Gene, virulence and related regulatory mechanisms in Cryptococcus gattii

Cryptococcus gattii is a kind of basidiomycetous yeast, which grows in human and animal hosts. C. gattii has four distinct genomes, VGI/AFLP4, VGII/AFLP6, VGIII/AFLP5, and VGIV/AFLP7. The virulence of C. gattii is closely associated with genotype and related stress-signaling pathways, but the pathogenic mechanism of C. gattii has not been fully identified. With the development of genomics and transcriptomics, the relationship among genes, regulatory mechanisms, virulence, and treatment is gradually being recognized. In this review, to better understand how C. gattii causes disease and to characterize hypervirulent C. gattii strains, we summarize the current understanding of C. gattii genotypes, phenotypes, virulence, and the regulatory mechanisms.

• Publication year

  2022

• Venue

  Acta Biochimica et Biophysica Sinica

• Publication date

  2022-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3724/abbs.2022029PMID 35593469PMCID 9828318
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Virulence in Cryptococcus species.

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• Melanin and virulence in Cryptococcus neoformans.

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• The molecular biology of metal ion transport in Saccharomyces cerevisiae.

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