Nedd4 and Nedd4-2: closely related ubiquitin-protein ligases with distinct physiological functions

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Cell Death and Differentiation

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/cdd.2009.84PMID 19557014PMCID PMC2818775
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Nedd4-2-mediated ubiquitination facilitates processing of surfactant protein-C.

  2010cited by this paper
• Anterograde Transport of Surfactant Protein C Proprotein to Distal Processing Compartments Requires PPDY-mediated Association with Nedd4 Ubiquitin Ligases*

  2009influential reference
• SCAMP3 negatively regulates epidermal growth factor receptor degradation and promotes receptor recycling.

  2009cited by this paper
• The inositol phosphatase MTMR4 is a novel target of the ubiquitin ligase Nedd4

  2009cited by this paper
• Quantitative proteomics reveals the function of unconventional ubiquitin chains in proteasomal degradation.

  2009cited by this paper
• Physiological functions of the HECT family of ubiquitin ligases

  2009cited by this paper
• The Cyclin-dependent Kinase Activator, Spy1A, Is Targeted for Degradation by the Ubiquitin Ligase NEDD4*

  2009cited by this paper
• Down-regulation of Active ACK1 Is Mediated by Association with the E3 Ubiquitin Ligase Nedd4-2*

  2009cited by this paper
• Functional Regulation of the Epithelial Na+ Channel by IκB Kinase-β Occurs via Phosphorylation of the Ubiquitin Ligase Nedd4-2*

  2009cited by this paper
• Abnormal development of the neuromuscular junction in Nedd4-deficient mice.

  2009cited by this paper
• Nedd4 Mediates Agonist-dependent Ubiquitination, Lysosomal Targeting, and Degradation of the β2-Adrenergic Receptor*

  2008cited by this paper
• The Ubiquitin-Protein Ligase Nedd4-2 Differentially Interacts with and Regulates Members of the Tweety Family of Chloride Ion Channels*

  2008cited by this paper
• The ubiquitin ligase Nedd4-1 is dispensable for the regulation of PTEN stability and localization

  2008influential reference
• Ear1p and Ssh4p are new adaptors of the ubiquitin ligase Rsp5p for cargo ubiquitylation and sorting at multivesicular bodies.

  2008cited by this paper
• An Obligatory Heterodimer of 14-3-3β and 14-3-3ϵ Is Required for Aldosterone Regulation of the Epithelial Sodium Channel*

  2008cited by this paper
• Nedd4 Controls Animal Growth by Regulating IGF-1 Signaling

  2008cited by this paper
• ISG15 Inhibits Nedd4 Ubiquitin E3 Activity and Enhances the Innate Antiviral Response*♦

  2008influential reference
• A quantitative atlas of mitotic phosphorylation

  2008cited by this paper
• Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2.

  2008cited by this paper
• Nedd4 Family-interacting Protein 1 (Ndfip1) Is Required for the Exosomal Secretion of Nedd4 Family Proteins*

  2008cited by this paper
• Regulation of Nedd4-2 self-ubiquitination and stability by a PY motif located within its HECT-domain.

  2008influential reference
• Nedd4 augments the adaptive immune response by promoting ubiquitin-mediated degradation of Cbl-b in activated T cells

  2008influential reference
• γ2-Adaptin, a Ubiquitin-interacting Adaptor, Is a Substrate to Coupled Ubiquitination by the Ubiquitin Ligase Nedd4 and Functions in the Endosomal Pathway*

  2008cited by this paper
• Salt-sensitive hypertension and cardiac hypertrophy in mice deficient in the ubiquitin ligase Nedd4-2.

  2008influential reference
• Arrestin-related ubiquitin-ligase adaptors regulate endocytosis and protein turnover at the cell surface.

  2008cited by this paper
• Identification of c-Cbl as a new ligase for insulin-like growth factor-I receptor with distinct roles from Mdm2 in receptor ubiquitination and endocytosis.

  2008cited by this paper
• Ubiquitin ligase E6-AP and its role in human disease.

  2008cited by this paper
• Arrestin-like proteins mediate ubiquitination and endocytosis of the yeast metal transporter Smf1

  2008cited by this paper
• Damage-induced ubiquitylation of human RNA polymerase II by the ubiquitin ligase Nedd4, but not Cockayne syndrome proteins or BRCA1.

  2007cited by this paper
• Ubiquitination regulates PTEN nuclear import and tumor suppression.

  2007cited by this paper
• Regulation of the Voltage-gated K+ Channels KCNQ2/3 and KCNQ3/5 by Ubiquitination

  2007cited by this paper
• NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN.

  2007cited by this paper
• Akt Mediates the Effect of Insulin on Epithelial Sodium Channels by Inhibiting Nedd4-2*

  2007cited by this paper
• The KCNQ1 potassium channel is down-regulated by ubiquitylating enzymes of the Nedd4/Nedd4-like family.

  2007cited by this paper
• Transgenic Mouse Proteomics Identifies New 14-3-3-associated Proteins Involved in Cytoskeletal Rearrangements and Cell Signaling*S

  2006cited by this paper
• Nedd4-WW Domain-Binding Protein 5 (Ndfip1) Is Associated with Neuronal Survival after Acute Cortical Brain Injury

  2006cited by this paper
• Cell survival through Trk neurotrophin receptors is differentially regulated by ubiquitination.

  2006cited by this paper
• Ubiquitin protein ligase Nedd4 binds to connexin43 by a phosphorylation-modulated process

  2006cited by this paper
• Transferrin receptor‐like proteins control the degradation of a yeast metal transporter

  2006cited by this paper
• Regulation of functional diversity within the Nedd4 family by accessory and adaptor proteins.

  2006influential reference
• RNA Interference Screen Reveals an Essential Role of Nedd4–2 in Dopamine Transporter Ubiquitination and Endocytosis

  2006cited by this paper
• 14-3-3 Mediates phosphorylation-dependent inhibition of the interaction between the ubiquitin E3 ligase Nedd4-2 and epithelial Na+ channels.

  2006cited by this paper
• Regulation of Amino Acid Transporter ATA2 by Ubiquitin Ligase Nedd4-2*

  2006cited by this paper
• Structural determinants for high-affinity binding in a Nedd4 WW3* domain-Comm PY motif complex.

  2006cited by this paper
• 14-3-3 Isoforms Are Induced by Aldosterone and Participate in Its Regulation of Epithelial Sodium Channels*

  2006cited by this paper
• Post‐translational regulation of EAAT2 function by co‐expressed ubiquitin ligase Nedd4‐2 is impacted by SGK kinases

  2006cited by this paper
• The ubiquitin-protein ligases Nedd4 and Nedd4-2 show similar ubiquitin-conjugating enzyme specificities.

  2006cited by this paper
• Ndfip1 protein promotes the function of itch ubiquitin ligase to prevent T cell activation and T helper 2 cell-mediated inflammation.

  2006cited by this paper
• 14-3-3 Proteins: A Number of Functions for a Numbered Protein

  2005cited by this paper
• NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta type I receptor.

  2005cited by this paper
• Nedd4-2 Phosphorylation Induces Serum and Glucocorticoid-regulated Kinase (SGK) Ubiquitination and Degradation*

  2005influential reference
• Serum- and glucocorticoid-regulated kinase 1 regulates ubiquitin ligase neural precursor cell-expressed, developmentally down-regulated protein 4-2 by inducing interaction with 14-3-3.

  2005cited by this paper
• Proteolysis: from the lysosome to ubiquitin and the proteasome

  2005influential reference
• Molecular determinants of voltage-gated sodium channel regulation by the Nedd4/Nedd4-like proteins.

  2005cited by this paper
• NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-β (transforming growth factor-β) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-β type I receptor

  2005cited by this paper
• Nedd4-2 isoforms differentially associate with ENaC and regulate its activity.

  2005cited by this paper
• Regulation of cardiac shal-related potassium channel Kv 4.3 by serum- and glucocorticoid-inducible kinase isoforms in Xenopus oocytes

  2005cited by this paper
• 14-3-3 Proteins Modulate the Expression of Epithelial Na+ Channels by Phosphorylation-dependent Interaction with Nedd4-2 Ubiquitin Ligase*

  2005influential reference
• Degradation of the Tumor Suppressor Smad4 by WW and HECT Domain Ubiquitin Ligases*

  2005cited by this paper
• Relative Contribution of Nedd4 and Nedd4-2 to ENaC Regulation in Epithelia Determined by RNA Interference*

  2004cited by this paper
• The Nedd4 family of E3 ubiquitin ligases: functional diversity within a common modular architecture

  2004cited by this paper
• Regulation of CLC-Ka/barttin by the ubiquitin ligase Nedd4-2 and the serum- and glucocorticoid-dependent kinases.

  2004cited by this paper
• Regulation of the voltage gated K+ channel Kv1.3 by the ubiquitin ligase Nedd4‐2 and the serum and glucocorticoid inducible kinase SGK1

  2004cited by this paper
• Cardiac Voltage-Gated Sodium Channel Nav1.5 Is Regulated by Nedd4-2 Mediated Ubiquitination

  2004cited by this paper
• Grb10 Prevents Nedd4-mediated Vascular Endothelial Growth Factor Receptor-2 Degradation*

  2004influential reference
• Regulation of Neuronal Voltage-gated Sodium Channels by the Ubiquitin-Protein Ligases Nedd4 and Nedd4-2*

  2004cited by this paper
• N4WBP5A (Ndfip2), a Nedd4-interacting protein, localizes to multivesicular bodies and the Golgi, and has a potential role in protein trafficking

  2004cited by this paper
• Bsd2 binds the ubiquitin ligase Rsp5 and mediates the ubiquitination of transmembrane proteins

  2004cited by this paper
• E3 ubiquitin ligases as T cell anergy factors

  2004cited by this paper
• Nedd4-2 Functionally Interacts with ClC-5

  2004cited by this paper
• Regulation of intestinal phosphate cotransporter NaPi IIb by ubiquitin ligase Nedd4-2 and by serum- and glucocorticoid-dependent kinase 1.

  2004cited by this paper
• Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins

  2004cited by this paper
• Regulation of glucose transporter SGLT1 by ubiquitin ligase Nedd4-2 and kinases SGK1, SGK3, and PKB.

  2004influential reference
• The Structure and Dynamics of Tandem WW Domains in a Negative Regulator of Notch Signaling, Suppressor of Deltex*

  2004cited by this paper
• The Grb10/Nedd4 Complex Regulates Ligand-Induced Ubiquitination and Stability of the Insulin-Like Growth Factor I Receptor

  2003cited by this paper
• Regulation of the glutamate transporter EAAT1 by the ubiquitin ligase Nedd4‐2 and the serum and glucocorticoid‐inducible kinase isoforms SGK1/3 and protein kinase B

  2003cited by this paper
• Dysfunction of the epithelial sodium channel expressed in the kidney of a mouse model for Liddle syndrome.

  2003cited by this paper
• Characterization of the interactions between Nedd4-2, ENaC, and sgk-1 using surface plasmon resonance.

  2003cited by this paper
• Mdm2-dependent ubiquitination and degradation of the insulin-like growth factor 1 receptor

  2003cited by this paper
• WW Domain HECT E3s Target Cbl RING Finger E3s for Proteasomal Degradation*

  2003cited by this paper
• Alternate promoters and variable splicing lead to hNedd4-2 isoforms with a C2 domain and varying number of WW domains.

  2003cited by this paper
• The role of individual Nedd4–2 (KIAA0439) WW domains in binding and regulating epithelial sodium channels

  2003cited by this paper
• Ligand‐Independent Degradation of Epidermal Growth Factor Receptor Involves Receptor Ubiquitylation and Hgs, an Adaptor Whose Ubiquitin‐Interacting Motif Targets Ubiquitylation by Nedd4

  2002cited by this paper
• Ubiquitin Modification of Serum and Glucocorticoid-induced Protein Kinase-1 (SGK-1)*

  2002cited by this paper
• Regulation of the Epithelial Sodium Channel by N4WBP5A, a Novel Nedd4/Nedd4-2-interacting Protein*

  2002influential reference
• N4WBP5, a Potential Target for Ubiquitination by the Nedd4 Family of Proteins, Is a Novel Golgi-associated Protein*

  2002cited by this paper
• Serum and Glucocorticoid-regulated Kinase Modulates Nedd4-2-mediated Inhibition of the Epithelial Na+Channel*

  2002cited by this paper
• Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation

  2002cited by this paper
• Raft-partitioning of the ubiquitin ligases Cbl and Nedd4 upon IgE-triggered cell signaling

  2001cited by this paper
• The adapter protein, Grb10, is a positive regulator of vascular endothelial growth factor signaling

  2001cited by this paper
• The Nedd4-like Protein KIAA0439 Is a Potential Regulator of the Epithelial Sodium Channel*

  2001cited by this paper
• A mutation in the surfactant protein C gene associated with familial interstitial lung disease.

  2001cited by this paper
• A novel mouse Nedd4 protein suppresses the activity of the epithelial Na+ channel

  2001cited by this paper
• Phosphorylation of Nedd4‐2 by Sgk1 regulates epithelial Na+ channel cell surface expression

  2001cited by this paper
• Anti-apoptotic Signaling of the Insulin-like Growth Factor-I Receptor through Mitochondrial Translocation of c-Raf and Nedd4*

  2001cited by this paper
• Apical Membrane Targeting of Nedd4 Is Mediated by an Association of Its C2 Domain with Annexin Xiiib

  2000cited by this paper
• Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4.

  2000cited by this paper
• The Epstein-Barr virus latent membrane protein 2A PY motif recruits WW domain-containing ubiquitin-protein ligases.

  2000influential reference
• A role for ubiquitin ligase recruitment in retrovirus release.

  2000cited by this paper
• A PPxY motif within the VP40 protein of Ebola virus interacts physically and functionally with a ubiquitin ligase: implications for filovirus budding.

  2000cited by this paper

• Lock, relax, load, and shoot: a molecular perspective on Nedd4 regulation.

  2026cites this paper
• Implicates of PIP5K1α in asthma-related biological processes: insights into mechanisms and therapeutic potential

  2025cites this paper
• The Potential of Pharmacological Intervention Targeting NEDD4 in Glioma

  2025cites this paper
• Targeting Atherosclerosis via NEDD4L Signaling—A Review of the Current Literature

  2025cites this paper
• Optimum level of NEDD4 and its interaction with nsP3 are crucial to facilitate efficient Chikungunya virus (CHIKV) infection

  2025cites this paper
• Histone lactylation promotes multidrug resistance in hepatocellular carcinoma by forming a positive feedback loop with PTEN

  2025cites this paper
• Selective clearance of aberrant membrane proteins by TORC1-mediated micro-ER-phagy

  2025cites this paper
• K27-linked RORγt ubiquitination by Nedd4 potentiates Th17-mediated autoimmunity

  2025cites this paper
• GDF-15 alleviates diabetic nephropathy via inhibiting NEDD4L-mediated IKK/NF-κB signalling pathways.

  2024cites this paper
• Update on the Pathogenesis of Keloid Formation

  2024cites this paper
• Reversal of endocrine resistance via N6AMT1-NEDD4L pathway-mediated p110α degradation

  2024cites this paper
• NEDD4 enhances bone‑tendon healing in rotator cuff tears by reducing fatty infiltration

  2024cites this paper
• The Nedd4L ubiquitin ligase is activated by FCHO2-generated membrane curvature

  2024cites this paper
• Role of the ubiquitin–proteasome system on macrophages in the tumor microenvironment

  2024cites this paper
• NEDD4 Knockdown Suppresses Human Endometrial Stromal Cell Growth and Invasion by Regulating PTGS2-Mediated Ferroptosis in Endometriosis.

  2024cites this paper
• Morinda Officinalis Polysaccharides Inhibit Osteoclast Differentiation by Regulating miR-214-3p/NEDD4L in Postmenopausal Osteoporosis Mice

  2024cites this paper
• Vimentin inhibits peste des petits ruminants virus replication by interaction with nucleocapsid protein.

  2024cites this paper
• Aberrant expression of NEDD4L disrupts mitochondrial homeostasis by downregulating CaMKKβ in diabetic kidney disease

  2024cites this paper
• NEDD4 activates mitophagy by interacting with LC3 to restrain reactive oxygen species and apoptosis in Apostichopus japonicus challenged with Vibrio splendidus.

  2023cites this paper
• Emerging roles of the HECT E3 ubiquitin ligases in gastric cancer

  2023cites this paper
• NEDD4-1 deficiency impairs satellite cell function during skeletal muscle regeneration

  2023cites this paper
• NEDD4L in human tumors: regulatory mechanisms and dual effects on anti-tumor and pro-tumor

  2023cites this paper
• NEDD4 E3 ubiquitin ligases: promising biomarkers and therapeutic targets for cancer.

  2023cites this paper
• KSHV-encoded LANA bypasses transcriptional block through the stabilization of RNA Pol II in hypoxia

  2023cites this paper
• Low temperature reduces occludin expression in bronchial epithelial cells: Implications in cold-induced asthma.

  2023cites this paper
• Identification of Ndfip1 as a novel negative regulator for spatial memory formation associated with increased ubiquitination of Beclin 1 and PTEN

  2023cites this paper
• Investigation of the Binding Interaction of Mfsd2a with NEDD4-2 via Molecular Dynamics Simulations.

  2023cites this paper
• Regulation of the intestinal Na+/H+ exchanger NHE3 by AMP-activated kinase is dependent on phosphorylation of NHE3 at S555 and S563.

  2023cites this paper
• Novel Therapeutic Avenues for Hypertrophic Cardiomyopathy

  2023cites this paper
• Hypoxic glioma‐derived extracellular vesicles harboring MicroRNA‐10b‐5p enhance M2 polarization of macrophages to promote the development of glioma

  2022cites this paper
• The regulatory roles of the E3 ubiquitin ligase NEDD4 family in DNA damage response

  2022cites this paper
• The Dual Regulation Effects of ESR1/NEDD4L on SLC7A11 in Breast Cancer Under Ionizing Radiation

  2022cites this paper
• Caffeine alleviates acute liver injury by inducing the expression of NEDD4L and deceasing GRP78 level via ubiquitination

  2022cites this paper
• TRIM27 cooperates with STK38L to inhibit ULK1‐mediated autophagy and promote tumorigenesis

  2022influential citation
• Molecular cloning, expression analysis and functional characterization of NEDD4 from Nile tilapia (Oreochromis niloticus).

  2022cites this paper
• Activation of Nedd4L Ubiquitin Ligase by FCHO2-generated Membrane Curvature

  2022cites this paper
• α-Arrestins and Their Functions: From Yeast to Human Health

  2022cites this paper
• E3 Ubiquitin Ligases: The Operators of the Ubiquitin Code That Regulates the RLR and cGAS-STING Pathways

  2022cites this paper
• The Role of NEDD4 E3 Ubiquitin–Protein Ligases in Parkinson’s Disease

  2022cites this paper
• Research progress of Nedd4L in cardiovascular diseases

  2022cites this paper
• The NEDD4 ubiquitin E3 ligase: a snapshot view of its functional activity and regulation.

  2022cites this paper
• An SS18::NEDD4 cutaneous spindled and epithelioid sarcoma: An hitherto unclassified cutaneous sarcoma, resembling epithelioid sarcoma with aggressive clinical behavior

  2022cites this paper
• Nedd4-2 binding to 14-3-3 modulates the accessibility of its catalytic site and WW domains.

  2022cites this paper
• Roles of E3 ubiquitin ligases in gastric cancer carcinogenesis and their effects on cisplatin resistance

  2021cites this paper
• Nedd4-2–dependent Ubiquitination Potentiates the Inhibition of Human NHE3 by Cholera Toxin and Enteropathogenic Escherichia coli

  2021cites this paper
• Adaptors as the regulators of HECT ubiquitin ligases

  2021cites this paper
• Insights Into the Biological Role of NEDD4L E3 Ubiquitin Ligase in Human Cancers

  2021cites this paper
• Signaling Pathways Regulated by UBR Box-Containing E3 Ligases

  2021cites this paper
• NEDD4-1 is a key regulator of epidermal homeostasis and wound repair.

  2021cites this paper
• Function and Regulation of the Epithelial Na+ Channel ENaC.

  2021cites this paper
• HECT E3 Ubiquitin Ligase Nedd4 Is Required for Antifungal Innate Immunity

  2021cites this paper
• Fungal–Metal Interactions: A Review of Toxicity and Homeostasis

  2021cites this paper
• The ubiquitin E3 ligase Nedd4‐2 relieves mechanical allodynia through the ubiquitination of TRPA1 channel in db/db mice

  2020cites this paper
• The endosomal trafficking regulator LITAF controls the cardiac Nav1.5 channel via the ubiquitin ligase NEDD4-2

  2020influential citation
• Characterization of small molecule induced changes in Parkinson’s-related trafficking via the Nedd4 ubiquitin signaling cascade

  2020cites this paper
• The Enigmatic Role of Serum & Glucocorticoid Inducible Kinase 1 in the Endometrium

  2020cites this paper
• The endosomal trafficking regulator LITAF controls the cardiac Nav1.5 channel via the ubiquitin ligase NEDD4-2.

  2020influential citation
• The N-terminal tail of the glycine transporter: role in transporter phosphorylation.

  2020cites this paper
• O2-Dependent Protein Internalization Underlies Astrocytic Sensing of Acute Hypoxia by Restricting Multimodal TRPA1 Channel Responses.

  2020cites this paper
• Identification of novel interacting partners of the NEDD4 ubiquitin ligase in mouse testis.

  2020cites this paper
• SARS-CoV-2 3CLpro whole human proteome cleavage prediction and enrichment/depletion analysis

  2020cites this paper
• Viruses go modular

  2020cites this paper
• Ubiquitination and E3 Ubiquitin Ligases in Rare Neurological Diseases with Comorbid Epilepsy.

  2020cites this paper
• IMP3 accelerates the progression of prostate cancer through inhibiting PTEN expression in a SMURF1-dependent way

  2020cites this paper
• The Proteasomal Deubiquitinating Enzyme PSMD14 Regulates Macroautophagy by Controlling Golgi-to-ER Retrograde Transport

  2020cites this paper
• Epithelial Sodium Channels (ENaC)

  2020cites this paper
• Auto-ubiquitination of NEDD4-1 Recruits USP13 to Facilitate Autophagy through Deubiquitinating VPS34.

  2020cites this paper
• Novel genetic variants in KIF16B and NEDD4L in the endosome‐related genes are associated with nonsmall cell lung cancer survival

  2020cites this paper
• E3 Ubiquitin ligase NEDD4 family‑regulatory network in cardiovascular disease

  2020cites this paper
• The Adaptor Protein Alix is Involved in the Interaction Between the Ubiquitin Ligase NEDD4-1 and its Targets, ABCG1 and ABCG4

  2019cites this paper
• Ubiquitination‑deubiquitination in the Hippo signaling pathway (Review).

  2019cites this paper
• MAL protein stabilizes luminal membrane PLCβ3 and negatively regulates ENaC in mouse cortical collecting duct cells.

  2019cites this paper
• NEDD4 Family of E3 Ubiquitin Ligases in Breast Cancer: Spotlight on SMURFs, WWPs and NEDD4.

  2019cites this paper
• Tracing Potential Covalent Inhibitors of an E3 Ubiquitin Ligase through Target-Focused Modelling

  2019cites this paper
• DMT1 and iron transport

  2019cites this paper
• HECT E3 Ubiquitin Ligase-Regulated Txnip Degradation Facilitates TLR2-Mediated Inflammation During Group A Streptococcal Infection

  2019cites this paper
• LITAF Regulates Cardiac L-type Calcium Channels by Modulating NEDD4-1 Ubiquitin Ligase.

  2019cites this paper
• Ubiquitylation Pathways In Insulin Signaling and Organismal Homeostasis

  2018cites this paper
• Exploring the Role of Human Endogenous Retroviral Gag in the Formation and Content of Extracellular Vesicles

  2018cites this paper
• Characterisation of LITAF, a protein associated with Charcot-Marie-Tooth disease type 1C

  2018cites this paper
• E3-ubiquitin ligase NEDD4 enhances bone formation by removing TGFβ1-induced pSMAD1 in immature osteoblast.

  2018cites this paper
• NEDD4‐induced degradative ubiquitination of phosphatidylinositol 4‐phosphate 5‐kinase α and its implication in breast cancer cell proliferation

  2018cites this paper
• The SGK3-triggered ubiquitin–proteasome degradation of podocalyxin (PC) and ezrin in podocytes was associated with the stability of the PC/ezrin complex

  2018cites this paper
• Physiological Functions of Nedd4-2: Lessons from Knockout Mouse Models.

  2018cites this paper
• Regulation of CNKSR2 protein stability by the HECT E3 ubiquitin ligase Smurf2, and its role in breast cancer progression

  2018cites this paper
• Herpesviruses possess conserved proteins for interaction with Nedd4 family ubiquitin E3 ligases

  2018cites this paper
• Downregulation of Nedd4L predicts poor prognosis, promotes tumor growth and inhibits MAPK/ERK signal pathway in hepatocellular carcinoma.

  2018cites this paper
• Loss of fragile X protein FMRP impairs homeostatic synaptic downscaling through tumor suppressor p53 and ubiquitin E3 ligase Nedd4-2

  2018cites this paper
• Pmepa1 induced by RANKL‐p38 MAPK pathway has a novel role in osteoclastogenesis

  2018cites this paper
• Wogonin Attenuates Isoprenaline-Induced Myocardial Hypertrophy in Mice by Suppressing the PI3K/Akt Pathway

  2018cites this paper
• Encoding human serine phosphopeptides in bacteria for proteome-wide identification of phosphorylation-dependent interactions

  2018cites this paper
• E3 ubiquitin ligases in cancer and implications for therapies

  2017cites this paper
• Thrombospondins: A Role in Cardiovascular Disease

  2017cites this paper
• Regulation of AMPA Receptor Trafficking by Protein Ubiquitination

  2017cites this paper
• Conditionally disordered proteins: bringing the environment back into the fold

  2017cites this paper
• Epilepsy-associated gene Nedd4-2 mediates neuronal activity and seizure susceptibility through AMPA receptors

  2017cites this paper
• The effects of curcumin on proliferation, apoptosis, invasion, and NEDD4 expression in pancreatic cancer

  2017cites this paper
• The E3 ubiquitin ligase Nedd4/Nedd4L is directly regulated by microRNA 1

  2017cites this paper
• Regulation of Kv1.4 potassium channels by PKC and AMPK kinases

  2017cites this paper
• Hormonally up‐regulated neu‐associated kinase: A novel target for breast cancer progression

  2017cites this paper