Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite development.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Neuron

• Publication date

  2010-02-11

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.neuron.2010.01.007PMID 20159449PMCID PMC2825371
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A centrosomal Cdc20-APC pathway controls dendrite morphogenesis in postmitotic neurons.

  2009cited by this paper
• The ubiquitin ligase Nedd4-1 is dispensable for the regulation of PTEN stability and localization

  2008influential reference
• Nedd4 Controls Animal Growth by Regulating IGF-1 Signaling

  2008cited by this paper
• Pyramidal neurons: dendritic structure and synaptic integration

  2008cited by this paper
• Targeting the Phosphoinositide‐3‐kinase/Akt/Mammalian Target of Rapamycin Pathway

  2008cited by this paper
• Ubiquitin chain editing revealed by polyubiquitin linkage-specific antibodies.

  2008cited by this paper
• MINK is a Rap2 effector for phosphorylation of the postsynaptic scaffold protein TANC1.

  2008cited by this paper
• CAPS-1 and CAPS-2 are essential synaptic vesicle priming proteins.

  2007cited by this paper
• LUTAMATE STIMULATES GLUTAMATE RECEPTOR INTERACTING ROTEIN 1 DEGRADATION BY UBIQUITIN-PROTEASOME SYSTEM TO EGULATE SURFACE EXPRESSION OF GluR2

  2007cited by this paper
• Mechanisms that regulate establishment, maintenance, and remodeling of dendritic fields.

  2007influential reference
• Glutamate stimulates glutamate receptor interacting protein 1 degradation by ubiquitin-proteasome system to regulate surface expression of GluR2.

  2007cited by this paper
• Regulation of Spine Development by Semaphorin3A through Cyclin-Dependent Kinase 5 Phosphorylation of Collapsin Response Mediator Protein 1

  2007cited by this paper
• Regulation of dendritogenesis via a lipid-raft-associated Ca2+/calmodulin-dependent protein kinase CLICK-III/CaMKIgamma.

  2007cited by this paper
• The requirement for Phr1 in CNS axon tract formation reveals the corticostriatal boundary as a choice point for cortical axons.

  2007cited by this paper
• SCRAPPER-dependent ubiquitination of active zone protein RIM1 regulates synaptic vesicle release.

  2007cited by this paper
• Differential roles of Rap1 and Rap2 small GTPases in neurite retraction and synapse elimination in hippocampal spiny neurons

  2007cited by this paper
• Retracted: Ubiquitination of the GTPase Rap1B by the ubiquitin ligase Smurf2 is required for the establishment of neuronal polarity

  2007influential reference
• LKB1 and SAD kinases define a pathway required for the polarization of cortical neurons.

  2007cited by this paper
• NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN.

  2007cited by this paper
• Differential modification of Ras proteins by ubiquitination.

  2006influential reference
• Neuroligins determine synapse maturation and function.

  2006cited by this paper
• Pten regulates neuronal arborization and social interaction in mice.

  2006cited by this paper
• Cell survival through Trk neurotrophin receptors is differentially regulated by ubiquitination.

  2006influential reference
• Ubiquitin protein ligase Nedd4 binds to connexin43 by a phosphorylation-modulated process

  2006cited by this paper
• Technical innovations for the automated identification of gel-separated proteins by MALDI-TOF mass spectrometry

  2006cited by this paper
• Genetic targeting of principal neurons in neocortex and hippocampus of NEX‐Cre mice

  2006influential reference
• Phosphorylation of Neurogenin2 specifies the migration properties and the dendritic morphology of pyramidal neurons in the neocortex.

  2005cited by this paper
• WW Domains Provide a Platform for the Assembly of Multiprotein Networks

  2005cited by this paper
• Control of Dendritic Arborization by the Phosphoinositide-3′-Kinase–Akt–Mammalian Target of Rapamycin Pathway

  2005influential reference
• Ubiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradation.

  2005cited by this paper
• The Traf2- and Nck-interacting Kinase as a Putative Effector of Rap2 to Regulate Actin Cytoskeleton*

  2004influential reference
• The sequential activity of the GTPases Rap1B and Cdc42 determines neuronal polarity

  2004cited by this paper
• Drosophila Nedd4 regulates endocytosis of notch and suppresses its ligand-independent activation.

  2004influential reference
• BRUCE, a Giant E2/E3 Ubiquitin Ligase and Inhibitor of Apoptosis Protein of the trans-Golgi Network, Is Required for Normal Placenta Development and Mouse Survival

  2004cited by this paper
• Regulation of notch endosomal sorting and signaling by Drosophila Nedd4 family proteins.

  2004influential reference
• Grb10 Prevents Nedd4-mediated Vascular Endothelial Growth Factor Receptor-2 Degradation*

  2004cited by this paper
• Lentivirus-based genetic manipulations of cortical neurons and their optical and electrophysiological monitoring in vivo

  2004cited by this paper
• Functional regions of the presynaptic cytomatrix protein bassoon: significance for synaptic targeting and cytomatrix anchoring.

  2003cited by this paper
• Trk receptors: roles in neuronal signal transduction.

  2003cited by this paper
• Regulation of Cell Polarity and Protrusion Formation by Targeting RhoA for Degradation

  2003cited by this paper
• The effects of temperature on vesicular supply and release in autaptic cultures of rat and mouse hippocampal neurons

  2002cited by this paper
• Fyn and Cdk5 mediate semaphorin-3A signaling, which is involved in regulation of dendrite orientation in cerebral cortex.

  2002cited by this paper
• Spatio-temporal images of growth-factor-induced activation of Ras and Rap1

  2001cited by this paper
• Nedd4 Regulates Ubiquitination and Stability of the Guanine-Nucleotide Exchange Factor CNrasGEF*

  2001cited by this paper
• Rap2 as a Slowly Responding Molecular Switch in the Rap1 Signaling Cascade

  2000cited by this paper
• Molecular cloning of MINK, a novel member of mammalian GCK family kinases, which is up‐regulated during postnatal mouse cerebral development

  2000influential reference
• TNIK, a Novel Member of the Germinal Center Kinase Family That Activates the c-Jun N-terminal Kinase Pathway and Regulates the Cytoskeleton*

  1999cited by this paper
• Mutation of the Angelman ubiquitin ligase in mice causes increased cytoplasmic p53 and deficits of contextual learning and long-term potentiation.

  1998cited by this paper
• Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain.

  1997cited by this paper
• Crystal structures of the small G protein Rap2A in complex with its substrate GTP, with GDP and with GTPγS

  1997cited by this paper
• De novo truncating mutations in E6-AP ubiquitin-protein ligase gene (UBE3A) in Angelman syndrome

  1997cited by this paper
• Definition of the readily releasable pool of vesicles at hippocampal synapses.

  1996influential reference
• UBE3A/E6-AP mutations cause Angelman syndrome

  1996cited by this paper
• Differential Interaction of the Ras Family GTP-binding Proteins H-Ras, Rap1A, and R-Ras with the Putative Effector Molecules Raf Kinase and Ral-Guanine Nucleotide Exchange Factor

  1996cited by this paper
• WW domains of Nedd4 bind to the proline‐rich PY motifs in the epithelial Na+ channel deleted in Liddle's syndrome.

  1996cited by this paper
• Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

  1995cited by this paper
• Production and characterization of monoclonal antibodies specific to multi‐ubiquitin chains of polyubiquitinated proteins

  1994cited by this paper
• Raf-1 protein kinase is required for growth of induced NIH/3T3 cells

  1991cited by this paper
• Excitatory and inhibitory autaptic currents in isolated hippocampal neurons maintained in cell culture.

  1991cited by this paper
• Lewy bodies are ubiquitinated

  1988cited by this paper
• The dendritic complexity and innervation of submandibular neurons in five species of mammals

  1987cited by this paper
• Geometry of neonatal neurones and the regulation of synapse elimination

  1981cited by this paper
• Dendritic organization in the neurons of the visual and motor cortices of the cat.

  1953influential reference
• Dendritic organization in the neurons of the visual and motor cortices of the cat.

  1953cited by this paper

• Neural crest cell-derived DKK1 and NEDD4 modulate Wnt signalling in the second heart field to orchestrate outflow tract development

  2026cites this paper
• Dlgap2 deficiency disrupts synaptic homeostasis by promoting ubiquitin-mediated Itsn1 degradation in a valproic acid-induced autism-like model.

  2026cites this paper
• NEDD4 promotes reactive astrogliosis by enhancing K63-linked ubiquitination and inhibiting chaperone-mediated autophagy degradation of YAP1

  2026cites this paper
• Targeting Atherosclerosis via NEDD4L Signaling—A Review of the Current Literature

  2025cites this paper
• NEDD4 Promotes Sertoli Cell Proliferation and Adult Leydig Cell Differentiation in the Murine Testis

  2025cites this paper
• The E3 ligase MEX3B forms a tripartite complex with Rest and Hotair to determine the proliferative capacity of neural progenitor cells

  2025cites this paper
• Deep Learning-coupled Proximity Proteomics to Deconvolve Kinase Signaling In Vivo

  2025cites this paper
• TNIK-driven regulation of ERK5 transcriptional activity in endothelial cells

  2025cites this paper
• Rap2a promotes cardiac fibrosis and exacerbates myocardial infarction through the TNIK/Merlin/YAP axis

  2025cites this paper
• Proteasome stress activates YAP/TAZ through the RAP2-MAP4Ks-LATS1/2 pathway and its therapeutic implications in solid tumors.

  2025cites this paper
• SAMD12 as a master regulator of MAP4Ks by decoupling kinases from the CNKSR2 scaffold.

  2025cites this paper
• Identification of E3 Ubiquitin Ligase Substrates Using Biotin Ligase-Based Proximity Labeling Approaches

  2025cites this paper
• TRAF2 and NCK interacting kinase: a novel regulator of integrin αIIbβ3 signaling in platelets

  2025influential citation
• The RNA binding ubiquitination ligase MEX3B regulates bFGF-dependent neuronal proliferation

  2024cites this paper
• PTBP1 mediates Sertoli cell actin cytoskeleton organization by regulating alternative splicing of actin regulators

  2024cites this paper
• NAD+ Precursors Reverse Experimental Diabetic Neuropathy in Mice

  2024cites this paper
• Mutations in the postsynaptic density signaling hub TNIK disrupt PSD signaling in human models of neurodevelopmental disorders

  2024cites this paper
• PTBP1 mediates Sertoli cell actin cytoskeleton organization by regulating alternative splicing of actin regulators

  2024cites this paper
• TNIK in disease: from molecular insights to therapeutic prospects

  2024cites this paper
• TNIK regulation of interferon signaling and endothelial cell response to virus infection

  2024cites this paper
• The E3 ubiquitin ligase Nedd4 fosters developmental myelination in the mouse central and peripheral nervous system

  2024cites this paper
• Biallelic variants identified in 36 Pakistani families and trios with autism spectrum disorder

  2024cites this paper
• The role and advance of ubiquitination and deubiquitination in depression pathogenesis and treatment

  2024cites this paper
• Understanding ubiquitination in neurodevelopment by integrating insights across space and time

  2024cites this paper
• Regulation of excitatory presynaptic activity by Ambra1 protein determines neuronal networks in sex-dimorphic manner

  2023cites this paper
• Nedd4-1 regulates human sodium-dependent vitamin C transporter-2 functional expression in neuronal and epithelial cells.

  2023cites this paper
• NEDD4 E3 ubiquitin ligases: promising biomarkers and therapeutic targets for cancer.

  2023cites this paper
• Cross-continental environmental and genome-wide association study on children and adolescent anxiety and depression

  2023cites this paper
• The Traf2 and NcK interacting kinase inhibitor NCB-0846 suppresses seizure activity involving the decrease of GRIA1

  2023cites this paper
• Cross-continental environmental and genome-wide association study on children and adolescent anxiety and depression

  2023cites this paper
• PHYSIOLOGICAL FUNCTIONS OF THE UBIQUITIN LIGASES NEDD4-1 AND NEDD4-2.

  2023cites this paper
• Thrombospondin1 mimics rapidly relieve depression via Shank3 dependent uncoupling between dopamine D1 and D2 receptors.

  2023cites this paper
• Reprogramming of tumor-associated macrophages via NEDD4-mediated CSF1R degradation by targeting USP18

  2023cites this paper
• Nedd4-2-dependent regulation of astrocytic Kir4.1 and Connexin43 controls neuronal network activity

  2023cites this paper
• The placental protein NRK promotes cell death through its plasma membrane-localizing CNH domain

  2023cites this paper
• Understanding neurodevelopmental proteasomopathies as new rare disease entities: A review of current concepts, molecular biomarkers, and perspectives

  2023cites this paper
• NEDD4-1 deficiency impairs satellite cell function during skeletal muscle regeneration

  2023cites this paper
• Rap2a Is Negatively Regulated by NF-κB and Contributes to Growth via Wnt Pathway in Shrimp

  2022cites this paper
• The Roles of NEDD4 Subfamily of HECT E3 Ubiquitin Ligases in Neurodevelopment and Neurodegeneration

  2022cites this paper
• Global ubiquitinome profiling identifies NEDD4 as a regulator of Profilin 1 and actin remodelling in neural crest cells

  2022cites this paper
• Lycorine suppresses cell growth and invasion via down-regulation of NEDD4 ligase in bladder cancer.

  2022cites this paper
• Multiubiquitination of TRPV4 reduces channel activity independent of surface localization

  2022cites this paper
• The Role of NEDD4 E3 Ubiquitin–Protein Ligases in Parkinson’s Disease

  2022cites this paper
• The influence of polymorphisms in TNIK gene on risperidone response in a Chinese Han population.

  2022cites this paper
• Unraveling the Potential Role of NEDD4-like E3 Ligases in Cancer

  2022cites this paper
• A Nedd4 E3 Ubiquitin Ligase Pathway Inhibits Robo1 Repulsion and Promotes Commissural Axon Guidance across the Midline

  2022cites this paper
• A proteomic study to unveil lead toxicity-induced memory impairments invoked by synaptic dysregulation

  2022cites this paper
• Mesenchymal stem cells-derived small extracellular vesicles alleviate diabetic retinopathy by delivering NEDD4

  2022cites this paper
• Studying the Interactions of U24 from HHV-6 in Order to Further Elucidate Its Potential Role in MS

  2022cites this paper
• The NEDD4 ubiquitin E3 ligase: a snapshot view of its functional activity and regulation.

  2022cites this paper
• CASK loss of function differentially regulates neuronal maturation and synaptic function in human induced cortical excitatory neurons

  2022cites this paper
• Rpsa Signaling Regulates Cortical Neuronal Morphogenesis via Its Ligand, PEDF, and Plasma Membrane Interaction Partner, Itga6.

  2021cites this paper
• Phosphorylation‐dependent control of Activity‐regulated cytoskeleton‐associated protein (Arc) protein by TNIK

  2021cites this paper
• The HECT family of E3 ubiquitin ligases and PTEN.

  2021cites this paper
• HECT E3 Ubiquitin Ligase Nedd4 Is Required for Antifungal Innate Immunity

  2021cites this paper
• Sushi domain-containing protein 4 controls synaptic plasticity and motor learning

  2021cites this paper
• NEDD4-1 is a key regulator of epidermal homeostasis and wound repair.

  2021cites this paper
• Explore the Mechanism of TiantaiWuyao Powder in Treating Depression Based on Network Pharmacology and Bioinformatics

  2021cites this paper
• The role of E3 ubiquitin ligases in synapse function in the healthy and diseased brain.

  2021cites this paper
• Phosphorylation-dependent control of Arc protein by synaptic plasticity regulator TNIK

  2021cites this paper
• Application of Machine Learning and Weighted Gene Co-expression Network Algorithm to Explore the Hub Genes in the Aging Brain

  2021cites this paper
• Exploration of Aberrant E3 Ligases Implicated in Alzheimer’s Disease and Development of Chemical Tools to Modulate Their Function

  2021cites this paper
• Ubiquitylation by Rab40b/Cul5 regulates Rap2 localization and activity during cell migration

  2021cites this paper
• Evidence for an Interaction Between NEDD4 and Childhood Trauma on Clinical Characters of Schizophrenia With Family History of Psychosis

  2021cites this paper
• Homeostatic Roles of the Proteostasis Network in Dendrites

  2020cites this paper
• Deciphering the genetics mechanisms that inhibit synapse formation

  2020cites this paper
• The murine ortholog of Kaufman oculocerebrofacial syndrome protein Ube3b regulates synapse number by ubiquitinating Ppp3cc

  2020cites this paper
• HECT E3 ubiquitin ligases – emerging insights into their biological roles and disease relevance

  2020cites this paper
• Shifts in Ribosome Engagement Impact Key Gene Sets in Neurodevelopment and Ubiquitination in Rett Syndrome.

  2020cites this paper
• The Daam2–VHL–Nedd4 axis governs developmental and regenerative oligodendrocyte differentiation

  2020cites this paper
• Abnormal expression of Rap2A as a prognostic marker for human breast cancer.

  2020cites this paper
• TNIK (TRAF2 and NCK interacting kinase)

  2020cites this paper
• Molecular Evolution, Neurodevelopmental Roles and Clinical Significance of HECT-Type UBE3 E3 Ubiquitin Ligases

  2020cites this paper
• NEDD4 E3 ligase: Functions and mechanism in human cancer.

  2020cites this paper
• PDCD4 regulates axonal growth by translational repression of neurite growth-related genes and is modulated during nerve injury responses

  2020cites this paper
• SUSD4 controls GLUA2 degradation, synaptic plasticity and motor learning

  2020cites this paper
• Shifts in Ribosome Engagement Impact Key Gene Sets in Neurodevelopment and Ubiquitination in Rett Syndrome

  2019cites this paper
• Inflammation-dependent ISG15 upregulation mediates MIA-induced dendrite damages and depression by disrupting NEDD4/Rap2A signaling.

  2019cites this paper
• Ubiquitin Ligases Involved in the Regulation of Wnt, TGF-β, and Notch Signaling Pathways and Their Roles in Mouse Development and Homeostasis

  2019cites this paper
• NEDD4 and NEDD4L regulate Wnt signalling and intestinal stem cell priming by degrading LGR5 receptor

  2019cites this paper
• TDP-43 and NOVA-1 RNA-binding proteins as competitive splicing regulators of the schizophrenia-associated TNIK gene.

  2019cites this paper
• Regulation of Dendritogenesis in Sympathetic Neurons, Autonomic Nervous System, Pavol Svorc

  2019cites this paper
• Evidence that melatonin downregulates Nedd4-1 E3 ligase and its role in cellular survival.

  2019cites this paper
• Physiological and pathophysiological homeostasis of astroglial channel proteins by Nedd4-2

  2019influential citation
• The Kaufman oculocerebrofacial syndrome protein Ube3b regulates synapse number by ubiquitinating Ppp3cc

  2019cites this paper
• NEDD4 promotes cell growth and motility in hepatocellular carcinoma

  2018cites this paper
• Regulation of Dendritogenesis in Sympathetic Neurons

  2018cites this paper
• Importin-8 Modulates Division of Apical Progenitors, Dendritogenesis and Tangential Migration During Development of Mouse Cortex

  2018cites this paper
• Monoubiquitination of Cancer Stem Cell Marker CD133 at Lysine 848 Regulates Its Secretion and Promotes Cell Migration

  2018cites this paper
• Rap2 and TNIK control Plexin-dependent tiled synaptic innervation in C. elegans

  2018cites this paper
• E3-ubiquitin ligase NEDD4 enhances bone formation by removing TGFβ1-induced pSMAD1 in immature osteoblast.

  2018cites this paper
• Molecular mechanisms of Streptococcus pneumoniae‐targeted autophagy via pneumolysin, Golgi‐resident Rab41, and Nedd4‐1‐mediated K63‐linked ubiquitination

  2018influential citation
• Polarity Acquisition in Cortical Neurons Is Driven by Synergistic Action of Sox9-Regulated Wwp1 and Wwp2 E3 Ubiquitin Ligases and Intronic miR-140.

  2018cites this paper
• Glycoprotein M6a as a signaling transducer in neuronal lipid rafts.

  2017cites this paper
• E3 Ubiquitin Ligase Nedd4 Promotes Japanese Encephalitis Virus Replication by Suppressing Autophagy in Human Neuroblastoma Cells

  2017cites this paper
• NEDD4 controls spermatogonial stem cell homeostasis and stress response by regulating messenger ribonucleoprotein complexes

  2017cites this paper
• Rap2 and TNIK control Plexin-dependent synaptic tiling in C. elegans

  2017influential citation
• H3 ubiquitination by NEDD4 regulates H3 acetylation and tumorigenesis

  2017cites this paper
• Nedd4 Deficiency in Vascular Smooth Muscle Promotes Vascular Calcification by Stabilizing pSmad1

  2017cites this paper
• GWAS links variants in neuronal development and actin remodeling related loci with pseudoexfoliation syndrome without glaucoma

  2017cites this paper