Effects of Low-Intensity Pulsed Ultrasound Therapy on Fracture Healing: A Systematic Review and Meta-Analysis

No abstract is available for this paper.

• Publication year

  2012

• Venue

  American Journal of Physical Medicine & Rehabilitation

• Publication date

  2012-04-01

• Fields of study

  Medicine, Engineering

• Identifiers
  DOI 10.1097/PHM.0b013e31822419baPMID 21904188
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Comparison of low-intensity pulsed ultrasound and pulsed electromagnetic field treatments on OPG and RANKL expression in human osteoblast-like cells.

  2010cited by this paper
• Bone stimulation for fracture healing: What's all the fuss?

  2009cited by this paper
• Growth modification of the rabbit mandible using therapeutic ultrasound: is it possible to enhance functional appliance results?

  2009cited by this paper
• Biological Aspects and Clinical Importance of Ultrasound Therapy in Bone Healing

  2009cited by this paper
• Low-intensity pulsed ultrasound for the treatment of bone delayed union or nonunion: a review.

  2009cited by this paper
• Fracture repair with ultrasound: clinical and cell-based evaluation.

  2008cited by this paper
• Low-intensity pulsed ultrasound accelerates periodontal wound healing after flap surgery.

  2008cited by this paper
• Low-intensity pulsed ultrasound (LIPUS) in fresh clavicle fractures: a multi-centre double blind randomised controlled trial.

  2008cited by this paper
• Low-intensity pulsed ultrasound increases bone volume, osteoid thickness and mineral apposition rate in the area of fracture healing in patients with a delayed union of the osteotomized fibula.

  2008cited by this paper
• The role of low intensity pulsed ultrasound therapy in the management of acute fractures: a systematic review.

  2008cited by this paper
• Low-intensity pulsed ultrasound treatment for postoperative delayed union or nonunion of long bone fractures

  2007influential reference
• Low‐intensity pulsed ultrasound and nonsteroidal anti‐inflammatory drugs have opposing effects during stress fracture repair

  2007cited by this paper
• Low-intensity pulsed ultrasound and pulsed electromagnetic field in the treatment of tibial fractures: a systematic review.

  2007cited by this paper
• Use of low-intensity pulsed ultrasound for posttraumatic nonunions of the tibia: a review of patients treated in the Netherlands.

  2007cited by this paper
• The enhancement of bone regeneration by ultrasound.

  2007influential reference
• The new bone biology: pathologic, molecular, and clinical correlates.

  2006cited by this paper
• Effects of low-intensity pulsed ultrasound on healing of mandibular fractures: an experimental study in rabbits.

  2006cited by this paper
• Dose‐dependent effect of low‐intensity pulsed ultrasound on callus formation during rapid distraction osteogenesis

  2006cited by this paper
• Low‐Level, High‐Frequency Mechanical Signals Enhance Musculoskeletal Development of Young Women With Low BMD

  2006cited by this paper
• Low-intensity pulsed ultrasound for bone healing: an overview.

  2006cited by this paper
• The effect of ultrasound on the healing of muscle-pediculated bone graft in scaphoid non-union

  2006cited by this paper
• The Ilizarov Technique for Bone Regeneration and Repair

  2005cited by this paper
• Preliminary Results of Tibial Bone Transports With Pulsed Low Intensity Ultrasound (Exogen™)

  2005cited by this paper
• The effect of low-intensity pulsed ultrasound on callus maturation in tibial distraction osteogenesis

  2005cited by this paper
• Effects of ultrasound on transforming growth factor-beta genes in bone cells.

  2005cited by this paper
• Effect of ultrasound therapy on bone healing of lateral malleolar fractures of the ankle joint fixed with bioabsorbable screws

  2005influential reference
• No Long-Term Effects of Ultrasound Therapy on Bioabsorbable Screw-Fixed Lateral Malleolar Fracture

  2005influential reference
• Pulsed Low-Intensity Ultrasound: A New Salvage Procedure for Delayed Unions and Nonunions After Leg Lengthening in Children

  2005cited by this paper
• Low-Intensity Ultrasound Enhances Maturation of Callus after Segmental Transport

  2005cited by this paper
• Ultrasound to stimulate early bone formation in a distraction gap: a double blind randomised clinical pilot trial in the edentulous mandible.

  2005influential reference
• The effect of low intensity ultrasound and bioabsorbable self-reinforced poly-L-lactide screw fixation on bone in lateral malleolar fractures

  2005influential reference
• Low-Intensity Pulsed Ultrasound in the Treatment of Traumatic Hand Fracture in an Elite Athlete

  2004cited by this paper
• Therapeutic ultrasound and fracture healing: a survey of beliefs and practices.

  2004cited by this paper
• Stimulation of bone cell differentiation by low‐intensity ultrasound—a histomorphometric in vitro study

  2004cited by this paper
• Mechanical bioeffects of ultrasound.

  2004cited by this paper
• Compound high-energy limb fractures with delayed union: our experience with adjuvant ultrasound stimulation (exogen).

  2004cited by this paper
• The stimulation of bone growth by ultrasound

  2004cited by this paper
• Current trends in the enhancement of biomaterial osteointegration: biophysical stimulation.

  2004cited by this paper
• Future applications for emergency ultrasound.

  2004cited by this paper
• Low-intensity pulsed ultrasound accelerates maturation of callus in patients treated with opening-wedge high tibial osteotomy by hemicallotasis.

  2004influential reference
• The effect of pulsed ultrasound in the treatment of tibial stress fractures.

  2004influential reference
• Complex tibial fracture outcomes following treatment with low-intensity pulsed ultrasound.

  2004influential reference
• Effects of He-Ne Laser Irradiation on Osteosynthesis

  2003cited by this paper
• Stimulators of bone healing. Biologic and biomechanical.

  2003cited by this paper
• Ultrasound stimulation of maxillofacial bone healing.

  2003cited by this paper
• Use of Physical Forces in Bone Healing

  2003cited by this paper
• Reliability of the PEDro scale for rating quality of randomized controlled trials.

  2003cited by this paper
• Ultrasound stimulates nitric oxide and prostaglandin E2 production by human osteoblasts.

  2002cited by this paper
• The effect of low-intensity pulsed ultrasound therapy on time to fracture healing: a meta-analysis.

  2002cited by this paper
• The Effect of Pulsed Ultrasound on Mandibular Distraction

  2002cited by this paper
• Use of ultrasound to assess healing of a mandibular distraction wound.

  2002cited by this paper
• Radiographic Results of Callus Distraction Aided by Pulsed Low-intensity Ultrasound

  2001cited by this paper
• Orthopaedic Basic Science. Biology and Biomechanics of the Musculoskeletal System. 2nd ed.

  2001cited by this paper
• Current trends in the enhancement of fracture healing.

  2001cited by this paper
• The use of low-intensity ultrasound to accelerate the healing of fractures.

  2001cited by this paper
• Low‐intensity ultrasound stimulates endochondral ossification in vitro

  2001cited by this paper
• Low-intensity pulsed ultrasound in the treatment of nonunions.

  2001influential reference
• Treatment of ununited fracture of the hook of hamate by low-intensity pulsed ultrasound: a case report.

  2000cited by this paper
• Effects of ultrasound and 1,25-dihydroxyvitamin D3 on growth factor secretion in co-cultures of osteoblasts and endothelial cells.

  2000cited by this paper
• Ultrasound – an alternative healing method for nonunions?

  2000cited by this paper
• Electromagnetic fields and magnets. Investigational treatment for musculoskeletal disorders.

  2000cited by this paper
• Acceleration of Fresh Fracture Repair Using the Sonic Accelerated Fracture Healing System (SAFHS): A Review

  2000cited by this paper
• Ultrasound therapy for musculoskeletal disorders: a systematic review

  1999cited by this paper
• Serum bone markers after intramedullary fixed tibial fractures.

  1999influential reference
• Effect of ultrasound on the production of IL-8, basic FGF and VEGF.

  1999cited by this paper
• Low‐intensity ultrasound stimulates proteoglycan synthesis in rat chondrocytes by increasing aggrecan gene expression

  1999cited by this paper
• No effect of low-intensity ultrasound on healing time of intramedullary fixed tibial fractures.

  1999influential reference
• Low intensity pulsed ultrasound exposure increases prostaglandin E2 production via the induction of cyclooxygenase-2 mRNA in mouse osteoblasts.

  1999cited by this paper
• Acceleration of increase in bone mineral content by low‐intensity ultrasound energy in leg lengthening.

  1999cited by this paper
• Ultrasound therapy for musculoskeletal disorders: a systematic review.

  1999cited by this paper
• Can conventional therapeutic ultrasound units be used to accelerate fracture repair

  1999cited by this paper
• Concepts of fracture union, delayed union, and nonunion.

  1998cited by this paper
• Enhancement of fracture healing by low intensity ultrasound.

  1998cited by this paper
• Accelerated Healing of Distal Radial Fractures with the Use of Specific, Low-Intensity Ultrasound. A Multicenter, Prospective, Randomized, Double-Blind, Placebo-Controlled Study*

  1997influential reference
• Acceleration of Tibia and Distal Radius Fracture Healing in Patients Who Smoke

  1997influential reference
• Exposure to low‐intensity ultrasound increases aggrecan gene expression in a rat femur fracture model

  1996cited by this paper
• Effect of therapeutic ultrasound on endochondral ossification.

  1995cited by this paper
• Enhancement of fracture-healing.

  1995cited by this paper
• Use of Capacitive Coupled Electric Fields in Stress Fractures in Athletes

  1995cited by this paper
• The effects of ultrasonic stimulation on DP-bioglass bone substitute.

  1995cited by this paper
• Infrared laser and bone metabolism: a pilot study.

  1994cited by this paper
• Acceleration of tibial fracture-healing by non-invasive, low-intensity pulsed ultrasound.

  1994influential reference
• Ultrasonic effect on fracture repair and prostaglandin E2 production.

  1992cited by this paper
• Preliminary studies of duration and intensity of ultrasonic treatments on fracture repair.

  1992cited by this paper
• Ultrasound can affect bone healing both locally and systemically.

  1991cited by this paper
• Bone stimulators for fusions and fractures.

  1991cited by this paper
• Bone stimulators for fusions and fractures.

  1991cited by this paper
• Rockwood and Green's Fractures in Adults

  1991cited by this paper
• A ten-year review of treatment of delayed union and nonunion with an implanted bone growth stimulator.

  1990cited by this paper
• The Effect of Low Power Specifically Programmed Ultrasound on the Healing Time of Fresh Fractures Using a Collesʼ Model

  1990cited by this paper
• Non-invasive low-intensity pulsed ultrasound accelerates bone healing in the rabbit.

  1990cited by this paper
• Wound healing : alternatives in management

  1990cited by this paper
• The influence of induced micromovement upon the healing of experimental tibial fractures.

  1985cited by this paper
• Treatment of nonunion with a constant direct current: a totally implantable system.

  1984cited by this paper
• Ultrasound propagation in 'in vivo' bone.

  1981cited by this paper
• Ultrasound-induced changes in rates of influx and efflux of potassium ions in rat thymocytes in vitro.

  1980cited by this paper
• [Effect of ultrasonics on the development of osseous callus in fractures].

  1953cited by this paper
• [Animal experiments in the study of the effect of ultrasonic waves on bone regeneration].

  1950cited by this paper

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  2026cites this paper
• Actin Filament and Cell Orientation Align with Surface Acoustic Wave Propagation and Cell Migration in Vibration-Enhanced Wound Healing.

  2025cites this paper
• Evaluating Bone Fracture Healing in a Rabbit Model Using Doppler Imaging Modes, Shear Wave Elastography, X‐Ray, and Dual‐Energy X‐Ray Absorptiometry

  2025cites this paper
• Simultaneous TKA and Revision of Post-ORIF Patellar Non-union with Bone Grafting: A Case Report

  2025cites this paper
• What's New in Hand and Wrist Surgery.

  2025cites this paper
• Effects of low-intensity pulsed ultrasound on muscle mass and Fndc5 mRNA expression in aged male mice

  2025cites this paper
• Physical Stimuli-Based Biomaterials for Bone Regeneration.

  2025cites this paper
• Ultrasound-assisted tissue engineering

  2024cites this paper
• Protective effect of low‐intensity pulsed ultrasound on immune checkpoint inhibitor-related myocarditis via fine-tuning CD4+ T-cell differentiation

  2024cites this paper
• Attenuation of orthodontically induced inflammatory root resorption by using low-intensity pulsed ultrasound as a therapeutic modality- a systematic review

  2024cites this paper
• Low-Intensity Pulsed Ultrasound Versus Sham in the Treatment of Operatively Managed Scaphoid Nonunions

  2024cites this paper
• Pulsed Low-Intensity Focused Ultrasound (LIFU) Activation of Ovarian Follicles

  2024cites this paper
• Pulsed surface acoustic waves accelerate wound healing and reveal new parameter limits for cell stimulation in vitro

  2024cites this paper
• Physiotherapy management of rib fractures.

  2023cites this paper
• Low-intensity pulsed ultrasound in acute multiple rib fracture—a prospective analysis, randomized controlled trial and pilot study

  2023cites this paper
• Ultrasound and shockwave therapy for acute fractures in adults.

  2023cites this paper
• Low‐Intensity Pulsed Ultrasound Maintains Bone Mass After Withdrawal of Human Parathyroid Hormone in Ovariectomized Mice

  2023cites this paper
• Evaluation of Low-Intensity Pulsed Ultrasound on Stress Fractures to Reduce the Time to Return to Sport or Activity in the Physically Active Population: A Systematic Review

  2023cites this paper
• Enhanced bone regeneration by low-intensity pulsed ultrasound and lipid microbubbles on PLGA/TCP 3D-printed scaffolds

  2023cites this paper
• Low-intensity pulsed ultrasound partially reversed the deleterious effects of a severe spinal cord injury-induced bone loss and osteoporotic fracture healing in paraplegic rats

  2022cites this paper
• Low-Intensity Pulsed Ultrasound Therapy in Patients With Post-traumatic Delayed Union and Non-union

  2022cites this paper
• Effect of low intensity ultra sound on bone regeneration and healing: a systematic review

  2022cites this paper
• Principles of management of hand fractures

  2022cites this paper
• Effects of Low-Intensity Pulsed Ultrasound on the Migration and Homing of Human Amnion–Derived Mesenchymal Stem Cells to Ovaries in Rats With Premature Ovarian Insufficiency

  2022cites this paper
• In vivo study on the healing of bone defect treated with non-thermal atmospheric pressure gas discharge plasma

  2021cites this paper
• Evaluating the Effectiveness of Biophysical Methods of Osteogenesis Stimulation: Review

  2021cites this paper
• Therapeutischer Ultraschall

  2021cites this paper
• Low Intensity Pulsed Ultrasound for Bone Tissue Engineering

  2021cites this paper
• Laser-generated focused ultrasound transducer using a perforated photoacoustic lens for tissue characterization.

  2021cites this paper
• Fracture Nonunions and Delayed Unions Treated With Low-Intensity Pulsed Ultrasound Therapy: A Clinical Series

  2021cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
• [A review of mechanisms by which low-intensity pulsed ultrasound affects bone regeneration].

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  2020cites this paper
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  2019cites this paper
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  2019cites this paper
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  2018cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
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