Homology modelling of integrin EF-hands. Evidence for widespread use of a conserved cation-binding site.

No abstract is available for this paper.

• Publication year

  1992

• Venue

  Biochemical Journal

• Publication date

  1992-07-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1042/BJ2850325PMID 1322124PMCID PMC1132784
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Receptor functions for the integrin VLA-3: fibronectin, collagen, and laminin binding are differentially influenced by Arg-Gly-Asp peptide and by divalent cations

  1991cited by this paper
• The minimal essential sequence for a major cell type-specific adhesion site (CS1) within the alternatively spliced type III connecting segment domain of fibronectin is leucine-aspartic acid-valine.

  1991cited by this paper
• Molecular dynamics simulations of small peptides: Dependence on dielectric model and pH

  1991cited by this paper
• Identification of a tetrapeptide recognition sequence for the alpha 2 beta 1 integrin in collagen.

  1991cited by this paper
• A discrete sequence in a platelet integrin is involved in ligand recognition

  1991cited by this paper
• Calcium as a potential physiological regulator of integrin-mediated cell adhesion.

  1991cited by this paper
• Labeling of integrin alpha v beta 3 with 58Co(III). Evidence of metal ion coordination sphere involvement in ligand binding.

  1991cited by this paper
• Adhesion receptors of the immune system

  1990cited by this paper
• Conformational sampling using high‐temperature molecular dynamics

  1990cited by this paper
• VLA proteins in the integrin family: structures, functions, and their role on leukocytes.

  1990cited by this paper
• The molecular basis and specificity of integrin-ligand interactions.

  1990cited by this paper
• The calcium binding sites in human annexin V by crystal structure analysis at 2.0 A resolution Implications for membrane binding and calcium channel activity

  1990cited by this paper
• Cell surface receptors for extracellular matrix components.

  1990cited by this paper
• Absorption and fluorescence spectroscopic studies of the Ca2(+)-dependent lipid binding protein p36: the annexin repeat as the Ca2+ binding site.

  1990cited by this paper
• Cation-dependent changes in the binding specificity of the platelet receptor GPIIb/IIIa.

  1990cited by this paper
• Collagen‐Binding proteins of mammary epithelial cells are related to Ca2+‐and phospholipid‐binding annexins

  1990cited by this paper
• Integrin (alpha v beta 3)-ligand interaction. Identification of a heterodimeric RGD binding site on the vitronectin receptor.

  1990cited by this paper
• The ligand binding site of the platelet integrin receptor GPIIb-IIIa is proximal to the second calcium binding domain of its alpha subunit.

  1990cited by this paper
• A beta 3 integrin mutation abolishes ligand binding and alters divalent cation-dependent conformation.

  1990cited by this paper
• Regulated expression of Mg2+ binding epitope on leukocyte integrin alpha subunits.

  1989cited by this paper
• Atrial natriuretic peptide vascular receptor: regulation of low-affinity binding by calcium.

  1989cited by this paper
• Human melanoma cell attachment involves an Arg-Gly-Asp-directed adhesion receptor and the disialoganglioside GD2.

  1989cited by this paper
• The primary structure of the alpha 4 subunit of VLA‐4: homology to other integrins and a possible cell‐cell adhesion function.

  1989cited by this paper
• Crystal structures of the helix-loop-helix calcium-binding proteins.

  1989cited by this paper
• Functional domains of the Escherichia coli dnaK heat shock protein as revealed by mutational analysis.

  1989cited by this paper
• A member of the Hsp70 family is localized in mitochondria and resembles Escherichia coli DnaK.

  1989cited by this paper
• Atrial natriuretic peptide clearance receptor. Complete sequence and functional expression of cDNA clones.

  1988cited by this paper
• Localization of an Arg-Gly-Asp recognition site within an integrin adhesion receptor.

  1988cited by this paper
• A protein sequence/structure database. Protein Engineering Club Database Group.

  1988cited by this paper
• Five distinct calcium and phospholipid binding proteins share homology with lipocortin I.

  1988cited by this paper
• Diversity in the lipocortin/calpactin family.

  1988cited by this paper
• Cytoadhesins, Integrins, and Platelets

  1988cited by this paper
• Structure of calmodulin refined at 2.2 A resolution.

  1988cited by this paper
• Induction of fibroblast spreading by Mn2+: a possible role for unusual binding sites for divalent cations in receptors for proteins containing Arg-Gly-Asp.

  1988cited by this paper
• Regulation of the fibronectin receptor affinity by divalent cations.

  1988cited by this paper
• Integrins: a family of cell surface receptors.

  1987cited by this paper
• A novel calcium binding site in the galactose-binding protein of bacterial transport and chemotaxis

  1987cited by this paper
• New perspectives in cell adhesion: RGD and integrins.

  1987cited by this paper
• cDNA cloning and complete primary structure of the alpha subunit of a leukocyte adhesion glycoprotein, p150,95.

  1987cited by this paper
• Specific binding of atrial natriuretic peptide to rat mesenteric artery: effect of calcium and 5-guanylylimidodiphosphate.

  1987cited by this paper
• Common domain structure of Ca2+ and lipid‐binding proteins

  1986cited by this paper
• An analysis of incorrectly folded protein models. Implications for structure predictions.

  1984cited by this paper
• Major heat shock gene of Drosophila and the Escherichia coli heat-inducible dnaK gene are homologous.

  1984cited by this paper
• Role of anchorin CII, a 31,000-mol-wt membrane protein, in the interaction of chondrocytes with type II collagen

  1984cited by this paper
• Platelet receptor recognition site on human fibrinogen. Synthesis and structure-function relationship of peptides corresponding to the carboxy-terminal segment of the gamma chain.

  1984cited by this paper
• Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule

  1984cited by this paper
• Comparative model-building of the mammalian serine proteases.

  1981cited by this paper

• Molecular Modeling Insights into the Structure and Behavior of Integrins: A Review

  2023cites this paper
• A Rice Ca 2 + Binding Protein Is Required for Tapetum Function and Pollen Formation 1 [ OPEN ]

  2016cites this paper
• A Rice Ca2+ Binding Protein Is Required for Tapetum Function and Pollen Formation1[OPEN]

  2016cites this paper
• Cell adhesion monitoring of human induced pluripotent stem cell based on intrinsic molecular charges

  2014cites this paper
• Integrin-α FG-GAP Repeat-Containing Protein 2 Is Critical for Normal B Cell Differentiation and Controls Disease Development in a Lupus Model

  2013cites this paper
• Cartilage Acidic Protein 2 a hyperthermostable, high affinity calcium-binding protein.

  2013cites this paper
• This information is current as Development in a Lupus Model Differentiation and Controls Disease Protein 2 Is Critical for Normal B Cell FG-GAP Repeat-Containing α Integrin-Anderson and Tamas Oravecz

  2013cites this paper
• 2012 Landes Bioscience. Do not distribute. The regulation of integrin function by divalent cations

  2012cites this paper
• Divalent cations regulate the folding and activation status of integrins during their intracellular trafficking

  2011cites this paper
• CRTAC1 homolog proteins are conserved from cyanobacteria to man and secreted by the teleost fish pituitary gland.

  2010cites this paper
• Solution structure of a biologically active cyclic LDV peptide analogue containing a type II' beta-turn mimetic.

  2009cites this paper
• The plasminogen activation system in inflammation.

  2008cites this paper
• Unexpected diversity of cnidarian integrins: expression during coral gastrulation

  2008cites this paper
• Anatomy of the Lymphocyte function-associated antigen-1

  2006cites this paper
• Integrins in Ocular Angiogenesis

  2006cites this paper
• Platelet Integrins and Signaling

  2005cites this paper
• Calcium-Binding Proteins 257

  2005cites this paper
• Calcium Binding by the Essential Virulence Factor BAD-1 of Blastomyces dermatitidis*

  2005cites this paper
• Mutations in and near the second calcium-binding domain of integrin αIIb affect the structure and function of integrin αIIbβ3

  2004cites this paper
• Mutations in and near the second calcium-binding domain of integrin alphaIIb affect the structure and function of integrin alphaIIbbeta3.

  2004cites this paper
• The role of cellular constituents and their interactions with the extracellular matrix through integrins in peritoneal healing and adhesion formation

  2003cites this paper
• Two novel mutations in the alpha IIb calcium-binding domains identify hydrophobic regions essential for alpha IIbbeta 3 biogenesis.

  2003cites this paper
• A C‐terminal EGF‐like domain governs BAD1 localization to the yeast surface and fungal adherence to phagocytes, but is dispensable in immune modulation and pathogenicity of Blastomyces dermatitidis

  2003cites this paper
• Two novel mutations in the αIIb calcium-binding domains identify hydrophobic regions essential for αIIbβ3 biogenesis

  2003cites this paper
• Predicted and experimental structures of integrins and beta-propellers.

  2002cites this paper
• Mutation of Putative Divalent Cation Sites in the Subunit of the Integrin VLA-4 : Distinct Effects on Adhesion to CS 1 / Fibronectin , VCAM-1 , and

  2002influential citation
• Predicted and experimental structures of integrins and β-propellers

  2002cites this paper
• Effect of Divalent Cations on the Affinity and Selectivity of α4 Integrins Towards the Integrin Ligands Vascular Cell Adhesion Molecule-1 and Mucosal Addressin Cell Adhesion Molecule-1: Ca 2+ Activation of Integrin α4β1 Confers a Distinct Ligand Specificity

  2002cites this paper
• Calcium sensors as new therapeutic targets for asthma and chronic obstructive pulmonary disease

  2002cites this paper
• The molecular basis of integrin-extracellular matrix interactions.

  2001cites this paper
• Integrin VLA‐5: modulator and activator of mast cells

  2001cites this paper
• Structure-function studies of integrin-ligand recognition

  2001influential citation
• Platelet integrin alphaIIbbeta3-ligand interactions: what can we learn from the structure?

  2001cites this paper
• Critical amino acid residues of the α4 subunit for α4β7 integrin function

  2001cites this paper
• Attenuation of Very Late Antigen-5-Mediated Adhesion of Bone Marrow-Derived Mast Cells to Fibronectin by Peptides with Inverted Hydropathy to EF-Hands1

  2001cites this paper
• Platelet Integrin αIIbβ3-Ligand Interactions: What Can We Learn From the Structure?

  2001cites this paper
• Dissertation zur Erlangung des Doktorgrades der Fakultät für Chemie und Pharmazie der Ludwig-Maximilians-Universität München Charakterisierung der funktionalen Rolle von Cytohesin-1 in der LFA-1-vermittelten T-Zell-Adhäsion

  2001cites this paper
• Critical amino acid residues of the alpha4 subunit for alpha4beta7 integrin function.

  2001cites this paper
• INTEGRIN AND TALIN IN THE JELLYFISH PODOCORYNE CARNEA

  2001cites this paper
• Integrin Activation

  2001cites this paper
• The Role of Integrin-Mediated Processes in the Biology of Metastasis

  2000cites this paper
• Overexpression, Purification, and Characterization of Bacillus subtilis N-Acetylmuramoyl-L-alanine Amidase CwlC

  2000cites this paper
• A Minimized Human Integrin α5β1 That Retains Ligand Recognition*

  2000cites this paper
• Molecular Basis of Ligand Recognition by Integrin α5β1

  2000cites this paper
• Structure and Function of GPI-Specific Phospholipases

  2000cites this paper
• Molecular basis of ligand recognition by integrin alpha 5beta 1. I. Specificity of ligand binding is determined by amino acid sequences in the second and third NH2-terminal repeats of the alpha subunit.

  2000cites this paper
• The role of αv integrins in regulating keratinocyte behaviour.

  2000influential citation
• Regulation of keratinocyte integrins by scatter factor.

  2000cites this paper
• A minimized human integrin alpha(5)beta(1) that retains ligand recognition.

  2000cites this paper
• Expression and Function of Calcium Binding Domain Chimeras of the Integrins αIIb and α5 *

  2000cites this paper
• Intracellular signaling pathways regulating integrin-mediated keratinocyte spreading and lamellipodia formation

  2000cites this paper
• The Role of Integrins in Peritoneal Healing

  2000cites this paper
• Integrin structure.

  2000cites this paper
• Sequence analysis or rat integrin alphaE1 and alphaE2 subunits: tissue expression reveals phenotypic similarities between intraepithelial lymphocytes and dendritic cells in lymph.

  2000cites this paper
• Ligand Binding to Integrins*

  2000cites this paper
• Expression and function of calcium binding domain chimeras of the integrins alpha(IIb) and alpha(5).

  2000cites this paper
• Hydropathy to EF-Hands Cells to Fibronectin by Peptides with Inverted Adhesion of Bone Marrow-Derived Mast Attenuation of Very Late Antigen-5-Mediated

  2000cites this paper
• A novel Ca2+ binding beta hairpin loop better resembles integrin sequence motifs than the EF hand.

  2000cites this paper
• The αBβC Integrin Is Expressed on the Surface of the Sea Urchin Egg and Removed at Fertilization

  2000cites this paper
• Biophysical and molecular properties of annexin-formed channels.

  2000cites this paper
• The alphaBbetaC integrin is expressed on the surface of the sea urchin egg and removed at fertilization.

  2000cites this paper
• Molecular Basis of Ligand Recognition by Integrin α5β1

  2000cites this paper
• Molecular basis of ligand recognition by integrin alpha5beta 1. II. Specificity of arg-gly-Asp binding is determined by Trp157 OF THE alpha subunit.

  2000cites this paper
• The Molecular Anatomy of Integrins

  1999cites this paper
• Inhibition of the plasma glycosylphosphatidylinositol-specific phospholipase D by synthetic analogs of lipid A and phosphatidic acid.

  1999cites this paper
• A cell-free system to study regulation of focal adhesions and of the connected actin cytoskeleton.

  1999cites this paper
• TNF Locus in the Human MHC Predicted Products of Novel Genes Close to V-ATPase G Subunit Are Among the A New Member of the Ig Superfamily and a

  1999cites this paper
• Increased expression of integrin and receptor tyrosine kinase genes during autograft fusion in the sponge Geodia cydonium.

  1999cites this paper
• Integrin-like proteins in Candida spp. and other microorganisms.

  1999cites this paper
• Fine mapping of inhibitory anti-alpha5 monoclonal antibody epitopes that differentially affect integrin-ligand binding.

  1999cites this paper
• Covalent immobilization of recombinant human alphavbeta3 integrin on a solid support with retention of functionality.

  1999cites this paper
• Studies of the role of the integrin EF-hand, Ca2+-binding sites in glycosylphosphatidylinositol-specific phospholipase D: reduced expression following mutagenesis of residues predicted to bind Ca2+.

  1999cites this paper
• How LFA-1 binds to different ligands.

  1999cites this paper
• A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC.

  1999cites this paper
• A New Member of the Ig Superfamily and a V-ATPase G Subunit Are Among the Predicted Products of Novel Genes Close to the TNF Locus in the Human MHC

  1999cites this paper
• Covalent Immobilization of Recombinant Human αvβ3Integrin on a Solid Support with Retention of Functionality

  1999cites this paper
• The Molecular Pathology of Glanzmann’s Thrombasthenia

  1999cites this paper
• Differential Effects of Integrin α Chain Mutations on Invasin and Natural Ligand Interaction*

  1998cites this paper
• Integrin-mediated signal transduction

  1998cites this paper
• The Cation-binding Domain from the α Subunit of Integrin α5β1 Is a Minimal Domain for Fibronectin Recognition*

  1998cites this paper
• Expression of the H52 epitope on the β2 subunit is dependent on its interaction with the α subunits of the leukocyte integrins LFA‐1, Mac‐1 and p150,95 and the presence of Ca2+

  1998cites this paper
• The molecular genetics of Glanzmann's thrombasthenia.

  1998cites this paper
• Isolation, Cloning, and Sequence Analysis of the Integrin Subunit α10, a β1-associated Collagen Binding Integrin Expressed on Chondrocytes*

  1998cites this paper
• Experimental support for a beta-propeller domain in integrin alpha-subunits and a calcium binding site on its lower surface.

  1998cites this paper
• The Fibrinogen-binding MSCRAMM (Clumping Factor) ofStaphylococcus aureus Has a Ca2+-dependent Inhibitory Site*

  1998cites this paper
• Identification of Amino Acid Residues That Form Part of the Ligand-binding Pocket of Integrin α5β1 *

  1998cites this paper
• The cation-binding domain from the alpha subunit of integrin alpha5 beta1 is a minimal domain for fibronectin recognition.

  1998cites this paper
• Identification of amino acid residues that form part of the ligand-binding pocket of integrin alpha5 beta1.

  1998cites this paper
• Asp-698 and Asp-811 of the Integrin α4-Subunit Are Critical for the Formation of a Functional Heterodimer*

  1998cites this paper
• Regulation of integrin function: evidence that bivalent-cation-induced conformational changes lead to the unmasking of ligand-binding sites within integrin alpha5 beta1.

  1998cites this paper
• Molecular View of the Integrin Cell Adhesion Receptors

  1998cites this paper
• Identification and characterization of functional cation coordination sites in platelet endothelial cell adhesion molecule-1.

  1997cites this paper
• Integrins—A Versatile and Old Family of Cell Adhesion Molecules

  1997cites this paper
• Stereoisomere Peptid-Bibliotheken und Peptidmimetika zum Design von selektiven Inhibitoren des αv β3-Integrins für eine neuartige Krebstherapie

  1997cites this paper
• The Platelet Integrin, GP IIb-IIIa (αIIbß3)

  1997cites this paper
• Sequence analysis of rat integrin alpha E1 and alpha E2 subunits: tissue expression reveals phenotypic similarities between intraepithelial lymphocytes and dendritic cells in lymph.

  1997cites this paper
• Signalling and adhesive properties of the integrin leucocyte function-associated antigen 1 (LFA-1).

  1997cites this paper
• Folding of the beta-propeller domain of the integrin alphaL subunit is independent of the I domain and dependent on the beta2 subunit.

  1997cites this paper
• Folding of the N-terminal, ligand-binding region of integrin α-subunits into a β-propeller domain

  1997cites this paper
• Structural analysis of natriuretic peptide receptor-C by truncation and site-directed mutagenesis.

  1997cites this paper