Cortical Thickness Abnormalities at Different Stages of the Illness Course in Schizophrenia

Youjin Zhao,Qian Zhang,C. Shah,Qian Li,J. Sweeney,Fei Li,Q. Gong

Published 2022 in JAMA psychiatry

ABSTRACT

Key Points Question Are there differences in cortical thickness (CTh) alterations between clinical high-risk (CHR), first episode of psychosis (FEP), and long-term illness stages of schizophrenia (SCZ)? Findings In meta-analyses comprising 2109 individuals across different illness stages of SCZ (10 studies of CHR, 12 studies of FEP, and 10 studies of long-term SCZ), CTh did not differ significantly between individuals with CHR and FEP, but those with long-term illness showed more pronounced CTh reductions than individuals with FEP. Accelerated age-related CTh reductions were found in frontotemporal cortex when combining all studies. Meaning The findings of this systematic review and meta-analysis do not indicate an emergence of CTh alterations with illness onset but suggest a progressively increasing thinning of CTh after illness onset.

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