NEDD4: The founding member of a family of ubiquitin-protein ligases.

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Gene

• Publication date

  2015-02-25

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.gene.2014.12.020PMID 25527121PMCID PMC6639052
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• NEDD4-2 (NEDD4L): the ubiquitin ligase for multiple membrane proteins.

  2015cited by this paper
• NEDD4: a promising target for cancer therapy.

  2014influential reference
• Regulation of Mdm2 protein stability and the p53 response by NEDD4-1 E3 ligase

  2014cited by this paper
• Peptide and small molecule inhibitors of HECT-type ubiquitin ligases

  2014cited by this paper
• SAG/RBX2 is a novel substrate of NEDD4-1 E3 ubiquitin ligase and mediates NEDD4-1 induced chemosensitization

  2014influential reference
• Tyrosine phosphorylation of NEDD4 activates its ubiquitin ligase activity

  2014cited by this paper
• Ubiquitin E3 ligase Nedd4-1 acts as a downstream target of PI3K/PTEN-mTORC1 signaling to promote neurite growth

  2014cited by this paper
• SCFβ-TRCP-mediated degradation of NEDD4 inhibits tumorigenesis through modulating the PTEN/Akt signaling pathway

  2014influential reference
• Subtle gait abnormalities in Nedd4 heterozygous mice.

  2014cited by this paper
• Abnormal splicing of NEDD4 in myotonic dystrophy type 2: possible link to statin adverse reactions.

  2014cited by this paper
• Brucella infection inhibits macrophages apoptosis via Nedd4-dependent degradation of calpain2.

  2014cited by this paper
• Mammalian HECT ubiquitin-protein ligases: biological and pathophysiological aspects.

  2014cited by this paper
• Impeded Nedd4-1-mediated Ras degradation underlies Ras-driven tumorigenesis.

  2014influential reference
• The E3 ubiquitin ligase NEDD4 negatively regulates HER3/ErbB3 level and signaling

  2014cited by this paper
• PTEN is a protein tyrosine phosphatase for IRS1

  2014cited by this paper
• NEDD4 ubiquitinates TRAF3 to promote CD40-mediated AKT activation

  2014cited by this paper
• Regulation of p63 Protein Stability via Ubiquitin-Proteasome Pathway

  2014cited by this paper
• The Antiproliferative Response of Indole-3-Carbinol in Human Melanoma Cells Is Triggered by an Interaction with NEDD4-1 and Disruption of Wild-Type PTEN Degradation

  2014influential reference
• NEDD4 is overexpressed in colorectal cancer and promotes colonic cell growth independently of the PI3K/PTEN/AKT pathway.

  2013cited by this paper
• p34 is a novel regulator of the oncogenic behavior of NEDD4-1 and PTEN

  2013influential reference
• The ubiquitin ligase Nedd4 regulates craniofacial development by promoting cranial neural crest cell survival and stem-cell like properties.

  2013cited by this paper
• Nedd4 and Nedd4-2: ubiquitin ligases at work in the neuron.

  2013cited by this paper
• Upregulation of SIRT1 by 17β-estradiol depends on ubiquitin-proteasome degradation of PPAR-γ mediated by NEDD4-1

  2013cited by this paper
• NEDD4 E3 ligase inhibits the activity of the Hippo pathway by targeting LATS1 for degradation

  2013cited by this paper
• ΔNp63α represses nuclear translocation of PTEN by inhibition of NEDD4-1 in keratinocytes

  2013cited by this paper
• Lipopolysaccharide Induces Degradation of Connexin43 in Rat Astrocytes via the Ubiquitin-Proteasome Proteolytic Pathway

  2013cited by this paper
• The Nedd4-binding protein 3 (N4BP3) is crucial for axonal and dendritic branching in developing neurons

  2013cited by this paper
• Upregulation of the E3 ligase NEDD4-1 by Oxidative Stress Degrades IGF-1 Receptor Protein in Neurodegeneration

  2012influential reference
• Ubiquitin-dependent Regulation of Phospho-AKT Dynamics by the Ubiquitin E3 Ligase, NEDD4-1, in the Insulin-like Growth Factor-1 Response*

  2012influential reference
• Rac1 acts in conjunction with Nedd4 and dishevelled-1 to promote maturation of cell–cell contacts

  2012influential reference
• Patched dependence receptor triggers apoptosis through ubiquitination of caspase-9

  2012cited by this paper
• Disruption of E3 ligase NEDD4 in peripheral neurons interrupts axon outgrowth: Linkage to PTEN.

  2012influential reference
• The Patched dependence receptor triggers apoptosis through ubiquitination of caspase-9

  2012cited by this paper
• The Ubiquitin Ligase Nedd4-1 Participates in Denervation-Induced Skeletal Muscle Atrophy in Mice

  2012cited by this paper
• E3 ubiquitin ligase Cbl-b regulates Pten via Nedd4 in T cells independently of its ubiquitin ligase activity.

  2012cited by this paper
• The histone deacetylase SIRT2 stabilizes Myc oncoproteins

  2012influential reference
• Identification of Nedd4 as a novel regulator in Hedgehog signaling.

  2012cited by this paper
• Drosophila Ndfip is a novel regulator of Notch signaling

  2011influential reference
• Neuronal Precursor Cell-expressed Developmentally Down-regulated 4-1 (NEDD4-1) Controls the Sorting of Newly Synthesized CaV1.2 Calcium Channels

  2011cited by this paper
• Ndfip1-deficient mice have impaired DMT1 regulation and iron homeostasis.

  2011influential reference
• Ubiquitin ligase Nedd4 promotes α-synuclein degradation by the endosomal–lysosomal pathway

  2011cited by this paper
• Nedd4‐1 binds and ubiquitylates activated FGFR1 to control its endocytosis and function

  2011cited by this paper
• Nedd4‐mediated AMPA receptor ubiquitination regulates receptor turnover and trafficking

  2011cited by this paper
• Respiratory distress and perinatal lethality in Nedd4-2-deficient mice

  2011cited by this paper
• Nedd4-dependent lysine-11-linked polyubiquitination of the tumour suppressor Beclin 1

  2011influential reference
• Calcium Activates Nedd4 E3 Ubiquitin Ligases by Releasing the C2 Domain-mediated Auto-inhibition*

  2010cited by this paper
• Arrestin domain‐containing protein 3 recruits the NEDD4 E3 ligase to mediate ubiquitination of the β2‐adrenergic receptor

  2010cited by this paper
• Nedd4-1 and β-Arrestin-1 Are Key Regulators of Na+/H+ Exchanger 1 Ubiquitylation, Endocytosis, and Function*

  2010cited by this paper
• FoxM1B regulates NEDD4-1 expression, leading to cellular transformation and full malignant phenotype in immortalized human astrocytes.

  2010cited by this paper
• Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite development.

  2010influential reference
• E3 Ligase Nedd4 Promotes Axon Branching by Downregulating PTEN

  2010cited by this paper
• Nedd4 and Nedd4-2: closely related ubiquitin-protein ligases with distinct physiological functions

  2010cited by this paper
• HECT E3 Ubiquitin Ligase Nedd4-1 Ubiquitinates ACK and Regulates Epidermal Growth Factor (EGF)-Induced Degradation of EGF Receptor and ACK

  2010cited by this paper
• Functional Interaction of Phosphatase and Tensin Homologue (PTEN) with the E3 Ligase NEDD4-1 during Neuronal Response to Zinc*

  2010cited by this paper
• CDD: a Conserved Domain Database for the functional annotation of proteins

  2010cited by this paper
• Faculty Opinions recommendation of Arrestin domain-containing protein 3 recruits the NEDD4 E3 ligase to mediate ubiquitination of the beta2-adrenergic receptor.

  2010cited by this paper
• Regulation of Marburg virus (MARV) budding by Nedd4.1: a different WW domain of Nedd4.1 is critical for binding to MARV and Ebola virus VP40.

  2010cited by this paper
• The ESCRT-Associated Protein Alix Recruits the Ubiquitin Ligase Nedd4-1 To Facilitate HIV-1 Release through the LYPXnL L Domain Motif

  2010influential reference
• RING domain E3 ubiquitin ligases.

  2009cited by this paper
• Physiological functions of the HECT family of ubiquitin ligases

  2009cited by this paper
• The Ubiquitin Ligase Nedd4-1 Is Required for Heart Development and Is a Suppressor of Thrombospondin-1*

  2009cited by this paper
• Nedd4 mediates ErbB4 JM‐a/CYT–1 ICD ubiquitination and degradation in MDCK II cells

  2009cited by this paper
• Abnormal development of the neuromuscular junction in Nedd4-deficient mice.

  2009cited by this paper
• The inositol phosphatase MTMR4 is a novel target of the ubiquitin ligase Nedd4

  2009cited by this paper
• Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays

  2009cited by this paper
• Rak functions as a tumor suppressor by regulating PTEN protein stability and function.

  2009cited by this paper
• The Cyclin-dependent Kinase Activator, Spy1A, Is Targeted for Degradation by the Ubiquitin Ligase NEDD4*

  2009cited by this paper
• Control of the activity of WW‐HECT domain E3 ubiquitin ligases by NDFIP proteins

  2009cited by this paper
• Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons

  2009cited by this paper
• Eps15 interacts with ubiquitinated Cx43 and mediates its internalization.

  2009cited by this paper
• Identification of c-Cbl as a new ligase for insulin-like growth factor-I receptor with distinct roles from Mdm2 in receptor ubiquitination and endocytosis.

  2008cited by this paper
• Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2.

  2008influential reference
• The ubiquitin ligase Nedd4-1 is dispensable for the regulation of PTEN stability and localization

  2008cited by this paper
• Nedd4 Controls Animal Growth by Regulating IGF-1 Signaling

  2008influential reference
• Nedd4 Mediates Agonist-dependent Ubiquitination, Lysosomal Targeting, and Degradation of the β2-Adrenergic Receptor*

  2008cited by this paper
• γ2-Adaptin, a Ubiquitin-interacting Adaptor, Is a Substrate to Coupled Ubiquitination by the Ubiquitin Ligase Nedd4 and Functions in the Endosomal Pathway*

  2008influential reference
• Nedd4 Family-interacting Protein 1 (Ndfip1) Is Required for the Exosomal Secretion of Nedd4 Family Proteins*

  2008influential reference
• Grb10/Nedd4‐mediated multiubiquitination of the insulin‐like growth factor receptor regulates receptor internalization

  2008cited by this paper
• ISG15 Inhibits Nedd4 Ubiquitin E3 Activity and Enhances the Innate Antiviral Response*♦

  2008influential reference
• Nedd4 augments the adaptive immune response by promoting ubiquitin-mediated degradation of Cbl-b in activated T cells

  2008influential reference
• Ubiquitination regulates PTEN nuclear import and tumor suppression.

  2007cited by this paper
• The Nedd4-like family of E3 ubiquitin ligases and cancer

  2007influential reference
• Damage-induced ubiquitylation of human RNA polymerase II by the ubiquitin ligase Nedd4, but not Cockayne syndrome proteins or BRCA1.

  2007cited by this paper
• NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN.

  2007influential reference
• COBALT: constraint-based alignment tool for multiple protein sequences

  2007cited by this paper
• Regulation of functional diversity within the Nedd4 family by accessory and adaptor proteins.

  2006cited by this paper
• Molecular mechanisms of coupled monoubiquitination

  2006cited by this paper
• Ubiquitin protein ligase Nedd4 binds to connexin43 by a phosphorylation-modulated process

  2006cited by this paper
• The ubiquitin-protein ligases Nedd4 and Nedd4-2 show similar ubiquitin-conjugating enzyme specificities.

  2006cited by this paper
• Transport of LAPTM5 to lysosomes requires association with the ubiquitin ligase Nedd4, but not LAPTM5 ubiquitination

  2006influential reference
• Tsg101 and Alix Interact with Murine Leukemia Virus Gag and Cooperate with Nedd4 Ubiquitin Ligases during Budding*

  2005cited by this paper
• The Nedd4 family of E3 ubiquitin ligases: functional diversity within a common modular architecture

  2004cited by this paper
• Grb10 Prevents Nedd4-mediated Vascular Endothelial Growth Factor Receptor-2 Degradation*

  2004influential reference
• Regulation of Neuronal Voltage-gated Sodium Channels by the Ubiquitin-Protein Ligases Nedd4 and Nedd4-2*

  2004influential reference
• Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins

  2004influential reference
• Drosophila Nedd4 regulates endocytosis of notch and suppresses its ligand-independent activation.

  2004influential reference
• The C2 domain of the Rsp5 ubiquitin ligase binds membrane phosphoinositides and directs ubiquitination of endosomal cargo

  2004cited by this paper
• The Grb 10 / Nedd 4 Complex Regulates Ligand-Induced Ubiquitination and Stability of the Insulin-Like Growth Factor I Receptor

  2003cited by this paper
• The Mason-Pfizer Monkey Virus PPPY and PSAP Motifs Both Contribute to Virus Release

  2003cited by this paper
• WW Domain HECT E3s Target Cbl RING Finger E3s for Proteasomal Degradation*

  2003cited by this paper

• WW Domain-Containing E3 Ubiquitin Protein Ligase 1 (WWP1) as a Factor in Obesity-Related Metabolic Disorders: Emerging Molecular Mechanisms in Metabolic Tissues

  2025cites this paper
• NEDD4 Promotes Sertoli Cell Proliferation and Adult Leydig Cell Differentiation in the Murine Testis

  2025influential citation
• Targeting Atherosclerosis via NEDD4L Signaling—A Review of the Current Literature

  2025cites this paper
• Alkaline Adjuvant Regulates Proteolytic Activity of Macrophages for Antigen Cross‐Presentation and Potentiates Radioimmunotherapy

  2025cites this paper
• NEDD4 facilitates the progression of endometrial carcinoma by enhancing PAMR1 protein degradation through ubiquitination

  2025cites this paper
• Structure-based design of potent and selective inhibitors of the HECT ligase NEDD4

  2025influential citation
• Comprehensive analysis of the role of NEDD4 in pan-cancer and experimental verification of its role in KIRC progression

  2025cites this paper
• Activity-based protein profiling and global proteome analysis reveal MASTL as a potential therapeutic target in gastric cancer

  2024cites this paper
• Glucose-induced endocytic degradation of the maltose transporter MalP is mediated through ubiquitination by the HECT-ubiquitin ligase HulA and its adaptor CreD in Aspergillus oryzae.

  2024cites this paper
• PUM2 promoted osteoarthritis progression through PTEN‐mediated chondrocyte ferroptosis by facilitating NEDD4 mRNA degradation

  2024cites this paper
• Multilevel Regulation of Membrane Proteins in Response to Metal and Metalloid Stress: A Lesson from Yeast

  2024cites this paper
• The E3 ubiquitin ligase ITCH negatively regulates intercellular communication via gap junctions by targeting connexin43 for lysosomal degradation

  2024cites this paper
• NEDD4L is a promoter for angiogenesis and cell proliferation in human umbilical vein endothelial cells

  2024cites this paper
• Identification of cuproptosis-related diagnostic biomarkers in idiopathic pulmonary fibrosis

  2024cites this paper
• PHB2 promotes SHIP2 ubiquitination via the E3 ligase NEDD4 to regulate AKT signaling in gastric cancer

  2024cites this paper
• NEDD4 enhances bone‑tendon healing in rotator cuff tears by reducing fatty infiltration

  2024cites this paper
• The E3 ubiquitin ligase Nedd4 fosters developmental myelination in the mouse central and peripheral nervous system

  2024cites this paper
• Therapeutic potential of earthworm-derived proteins: Targeting NEDD4 for cardiovascular disease intervention

  2024cites this paper
• Research Progress in Function and Regulation of E3 Ubiquitin Ligase SMURF1

  2023cites this paper
• Reprogramming of tumor-associated macrophages via NEDD4-mediated CSF1R degradation by targeting USP18

  2023cites this paper
• As a matter of fat: Emerging roles of lipid‐sensitive E3 ubiquitin ligases

  2023cites this paper
• Complex Genomic Rearrangements Involving ETV6::ABL1 Gene Fusion in an Individual with Myeloid Neoplasm

  2023cites this paper
• The role of ubiquitination and deubiquitination in PI3K/AKT/mTOR pathway: a potential target for cancer therapy.

  2023cites this paper
• TMEM127 suppresses tumor development by promoting RET ubiquitination, positioning, and degradation

  2023cites this paper
• An insulin-regulated arrestin domain protein controls hepatic glucagon action

  2023cites this paper
• E3 ubiquitin ligase neural precursor cell‐expressed developmentally downregulated gene 4 motivates FOXA1 ubiquitination and restrains proliferation of diffuse large B‐cell lymphoma cells via the Wnt/β‐Catenin pathway

  2023cites this paper
• Expression and regulatory network of E3 ubiquitin ligase NEDD4 family in cancers

  2023cites this paper
• NEDD4-1 deficiency impairs satellite cell function during skeletal muscle regeneration

  2023cites this paper
• Aldosterone: Renal Action and Physiological Effects.

  2023cites this paper
• The role of the NDRG1 in the pathogenesis and treatment of breast cancer.

  2023cites this paper
• E3 Ubiquitin Ligase NEDD4 Affects Estrogen Receptor α Expression and the Prognosis of Patients with Hormone Receptor-Positive Breast Cancer

  2023cites this paper
• Celastrol targeting Nedd4 reduces Nrf2-mediated oxidative stress in astrocytes after ischemic stroke

  2023cites this paper
• Research progress of Nedd4L in cardiovascular diseases

  2022cites this paper
• NEDD4 attenuates phosgene‐induced acute lung injury through the inhibition of Notch1 activation

  2022cites this paper
• Ubiquitination/de-ubiquitination: A promising therapeutic target for PTEN reactivation in cancer.

  2022cites this paper
• Multiubiquitination of TRPV4 reduces channel activity independent of surface localization

  2022cites this paper
• Phage display identification of nanomolar ligands for human NEDD4-WW3: Energetic and dynamic implications for the development of broad-spectrum antivirals.

  2022cites this paper
• The Ubiquitin E3 Ligase Nedd4 Regulates the Expression and Amyloid-β Peptide Export Activity of P-Glycoprotein

  2022cites this paper
• Environmental control of Pub1 (NEDD4 family E3 ligase) in Schizosaccharomyces pombe is regulated by TORC2 and Gsk3

  2022cites this paper
• Viral Proteins with PxxP and PY Motifs May Play a Role in Multiple Sclerosis

  2022cites this paper
• Regulation of Cdc42 protein turnover modulates the filamentous growth MAPK pathway

  2022cites this paper
• Unraveling the Potential Role of NEDD4-like E3 Ligases in Cancer

  2022cites this paper
• Molecular cloning, expression analysis and functional characterization of NEDD4 from Nile tilapia (Oreochromis niloticus).

  2022cites this paper
• Mesenchymal stem cells-derived small extracellular vesicles alleviate diabetic retinopathy by delivering NEDD4

  2022cites this paper
• Human cytomegalovirus UL42 protein inhibits the degradation of glycoprotein B through inhibition of Nedd4 family ubiquitin E3 ligases

  2021cites this paper
• Complement-Induced Post-Translational Regulation Of Tgf-SS Signaling On Endothelial Cells

  2021cites this paper
• Evidence for an Interaction Between NEDD4 and Childhood Trauma on Clinical Characters of Schizophrenia With Family History of Psychosis

  2021cites this paper
• The emerging role of WWP1 in cancer development and progression

  2021cites this paper
• NEDD4 Induces K48-Linked Degradative Ubiquitination of Hepatitis B Virus X Protein and Inhibits HBV-Associated HCC Progression

  2021cites this paper
• Sushi domain-containing protein 4 controls synaptic plasticity and motor learning

  2021cites this paper
• A HECT domain ubiquitin ligase CgWWP1 regulates granulocytes proliferation in oyster Crassostrea gigas.

  2021cites this paper
• Association of Cystic Fibrosis Transmembrane Conductance Regulator with Epithelial Sodium Channel Subunits Carrying Liddle's Syndrome Mutations.

  2021cites this paper
• Environmental control of Pub1 (NEDD4 family E3 ligase) in S. pombe is regulated by TORC2 and Gsk3

  2021influential citation
• MEKK5 Interacts with and Negatively Regulates the E3 Ubiquitin Ligase NEDD4 for Mediating Lung Cancer Cell Migration

  2021cites this paper
• Calcium | Calcium-Binding Proteins: Cytosolic (Annexins, Gelsolins, and C2-Domain Proteins)

  2021cites this paper
• NEDD4-1 is a key regulator of epidermal homeostasis and wound repair.

  2021cites this paper
• Implications of Phosphoinositide 3-Kinase-Akt (PI3K-Akt) Pathway in the Pathogenesis of Alzheimer’s Disease

  2021cites this paper
• Predicting PY motif-mediated protein-protein interactions in the Nedd4 family of ubiquitin ligases

  2021cites this paper
• Ubiquitin pathways regulate the pathogenesis of chronic liver disease.

  2021cites this paper
• Integrated bioinformatics analysis of the NEDD4 family reveals a prognostic value of NEDD4L in clear-cell renal cell cancer

  2021cites this paper
• Relevance of Connexin 26 (GJB2) Gene Mutations With Congenital Nonsyndromic Sensorineural Hearing Loss in Lraqi Deafness Patients.

  2021cites this paper
• Functions and Molecular Mechanisms of Deltex Family Ubiquitin E3 Ligases in Development and Disease

  2021cites this paper
• Neuronal Precursor Cell Expressed Developmentally Down Regulated 4 (NEDD4) Gene Polymorphism Contributes to Keloid Development in Egyptian Population Clinical, Cosmetic and Investigational Dermatology

  2020cites this paper
• Novel SS18‐NEDD4 gene fusion in a primary renal synovial sarcoma

  2020cites this paper
• SUSD4 Controls Activity-Dependent Degradation of AMPA Receptor GLUA2 and Synaptic Plasticity

  2020cites this paper
• Role of WW domain E3 ubiquitin protein ligase 2 in modulating ubiquitination and Degradation of Septin4 in oxidative stress endothelial injury

  2020cites this paper
• An outlined review for the role of Nedd4-1 and Nedd4-2 in lung disorders.

  2020cites this paper
• MTMR4 SNVs modulate ion channel degradation and clinical severity in congenital long QT syndrome: insights in the mechanism of action of protective modifier genes

  2020cites this paper
• Shifts in Ribosome Engagement Impact Key Gene Sets in Neurodevelopment and Ubiquitination in Rett Syndrome.

  2020cites this paper
• Robust and facile purification of full-length, untagged human Nedd4 as a recombinant protein from Escherichia coli.

  2020cites this paper
• Identification of novel interacting partners of the NEDD4 ubiquitin ligase in mouse testis.

  2020cites this paper
• O2-Dependent Protein Internalization Underlies Astrocytic Sensing of Acute Hypoxia by Restricting Multimodal TRPA1 Channel Responses.

  2020cites this paper
• Structure and Function of HECT E3 Ubiquitin Ligases and their Role in Oxidative Stress

  2020cites this paper
• Deletion of ubiquitin ligase Nedd4l exacerbates ischemic brain damage

  2020influential citation
• Role of Ubiquitination in PTEN Cellular Homeostasis and Its Implications in GB Drug Resistance

  2020cites this paper
• Neuronal Precursor Cell Expressed Developmentally Down Regulated 4 (NEDD4) Gene Polymorphism Contributes to Keloid Development in Egyptian Population

  2020cites this paper
• PRRG4 promotes breast cancer metastasis through the recruitment of NEDD4 and downregulation of Robo1

  2020cites this paper
• The endosomal trafficking regulator LITAF controls the cardiac Nav1.5 channel via the ubiquitin ligase NEDD4-2

  2020cites this paper
• Bioinformatic and computational analysis reveals the prevalence and nature of PY motif-mediated protein-protein interactions in the Nedd4 family of ubiquitin ligases

  2020cites this paper
• A novel analysis of the differentiated expression of long noncoding RNAs profiles in human prostate cancer

  2020influential citation
• SUSD4 controls GLUA2 degradation, synaptic plasticity and motor learning

  2020cites this paper
• The endosomal trafficking regulator LITAF controls the cardiac Nav1.5 channel via the ubiquitin ligase NEDD4-2.

  2020cites this paper
• Binding site plasticity in viral PPxY Late domain recognition by the third WW domain of human NEDD4

  2019cites this paper
• Shifts in Ribosome Engagement Impact Key Gene Sets in Neurodevelopment and Ubiquitination in Rett Syndrome

  2019cites this paper
• Exosomal hsa-miR199a-3p Promotes Proliferation and Migration in Neuroblastoma

  2019cites this paper
• The Adaptor Protein Alix is Involved in the Interaction Between the Ubiquitin Ligase NEDD4-1 and its Targets, ABCG1 and ABCG4

  2019cites this paper
• Regulation of Krüppel-like factor 8 by the NEDD4 E3 ubiquitin ligase.

  2019cites this paper
• Nedd4 E3 ligase and beta-arrestins regulate ubiquitination, trafficking, and stability of the mGlu7 receptor

  2019cites this paper
• Ticket to a bubble ride: Cargo sorting into exosomes and extracellular vesicles.

  2019cites this paper
• E3 ubiquitin ligase Nedd4 is a key negative regulator for non-canonical inflammasome activation

  2019cites this paper
• Ubiquitination‑deubiquitination in the Hippo signaling pathway (Review).

  2019cites this paper
• A Role for the E3 Ubiquitin Ligase NEDD4 in Keloid Pathogenesis.

  2019cites this paper
• NEDD4 Is Involved in Inflammation Development during Keloid Formation.

  2019cites this paper
• Directing Traffic: Regulation of COPI Transport by Post-translational Modifications

  2019cites this paper
• Regulation of gap junction intercellular communication by connexin ubiquitination: physiological and pathophysiological implications

  2019cites this paper
• STAT3 operates as a novel transcription factor that regulates NEDD4 in Keloid.

  2019cites this paper
• Regulation of the p53 Family Proteins by the Ubiquitin Proteasomal Pathway

  2019cites this paper
• The regulation of deubiquitinases by oxidative stress in Saccharomyces cerevisiae

  2019cites this paper
• Diosgenin inhibits the expression of NEDD4 in prostate cancer cells.

  2019cites this paper
• NEDD4‐induced degradative ubiquitination of phosphatidylinositol 4‐phosphate 5‐kinase α and its implication in breast cancer cell proliferation

  2018influential citation