2-hydroxyglutarate controls centromere and heterochromatin conformation and function in the male germline

No abstract is available for this paper.

• Publication year

  2022

• Venue

  bioRxiv

• Publication date

  2022-11-19

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1101/2022.05.29.493890
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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  2007influential reference
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• Culture of pachytene spermatocytes for analysis of meiosis.

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  1965cited by this paper
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