White matter microstructure and the clinical risk for psychosis: A diffusion tensor imaging study of individuals with basic symptoms and at ultra-high risk

L. Smigielski,P. Stämpfli,D. Wotruba,Roman Buechler,S. Sommer,M. Gerstenberg,A. Theodoridou,S. Walitza,W. Rössler,K. Heekeren

Published 2022 in NeuroImage: Clinical

ABSTRACT

Highlights • This DTI cross-sectional study compared UHR, basic symptom & control groups (n = 112).• The splenium of UHR individuals exhibited differences in fractional anisotropy (FA).• Basic symptoms alone were not associated with white matter microstructure changes.• Large differences in FA & radial diffusivity were found in converters to psychosis.• Regional FA was inversely correlated with the general psychopathology domain.

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