SMG-2 Is a Phosphorylated Protein Required for mRNA Surveillance in Caenorhabditis elegans and Related to Upf1p of Yeast

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Molecular and Cellular Biology

• Publication date

  1999-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/MCB.19.9.5943PMID 10454541PMCID PMC84455
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Inhibition of protein phosphatases by microcystis and nodularin associated with hepatotoxicity

  2005cited by this paper
• A perfect message: RNA surveillance and nonsense-mediated decay.

  1999cited by this paper
• smg-7 is required for mRNA surveillance in Caenorhabditis elegans.

  1999cited by this paper
• The surveillance complex interacts with the translation release factors to enhance termination and degrade aberrant mRNAs.

  1998cited by this paper
• Intron function in the nonsense-mediated decay of beta-globin mRNA: indications that pre-mRNA splicing in the nucleus can influence mRNA translation in the cytoplasm.

  1998cited by this paper
• Nonsense surveillance in lymphocytes?

  1998cited by this paper
• Identifying the right stop: determining how the surveillance complex recognizes and degrades an aberrant mRNA

  1998cited by this paper
• The 3′ to 5′ degradation of yeast mRNAs is a general mechanism for mRNA turnover that requires the SKI2 DEVH box protein and 3′ to 5′ exonucleases of the exosome complex

  1998cited by this paper
• A mutated human homologue to yeast Upf1 protein has a dominant-negative effect on the decay of nonsense-containing mRNAs in mammalian cells.

  1998cited by this paper
• Binary specification of nonsense codons by splicing and cytoplasmic translation

  1998cited by this paper
• At Least One Intron Is Required for the Nonsense-Mediated Decay of Triosephosphate Isomerase mRNA: a Possible Link between Nuclear Splicing and Cytoplasmic Translation

  1998cited by this paper
• Upf1p, Nmd2p, and Upf3p are interacting components of the yeast nonsense-mediated mRNA decay pathway

  1997cited by this paper
• Phosphorylation of Sic1p by G1 Cdk required for its degradation and entry into S phase.

  1997cited by this paper
• Mapping of Amino Acid Residues in the p34 Subunit of Human Single-stranded DNA-binding Protein Phosphorylated by DNA-dependent Protein Kinase and Cdc2 Kinase in Vitro *

  1997cited by this paper
• Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation

  1997cited by this paper
• Translational controls impinging on the 5'-untranslated region and initiation factor proteins.

  1997cited by this paper
• Interaction between ATM protein and c-Abl in response to DNA damage

  1997cited by this paper
• smg mutants affect the expression of alternatively spliced SR protein mRNAs in Caenorhabditis elegans.

  1997cited by this paper
• Cloning and characterization of HUPF1, a human homolog of the Saccharomyces cerevisiae nonsense mRNA-reducing UPF1 protein.

  1997cited by this paper
• Relationship between Yeast Polyribosomes and Upf Proteins Required for Nonsense mRNA Decay*

  1997cited by this paper
• Polysome-associated mRNAs are substrates for the nonsense-mediated mRNA decay pathway in Saccharomyces cerevisiae.

  1997cited by this paper
• Sequence-specific DNA Binding and Transcription Factor Phosphorylation by Ku Autoantigen/DNA-dependent Protein Kinase

  1997cited by this paper
• An essential component of the decapping enzyme required for normal rates of mRNA turnover

  1996cited by this paper
• Genetic and biochemical characterization of mutations in the ATPase and helicase regions of the Upf1 protein

  1996cited by this paper
• A splicing‐dependent regulatory mechanism that detects translation signals.

  1996cited by this paper
• Mechanisms and control of mRNA turnover in Saccharomyces cerevisiae.

  1996cited by this paper
• Interrelationships of the pathways of mRNA decay and translation in eukaryotic cells.

  1996cited by this paper
• Making sense of nonsense in yeast.

  1996cited by this paper
• THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

  1996cited by this paper
• The NF-kappa B and I kappa B proteins: new discoveries and insights.

  1996cited by this paper
• Mammalian orthologues of a yeast regulator of nonsense transcript stability.

  1996cited by this paper
• Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress.

  1996cited by this paper
• Mechanisms and control of mRNA turnover in Saccharomyces cerevisiae

  1996cited by this paper
• The tra‐3 sex determination gene of Caenorhabditis elegans encodes a member of the calpain regulatory protease family.

  1996cited by this paper
• The heterochronic gene lin-29 encodes a zinc finger protein that controls a terminal differentiation event in Caenorhabditis elegans.

  1995cited by this paper
• The genome of Caenorhabditis elegans.

  1995cited by this paper
• AU-rich elements: characterization and importance in mRNA degradation.

  1995cited by this paper
• Purification and characterization of the Upf1 protein: a factor involved in translation and mRNA degradation.

  1995cited by this paper
• Identification of an additional gene required for eukaryotic nonsense mRNA turnover.

  1995cited by this paper
• Turnover mechanisms of the stable yeast PGK1 mRNA

  1995cited by this paper
• Characterization of cis-acting sequences and decay intermediates involved in nonsense-mediated mRNA turnover

  1995cited by this paper
• When cells stop making sense: effects of nonsense codons on RNA metabolism in vertebrate cells.

  1995cited by this paper
• Identification of a novel component of the nonsense-mediated mRNA decay pathway by use of an interacting protein screen.

  1995cited by this paper
• Human DNA helicase IV is nucleolin, an RNA helicase modulated by phosphorylation.

  1995cited by this paper
• Identification and characterization of genes that are required for the accelerated degradation of mRNAs containing a premature translational termination codon.

  1995cited by this paper
• mRNA stability in mammalian cells.

  1995cited by this paper
• Chapter 16 Immunofluorescence Microscopy

  1995cited by this paper
• Caenorhabditis elegans : modern biological analysis of an organism

  1995cited by this paper
• Chapter 2 Mutagenesis

  1995cited by this paper
• Chapter 19 DNA Transformation

  1995cited by this paper
• Immunofluorescence microscopy.

  1995cited by this paper
• Mutagenesis.

  1995cited by this paper
• Alphavirus expression systems.

  1994cited by this paper
• Primary structural constraints of P-loop of mitochondrial F1-ATPase from yeast.

  1994cited by this paper
• Regulation of p68 RNA helicase by calmodulin and protein kinase C.

  1994cited by this paper
• The glycine-rich sequence of protein kinases: a multifunctional element.

  1994cited by this paper
• Deadenylation of the unstable mRNA encoded by the yeast MFA2 gene leads to decapping followed by 5'-->3' digestion of the transcript.

  1994cited by this paper
• Premature translational termination triggers mRNA decapping

  1994cited by this paper
• mRNA surveillance by the Caenorhabditis elegans smg genes.

  1993cited by this paper
• c-Jun is phosphorylated by the DNA-dependent protein kinase in vitro; definition of the minimal kinase recognition motif.

  1993cited by this paper
• Evidence to implicate translation by ribosomes in the mechanism by which nonsense codons reduce the nuclear level of human triosephosphate isomerase mRNA.

  1993cited by this paper
• A turnover pathway for both stable and unstable mRNAs in yeast: evidence for a requirement for deadenylation.

  1993cited by this paper
• Expression, purification, crystallization, and biochemical characterization of a recombinant protein phosphatase.

  1993cited by this paper
• Yeast cells lacking 5'-->3' exoribonuclease 1 contain mRNA species that are poly(A) deficient and partially lack the 5' cap structure

  1993cited by this paper
• The nuclear serine/threonine protein kinase DNA-PK.

  1992influential reference
• A new group of putative RNA helicases.

  1992cited by this paper
• NAM7 nuclear gene encodes a novel member of a family of helicases with a Zn-ligand motif and is involved in mitochondrial functions in Saccharomyces cerevisiae.

  1992influential reference
• Gene products that promote mRNA turnover in Saccharomyces cerevisiae

  1992cited by this paper
• tra-2 encodes a membrane protein and may mediate cell communication in the Caenorhabditis elegans sex determination pathway.

  1992cited by this paper
• The product of the yeast UPF1 gene is required for rapid turnover of mRNAs containing a premature translational termination codon.

  1991cited by this paper
• Purification of his-tagged proteins in non-denaturing conditions suggests a convenient method for protein interaction studies.

  1991cited by this paper
• In the beginning is the end: regulation of poly(A) addition and removal during early development.

  1990cited by this paper
• The Caenorhabditis elegans rol-6 gene, which interacts with the sqt-1 collagen gene to determine organismal morphology, encodes a collagen

  1990cited by this paper
• The P-loop--a common motif in ATP- and GTP-binding proteins.

  1990cited by this paper
• A new kind of informational suppression in the nematode Caenorhabditis elegans.

  1989cited by this paper
• Site-directed mutagenesis of Gly-15 and Gly-20 in the glycine-rich region of adenylate kinase.

  1989cited by this paper
• The basal component of the nematode dense-body is vinculin.

  1989cited by this paper
• E. coli F1 ‐ATPase: Site‐directed mutagenesis of the β‐subunit

  1988cited by this paper
• E. coli F1-ATPase: site-directed mutagenesis of the beta-subunit.

  1988cited by this paper
• Site-directed mutagenesis of a nucleotide-binding domain in HSV-1 thymidine kinase: effects on catalytic activity.

  1988cited by this paper
• A trans-spliced leader sequence on actin mRNA in C. elegans

  1987cited by this paper
• Activation of a transposable element in the germ line but not the soma of Caenorhabditis elegans

  1987cited by this paper
• DNA cloning : a practical approach

  1985cited by this paper
• Sequences that regulate the divergent GAL1-GAL10 promoter in Saccharomyces cerevisiae

  1984cited by this paper
• Identification and Characterization of a Sequence Motif Involved in Nonsense-Mediated mRNA Decay

  year unknowncited by this paper
• Identification and Characterization of Mutations in the UPF1 Gene That Affect Nonsense Suppression and the Formation of the Upf Protein Complex but Not mRNA Turnover

  year unknowncited by this paper

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  2025cites this paper
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  2025cites this paper
• Tri-snRNP activity modulates tauopathy phenotypes.

  2025cites this paper
• An RNA splicing system that excises DNA transposons from animal mRNAs

  2025cites this paper
• Cytoplasmic mRNA decay and quality control machineries in eukaryotes

  2025cites this paper
• An RNA Splicing System that Excises Transposons from Animal mRNAs

  2025cites this paper
• Noncanonical Amino Acid Incorporation in Animals and Animal Cells.

  2024cites this paper
• UPF1 promotes rapid degradation of m6A-containing RNAs.

  2022cites this paper
• EMILIN1 deficiency causes arterial tortuosity with osteopenia and connects impaired elastogenesis with defective collagen fibrillogenesis.

  2022cites this paper
• Unusual SMG suspects recruit degradation enzymes in nonsense‐mediated mRNA decay

  2022cites this paper
• Identification of a Novel de Novo Variant in the CASZ1 Causing a Rare Type of Dilated Cardiomyopathy

  2022influential citation
• Characterization of the mIF4G domains in the RNA surveillance protein Upf2

  2022cites this paper
• Role of Proteins Interacting with the eRF1 and eRF3 Release Factors in the Regulation of Translation and Prionization

  2022cites this paper
• Processing body (P-body) and its mediators in cancer

  2022cites this paper
• Translation-dependent mRNA localization to Caenorhabditis elegans adherens junctions

  2021cites this paper
• An alternative UPF1 isoform drives conditional remodeling of nonsense-mediated mRNA decay

  2021cites this paper
• mRNA Editing, Processing and Quality Control in Caenorhabditis elegans

  2020cites this paper
• Nonsense-mediated mRNA decay relies on “two-factor authentication” by SMG5-SMG7

  2020cites this paper
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  2020cites this paper
• Nonsense-Mediated mRNA Decay: Pathologies and the Potential for Novel Therapeutics

  2020cites this paper
• Therapeutic strategies for targeting telomerase in cancer

  2020cites this paper
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  2019cites this paper
• Genetic code expansion in mammalian cells

  2019cites this paper
• MicroRNA 4651 regulates nonsense-mediated mRNA decay by targeting SMG9 mRNA.

  2019cites this paper
• A nuclease specific to lepidopteran insects suppresses RNAi

  2018cites this paper
• Dissecting the functions of SMG5, SMG7, and PNRC2 in nonsense-mediated mRNA decay of human cells

  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2017cites this paper
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  2017influential citation
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  2017cites this paper
• DNA substrate recognition and processing by the full-length human UPF1 helicase

  2017cites this paper
• mRNA Decay Pathways Use Translation Fidelity and Competing Decapping Complexes for Substrate Selection

  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
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  2014cites this paper
• Expanding and reprogramming the genetic code of cells and animals.

  2014cites this paper
• Regulation of Natural mRNAs by the Nonsense-Mediated mRNA Decay Pathway

  2014cites this paper
• Nonsense-Mediated mRNA Decay Pathway Regulation of Natural mRNAs by the

  2014cites this paper
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  2014cites this paper
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  2014cites this paper
• Identification and functional analysis of novel phosphorylation sites in the RNA surveillance protein Upf 1

  2014cites this paper
• Nonsense-mediated mRNA decay: inter-individual variability and human disease.

  2014cites this paper
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  2013cites this paper
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  2013influential citation
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  2013influential citation
• Comparison of EJC-enhanced and EJC-independent NMD in human cells reveals two partially redundant degradation pathways

  2013cites this paper
• Nonsense-mediated mRNA decay - mechanisms of substrate mRNA recognition and degradation in mammalian cells.

  2013cites this paper
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  2013influential citation
• Nonsense-mediated mRNA decay of collagen –emerging complexity in RNA surveillance mechanisms

  2013cites this paper
• Global analysis of mRNA metabolism by comparative dynamic transcriptome analysis.

  2013cites this paper
• Nonsense-mediated mRNA decay: from mechanistic insights to impacts on human health.

  2013cites this paper
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  2013cites this paper
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  2013cites this paper
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  2013cites this paper
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  2012influential citation
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  2012influential citation
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  2012cites this paper
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  2012cites this paper
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  2012cites this paper
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  2012cites this paper
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  2012cites this paper
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  2012cites this paper
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  2011cites this paper
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  2011cites this paper
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  2011cites this paper
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  2011cites this paper
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  2011cites this paper
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