Periodic retinoic acid–STRA8 signaling intersects with periodic germ-cell competencies to regulate spermatogenesis

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  2015-04-20

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1073/pnas.1505683112PMID 25902548PMCID PMC4426408
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• SOX4 regulates gonad morphogenesis and promotes male germ cell differentiation in mice.

  2017cited by this paper
• Single-Cell Transcriptional Analysis.

  2017cited by this paper
• SOX30 is required for male fertility in mice

  2017cited by this paper
• Human spermatogonial markers.

  2017influential reference
• Single-Cell RNA-Seq Analysis Maps Development of Human Germline Cells and Gonadal Niche Interactions.

  2017cited by this paper
• The macrophages in testis function.

  2017cited by this paper
• Spermatogonial kinetics in humans

  2017influential reference
• Chromatin and Single-Cell RNA-Seq Profiling Reveal Dynamic Signaling and Metabolic Transitions during Human Spermatogonial Stem Cell Development

  2017cited by this paper
• DMRT proteins and coordination of mammalian spermatogenesis.

  2017influential reference
• The Human Protein Atlas – an important resource for basic and clinical research

  2016cited by this paper
• In Situ Transcription Profiling of Single Cells Reveals Spatial Organization of Cells in the Mouse Hippocampus.

  2016cited by this paper
• Spermatogenesis: The Commitment to Meiosis.

  2016cited by this paper
• TEtranscripts: a package for including transposable elements in differential expression analysis of RNA-seq datasets

  2015cited by this paper
• Epigenetic regulation of germ cells-remember or forget?

  2015cited by this paper
• Processive Pulses of Retinoic Acid Propel Asynchronous and Continuous Murine Sperm Production1

  2015influential reference
• Spatial reconstruction of single-cell gene expression

  2015cited by this paper
• Macrophages Contribute to the Spermatogonial Niche in the Adult Testis.

  2015cited by this paper
• Role of retinoic acid receptor (RAR) signaling in post-natal male germ cell differentiation.

  2015cited by this paper
• Mouse Spermatogenic Stem Cells Continually Interconvert between Equipotent Singly Isolated and Syncytial States

  2014cited by this paper
• Chromatin and transcription transitions of mammalian adult germline stem cells and spermatogenesis.

  2014cited by this paper
• Fluorescence- and magnetic-activated cell sorting strategies to isolate and enrich human spermatogonial stem cells.

  2014cited by this paper
• Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position

  2013influential reference
• CXCL12–CXCR4 signaling is required for the maintenance of mouse spermatogonial stem cells

  2013cited by this paper
• Spermatogonial stem cell self-renewal and development.

  2013cited by this paper
• Turning a Spermatogenic Wave into a Tsunami: Synchronizing Murine Spermatogenesis Using WIN 18,4461

  2013cited by this paper
• Retinoic acid signaling in Sertoli cells regulates organization of the blood-testis barrier through cyclical changes in gene expression

  2012influential reference
• Retinoic acid induces Sertoli cell paracrine signals for spermatogonia differentiation but cell autonomously drives spermatocyte meiosis

  2012cited by this paper
• Molecular control of rodent spermatogenesis.

  2012cited by this paper
• Human Epididymis Protein-4 (HE-4): A Novel Cross-Class Protease Inhibitor

  2012cited by this paper
• Retinoic acid metabolism links the periodical differentiation of germ cells with the cycle of Sertoli cells in mouse seminiferous epithelium.

  2012cited by this paper
• Spermatogonia differentiation requires retinoic acid receptor γ.

  2012cited by this paper
• Identification and characterization of repopulating spermatogonial stem cells from the adult human testis.

  2011cited by this paper
• Suppression of Stra8 Expression in the Mouse Gonad by WIN 18,4461

  2011cited by this paper
• Suppression of spermatogenesis by bisdichloroacetyldiamines is mediated by inhibition of testicular retinoic acid biosynthesis.

  2011cited by this paper
• Genetics of mammalian meiosis: regulation, dynamics and impact on fertility

  2010influential reference
• Retinoic Acid Availability Drives the Asynchronous Initiation of Spermatogonial Differentiation in the Mouse1

  2010cited by this paper
• Functional Hierarchy and Reversibility Within the Murine Spermatogenic Stem Cell Compartment

  2010cited by this paper
• Tbx3 improves the germ-line competency of induced pluripotent stem cells

  2010cited by this paper
• TopHat: discovering splice junctions with RNA-Seq

  2009cited by this paper
• edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

  2009cited by this paper
• Colony stimulating factor 1 is an extrinsic stimulator of mouse spermatogonial stem cell self-renewal

  2009cited by this paper
• The pluripotency factor LIN28 marks undifferentiated spermatogonia in mouse

  2009cited by this paper
• Dedifferentiating spermatogonia outcompete somatic stem cells for niche occupancy in the Drosophila testis.

  2009cited by this paper
• Stra8 and its inducer, retinoic acid, regulate meiotic initiation in both spermatogenesis and oogenesis in mice

  2008influential reference
• Expression of Stimulated by Retinoic Acid Gene 8 (Stra8) in Spermatogenic Cells Induced by Retinoic Acid: An In Vivo Study in Vitamin A-Sufficient Postnatal Murine Testes1

  2008cited by this paper
• Expression of Stimulated by Retinoic Acid Gene 8 (Stra8) and Maturation of Murine Gonocytes and Spermatogonia Induced by Retinoic Acid In Vitro1

  2008cited by this paper
• Meiotic sex chromosome inactivation

  2007cited by this paper
• Functional identification of the actual and potential stem cell compartments in mouse spermatogenesis.

  2007cited by this paper
• CDH1 Is a Specific Marker for Undifferentiated Spermatogonia in Mouse Testes1

  2007cited by this paper
• Retinoic acid metabolism and signaling pathways in the adult and developing mouse testis.

  2006cited by this paper
• Postmeiotic sex chromatin in the male germline of mice.

  2006cited by this paper
• Inaugural Articles: Retinoic acid regulates sex-specific timing of meiotic initiation in mice

  2006cited by this paper
• Retinoid Signaling Determines Germ Cell Fate in Mice

  2006cited by this paper
• In germ cells of mouse embryonic ovaries, the decision to enter meiosis precedes premeiotic DNA replication

  2006cited by this paper
• Bioinformatics and Computational Biology Solutions Using R and Bioconductor

  2005cited by this paper
• limma: Linear Models for Microarray Data

  2005cited by this paper
• Vitamin A regulation of BMP4 expression in the male germ line.

  2005cited by this paper
• Focus on Meiosis Stops and starts in mammalian oocytes: recent advances in understanding the regulation of meiotic arrest and oocyte maturation

  2005cited by this paper
• Generation of pluripotent stem cells from neonatal mouse testis.

  2004cited by this paper
• Plzf is required in adult male germ cells for stem cell self-renewal

  2004cited by this paper
• Regeneration of Male Germline Stem Cells by Spermatogonial Dedifferentiation in Vivo

  2004cited by this paper
• Essential role of Plzf in maintenance of spermatogonial stem cells

  2004cited by this paper
• Desert Hedgehog/Patched 1 signaling specifies fetal Leydig cell fate in testis organogenesis.

  2002cited by this paper
• The prion gene complex encoding PrP(C) and Doppel: insights from mutational analysis.

  2001cited by this paper
• An abundance of X-linked genes expressed in spermatogonia

  2001cited by this paper
• Regulation of cell fate decision of undifferentiated spermatogonia by GDNF.

  2000cited by this paper
• The murine SCP3 gene is required for synaptonemal complex assembly, chromosome synapsis, and male fertility.

  2000cited by this paper
• Spermatogonial stem cell enrichment by multiparameter selection of mouse testis cells.

  2000cited by this paper
• DNA Double-stranded Breaks Induce Histone H2AX Phosphorylation on Serine 139*

  1998cited by this paper
• Meiotic prophase arrest with failure of chromosome synapsis in mice deficient for Dmc1, a germline-specific RecA homolog.

  1998cited by this paper
• Differential expression of the Oct-4 transcription factor during mouse germ cell differentiation.

  1998cited by this paper
• Characterization of a premeiotic germ cell-specific cytoplasmic protein encoded by Stra8, a novel retinoic acid-responsive gene

  1996influential reference
• Preparation of spermatogonia, spermatocytes, and round spermatids for analysis of gene expression using fluorescence-activated cell sorting.

  1995cited by this paper
• Spermatogenesis following male germ-cell transplantation.

  1994cited by this paper
• Multiple pathways of deletion formation in Escherichia coli.

  1993cited by this paper
• A quantitative study of spermatogonial multiplication and stem cell renewal in the C3H/101 F1 hybrid mouse.

  1993cited by this paper
• A quantitative study of spermatogonial multiplication and stem cell renewal in the C3H/101 F1 hybrid mouse

  1993cited by this paper
• Expression of Xist in mouse germ cells correlates with X–chromosome inactivation

  1992cited by this paper
• Retinoic acid is able to reinitiate spermatogenesis in vitamin A-deficient rats and high replicate doses support the full development of spermatogenic cells.

  1991cited by this paper
• The origin of the synchronization of the seminiferous epithelium in vitamin A-deficient rats after vitamin A replacement.

  1990cited by this paper
• Histological and Histopathological Evaluation of the Testis

  1990cited by this paper
• Synchronization of the seminiferous epithelium after vitamin A replacement in vitamin A-deficient mice.

  1990cited by this paper
• Retinol-induced stage synchronization in seminiferous tubules of the rat.

  1987cited by this paper
• Critical components of testicular function and sensitivity to disruption.

  1986cited by this paper
• Spermatogonial multiplication in the Chinese hamster. III. Labelling indices of undifferentiated spermatogonia throughout the cycle of the seminiferous epithelium.

  1983cited by this paper
• Morphology, proliferation, and differentiation of undifferentiated spermatogonia in the chinese hamster and the ram

  1982cited by this paper
• Relationship between growth and meiotic maturation of the mouse oocyte.

  1976cited by this paper
• Kinetics of spermatogenesis in mammals: seminiferous epithelium cycle and spermatogonial renewal.

  1972cited by this paper
• The spermatogonial stem cell population in adult rats. I. Their morphology, proliferation and maturation

  1971cited by this paper
• Spermatogonial stem‐cell renewal in the mouse

  1971cited by this paper
• THE SPERMATOGONIAL STEM CELL POPULATION IN ADULT RATS

  1971cited by this paper
• Duration of spermatogenesis in the mouse and timing of stages of the cycle of the seminiferous epithelium.

  1956cited by this paper
• A description of spermiogenesis in the mouse and its use in analysis of the cycle of the seminiferous epithelium and germ cell renewal.

  1956cited by this paper
• Spermiogenesis of rat, mouse, hamster and guinea pig as revealed by the periodic acid-fuchsin sulfurous acid technique.

  1952cited by this paper
• Zur Spermatogenese bei den Säugethieren

  1887cited by this paper

• PTBP1 supports mouse spermatogenesis by facilitating cytoskeletal organization through the mTORC2–PKCα pathway in Sertoli cells

  2026influential citation
• Photoperiod alters the diurnal rhythm pattern of testicular transcription and metabolism in Brandt's voles.

  2026cites this paper
• Metabolomics and Lipidomics in the Study of Reproductive Performance in Livestock.

  2026cites this paper
• Mechanisms of Hormonal, Genetic, and Temperature Regulation of Germ Cell Proliferation, Differentiation, and Death During Spermatogenesis

  2025cites this paper
• Deep-learning-based automated prediction of mouse seminiferous tubule stage by using bright-field microscopy

  2025cites this paper
• Utilization of the QuPath open-source software platform for analysis of mammalian spermatogenesis

  2025cites this paper
• Profiling Histone Modifications in Differentiating Mouse Spermatogonia with CUT&Tag.

  2025cites this paper
• The action of retinoic acid on spermatogonia in the testis.

  2025cites this paper
• Maternal CENP-C restores centromere symmetry in mammalian zygotes to ensure proper chromosome segregation

  2025cites this paper
• PPP6R3-mediated dephosphorylation regulates mRNA translation during spermatogonial differentiation

  2025cites this paper
• Sertoli cells as a hub in testicular development and male reproductive

  2025cites this paper
• TRAPPC2l Participates in Male Germ Cell Development by Regulating Cell Division

  2025cites this paper
• Essential Regulation of Spermatogonial Stem Cell Fate Decisions and Male Fertility by APBB1 via Interaction with KAT5 and GDF15 in Humans and Mice

  2025cites this paper
• The SMARCA5–DMRT1 Pioneer Complex Establishes Epigenetic Priming to Direct Male Germline Development

  2025cites this paper
• Erucic acid impairs male fertility by suppressing retinoic acid synthesis in sertoli cells.

  2025cites this paper
• CITED2 Binding to EP300 Regulates Human Spermatogonial Stem Cell Proliferation and Survival Through HSPA6

  2025cites this paper
• Programming for Meiotic Competence in Mouse Male Germ Cells is Established at the Perinatal Precursor Stage of Development

  2025cites this paper
• Quantitative CUT&Tag for Epigenomic Profiling of Mouse Germ Cells.

  2025cites this paper
• The dynamic transcriptome profiles in turbot prepubertal testes and the important role of GDNF in maintaining spermatogonial stem cell self-renewal

  2025cites this paper
• Maternal CENP-C restores centromere symmetry in mammalian zygotes to ensure proper chromosome segregation.

  2025cites this paper
• Effect of Alternative Splicing Euchromatic Histone Lysine Methyltransferase 2 (EHMT2/G9A) on Spermatogenesis in Mongolian Horses

  2025cites this paper
• A novel CHD4-CTCF regulatory axis drives key developmental programs and transitions in male germ cells

  2025cites this paper
• The SMARCA5–DMRT1 Pioneer Complex Establishes Epigenetic Priming to Direct Male Germline Development

  2025cites this paper
• Sertoli cell-conditioned medium restores spermatogenesis in mice induced by scrotal hyperthermia

  2025cites this paper
• Chromatin remodeler CHD8 is required for spermatogonial proliferation and early meiotic progression

  2024cites this paper
• Mechanisms of meiosis initiation and meiotic prophase progression during spermatogenesis.

  2024cites this paper
• An aberrant protamine ratio is associated with decreased H4ac levels in murine and human sperm

  2024cites this paper
• Single-cell analysis identifies critical regulators of spermatogonial development and differentiation in cattle-yak bulls.

  2024cites this paper
• High resolution maps of chromatin reorganization through mouse meiosis reveal novel features of the 3D meiotic structure

  2024cites this paper
• Multiple ageing effects on testicular/epididymal germ cells lead to decreased male fertility in mice

  2024influential citation
• Synergistic enhancement of the mouse Pramex1 and Pramel1 in repressing retinoic acid (RA) signaling during gametogenesis

  2024cites this paper
• Targeting nuclear receptor corepressors for reversible male contraception

  2024cites this paper
• Imatinib decreases germ cell survival and germline stem cell proliferation in rodent testis ex vivo and in vitro

  2024cites this paper
• Retinoic Acid Regulates Spermiogenesis Via Hoxb1 and Shh Signaling in Testicular Germ Cells

  2024cites this paper
• Effect of Salinity Stress on Gut-Brain-Gonad Axis in the Red-Eared Slider (Trachemys scripta elegans).

  2024cites this paper
• The Potential Reversible Transition between Stem Cells and Transient-Amplifying Cells: The Limbal Epithelial Stem Cell Perspective

  2024cites this paper
• RNA-Seq and ATAC-Seq Reveal CYP26A1-Mediated Regulation of Retinoic Acid-Induced Meiosis in Chicken Primordial Germ Cells

  2024cites this paper
• The Role of Retinoic Acid in Spermatogenesis and Its Application in Male Reproduction

  2024cites this paper
• miR-1458 is inhibited by low concentrations of Vitamin B6 and targets TBX6 to promote the formation of spermatogonial stem cells in Rugao Yellow Chicken

  2024cites this paper
• The role of Sertoli cells-secreted factors in different stages of germ cells development in mice exposed to BDE-209.

  2024cites this paper
• Temporal maturation of Sertoli cells during the establishment of the cycle of the seminiferous epithelium

  2024cites this paper
• MAGEB2-Mediated Degradation of EGR1 Regulates the Proliferation and Apoptosis of Human Spermatogonial Stem Cell Lines

  2023cites this paper
• Perspectives: Approaches for Studying Livestock Spermatogonia.

  2023cites this paper
• Transcriptional metabolic reprogramming implements meiotic fate decision in mouse testicular germ cells

  2023cites this paper
• Protective effects of human amniotic membrane derived mesenchymal stem cells (hAMSCs) secreted factors on mouse spermatogenesis and sperm chromatin condensation following unilateral testicular torsion.

  2023cites this paper
• Molecular characterization and potential function of Rxrγ in gonadal differentiation of Chinese soft-shelled turtle (Pelodiscus sinensis).

  2023cites this paper
• Interplay of spermatogonial subpopulations during initial stages of spermatogenesis in adult primates.

  2023cites this paper
• Journal of Reproduction and Development

  2023cites this paper
• N-acetylcysteine rescues meiotic arrest during spermatogenesis in mice exposed to BDE-209

  2023cites this paper
• PRC1 directs PRC2-H3K27me3 deposition to shield adult spermatogonial stem cells from differentiation

  2023cites this paper
• The MYBL1/TCFL5 transcription network: two collaborative factors with central role in male meiosis

  2023cites this paper
• Differential responsiveness of spermatogonia to retinoic acid dictates precocious differentiation but not meiotic entry during steady-state spermatogenesis

  2023cites this paper
• Retinoic acid signaling in development and differentiation commitment and its regulatory topology.

  2023cites this paper
• Tissue engineering studies in male infertility disorder

  2023cites this paper
• SRSF1-mediated alternative splicing is required for spermatogenesis

  2023cites this paper
• Destabilization of mRNAs enhances competence to initiate meiosis in mouse spermatogenic cells

  2023cites this paper
• : SRSF2 is required for mRNA splicing and spermatogenesis

  2023cites this paper
• STRA8–RB interaction is required for timely entry of meiosis in mouse female germ cells

  2023cites this paper
• SRSF2 is required for mRNA splicing during spermatogenesis

  2023cites this paper
• Cell type-specific role of CBX2 and its disordered region in spermatogenesis

  2023cites this paper
• Sperm competition intensity shapes divergence in both sperm morphology and reproductive genes across murine rodents

  2023cites this paper
• Retinoic acid is dispensable for meiotic initiation but required for spermiogenesis in the mammalian testis

  2023cites this paper
• SPRY4-dependent ERK negative feedback demarcates functional adult stem cells in the male mouse germline

  2023cites this paper
• Mechanism of initiation of meiosis in mouse germ cells.

  2023cites this paper
• Chromatin Remodeling via Retinoic Acid Action during Murine Spermatogonial Development

  2023cites this paper
• Effects of Growth Factors on In Vitro Culture of Neonatal Piglet Testicular Tissue Fragments

  2023cites this paper
• Loss of Atg5 in Sertoli cells enhances the susceptibility of cadmium-impaired testicular spermatogenesis in mice.

  2023cites this paper
• Cell type-specific role of CBX2-cPRC1 at the onset of spermatogonial differentiation

  2022cites this paper
• Postnatal ontogeny of Neuromedin S and its receptors NMUR1 and NMUR2 expression in mouse testis.

  2022cites this paper
• Combination of high-fat diet and cadmium impairs testicular spermatogenesis in an m6A-YTHDF2-dependent manner.

  2022cites this paper
• Retinoic acid induced meiosis initiation in female germline stem cells by remodelling three‐dimensional chromatin structure

  2022cites this paper
• Updates in Sertoli Cell-Mediated Signaling During Spermatogenesis and Advances in Restoring Sertoli Cell Function

  2022cites this paper
• Trim41 is required to regulate chromosome axis protein dynamics and meiosis in male mice

  2022cites this paper
• 2-hydroxyglutarate controls centromere and heterochromatin conformation and function in the male germline

  2022cites this paper
• SRSF2 is required for mRNA splicing and spermatogenesis

  2022cites this paper
• FBXO38 Ubiquitin Ligase Controls Sertoli Cell Maturation

  2022cites this paper
• Recent Update on Retinoic Acid-Driven Initiation of Spermatogonial Differentiation

  2022cites this paper
• Function of Retinoic Acid in Development of Male and Female Gametes

  2022cites this paper
• The netrin-1 receptor UNC5C contributes to the homeostasis of undifferentiated spermatogonia in adult mice.

  2022cites this paper
• CEP250 is Required for Maintaining Centrosome Cohesion in the Germline and Fertility in Male Mice

  2022cites this paper
• NANOS3 suppresses premature spermatogonial differentiation to expand progenitors and fine-tunes spermatogenesis in mice

  2022cites this paper
• Action and Interaction between Retinoic Acid Signaling and Blood–Testis Barrier Function in the Spermatogenesis Cycle

  2022cites this paper
• Proximity-dependent biotin labeling in testicular germ cells identified TESMIN-associated proteins

  2022cites this paper
• BDE-209 induced spermatogenesis disorder by inhibiting SETD8/H4K20me1 related histone methylation in mice.

  2022cites this paper
• : SRSF2 is required for mRNA splicing and spermatogenesis

  2022cites this paper
• The transcription factor TCFL5 responds to A-MYB to elaborate the male meiotic program in mice

  2022cites this paper
• Single-cell-resolution transcriptome map revealed novel genes involved in testicular germ cell progression and somatic cells specification in Chinese tongue sole with sex reversal

  2022cites this paper
• Carotenoids in female and male reproduction.

  2022cites this paper
• Equalizing epigenetically imprinted centromeres in early mammalian embryos

  2022cites this paper
• Defects of microtubule cytoskeletal organization in NOA human testes

  2022cites this paper
• Global Deletion of ALDH1A1 and ALDH1A2 Genes Does Not Affect Viability but Blocks Spermatogenesis

  2022influential citation
• Chromodomain helicase DNA-binding domain 2 maintains spermatogonial self-renewal by promoting chromatin accessibility and mRNA stability

  2022cites this paper
• Loss of Ubiquitin Carboxy-Terminal Hydrolase L1 Impairs Long-Term Differentiation Competence and Metabolic Regulation in Murine Spermatogonial Stem Cells

  2021cites this paper
• The role of retinoic acid in the commitment to meiosis

  2021cites this paper
• Impact of chronic vitamin A excess on sperm morphogenesis in mice

  2021cites this paper
• Sheng Jing Decoction Can Promote Spermatogenesis and Increase Sperm Motility of the Oligozoospermia Mouse Model

  2021cites this paper
• Sheng Jing Decoction, as a Traditional Chinese Medicine Prescription, Can Promote Spermatogenesis and Increase Sperm Motility

  2021influential citation
• MicroRNA-202 prevents precocious spermatogonial differentiation and meiotic initiation during mouse spermatogenesis

  2021influential citation
• Mtor inhibition by INK128 extends functions of the ovary reconstituted from germline stem cells in aging and premature aging mice

  2021cites this paper
• The microRNA miR-202 prevents precocious spermatogonial differentiation and meiotic initiation during mouse spermatogenesis.

  2021cites this paper