored receptor Atg32 mediates degradation of mitochondria via selective autophagy.

  2009cited by this paper
• Nix directly binds to GABARAP: A possible crosstalk between apoptosis and autophagy

  2009cited by this paper
• Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor Induction of BNIP3 and BNIP3L via Their BH3 Domains

  2009cited by this paper
• Shigella phagocytic vacuolar membrane remnants participate in the cellular response to pathogen invasion and are regulated by autophagy.

  2009cited by this paper
• A role for NBR1 in autophagosomal degradation of ubiquitinated substrates.

  2009influential reference
• Rab GTPases as coordinators of vesicle traffic

  2009cited by this paper
• A role for ubiquitin in selective autophagy.

  2009influential reference
• The Adaptor Protein p62/SQSTM1 Targets Invading Bacteria to the Autophagy Pathway1

  2009influential reference
• The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria

  2009influential reference
• Atg32 is a mitochondrial protein that confers selectivity during mitophagy.

  2009cited by this paper
• Dynamics and diversity in autophagy mechanisms: lessons from yeast

  2009cited by this paper
• The structure of Atg4B–LC3 complex reveals the mechanism of LC3 processing and delipidation during autophagy

  2009cited by this paper
• Role of BNIP3 and NIX in cell death, autophagy, and mitophagy

  2009cited by this paper
• Midbody ring disposal by autophagy is a post-abscission event of cytokinesis

  2009cited by this paper
• The TP53INP2 protein is required for autophagy in mammalian cells.

  2008cited by this paper
• Selective turnover of p62/A170/SQSTM1 by autophagy

  2008influential reference
• Essential role for Nix in autophagic maturation of erythroid cells

  2008cited by this paper
• Golgi-resident small GTPase Rab33B interacts with Atg16L and modulates autophagosome formation.

  2008cited by this paper
• Autophagy in the pathogenesis of disease.

  2008cited by this paper
• Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia*

  2008cited by this paper
• Structural basis of target recognition by Atg8/LC3 during selective autophagy

  2008influential reference
• Structural Basis for Sorting Mechanism of p62 in Selective Autophagy*

  2008influential reference
• The N-terminus and Phe52 residue of LC3 recruit p62/SQSTM1 into autophagosomes

  2008cited by this paper
• Identification of clathrin heavy chain as a direct interaction partner for the gamma-aminobutyric acid type A receptor associated protein.

  2007influential reference
• p62/SQSTM1 Binds Directly to Atg8/LC3 to Facilitate Degradation of Ubiquitinated Protein Aggregates by Autophagy*

  2007influential reference
• NIX is required for programmed mitochondrial clearance during reticulocyte maturation

  2007cited by this paper
• Identification of calreticulin as a ligand of GABARAP by phage display screening of a peptide library

  2007influential reference
• Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice.

  2007influential reference
• Signal integration and diversification through the p62 scaffold protein.

  2007influential reference
• p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death

  2005cited by this paper
• A renaissance for SRC

  2004cited by this paper
• p62 Is a common component of cytoplasmic inclusions in protein aggregation diseases.

  2002cited by this paper

• RNA-binding motif protein 15 promotes gastric cancer growth and drug resistance via USP10-mediated deubiquitination and stabilization of nuclear NRF2.

  2026cites this paper
• A proteome-wide biochemical screen defines binding determinants of the core autophagy protein LC3B

  2026cites this paper
• A lineage-specific selective autophagy receptor module mediates P-body turnover.

  2026cites this paper
• SlATG8f modulates tomato thermotolerance and fruit quality, correlating with changes in autophagy and heat shock-related genes

  2026cites this paper
• Effect of Mitophagy on the Tension-Driven Osteogenic Differentiation of Periodontal Ligament Stem Cells During Ageing

  2026cites this paper
• The molecular arms race: Xenophagy, pathogen evasion, and emerging host-directed therapies.

  2026cites this paper
• Electroacupuncture pretreatment regulates mitophagy in ULK1 knockout mice subjected to cerebral ischemia-reperfusion injury.

  2026cites this paper
• Autophagy in lipid metabolism.

  2026cites this paper
• A GluN2B disease-associated variant promotes the degradation of NMDA receptors via autophagy

  2026cites this paper
• A non-canonical ARMS-GABARAP interaction modulates dendritic spine formation and synaptic development

  2026cites this paper
• The mechanistic basis and cellular functions of UFMylation.

  2026cites this paper
• p62 protein pleomorphism confers tissue-specific function

  2026cites this paper
• NCOA4 initiates ferritinophagy by avidly binding GATE16 using two short linear interaction motifs

  2026cites this paper
• Decoding the brain’s ATG8 paralog code: LC3–GABARAP specialization at synapses and the astrocyte–neuron interface

  2026cites this paper
• The ribonuclease RNase T2 mediates selective autophagy of ribosomes induced by starvation in Saccharomyces cerevisiae

  2025cites this paper
• Decoding phospho-regulation and flanking regions in autophagy-associated short linear motifs

  2025cites this paper
• Induction of the ISR by AB5 subtilase cytotoxin drives type-I IFN expression in pDCs via STING activation

  2025cites this paper
• The role of TP53INP2 as an adaptor protein in the regulation of lipophagy in mature adipocytes.

  2025cites this paper
• Naringenin attenuates slow-transit constipation by regulating the AMPK/mTOR/ULK1 signalling pathway: in vivo and in vitro studies

  2025cites this paper
• Autophagy inhibition in intestinal stem cells favors enteroendocrine cell differentiation through Stat92E activity

  2025cites this paper
• Unc-51-like kinase 1 (ULK1) regulates bacterial ubiquitylation and p62 recruitment during xenophagic clearance of Listeria monocytogenes

  2025cites this paper
• Identification and validation of mitophagy-related genes in acute myocardial infarction and ischemic cardiomyopathy and study of immune mechanisms across different risk groups

  2025cites this paper
• Advances in mitophagy initiation mechanisms.

  2025cites this paper
• ACSS2 drives senescence-associated secretory phenotype by limiting purine biosynthesis through PAICS acetylation

  2025cites this paper
• A fijivirus capsid protein hijacks autophagy degrading an ω‐3 fatty acid desaturase to suppress jasmonate‐mediated antiviral defence

  2025cites this paper
• Structural insights into autophagy in the AlphaFold era.

  2025cites this paper
• Naringenin attenuates slow-transit constipation by regulating the AMPK/mTOR/ULK1 signaling pathway: In vivo and in vitro studies.

  2025cites this paper
• Autophagosome marker, LC3, is released extracellularly via several distinct pathways

  2025cites this paper
• The AP-4 accessory protein tepsin exhibits multivalent binding to LC3B.

  2025cites this paper
• Two specific interactions of GATE16 with TRPML3 and RAB33B regulate autophagy

  2025cites this paper
• Shrimp autophagy receptor protein PvTAX1BP1 regulates autophagy and facilitates white spot syndrome virus replication in Penaeus vannamei.

  2025cites this paper
• ATP2A2 regulates STING1/MITA-driven signal transduction including selective autophagy

  2025cites this paper
• TBB inhibits CK2/PD-L1/EGFR pathway-mediated tumor progression.

  2025cites this paper
• Hypoxia-Induced Mitochondrial Dysfunction and Mitophagy in the small yellow croaker (Larimichthys polyactis).

  2025cites this paper
• ANKZF1 helps to eliminate stress-damaged mitochondria by LC3-mediated mitophagy

  2025cites this paper
• Autophagy is required for the development and functionality of lacrimal gland-like organoids.

  2025cites this paper
• Retinal Pigment Epithelium Under Oxidative Stress: Chaperoning Autophagy and Beyond

  2025cites this paper
• PANCS-spec-Binders: A system for rapidly discovering isoform– or epitope–specific binders

  2025cites this paper
• Nestin Regulates Autophagy‐Dependent Ferroptosis Mediated Skeletal Muscle Atrophy by Ubiquitinating MAP 1LC3B

  2025cites this paper
• Crystal Structure of Autophagy-Associated Protein 8 at 1.36 Å Resolution and Its Inhibitory Interactions with Indole Analogs

  2025cites this paper
• Region-specific mitophagy in nucleus pulposus, annulus fibrosus, and cartilage endplate of intervertebral disc degeneration: mechanisms and therapeutic strategies

  2025cites this paper
• Bioinformatic Analysis of the Value of Mitophagy and Immune Responses in Corneal Endothelial Dysfunction

  2025cites this paper
• Lysosomes: guardians and healers within cells- multifaceted perspective and outlook from injury repair to disease treatment

  2025cites this paper
• The sigma-1 receptor as a neurohomeostatic decision hub for GABARAP-mediated receptor trafficking and macroautophagy

  2025cites this paper
• Role of TRIM24 in the regulation of proteasome-autophagy crosstalk in bortezomib-resistant mantle cell lymphoma

  2025cites this paper
• Host Immunity and Intracellular Bacteria Evasion Mechanisms: Enhancing Host-Directed Therapies with Drug Delivery Systems.

  2025cites this paper
• Structural organization of p62 filaments and the cellular ultrastructure of calcium-rich p62-enwrapped lipid droplet cargo

  2025cites this paper
• The Role of the Beclin1 Complex in Rab9-Dependent Alternative Autophagy

  2025cites this paper
• The LC3-interacting region of NBR1 is a protein interaction hub enabling optimal flux.

  2025cites this paper
• Endothelial mitochondria in the blood-brain barrier

  2025cites this paper
• SlATG8f enhances tomato thermotolerance and fruit quality via autophagy and HS pathways

  2025cites this paper
• Tubulin Polymerization Promoting Proteins: Functional Diversity With Implications in Neurological Disorders

  2025cites this paper
• Mitophagy and oxidative stress in chronic kidney disease (Review)

  2025cites this paper
• A new role of RAB21 and VARP in autophagy and autophagic exocytosis of ATP

  2025cites this paper
• Phase separation of p62: roles and regulations in autophagy.

  2025cites this paper
• Structural Insights into the GABARAP-ATG3 Backside Interaction and Apo ATG3 Conformation.

  2025cites this paper
• Post-Translational Modification of p62: Roles and Regulations in Autophagy

  2025cites this paper
• The loss of OPA1 accelerates intervertebral disc degeneration and osteoarthritis in aged mice

  2025cites this paper
• Structural Flexibility and Shape Similarity Contribute to Exclusive Functions of Certain Atg8 Isoforms in the Autophagy Process

  2025cites this paper
• Conserved LIR-specific interaction of Sigma-1 receptor and GABARAP

  2025cites this paper
• PANCS-Binders: a rapid, high-throughput binder discovery platform

  2025cites this paper
• Characterization of a novel mitophagy-related 5-genes signature for diagnosis of acute myocardial infarction.

  2024cites this paper
• Manipulation of Macrophages: Emerging Mechanisms of Leishmaniasis.

  2024cites this paper
• Cytosolic FKBPL and ER-resident CKAP4 co-regulates ER-phagy and protein secretion

  2024cites this paper
• Structural Analyses of a GABARAP~ATG3 Conjugate Uncover a Novel Non-covalent Ubl-E2 Backside Interaction

  2024cites this paper
• Calreticulin from Apostichopus japonicus relieves endoplasmic reticulum stress induced by Vibrio splendidus through autophagy.

  2024cites this paper
• RNF144B negatively regulates antiviral immunity by targeting MDA5 for autophagic degradation

  2024cites this paper
• Epithelial–mesenchymal plasticity in cancer: signaling pathways and therapeutic targets

  2024cites this paper
• Serum metabolomic profile of myasthenia gravis and potential values as biomarkers in disease monitoring.

  2024cites this paper
• Toward Systemic Lipofuscin Removal

  2024cites this paper
• NCOA4 initiates ferritinophagy by binding GATE16 using two highly avid short linear interaction motifs

  2024cites this paper
• YIPF3 and YIPF4 regulate autophagic turnover of the Golgi apparatus

  2024cites this paper
• Advancements in unravelling the fundamental function of the ATAD3 protein in multicellular organisms.

  2024cites this paper
• The LC3-interacting region of NBR1 is a protein interaction hub enabling optimal flux

  2024cites this paper
• α-Synuclein amyloid fibril directly binds to LC3B and suppresses SQSTM1/p62-mediated selective autophagy

  2024cites this paper
• Structure-Based Design and Discovery of a Potent and Cell-Active LC3A/B Covalent Inhibitor.

  2024cites this paper
• Lack of compensatory mitophagy in skeletal muscles during sepsis

  2024cites this paper
• Glutamine deprivation in glioblastoma stem cells triggers autophagic SIRT3 degradation to epigenetically restrict CD133 expression and stemness

  2024cites this paper
• Dysregulation of autophagy in gastric carcinoma: Pathways to tumor progression and resistance to therapy.

  2024cites this paper
• Rbm46 inhibits reactive oxygen species in mouse embryonic stem cells through modulating BNIP3-mediated mitophagy.

  2024cites this paper
• Clathrin light chains negatively regulate plant immunity by hijacking the autophagy pathway

  2024cites this paper
• Gonococcal OMV-delivered PorB induces epithelial cell mitophagy

  2024cites this paper
• ALLO-1- and IKKE-1-dependent positive feedback mechanism promotes the initiation of paternal mitochondrial autophagy

  2024cites this paper
• CLU (clusterin) and PPARGC1A/PGC1α coordinately control mitophagy and mitochondrial biogenesis for oral cancer cell survival

  2024cites this paper
• Mitophagy Regulates the Circadian Rhythms by Degrading NR1D1 in Simulated Microgravity and Isolation Environments

  2024cites this paper
• Innate immune and proinflammatory signals activate the Hippo pathway via a Tak1-STRIPAK-Tao axis

  2024cites this paper
• Inhibition of ADAM9 promotes the selective degradation of KRAS and sensitizes pancreatic cancers to chemotherapy

  2024influential citation
• Three-step docking by WIPI2, ATG16L1, and ATG3 delivers LC3 to the phagophore

  2024cites this paper
• Tepsin binds LC3B to promote ATG9A trafficking and delivery

  2024cites this paper
• Lnc-PLCB1 is stabilized by METTL14 induced m6A modification and inhibits Helicobacter pylori mediated gastric cancer by destabilizing DDX21.

  2024cites this paper
• The loss of OPA1 accelerates intervertebral disc degeneration and osteoarthritis in aged mice

  2024cites this paper
• Molecular Mechanism of Autophagosome–Lysosome Fusion in Mammalian Cells

  2024cites this paper
• An LIR motif in the Rift Valley fever virus NSs protein is critical for the interaction with LC3 family members and inhibition of autophagy

  2024cites this paper
• The matrix protein of lyssavirus hijacks autophagosome for efficient egress by recruiting NEDD4 through its PPxY motif

  2024cites this paper
• Targeting autophagy drug discovery: Targets, indications and development trends.

  2024cites this paper
• The two autophagy-related proteins 8a and 8b play distinct physiological roles in Drosophila.

  2024cites this paper
• Molecular mechanisms underlying the BIRC6-mediated regulation of apoptosis and autophagy

  2024cites this paper
• Hhatl ameliorates endoplasmic reticulum stress through autophagy by associating with LC3

  2024cites this paper
• TFAM is an autophagy receptor that limits inflammation by binding to cytoplasmic mitochondrial DNA

  2024cites this paper
• Non-lytic spread of poliovirus requires the nonstructural protein 3CD

  2024cites this paper