Autocrine IL-6-induced Stat3 activation contributes to the pathogenesis of lung adenocarcinoma and malignant pleural effusion

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Oncogene

• Publication date

  2006-07-20

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/sj.onc.1209464PMID 16518408
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Lung Cancer

  2015cited by this paper
• STAT proteins as novel targets for cancer drug discovery

  2004cited by this paper
• The STATs of cancer — new molecular targets come of age

  2004cited by this paper
• Activation of Stat3 by receptor tyrosine kinases and cytokines regulates survival in human non-small cell carcinoma cells

  2003influential reference
• Interleukin-6 promotes cervical tumor growth by VEGF-dependent angiogenesis via a STAT3 pathway

  2003cited by this paper
• Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis

  2002cited by this paper
• Signalling: STATs: transcriptional control and biological impact

  2002influential reference
• Target Gene Specificity of E2F and Pocket Protein Family Members in Living Cells

  2000cited by this paper
• Production of experimental malignant pleural effusions is dependent on invasion of the pleura and expression of vascular endothelial growth factor/vascular permeability factor by human lung cancer cells.

  2000influential reference
• Effect of IL-6 elevation in malignant pleural effusion on hyperfibrinogenemia in lung cancer patients.

  2000cited by this paper
• Treatment for malignant pleural effusion of human lung adenocarcinoma by inhibition of vascular endothelial growth factor receptor tyrosine kinase phosphorylation.

  2000cited by this paper
• ErbB‐2 kinase is required for constitutive stat 3 activation in malignant human lung epithelial cells

  1999cited by this paper
• Stat3 as an oncogene.

  1999cited by this paper
• Proinflammatory Cytokine Levels in Patients with Lung Cancer and Carcinomatous Pleurisy

  1998cited by this paper
• Proliferation of human non-small-cell lung cancer cell lines: role of interleukin-6.

  1998cited by this paper
• Role of vascular endothelial growth factor in ovarian cancer: inhibition of ascites formation by immunoneutralization.

  1998cited by this paper
• Prognostic value of pleural effusion in patients with non-small cell lung cancer.

  1997cited by this paper
• A central role for Stat3 in IL‐6‐induced regulation of growth and differentiation in M1 leukemia cells.

  1996cited by this paper
• Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

  1996cited by this paper
• Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

  1996cited by this paper
• Interleukin 6 receptor mRNA in prostate carcinomas and benign prostate hyperplasia.

  1994cited by this paper
• Regulation of ICAM‐1 (CD54) expression in human breast cancer cell lines by interleukin 6 and fibroblast‐derived factors

  1994cited by this paper
• Interleukin-6 and its receptor: a paradigm for cytokines.

  1992cited by this paper
• Interleukin 6 activity in pleural effusion. Its diagnostic value and thrombopoietic activity.

  1992cited by this paper
• Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid.

  1983cited by this paper
• Malignant effusions: diagnostic evaluation and therapeutic strategy.

  1981cited by this paper
• The treatment of malignant pleural effusions

  1974cited by this paper

• Pathobiology and clinical significance of malignant pleural effusions

  2026cites this paper
• Ursolic Acid from Carissa carandas L. as a Multi-Target Agent Against NSCLC: An Integrative In Silico and In Vitro Study.

  2025cites this paper
• Multi-omics reveals FAT10 as an immunometabolic survival factor rewiring global metabolism in cancer

  2025cites this paper
• STK31 drives tumor immune evasion through STAT3-IL-6 mediated CD8+ T cell exhaustion

  2025cites this paper
• A novel agent, p-toluenesulfonamide, in the management of malignant pleural effusions.

  2025cites this paper
• Biomaterial-based drug delivery systems for the therapy of malignant pleural effusion

  2025cites this paper
• Autocrine Regulation of Interleukin-6 via the Activation of STAT3 and Akt in Cardiac Myxoma Cells

  2024cites this paper
• Defective N-glycosylation of IL6 induces metastasis and tyrosine kinase inhibitor resistance in lung cancer

  2024cites this paper
• Equivocating and Deliberating on the Probability of COVID-19 Infection Serving as a Risk Factor for Lung Cancer and Common Molecular Pathways Serving as a Link

  2024cites this paper
• Malignant pleural effusion: current understanding and therapeutic approach

  2024cites this paper
• B cell receptor-induced IL-10 production from neonatal mouse CD19+CD43- cells depends on STAT5-mediated IL-6 secretion

  2023cites this paper
• Dual gene‐activated dermal scaffolds regulate angiogenesis and wound healing by mediating the coexpression of VEGF and angiopoietin‐1

  2023cites this paper
• A Novel Aldisine Derivative Exhibits Potential Antitumor Effects by Targeting JAK/STAT3 Signaling

  2023cites this paper
• Abnormal expression of CEBPB promotes the progression of renal cell carcinoma through regulating the generation of IL-6

  2023cites this paper
• MicroRNAs Present in Malignant Pleural Fluid Increase the Migration of Normal Mesothelial Cells In Vitro and May Help Discriminate between Benign and Malignant Effusions

  2023cites this paper
• The effect of immunonutrition support on the prognostic nutritional index in the postoperative period in brain tumors

  2023cites this paper
• Lung cancer treatment potential and limits associated with the STAT family of transcription factors.

  2023cites this paper
• mRNA expression levels of CCL4, IL6, and CXCL2 in multiwalled carbon nanotube induced lung tumors in rats

  2023cites this paper
• COVID-19 and cancer: insights into their association and influence on genetic and epigenetic landscape

  2023cites this paper
• The role of IL-6/JAK2/STAT3 signaling pathway in cancers

  2022cites this paper
• Epithelial Stem Cells: Making, Shaping and Breaking the Niche.

  2022cites this paper
• Systematic analysis of IL-6 as a predictive biomarker and desensitizer of immunotherapy responses in patients with non-small cell lung cancer

  2022cites this paper
• Th17 cells and their related cytokines: vital players in progression of malignant pleural effusion

  2022cites this paper
• EGFR-Mutated Non-Small Cell Lung Cancer and Resistance to Immunotherapy: Role of the Tumor Microenvironment

  2022cites this paper
• Inside the stemness engine: Mechanistic links between deregulated transcription factors and stemness in cancer.

  2022cites this paper
• B cell receptor induced IL-10 production from neonatal CD19+CD43- cells depends on STAT5 mediated IL-6 secretion

  2022cites this paper
• SARS-CoV-2 and cancer: the intriguing and informative cross-talk

  2022cites this paper
• The role of angiogenesis in malignant pleural effusion: from basic research to clinical application.

  2022cites this paper
• Research progress on the therapeutic effect and mechanism of metformin for lung cancer

  2022cites this paper
• Acacetin Inhibits Cell Proliferation and Induces Apoptosis in Human Hepatocellular Carcinoma Cell Lines

  2022cites this paper
• BMP2 promotes lung adenocarcinoma metastasis through BMP receptor 2-mediated SMAD1/5 activation

  2022cites this paper
• Serum  JAK/STAT profile is related to the IL expression but not with the outcome in pancreatic adenocarcinoma patients.

  2021cites this paper
• Vascular Changes and Hypoxia in Periodontal Disease as a Link to Systemic Complications

  2021cites this paper
• Multicellular Effects of STAT3 in Non-small Cell Lung Cancer: Mechanistic Insights and Therapeutic Opportunities

  2021cites this paper
• HIF1A-AS2 induces osimertinib resistance in lung adenocarcinoma patients by regulating the miR-146b-5p/IL-6/STAT3 axis

  2021cites this paper
• COVID-19 and Malignancy: Exploration of the possible genetic and epigenetic interlinks and overview of the vaccination scenario

  2021cites this paper
• Suppressing STAT3 activity protects the endothelial barrier from VEGF-mediated vascular permeability

  2021cites this paper
• IL‐26 promotes the pathogenesis of malignant pleural effusion by enhancing CD4+IL‐22+ T‐cell differentiation and inhibiting CD8+ T‐cell cytotoxicity

  2021cites this paper
• Research progress on the molecular mechanisms of hepatic metastasis in lung cancer: a narrative review.

  2021cites this paper
• Malignant Pleural Effusions—A Window Into Local Anti-Tumor T Cell Immunity?

  2021cites this paper
• Study protocol of a phase 1 clinical trial establishing the safety of intrapleural administration of liposomal curcumin: curcumin as a palliative treatment for malignant pleural effusion (IPAL-MPE)

  2021cites this paper
• IL-6 family cytokines in respiratory health and disease.

  2021cites this paper
• The intersection of COVID-19 and cancer: signaling pathways and treatment implications

  2021cites this paper
• Local biomaterial-assisted antitumour immunotherapy for effusions in the pleural and peritoneal cavities caused by malignancies.

  2021cites this paper
• Suppressing STAT3 activity protects the endothelial barrier from VEGF-mediated vascular permeability

  2020cites this paper
• Role of IL-6 and STAT3 signaling in dihydropyridine-induced gingival overgrowth fibroblasts.

  2020cites this paper
• Cardiomyopathies and Arrhythmias Induced by Cancer Therapies

  2020cites this paper
• Targeting interleukin 6 signaling by monoclonal antibody siltuximab on cholangiocarcinoma

  2020cites this paper
• Mechanistic insights of adipocyte metabolism in regulating breast cancer progression.

  2020cites this paper
• Etiopathogenesis of malignant pleural effusion

  2020cites this paper
• Multiplexed molecular profiling of lung cancer with malignant pleural effusion using next generation sequencing in Chinese patients

  2020cites this paper
• The Safety and Exploration of the Pharmacokinetics of Intrapleural Liposomal Curcumin

  2020cites this paper
• Shikonin blocks human lung adenocarcinoma cell migration and invasion in the inflammatory microenvironment via the IL-6/STAT3 signaling pathway

  2020cites this paper
• DDIAS promotes STAT3 activation by preventing STAT3 recruitment to PTPRM in lung cancer cells

  2020cites this paper
• Cytotoxicity, in silico predictions and molecular studies for androstane heterocycle compounds revealed potential antitumor agent against lung cancer cells

  2020cites this paper
• Cytokine Storms in Cancer and COVID-19

  2020cites this paper
• IL-6 in inflammation, autoimmunity and cancer

  2020cites this paper
• Identification of novel factors involved in the exacerbation of HIV-1 infection and spread among macrophages in the tuberculosis context

  2019cites this paper
• Expression profile and prognostic values of STAT family members in non-small cell lung cancer.

  2019cites this paper
• Iron and Lung Cancer.

  2019cites this paper
• The subpopulation of CD44-positive cells promoted tumorigenicity and metastatic ability in lung adenocarcinoma

  2019cites this paper
• Inhibition of Tyrosine-Phosphorylated STAT3 in Human Breast and Lung Cancer Cells by Manuka Honey is Mediated by Selective Antagonism of the IL-6 Receptor

  2019cites this paper
• Metformin reverses mesenchymal phenotype of primary breast cancer cells through STAT3/NF-κB pathways

  2019cites this paper
• Iron-dependent CDK1 activity promotes lung carcinogenesis via activation of the GP130/STAT3 signaling pathway

  2019cites this paper
• C-reactive protein (CRP) promotes malignant properties in pancreatic neuroendocrine neoplasms

  2019cites this paper
• Alterations in IL-6/STAT3 Signaling by Korean Mistletoe Lectin Regulate the Self-Renewal Activity of Placenta-Derived Mesenchymal Stem Cells

  2019cites this paper
• Zelnorm, an agonist of 5-Hydroxytryptamine 4-receptor, acts as a potential antitumor drug by targeting JAK/STAT3 signaling

  2019cites this paper
• Therapeutic Implication of SOCS1 Modulation in the Treatment of Autoimmunity and Cancer

  2019cites this paper
• 2-Hydroxy-3-methylanthraquinone inhibits lung carcinoma cells through modulation of IL-6-induced JAK2/STAT3 pathway.

  2019cites this paper
• Major vault protein suppresses lung cancer cell proliferation by inhibiting STAT3 signaling pathway

  2019cites this paper
• ARHGAP15 regulates lung cancer cell proliferation and metastasis via the STAT3 pathway.

  2019cites this paper
• Mast cells and its crosstalk with mesenchymal cells in chronic lung diseases

  2019cites this paper
• Reactive Oxygen Species and Oncoprotein Signaling-A Dangerous Liaison

  2018cites this paper
• Targeting STAT3 and oxidative phosphorylation in oncogene-addicted tumors

  2018cites this paper
• Identifying genes as potential prognostic indicators in patients with serous ovarian cancer resistant to carboplatin using integrated bioinformatics analysis

  2018cites this paper
• The role of the interleukin (IL)-6/IL-6 receptor axis in cancer.

  2018cites this paper
• Ophiopogonin Binduceshepatocellular carcinoma MHCC 97-H cell apoptosis and decreases invasion through inhibition of the JAK 2 / STAT 3 signaling pathway

  2018cites this paper
• 17β-estradiol upregulates IL6 expression through the ERβ pathway to promote lung adenocarcinoma progression

  2018cites this paper
• MicroRNA-425 promotes the development of lung adenocarcinoma via targeting A disintegrin and metalloproteinases 9 (ADAM9)

  2018cites this paper
• Pleural Effusions in Lung Cancer: Detection and Treatment

  2018cites this paper
• Combinations of Genomically and Immune-Targeted Therapies in Early-Phase Clinical Trials

  2018cites this paper
• Anti-metastatic effect of metformin via repression of interleukin 6-induced epithelial–mesenchymal transition in human colon cancer cells

  2018cites this paper
• Preclinical Evidence for Combined Use of Aromatase Inhibitors and NSAIDs as Preventive Agents of Tobacco‐Induced Lung Cancer

  2017cites this paper
• Novel Synthetic bisindolylmaleimide alkaloids inhibit STAT3 activation by binding to the SH2 domain and suppress breast xenograft tumor growth

  2017cites this paper
• Malignant pleural fluid from mesothelioma has potent biological activities

  2017cites this paper
• Optimising the use of indwelling pleural catheter in the management of malignant pleural effusion

  2017cites this paper
• The Mevalonate Pathway and Innate Immune Hyper-Responsiveness in the Pathogenesis of COPD and Lung Cancer: Potential for Chemoprevention.

  2017cites this paper
• Adenocarcinoma of the lung: an exploration of the relationships between histopathology, molecular pathology and inflammatory markers and their relationship to patient outcomes

  2017influential citation
• The role of Lutheran/basal cell adhesion molecule in human bladder carcinogenesis

  2017influential citation
• MiR-26a functions as a tumor suppressor in ambient particulate matter-bound metal-triggered lung cancer cell metastasis by targeting LIN28B–IL6–STAT3 axis

  2017cites this paper
• EGFR and KRAS mutations do not enrich for the activation of IL-6, JAK1 or phosphorylated STAT3 in resected lung adenocarcinoma

  2017cites this paper
• Cancer-Associated Fibroblasts Share Characteristics and Protumorigenic Activity with Mesenchymal Stromal Cells.

  2017cites this paper
• RIP4 inhibits STAT3 signaling to sustain lung adenocarcinoma differentiation

  2017cites this paper
• Clinical implications of the novel cytokine IL-38 expressed in lung adenocarcinoma: Possible association with PD-L1 expression

  2017cites this paper
• Longitudinal Measurement of Pleural Fluid Biochemistry and Cytokines in Malignant Pleural Effusions.

  2016cites this paper
• Proteomic-Based Approaches for the Study of Cytokines in Lung Cancer

  2016cites this paper
• Malignant pleural effusion: from bench to bedside

  2016cites this paper
• Translational Research in Pleural Infection and Beyond.

  2016cites this paper
• Tocilizumab inhibits neuronal cell apoptosis and activates STAT3 in cerebral infarction rat model

  2016cites this paper
• Inflammatory cytokines and non-small cell lung cancer in a CT-scan screening cohort: Background review of the literature

  2016cites this paper