The Grb 10 / Nedd 4 Complex Regulates Ligand-Induced Ubiquitination and Stability of the Insulin-Like Growth Factor I Receptor

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  2003

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• Drosophila Nedd4, a ubiquitin ligase, is recruited by Commissureless to control cell surface levels of the roundabout receptor.

  2002cited by this paper
• Inhibition of Insulin Receptor Catalytic Activity by the Molecular Adapter Grb14*

  2002cited by this paper
• Role for the Adaptor Protein Grb10 in the Activation of Akt

  2002cited by this paper
• Solution structure of a Nedd4 WW domain–ENaC peptide complex

  2001cited by this paper
• A novel mouse Nedd4 protein suppresses the activity of the epithelial Na+ channel

  2001cited by this paper
• Proteins related to the Nedd4 family of ubiquitin protein ligases interact with the L domain of Rous sarcoma virus and are required for gag budding from cells

  2001cited by this paper
• Components of a Ubiquitin Ligase Complex Specify Polyubiquitination and Intracellular Trafficking of the General Amino Acid Permease

  2001cited by this paper
• Cbl Promotes Ubiquitination of the T Cell Receptor ζ through an Adaptor Function of Zap-70*

  2001cited by this paper
• Identification of a Novel Human Tankyrase through Its Interaction with the Adaptor Protein Grb14*

  2001cited by this paper
• Nedd4 Regulates Ubiquitination and Stability of the Guanine-Nucleotide Exchange Factor CNrasGEF*

  2001cited by this paper
• Endocytosis and Signaling: An Inseparable Partnership

  2001cited by this paper
• The BPS domain of Grb10 inhibits the catalytic activity of the insulin and IGF1 receptors

  2001cited by this paper
• The guanine nucleotide exchange factor CNrasGEF activates ras in response to cAMP and cGMP.

  2000cited by this paper
• Ubiquitination and Endocytosis of Plasma Membrane Proteins: Role of Nedd4/Rsp5p Family of Ubiquitin-Protein Ligases

  2000cited by this paper
• Endocytosis and Degradation of the Growth Hormone Receptor Are Proteasome-dependent*

  2000cited by this paper
• Degradation of the Epstein-Barr Virus Latent Membrane Protein 1 (LMP1) by the Ubiquitin-Proteasome Pathway

  2000cited by this paper
• Grb10 proteins in insulin-like growth factor and insulin receptor signaling (review).

  2000cited by this paper
• Apical Membrane Targeting of Nedd4 Is Mediated by an Association of Its C2 Domain with Annexin Xiiib

  2000cited by this paper
• The ubiquitin system

  2000cited by this paper
• Grb10, a Positive, Stimulatory Signaling Adapter in Platelet-Derived Growth Factor BB-, Insulin-Like Growth Factor I-, and Insulin-Mediated Mitogenesis

  1999cited by this paper
• Proteasome-dependent degradation of the human estrogen receptor.

  1999cited by this paper
• The Cbl protooncoprotein stimulates CSF‐1 receptor multiubiquitination and endocytosis, and attenuates macrophage proliferation

  1999influential reference
• Defective regulation of the epithelial Na+ channel by Nedd4 in Liddle's syndrome.

  1999cited by this paper
• Rsp5 Ubiquitin-Protein Ligase Mediates DNA Damage-Induced Degradation of the Large Subunit of RNA Polymerase II in Saccharomyces cerevisiae

  1999cited by this paper
• Trafficking of the HIV Coreceptor CXCR4

  1999influential reference
• Cbl-mediated Negative Regulation of Platelet-derived Growth Factor Receptor-dependent Cell Proliferation

  1999cited by this paper
• mGrb10 Interacts with Nedd4*

  1999cited by this paper
• The RING Finger of c-Cbl Mediates Desensitization of the Epidermal Growth Factor Receptor*

  1999influential reference
• Grb10 Interacts Differentially with the Insulin Receptor, Insulin-like Growth Factor I Receptor, and Epidermal Growth Factor Receptor via the Grb10 Src Homology 2 (SH2) Domain and a Second Novel Domain Located between the Pleckstrin Homology and SH2 Domains*

  1998cited by this paper
• The SH2-containing adapter protein GRB10 interacts with BCR-ABL

  1998cited by this paper
• Inhibition of the Epithelial Na+ Channel by Interaction of Nedd4 with a PY Motif Deleted in Liddle’s Syndrome*

  1998cited by this paper
• The tyrosine kinase regulator Cbl enhances the ubiquitination and degradation of the platelet-derived growth factor receptor alpha.

  1998cited by this paper
• Insulin-like Growth Factor-I Receptor Internalization Regulates Signaling via the Shc/Mitogen-activated Protein Kinase Pathway, but Not the Insulin Receptor Substrate-1 Pathway*

  1998influential reference
• Interaction of the Grb10 Adapter Protein with the Raf1 and MEK1 Kinases*

  1998cited by this paper
• c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor.

  1998influential reference
• Molecular markers of IGF-I-mediated mitogenesis.

  1998cited by this paper
• Grb10 Identified as a Potential Regulator of Growth Hormone (GH) Signaling by Cloning of GH Receptor Target Proteins*

  1998cited by this paper
• Identification of the Meg1/Grb10 imprinted gene on mouse proximal chromosome 11, a candidate for the Silver-Russell syndrome gene.

  1998cited by this paper
• The C2 Domain of the Ubiquitin Protein Ligase Nedd4 Mediates Ca2+-dependent Plasma Membrane Localization*

  1997cited by this paper
• Site-directed mutagenesis and yeast two-hybrid studies of the insulin and insulin-like growth factor-1 receptors: the Src homology-2 domain-containing protein hGrb10 binds to the autophosphorylated tyrosine residues in the kinase domain of the insulin receptor.

  1997cited by this paper
• Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination

  1997cited by this paper
• The adapter protein Grb10 associates preferentially with the insulin receptor as compared with the IGF-I receptor in mouse fibroblasts.

  1997cited by this paper
• Degradation of the Met tyrosine kinase receptor by the ubiquitin-proteasome pathway

  1997cited by this paper
• The Role of mGrb10α in Insulin-like Growth Factor I-mediated Growth*

  1997cited by this paper
• Cloning, Chromosome Localization, Expression, and Characterization of an Src Homology 2 and Pleckstrin Homology Domain-containing Insulin Receptor Binding Protein hGrb10γ*

  1997cited by this paper
• Human GRB-IRbeta/GRB10. Splice variants of an insulin and growth factor receptor-binding protein with PH and SH2 domains.

  1997cited by this paper
• Grb10: A new substrate of the insulin-like growth factor I receptor.

  1996cited by this paper
• Evidence for the direct interaction of the insulin-like growth factor I receptor with IRS-1, Shc, and Grb10.

  1996cited by this paper
• Interaction of a GRB-IR Splice Variant (a Human GRB10 Homolog) with the Insulin and Insulin-like Growth Factor I Receptors

  1996cited by this paper
• Interaction between the Grb10 SH2 Domain and the Insulin Receptor Carboxyl Terminus (*)

  1996cited by this paper
• WW domains of Nedd4 bind to the proline‐rich PY motifs in the epithelial Na+ channel deleted in Liddle's syndrome.

  1996cited by this paper
• Ligand Activation of ELK Receptor Tyrosine Kinase Promotes Its Association with Grb10 and Grb2 in Vascular Endothelial Cells*

  1996cited by this paper
• Degradation Process of Ligand-stimulated Platelet-derived Growth Factor β -Receptor Involves Ubiquitin-Proteasome Proteolytic Pathway *

  1995cited by this paper
• A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase.

  1995cited by this paper
• Grb-IR: a SH2-domain-containing protein that binds to the insulin receptor and inhibits its function.

  1995cited by this paper
• Herbimycin A Induces the 20 S Proteasome- and Ubiquitindependent Degradation of Receptor Tyrosine Kinases (*)

  1995cited by this paper
• The cloning of Grb10 reveals a new family of SH2 domain proteins.

  1995influential reference
• The WW domain: a signalling site in dystrophin?

  1994cited by this paper
• Ubiquitin-dependent c-Jun degradation in vivo is mediated by the delta domain.

  1994cited by this paper
• The role of the insulin-like growth factor I receptor in the transformation by simian virus 40 T antigen.

  1994cited by this paper
• Mammalian Ras interacts directly with the serine/threonine kinase Raf.

  1993cited by this paper
• Identification of a set of genes with developmentally down-regulated expression in the mouse brain.

  1992cited by this paper

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• Molecular Basis of Signaling Specificity of Insulin and IGF Receptors: Neglected Corners and Recent Advances

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• Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays

  2009cites this paper
• [The expression analysis of Grb10 during mouse embryonic development].

  2009cites this paper
• Glypican-3-mediated oncogenesis involves the Insulin-like growth factor-signaling pathway

  2008cites this paper
• Nedd4 Controls Animal Growth by Regulating IGF-1 Signaling

  2008cites this paper
• Regulation of insulin receptor substrate‐1 expression levels by caveolin‐1

  2008cites this paper
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• Degradation of insulin‐like growth factor‐I receptor occurs via ubiquitin‐proteasome pathway in human lung cancer cells

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• Morphogen gradient interpretation by a regulated trafficking step during ligand-receptor transduction.

  2005cites this paper
• Negative regulation of receptor tyrosine kinases: unexpected links to c-Cbl and receptor ubiquitylation

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