Reperfusion after Thrombolytic Therapy of Embolic Stroke in the Rat: Magnetic Resonance and Biochemical Imaging

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Journal of Cerebral Blood Flow and Metabolism

• Publication date

  1998-04-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1097/00004647-199804000-00009PMID 9538906
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Improved model of thromboembolic stroke and rt-PA induced reperfusion in the rat.

  1997cited by this paper
• Blood-brain barrier disturbances after rt-PA treatment of thromboembolic stroke in the rat.

  1997cited by this paper
• When is thrombolysis justified in patients with acute ischemic stroke? A bioethical perspective.

  1997cited by this paper
• When is thrombolysis justified in patients with acute ischemic stroke?

  1997cited by this paper
• Ultrafast Perfusion‐Weighted MRI of Functional Brain Activation in Rats During Forepaw Stimulation: Comparison with T*2‐Weighted MRI

  1996cited by this paper
• Brain capillary tissue plasminogen activator in a diabetes stroke model.

  1996cited by this paper
• Apoptosis in focal cerebral ischemia.

  1996cited by this paper
• Evolution of photochemically induced focal cerebral ischemia in the rat. Magnetic resonance imaging and histology.

  1996cited by this paper
• Imaging of the apparent diffusion coefficient for the evaluation of cerebral metabolic recovery after cardiac arrest.

  1995cited by this paper
• Transgenic Mice and Knockout Mutants in the Study of Oxidative Stress in Brain Injury

  1995cited by this paper
• Evolution of Regional Changes in Apparent Diffusion Coefficient during Focal Ischemia of Rat Brain: The Relationship of Quantitative Diffusion NMR Imaging to Reduction in Cerebral Blood Flow and Metabolic Disturbances

  1995cited by this paper
• Local hemodynamic changes during transient middle cerebral artery occlusion and recirculation in the rat: a [14C]iodoantipyrine autoradiographic study.

  1995cited by this paper
• Induction of DNA fragmentation after 10 to 120 minutes of focal cerebral ischemia in rats.

  1995cited by this paper
• Delayed tissue-plasminogen activator therapy in a rabbit model of thromboembolic stroke.

  1995cited by this paper
• Relationship between diffusion-weighted MR images, cerebral blood flow, and energy state in experimental brain infarction.

  1995cited by this paper
• Neutrophil inhibitory factor is neuroprotective after focal Ischemia in rats

  1995cited by this paper
• Correction of Gradient Crosstalk and Optimization of Measurement Parameters in Diffusion MR Imaging

  1995cited by this paper
• Diffusion-weighted MR imaging of experimental brain tumors in rats

  1995cited by this paper
• Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group.

  1995cited by this paper
• Haemostatic Functions of the Blood-Brain Barrier: Possible Implications in the Pathogenesis of Stroke

  1995cited by this paper
• Tissue plasminogen activator for acute ischemic stroke.

  1995cited by this paper
• Risk factors for cerebrovascular disease and the role of coagulation and fibrinolysis.

  1995cited by this paper
• [Early reperfusion as a rationale from of therapy in ischemic stroke].

  1995cited by this paper
• Beyond Thrombolysis: Other Effects of Thrombolytic Drugs

  1994cited by this paper
• Activity of coagulation and fibrinolysis parameters in animals.

  1994cited by this paper
• Microvascular changes during cerebral ischemia and reperfusion.

  1994cited by this paper
• A “radical” view of cerebral ischemic injury

  1994cited by this paper
• Fibrinolysis in patients with acute ischaemic heart disease. With particular reference to systemic effects of tissue-type plasminogen activator treatment on fibrinolysis, coagulation and complement pathways.

  1993cited by this paper
• Bioluminescence and fluoroscopic imaging of tissue pH and metabolites in experimental brain tumors of cat

  1992cited by this paper
• A Rat Model of Reproducible Cerebral Infarction Using Thrombotic Blood Clot Emboli

  1992cited by this paper
• Perfusion imaging

  1992cited by this paper
• Thrombolysis with recombinant tissue plasminogen activator in acute ischemic stroke: evaluation with rCBF‐SPECT

  1991cited by this paper
• Molecular diffusion nuclear magnetic resonance imaging.

  1991cited by this paper
• Temporal thresholds for neocortical infarction in rats subjected to reversible focal cerebral ischemia.

  1991cited by this paper
• Interrelationship between coagulant activity and tissue‐type plasminogen activator (t‐PA) system in acute ischaemic heart disease. Possible role of the endothelium

  1990cited by this paper
• A Semiautomated Method for Measuring Brain Infarct Volume

  1990cited by this paper
• The effects of a new tissue plasminogen activator analogue, Fb‐Fb‐CF, on cerebral reperfusion in a rabbit embolic stroke model

  1989cited by this paper
• 31P spectroscopy in thrombolytic treatment of experimental cerebral infarct.

  1989cited by this paper
• Local intraarterial fibrinolysis in the carotid territory.

  1989cited by this paper
• Continuous Measurement of Cerebral Cortical Blood Flow by Laser—Doppler Flowmetry in a Rat Stroke Model

  1989cited by this paper
• The safety and angiographic efficacy of tissue plasminogen activator in a cerebral embolization model

  1988cited by this paper
• Recombinant human tissue-type plasminogen activator therapy in acute thromboembolic stroke.

  1987cited by this paper
• Experimental studies of ischemic brain edema

  1986cited by this paper
• Pharmacokinetics and systemic fibrinogenolytic effects of recombinant human tissue-type plasminogen activator (rt-PA) in humans.

  1985cited by this paper
• A Bioluminescence Method for the Demonstration of Regional Glucose Distribution in Brain Slices

  1981cited by this paper
• Studies on the Specific Fibrinolytic Effect of Human Extrinsic (Tissue-Type) Plasminogen Activator in Human Blood and in Various Animal Species in Vitro

  1981cited by this paper
• Measurement of local cerebral blood flow with iodo [14C] antipyrine.

  1978cited by this paper
• Cerebral microembolization. II. Morphological studies.

  1978cited by this paper
• Insulin effects on monovalent cation transport and Na-K-ATPase activity.

  1978cited by this paper
• A pictorial representation of endogenous brain ATP by a bioluminescent method.

  1978cited by this paper
• Spin diffusion measurements : spin echoes in the presence of a time-dependent field gradient

  1965cited by this paper

• Chemical Optimization of Cerebral Embolectomy 2 (CHOICE 2) trial: study protocol

  2025cites this paper
• Assessing the Efficacy and Safety of Tirofiban in Combination With Dual-antiplatelet Therapy in Progressive Ischemic Stroke Patients

  2021cites this paper
• Benefit and risk of early intravenous heparin after thrombolysis in patients with acute ischemic stroke

  2020cites this paper
• Safety and efficacy of tirofiban in acute ischemic stroke patients not receiving endovascular treatment: a systematic review and meta-analysis.

  2020cites this paper
• Determining T2 relaxation time and stroke onset relationship in ischaemic stroke within apparent diffusion coefficient-defined lesions. A user-independent method for quantifying the impact of stroke in the human brain

  2019cites this paper
• (2019). Determining T2 relaxation time and stroke onset relationship in ischaemic stroke within apparent diffusion coefficient-defined lesions. A user-independent method for quantifying the impact of stroke in the human brain. Biomedical Spectroscopy and Imaging , 1-18.

  2019cites this paper
• The Chemical Optimization of Cerebral Embolectomy trial: Study protocol

  2019cites this paper
• Simultaneous functional photoacoustic microscopy and electrocorticography reveal the impact of rtPA on dynamic neurovascular functions after cerebral ischemia

  2018influential citation
• Investigation of a Photothrombosis Inducing System for an Observation of Transient Variations in an in vivo Rat Brain

  2018cites this paper
• Neuroprotectants in the Era of Reperfusion Therapy

  2018cites this paper
• Pharmacologically increasing collateral perfusion during acute stroke using a carboxyhemoglobin gas transfer agent (Sanguinate™) in spontaneously hypertensive rats

  2017cites this paper
• DEVICE FOR INDUCING VASCULAR INURY AND/OR BLOCKAGE IN AN ANIMAL MODEL RELATED APPLICATIONS

  2017cites this paper
• Prospects of modeling poststroke epileptogenesis

  2017cites this paper
• Improving Reperfusion Therapies in the Era of Mechanical Thrombectomy

  2016cites this paper
• Thromboembolic Model of Cerebral Ischemia and Reperfusion in Mice.

  2016cites this paper
• Examination of the protective effects of heparin and recombinant tissue plasminogen activator (rtPA) in compromised adipocutaneous free flaps in the rat model using intravital video microscopy

  2015cites this paper
• Postischemic Reperfusion Causes Smooth Muscle Calcium Sensitization and Vasoconstriction of Parenchymal Arterioles

  2014cites this paper
• Interleaved imaging of cerebral hemodynamics and blood flow index to monitor ischemic stroke and treatment in rat by volumetric diffuse optical tomography

  2014cites this paper
• Therapeutic Hypothermia in Acute Stroke

  2013cites this paper
• Hemostasis and Alterations of the Central Nervous System

  2013cites this paper
• Therapeutic Hypothermia in Brain Injury

  2013influential citation
• Can Restoring Incomplete Microcirculatory Reperfusion Improve Stroke Outcome after Thrombolysis?

  2012cites this paper
• The Two Pathophysiologies of Focal Brain Ischemia: Implications for Translational Stroke Research

  2012cites this paper
• Stem cells in stroke repair: current success and future prospects.

  2011cites this paper
• Experimental stroke research: the contributions of in vivo MRI.

  2011cites this paper
• Are Underlying Assumptions of Current Animal Models of Human Stroke Correct: from STAIRs to High Hurdles?

  2011cites this paper
• A translationally relevant thromboembolic stroke model for the study of secondary hemorrhage after thrombolysis in rats.

  2011cites this paper
• Outcome in Acute Stroke with Different Intra-Arterial Infusion Rate of Urokinase on Thrombolysis

  2010cites this paper
• Animal Models of Ischemic Stroke. Part Two: Modeling Cerebral Ischemia

  2010cites this paper
• Experimental animal models of neurogenic bladder dysfunction.

  2010cites this paper
• Experimental model of brainstem stroke in rabbits via endovascular occlusion of the basilar artery.

  2009cites this paper
• A feasibility study on model-based evaluation of kidney perfusion measured by means of FAIR prepared true-FISP arterial spin labeling (ASL) on a 3-T MR scanner.

  2009cites this paper
• Detection of necrotic neural response in super‐acute cerebral ischemia using activity‐induced manganese‐enhanced (AIM) MRI

  2009cites this paper
• Delayed post-ischaemic neuroprotection following systemic neural stem cell transplantation involves multiple mechanisms.

  2009cites this paper
• New Targets of Neuroprotection in Ischemic Stroke

  2008cites this paper
• Review: Future perspectives for brain pharmacotherapies: implications of drug transport processes at the blood—brain barrier

  2008cites this paper
• Imaging of tissue injury-repair addressing the significance of oxygen and its derivatives

  2007cites this paper
• Efficacy of recombinant annexin 2 for fibrinolytic therapy in a rat embolic stroke model: a magnetic resonance imaging study.

  2007influential citation
• Therapeutic Hypothermia for Global and Focal Ischemic Brain Injury—A Cool Way to Improve Neurologic Outcomes

  2007cites this paper
• MRI and MRS in Animal Models of Focal Cerebral Ischemia

  2006cites this paper
• MRI in preclinical drug development.

  2006cites this paper
• Present Status of Magnetic Resonance Imaging and Spectroscopy in Animal Stroke Models

  2006cites this paper
• Insights from Experimental Studies

  2006cites this paper
• Clot Fragments Formed from Original Thrombus Obstruct Downstream Arteries in the Ischemic Injured Brain

  2006cites this paper
• Foundations of advanced magnetic resonance imaging

  2005cites this paper
• Tissue‐plasminogen activator‐induced ischemic brain injury is reversed by melatonin: role of iNOS and Akt

  2005cites this paper
• Uric acid improves the beneficial effects of rt-PA in a rat model of thromboembolic ischemia

  2005cites this paper
• Gene Discovery Underlying Stroke

  2005cites this paper
• Tissue Plasminogen Activator-Induced Ischemic Injury Is Reversed by NMDA Antagonist MK-801 in vivo

  2005cites this paper
• Assessment of Tissue Viability Using Diffusion- and Perfusion-Weighted MRI in Hyperacute Stroke

  2005cites this paper
• Systemic Thrombolysis With Recombinant Tissue Plasminogen Activator and Tirofiban in Acute Middle Cerebral Artery Occlusion

  2004cites this paper
• Attenuation of ischemia and/or reperfusion injury during myocardial infarction using mild hypothermia in rats: An immunohistochemical study of Bcl‐2, Bax, Bak and TUNEL

  2004cites this paper
• Tracing neuronal tracts in the olfactory pathway of rat and detecting ischemic core in a rat model of focal ischemia using manganese enhanced magnetic resonance imaging

  2004cites this paper
• All-optical thrombotic stroke model for near-surface blood vessels in rat: focal illumination of exogeneous photosensitizers combined with real-time two-photon imaging

  2003cites this paper
• Detection of the anoxic depolarization of focal ischemia using manganese‐enhanced MRI

  2003cites this paper
• Thrombolysis With Recombinant Tissue Plasminogen Activator and Tirofiban in Stroke: Preliminary Observations

  2003cites this paper
• Microvascular Basal Lamina Damage after Embolic Stroke in the Rat: Relationship to Cerebral Blood Flow

  2003cites this paper
• Can the Time Window for Administration of Thrombolytics in Stroke be Increased?

  2003cites this paper
• MRI measurement of cerebral perfusion and the application to experimental neuroscience

  2002cites this paper
• Diffusion and perfusion MRI for the assessment of carotid atherosclerosis.

  2002cites this paper
• Thrombolytic Treatment of Clot Embolism in Rat: Comparison of Intra-arterial and Intravenous Application of Recombinant Tissue Plasminogen Activator

  2002cites this paper
• Dynamic changes of ADC, perfusion, and NMR relaxation parameters in transient focal ischemia of rat brain

  2002cites this paper
• Prediction of Hemorrhagic Transformation After Thrombolytic Therapy of Clot Embolism: An MRI Investigation in Rat Brain

  2002cites this paper
• Time evolution of cerebral perfusion and apparent diffusion coefficient measured by magnetic resonance imaging in a porcine stroke model

  2002cites this paper
• Magnetic Resonance Angiography of Thromboembolic Stroke in Rats: Indicator of Recanalization Probability and Tissue Survival after Recombinant Tissue Plasminogen Activator Treatment

  2002cites this paper
• Glycoprotein IIb/IIIa Antagonist, Murine 7E3 F(ab′)2, and Tissue Plasminogen Activator in Focal Ischemia: Evaluation of Efficacy and Risk of Hemorrhage with Combination Therapy

  2002cites this paper
• Protocol of a Thromboembolic Stroke Model in the Rat: Review of the Experimental Procedure and Comparison of Models

  2002cites this paper
• Combined X-ray angiography and diffusion-perfusion MRI for studying stroke evolution after rt-PA treatment in rats.

  2002cites this paper
• Small animal neuroimaging using magnetic resonance microscopy

  2002cites this paper
• Stroke Genomics: Approaches to Identify, Validate, and Understand Ischemic Stroke Gene Expression

  2001cites this paper
• Angiographic evaluation of middle cerebral artery reperfusion caused by platelet glycoprotein IIb/IIIa receptor complex antagonist murine 7E3 F(ab')2 in a model of focal cerebral ischemia in rats.

  2001cites this paper
• MRI Demonstrates that Tissue-Type Plasminogen Activator Increases Stroke Volume if Cerebral Arteries Are not Successfully Recanalized

  2001cites this paper
• Methodology of brain perfusion imaging

  2001cites this paper
• Experimentelle Pathophysiologie zerebraler Durchblutungsstörungen

  2001cites this paper
• Evolution of apparent diffusion coefficient, diffusion-weighted, and T2-weighted signal intensity of acute stroke.

  2001cites this paper
• Is There an Apparent Diffusion Coefficient Threshold in Predicting Tissue Viability in Hyperacute Stroke?

  2001cites this paper
• Prediction of tissue survival after middle cerebral artery occlusion based on changes in the apparent diffusion of water.

  2001cites this paper
• Viability Thresholds of Ischemic Penumbra of Hyperacute Stroke Defined by Perfusion-Weighted MRI and Apparent Diffusion Coefficient

  2001cites this paper
• Use of Exponential Diffusion Imaging to Determine the Age of Ischemic Infarcts

  2001cites this paper
• Effects of Nitric Oxide on Reactive Oxygen Species Production and Infarction Size after Brain Reperfusion Injury

  2001cites this paper
• Patency of Cerebral Microvessels after Focal Embolic Stroke in the Rat

  2001cites this paper
• Delayed rt-PA Treatment in a Rat Embolic Stroke Model: Diagnosis and Prognosis of Ischemic Injury and Hemorrhagic Transformation with Magnetic Resonance Imaging

  2001cites this paper
• Evolution of cerebral ischaemia induced by thromboembolism in rats detected by early sequential MR imaging.

  2001cites this paper
• Magnetic resonance prediction of outcome after thrombolytic treatment.

  2001cites this paper
• Application of magnetic resonance to animal models of cerebral ischemia

  2001cites this paper
• Bleeding Risk of Tirofiban, a Nonpeptide GPIIb/IIIa Platelet Receptor Antagonist in Progressive Stroke: An Open Pilot Study

  2001cites this paper
• Treatment of acute basilar artery thrombosis with a combination of systemic alteplase and tirofiban, a nonpeptide platelet glycoprotein IIb/IIIa inhibitor: report of four cases.

  2001cites this paper
• Effect of citicoline on ischemic lesions as measured by diffusion‐weighted magnetic resonance imaging

  2000cites this paper
• MRI of small human stroke shows reversible diffusion changes in subcortical gray matter

  2000cites this paper
• Diffusion-weighted and perfusion-weighted magnetic resonance imaging to monitor acute intra-arterial thrombolysis.

  2000cites this paper
• High Speed Diffusion Magnetic Resonance Imaging of Ischemia and Spontaneous Periinfarct Spreading Depression after Thromboembolic Stroke in the Rat

  2000cites this paper
• Effect of citicoline on ischemic lesions as measured by diffusion-weighted magnetic resonance imaging. Citicoline 010 Investigators.

  2000cites this paper
• Late Resolution of Diffusion-Weighted MRI Changes in a Patient With Prolonged Reversible Ischemic Neurological Deficit After Thrombolytic Therapy

  2000cites this paper
• Serial MRI after transient focal cerebral ischemia in rats: dynamics of tissue injury, blood-brain barrier damage, and edema formation.

  2000cites this paper
• Recombinant tissue-plasminogen activator-induced thrombolysis after cerebral thromboembolism in mice

  2000cites this paper
• Diffusions- und Perfusionsbildgebung in der Akutdiagnostik der zerebralen Ischämie

  2000cites this paper
• Production of reactive oxygen species after reperfusion in vitro and in vivo: protective effect of nitric oxide.

  2000cites this paper
• Histogram‐based characterization of healthy and ischemic brain tissues using multiparametric MR imaging including apparent diffusion coefficient maps and relaxometry

  2000cites this paper
• Probability of Metabolic Tissue Recovery after Thrombolytic Treatment of Experimental Stroke: A Magnetic Resonance Spectroscopic Imaging Study in Rat Brain

  2000cites this paper
• Effect of Thrombolysis on the Dynamics of Infarct Evolution After Clot Embolism of Middle Cerebral Artery in Mice

  2000cites this paper