Characterization of the major brain osmolytes that accumulate in salt-loaded rats.

No abstract is available for this paper.

• Publication year

  1989

• Venue

  American Journal of Physiology

• Publication date

  1989-12-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1152/AJPRENAL.1989.257.6.F1108PMID 2603957
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• TREATMENT OF HYPOPITUITARISM WITH RECOMBINANT MET-HGH (LILLY)

  1988cited by this paper
• Survey of osmolytes in renal cell lines.

  1988cited by this paper
• 31P‐NMR spectroscopy of human cancer cells proliferating in a basement membrane gel

  1988cited by this paper
• Accumulation of major organic osmolytes in rat renal inner medulla in dehydration.

  1988cited by this paper
• Effect of acute and chronic hypernatremia on myoinositol and sorbitol concentration in rat brain and kidney.

  1988cited by this paper
• Osmotically active organic solutes in the renal inner medulla.

  1987cited by this paper
• Isolation of glycine betaine and proline betaine from human urine. Assessment of their role as osmoprotective agents for bacteria and the kidney.

  1987cited by this paper
• Role and regulation of glycerophosphorylcholine in rat renal papilla

  1987cited by this paper
• Atrial natriuretic peptide levels during acute and chronic saline loading in conscious dogs.

  1986cited by this paper
• Protons, osmolytes, and fitness of internal milieu for protein function.

  1986cited by this paper
• Predominant osmotically active organic solutes in rat and rabbit renal medullas.

  1986cited by this paper
• Effect of Hypoglycemic Encephalopathy upon Amino Acids, High‐Energy Phosphates, and pHi in the Rat Brain In Vivo: Detection by Sequential 1H and 31P NMR Spectroscopy

  1985cited by this paper
• Detection of cerebral lactate in vivo during hypoxemia by 1H NMR at relatively low field strengths (1.9 T).

  1984cited by this paper
• High-resolution 1H nuclear magnetic resonance study of cerebral hypoxia in vivo.

  1983cited by this paper
• Living with water stress: evolution of osmolyte systems.

  1982cited by this paper
• Taurine: a role in osmotic regulation of mammalian brain and possible clinical significance.

  1980cited by this paper
• Elevation of rat brain amino acids, ammonia and idiogenic osmoles induced by hyperosmolality.

  1979cited by this paper
• EFFECTS OF SALT AND WATER LOADING ON CARBOHYDRATE AND ENERGY METABOLISM AND LEVELS OF SELECTED AMINO ACIDS IN THE BRAINS OF YOUNG MICE 1

  1975cited by this paper
• Acute and chronic hyperosmolality. Effects on cerebral amino acids and energy metabolism.

  1975cited by this paper
• METABOLISM OF GLUCOSE, AMINO ACIDS, AND SOME RELATED METABOLITES IN THE BRAIN OF TOADS (BUFO BOREAS) ADAPTED TO FRESH WATER OR HYPEROSMOTIC ENVIRONMENTS

  1973cited by this paper
• Hyperglycemia, polyol accumulation, and increased intracranial pressure.

  1971cited by this paper
• THE MEASUREMENT OF FREE AND N‐ACETYLATED ASPARTIC ACIDS IN THE NERVOUS SYSTEM *

  1966cited by this paper
• Studies on the Role of N-Acetylaspartic Acid in Mammalian Brain

  1959cited by this paper
• Osmotic volumes of distribution; idiogenic changes in osmotic pressure associated with administration of hypertonic solutions.

  1955cited by this paper
• Protein measurement with the Folin phenol reagent.

  1951cited by this paper

• Experimental Measurement and Mathematical Quantification of Fixed-Charged Density in Rat and Pig Brain Tissue

  2024influential citation
• Longitudinal study of neurochemical, volumetric and behavioral changes in Q140 & BACHD mouse models of Huntington’s disease

  2024cites this paper
• Neurometabolic changes in a rat pup model of type C hepatic encephalopathy depend on age at liver disease onset

  2023cites this paper
• Glucose and Inositol Transporters, SLC5A1 and SLC5A3, in Glioblastoma Cell Migration

  2022cites this paper
• Case Report: Severe hypernatremia from psychogenic adipsia [version 1; peer review: 2 approved]

  2022cites this paper
• Impact of donor sodium levels on clinical outcomes in liver transplant recipients: a systematic review

  2020cites this paper
• γ-Aminobutyric acid transporters as relevant biological target: Their function, structure, inhibitors and role in the therapy of different diseases.

  2020cites this paper
• Characterisation of organic osmolytes and biomarkers of smoltification in the Atlantic salmon (Salmo salar)

  2020cites this paper
• Simulating cerebral edema and delayed fatality after traumatic brain injury using triphasic swelling biomechanics

  2019cites this paper
• Management of Dehydration in Patients Suffering Swallowing Difficulties

  2019cites this paper
• Sodium and Water Balance

  2018cites this paper
• Uncoupling N-acetylaspartate from brain pathology: implications for Canavan disease gene therapy

  2017cites this paper
• Case Report: Severe hypernatremia from psychogenic adipsia

  2017cites this paper
• Metabolic mechanisms of development and compensation of osmotic stress in the brain

  2017cites this paper
• Diagnosis and treatment of hypernatremia.

  2016cites this paper
• Open Peer Review

  2016cites this paper
• Hypertonicity: Pathophysiologic Concept and Experimental Studies

  2016cites this paper
• Disequilibrium Syndrome and Prevention in Nonhemodialysis Patients

  2015cites this paper
• Central Control of Fluid and Electrolyte Homeostasis A comparison of physiological and transcriptome responses to water deprivation and salt loading in the rat supraoptic nucleus

  2015cites this paper
• hyperosmolality in ovine fetuses, lambs, and adults Regulation of brain water during acute

  2015cites this paper
• 300 CHAPTER 10 Posterior Pituitary

  2015cites this paper
• Energy Metabolism of the Brain, Including the Cooperation between Astrocytes and Neurons, Especially in the Context of Glycogen Metabolism

  2015cites this paper
• A comparison of physiological and transcriptome responses to water deprivation and salt loading in the rat supraoptic nucleus.

  2015cites this paper
• CALL FOR PAPERS Central Control of Fluid and Electrolyte Homeostasis A comparison of physiological and transcriptome responses to water deprivation and salt loading in the rat supraoptic nucleus

  2015cites this paper
• Title: A comparison of physiological and transcriptome responses to water

  2015cites this paper
• Correction of hyponatremia and osmotic demyelinating syndrome: have we neglected to think intracellularly?

  2015cites this paper
• Protection by Polarized, Regulated Transport of Taurine

  2014cites this paper
• Glycine modulates membrane potential, cell volume, and phagocytosis in murine microglia

  2014cites this paper
• Acute hypernatremia promotes anxiolysis and attenuates stress-induced activation of the hypothalamic-pituitary-adrenal axis in male mice.

  2014cites this paper
• The betaine/GABA transporter and betaine: roles in brain, kidney, and liver

  2014influential citation
• Chapter 45 – Hypernatremic States

  2013cites this paper
• Acute hypernatremia exerts an inhibitory oxytocinergic tone that is associated with anxiolytic mood in male rats.

  2013cites this paper
• A Guide to the Metabolic Pathways and Function of Metabolites Observed in Human Brain 1H Magnetic Resonance Spectra

  2013cites this paper
• Tilapia (Oreochromis mossambicus) brain cells respond to hyperosmotic challenge by inducing myo-inositol biosynthesis

  2013cites this paper
• Effects of acute and chronic hyperglycemia on the neurochemical profiles in the rat brain with streptozotocin‐induced diabetes detected using in vivo1H MR spectroscopy at 9.4 T

  2012cites this paper
• Neurochemical Analysis of Primary Motor Cortex in Chronic Low Back Pain

  2012cites this paper
• Longitudinal in vivo developmental changes of metabolites in the hippocampus of Fmr1 knockout mice

  2012cites this paper
• Associations among parenting experiences during childhood and adolescence, hypothalamus‐pituitary‐adrenal axis hypoactivity, and hippocampal gray matter volume reduction in young adults

  2012cites this paper
• Dehydration in Dysphagia

  2011cites this paper
• The Role of Organic Osmolytes in the Response of Cultured Astrocytes to Hyperosmolarity

  2011cites this paper
• Primary Motor Cortex in Stroke: A Functional MRI-Guided Proton MR Spectroscopic Study

  2011cites this paper
• Hippocampal betaine/GABA transporter mRNA expression is not regulated by inflammation or dehydration post‐status epilepticus

  2011cites this paper
• Primary somatosensory cortex in chronic low back pain – a 1H-MRS study

  2011cites this paper
• ESSENTIAL PHYSIOLOGIC CONCERNS CHAPTER 41 ■ FLUIDS AND ELECTROLYTES

  2010cites this paper
• Brain volume regulation in response to changes in osmolality.

  2010cites this paper
• What's new about osmotic regulation of glycerophosphocholine.

  2009cites this paper
• Papel del factor transcripcional TonEBP en el daño cardíaco inducido por hiperosmolaridad

  2009cites this paper
• Effects of altered corticosteroid milieu on rat hippocampal neurochemistry and structure--an in vivo magnetic resonance spectroscopy and imaging study.

  2008cites this paper
• Risk for metabolic syndrome predisposes to alterations in the thalamic metabolism

  2008cites this paper
• The effect of hypernatraemia on ketamine anaesthesia in male rats

  2008cites this paper
• THE EFFECT OF HYPERNATREMIC STATE ON ANESTHESIA: MALE WISTAR RAT

  2008cites this paper
• Gene expression profiling in brain following acute systemic hypertonicity: novel genes possibly involved in osmoadaptation

  2008cites this paper
• Selective tonicity-induced expression of the neutral amino-acid transporter SNAT2 in oligodendrocytes in rat brain following systemic hypertonicity.

  2008cites this paper
• Dysnatremias: Diagnosis and Treatment

  2008cites this paper
• 10 Amino Acids and Brain Volume Regulation: Contribution and Mechanisms

  2007cites this paper
• N-Acetylaspartate in the CNS: from neurodiagnostics to neurobiology.

  2007cites this paper
• Neurochemical changes in Huntington R6/2 mouse striatum detected by in vivo1H NMR spectroscopy

  2007cites this paper
• CSF sub-compartments in relation to plasma osmolality in healthy controls and in patients with first episode schizophrenia.

  2007cites this paper
• Altered cerebral glucose and acetate metabolism in succinic semialdehyde dehydrogenase‐deficient mice: evidence for glial dysfunction and reduced glutamate/glutamine cycling

  2007cites this paper
• The effect of hypernatremia on ketamine anesthesia in male rat

  2007cites this paper
• Hypernatemia : Successful Treatment

  2006cites this paper
• Large discrepancies in cellular distribution of the tonicity-induced expression of osmoprotective genes and their regulatory transcription factor TonEBP in rat brain.

  2006cites this paper
• Differential cellular distribution of tonicity-induced expression of transcription factor TonEBP in the rat brain following prolonged systemic hypertonicity.

  2006cites this paper
• Lithium and inositol: effects on brain water homeostasis in the rat

  2006cites this paper
• [Controlled hypernatremia].

  2006cites this paper
• Control of brain volume during hypoosmolality and hyperosmolality.

  2006cites this paper
• 1 Myelin and White Matter

  2005cites this paper
• Effect of Hyperosmotic Conditions on the Expression of the Betaine-GABA-Transporter (BGT-1) in Cultured Mouse Astrocytes

  2005cites this paper
• Magnetic Resonance Spectroscopy: Basic Principles and Application in White Matter Disorders

  2005cites this paper
• Untersuchung von intrazellulären Osmolytkonzentrationen im Hirn nach Dehydratation durch Ausdauerbelastung

  2005cites this paper
• Cell volume regulation: a review of cerebral adaptive mechanisms and implications for clinical treatment of osmolal disturbances. I

  2004cites this paper
• Regulation of brain water during acute glucose-induced hyperosmolality in ovine fetuses, lambs, and adults.

  2004cites this paper
• Transcription factor tonicity-responsive enhancer-binding protein (TonEBP) which transactivates osmoprotective genes is expressed and upregulated following acute systemic hypertonicity in neurons in brain.

  2004cites this paper
• Changes in GABA transporters in the rat hippocampus after kainate‐induced neuronal injury: Decrease in GAT‐1 and GAT‐3 but upregulation of betaine/GABA transporter BGT‐1

  2004cites this paper
• Longitudinal study of MRS metabolites in Rasmussen encephalitis.

  2004cites this paper
• Taurine transporter knockout depletes muscle taurine levels and results in severe skeletal muscle impairment but leaves cardiac function uncompromised

  2004cites this paper
• Cotransport in Rat Cortical Astrocytes

  2004cites this paper
• A light and electron microscopic study of betaine/GABA transporter distribution in the monkey cerebral neocortex and hippocampus

  2004cites this paper
• Extracellular glutamate and other amino acids in experimental intracerebral hemorrhage: An in vivo microdialysis study

  2003cites this paper
• Regulation of brain water during acute hyperosmolality in ovine fetuses, lambs, and adults.

  2003cites this paper
• N-acetyl-aspartate, total creatine, and myo-inositol in the epileptogenic human hippocampus

  2003cites this paper
• Putative osmolytes in the kidney of the Australian brush-tailed possum, Trichosurus vulpecula.

  2002cites this paper
• The effects of hypoosmotic infusion on the composition of renal tissue of the Australian brush-tailed possum Trichosurus vulpecula.

  2002cites this paper
• γ‐aminobutyric acid transporter (BGT‐1) expressed in human astrocytoma U373 MG cells: Pharmacological and molecular characterization and phorbol ester‐induced inhibition

  2002cites this paper
• Glial transporters for glutamate, glycine, and GABA: II. GABA transporters

  2001cites this paper
• Glial transporters for glutamate, glycine, and GABA III. Glycine transporters

  2001cites this paper
• Glycine betaine excretion is not directly linked to plasma glucose concentrations in hyperglycaemia.

  2001cites this paper
• Gene expression of taurine transporter and taurine biosynthetic enzymes in brain of rats with acute or chronic hyperosmotic plasma. A comparative study with gene expression of myo-inositol transporter, betaine transporter and sorbitol biosynthetic enzyme.

  2000cites this paper
• Gene expression of the transporters and biosynthetic enzymes of the osmolytes in astrocyte primary cultures exposed to hyperosmotic conditions

  2000cites this paper
• Developmental changes in organic osmolytes in prenatal and postnatal rat tissues.

  2000cites this paper
• Purification, identification, and characterization of an osmotic response element binding protein.

  2000cites this paper
• Expression und Charakterisierung volumenregulierter Osmolyt-Transportmoleküle des Gehirns

  2000influential citation
• Gene expression of taurine transporter and taurine biosynthetic enzymes in hyperosmotic states: a comparative study with the expression of the genes involved in the accumulation of other osmolytes.

  2000cites this paper
• Salt and Water Homeostasis

  1999cites this paper
• Selective induction of glial glutamate transporter GLT-1 by hypertonic stress in C6 glioma cells.

  1999cites this paper
• Amino acid efflux and cell volume regulation in cerebrocortical minislices prepared from chronically hyponatraemic and hypernatraemic rats.

  1999cites this paper
• Kainic acid-induced seizure upregulates Na(+)/myo-inositol cotransporter mRNA in rat brain.

  1999cites this paper
• Functional significance of cell volume regulatory mechanisms.

  1998cites this paper
• Molecular biology of mammalian plasma membrane amino acid transporters.

  1998cites this paper
• Changes in brain organic osmolytes in experimental cerebral ischemia.

  1998cites this paper