Glioma progression is shaped by genetic evolution and microenvironment interactions.

No abstract is available for this paper.

• Publication year

  2022

• Venue

  Cell

• Publication date

  2022-05-24

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.cell.2022.04.038PMID 35649412PMCID PMC9189056
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma.

  2021cited by this paper
• Radiotherapy is associated with a deletion signature that contributes to poor outcomes in cancer patients

  2021cited by this paper
• Single-cell characterization of macrophages in glioblastoma reveals MARCO as a mesenchymal pro-tumor marker

  2021cited by this paper
• Gradient of Developmental and Injury Response transcriptional states defines functional vulnerabilities underpinning glioblastoma heterogeneity

  2021cited by this paper
• Glioblastomas acquire myeloid-affiliated transcriptional programs via epigenetic immunoediting to elicit immune evasion

  2021cited by this paper
• Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization

  2021cited by this paper
• Perspective of mesenchymal transformation in glioblastoma

  2021cited by this paper
• Single-cell RNA sequencing reveals functional heterogeneity of glioma-associated brain macrophages

  2021cited by this paper
• Pathway-based classification of glioblastoma uncovers a mitochondrial subtype with therapeutic vulnerabilities

  2021cited by this paper
• Glioblastoma in Adults: A Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) Consensus Review on Current Management and Future Directions.

  2020cited by this paper
• Outer Radial Glia-like Cancer Stem Cells Contribute to Heterogeneity of Glioblastoma.

  2020cited by this paper
• Profiling Cell Type Abundance and Expression in Bulk Tissues with CIBERSORTx.

  2020cited by this paper
• Single-cell analyses reveal YAP/TAZ as regulators of stemness and cell plasticity in Glioblastoma

  2020cited by this paper
• Transcriptional regulatory networks of tumor-associated macrophages that drive malignancy in mesenchymal glioblastoma

  2020cited by this paper
• Single-cell multimodal glioma analyses identify epigenetic regulators of cellular plasticity and environmental stress response

  2020cited by this paper
• iGLASS: Imaging integration into the Glioma Longitudinal AnalySiS Consortium.

  2020cited by this paper
• Single-cell RNA-seq reveals that glioblastoma recapitulates a normal neurodevelopmental hierarchy

  2020cited by this paper
• Surveying brain tumor heterogeneity by single-cell RNA-sequencing of multi-sector biopsies

  2020cited by this paper
• Interrogation of the Microenvironmental Landscape in Brain Tumors Reveals Disease-Specific Alterations of Immune Cells.

  2020cited by this paper
• Visualizing and interpreting cancer genomics data via the Xena platform

  2020cited by this paper
• CD8+ T-cell–Mediated Immunoediting Influences Genomic Evolution and Immune Evasion in Murine Gliomas

  2019cited by this paper
• Immune and genomic correlates of response to anti-PD-1 immunotherapy in glioblastoma

  2019cited by this paper
• Neoantigen-directed immune escape in lung cancer evolution

  2019cited by this paper
• Evolutionary Trajectories of IDHWT Glioblastomas Reveal a Common Path of Early Tumorigenesis Instigated Years ahead of Initial Diagnosis.

  2019cited by this paper
• Determining cell-type abundance and expression from bulk tissues with digital cytometry

  2019cited by this paper
• Molecular pathology of tumors of the central nervous system

  2019cited by this paper
• An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma.

  2019cited by this paper
• BBKNN: fast batch alignment of single cell transcriptomes

  2019cited by this paper
• Electrical and synaptic integration of glioma into neural circuits

  2019cited by this paper
• Glutamatergic synaptic input to glioma cells drives brain tumour progression

  2019cited by this paper
• The phenotypes of proliferating glioblastoma cells reside on a single axis of variation.

  2019cited by this paper
• LONGITUDINAL MOLECULAR TRAJECTORIES OF DIFFUSE GLIOMA IN ADULTS

  2019cited by this paper
• Single-cell transcriptome analysis of lineage diversity in high-grade glioma

  2018cited by this paper
• fastp: an ultra-fast all-in-one FASTQ preprocessor

  2018cited by this paper
• Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma

  2018cited by this paper
• Cancer‐Cell‐Intrinsic Mechanisms Shaping the Tumor Immune Landscape

  2018cited by this paper
• Comprehensive integration of single cell data

  2018cited by this paper
• SCANPY: large-scale single-cell gene expression data analysis

  2018cited by this paper
• How to analyse the spatiotemporal tumour samples needed to investigate cancer evolution: A case study using paired primary and recurrent glioblastoma

  2018cited by this paper
• Genetic Mechanisms of Immune Evasion in Colorectal Cancer.

  2018cited by this paper
• Interfaces of Malignant and Immunologic Clonal Dynamics in Ovarian Cancer.

  2018cited by this paper
• An anatomic transcriptional atlas of human glioblastoma

  2018cited by this paper
• Glioma through the looking GLASS: molecular evolution of diffuse gliomas and the Glioma Longitudinal Analysis Consortium

  2018cited by this paper
• IL1 Receptor Antagonist Controls Transcriptional Signature of Inflammation in Patients with Metastatic Breast Cancer.

  2018cited by this paper
• Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq

  2017cited by this paper
• Humanized mice in studying efficacy and mechanisms of PD-1-targeted cancer immunotherapy

  2017cited by this paper
• Single-cell profiling of human gliomas reveals macrophage ontogeny as a basis for regional differences in macrophage activation in the tumor microenvironment

  2017cited by this paper
• Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment.

  2017cited by this paper
• Oncostatin M promotes cancer cell plasticity through cooperative STAT3-SMAD3 signaling

  2017cited by this paper
• Targeting neuronal activity-regulated neuroligin-3 dependency in high-grade glioma

  2017cited by this paper
• Allele-Specific HLA Loss and Immune Escape in Lung Cancer Evolution

  2017cited by this paper
• The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary

  2016cited by this paper
• Near-optimal probabilistic RNA-seq quantification

  2016cited by this paper
• pVAC-Seq: A genome-guided in silico approach to identifying tumor neoantigens

  2016cited by this paper
• Clonal evolution of glioblastoma under therapy

  2016cited by this paper
• Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma.

  2016cited by this paper
• Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma

  2016cited by this paper
• Neuronal Activity Promotes Glioma Growth through Neuroligin-3 Secretion.

  2015cited by this paper
• Whole-genome and multisector exome sequencing of primary and post-treatment glioblastoma reveals patterns of tumor evolution

  2015cited by this paper
• Spatiotemporal Evolution of the Primary Glioblastoma Genome.

  2015cited by this paper
• Molecular and genetic properties of tumors associated with local immune cytolytic activity.

  2015cited by this paper
• Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas.

  2015cited by this paper
• DNA Methylation and Somatic Mutations Converge on the Cell Cycle and Define Similar Evolutionary Histories in Brain Tumors.

  2015cited by this paper
• A draft network of ligand–receptor-mediated multicellular signalling in human

  2015cited by this paper
• MRI-localized biopsies reveal subtype-specific differences in molecular and cellular composition at the margins of glioblastoma

  2014cited by this paper
• Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation

  2014cited by this paper
• OptiType: precision HLA typing from next-generation sequencing data

  2014cited by this paper
• TITAN: inference of copy number architectures in clonal cell populations from tumor whole-genome sequence data

  2014cited by this paper
• Mesenchymal differentiation mediated by NF-κB promotes radiation resistance in glioblastoma.

  2013cited by this paper
• The somatic genomic landscape of glioblastoma.

  2013cited by this paper
• STAR: ultrafast universal RNA-seq aligner

  2013cited by this paper
• The tumor microenvironment strongly impacts master transcriptional regulators and gene expression class of glioblastoma.

  2012cited by this paper
• Histo-cytometry: a method for highly multiplex quantitative tissue imaging analysis applied to dendritic cell subset microanatomy in lymph nodes.

  2012cited by this paper
• Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1.

  2010cited by this paper
• The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data.

  2010cited by this paper

• Identification of an age-related monocyte-derived macrophages characteristic genes-based signature for high-grade diffuse glioma.

  2026cites this paper
• Comparative cross-methodological analysis of the IDH-wildtype glioblastoma tumor microenvironment

  2026cites this paper
• Reactive oligodendrocytes promote glioblastoma progression through CCL5/CCR5-mediated glioma stem cell maintenance.

  2026cites this paper
• Critical role of cell competition in gliomagenesis

  2026cites this paper
• Natural progression of glioma enhances functional connection with the cerebral cortex through synaptogenesis

  2026cites this paper
• Detection of Aggressive Mesenchymal Glioblastoma by Mannose-Weighted CEST MRI

  2026cites this paper
• Bridging cancer cell-intrinsic driver genes and -extrinsic cell-cell communication with Driver2Comm.

  2026cites this paper
• Mitochondrial protein carboxyl-terminal alanine-threonine tailing promotes human glioblastoma growth by regulating mitochondrial function

  2026influential citation
• Tumor microenvironment-triggered aggregation of semiconducting polymer nanochangers for self-programable theranostics of orthotopic glioma

  2026cites this paper
• Characterization of a pathogenic subpopulation of human glioma associated macrophages linked to glioma progression.

  2026cites this paper
• Nested ecosystems theory for conceptualizing brain tumors.

  2026cites this paper
• Immune Cell Infiltration in Primary and Recurrent Glioblastoma, IDH‐Wild Type: Validation of an Immunohistochemistry‐Based Scoring System for Research and Clinical Practice

  2026cites this paper
• Subtype-Specific SASP Dynamics Predict Mesenchymal Transition in Recurrent Glioblastoma

  2026cites this paper
• tRF-3021a, a tRNA-Ala-TGC derived 3’ fragment, promotes glioblastoma cell invasion, suppresses apoptosis, and is required for normal levels of protein synthesis

  2026cites this paper
• SERPINE1 maintained expression by NR4A1 promotes invasion and migration of glioblastoma in hypoxic microenvironment

  2026cites this paper
• From Diagnosis Delay to Targeted Therapy: A Retrospective Study of Pediatric DLGNT with a Comprehensive Literature Review.

  2026cites this paper
• Overcoming Chemoresistance in Glioblastoma: Mechanisms, Therapeutic Strategies, and Functional Precision Medicine

  2026cites this paper
• Cancer neuroscience: signaling pathways and new therapeutic strategies for cancer

  2026cites this paper
• Immunosuppressive mechanisms and therapeutic interventions shaping glioblastoma immunity

  2026cites this paper
• A prognostic matrix gene expression signature defines functional glioblastoma phenotypes and niches

  2026cites this paper
• Circulating immune profiling reveals impaired monocyte states and trajectories driving immunosuppression in glioblastoma

  2026cites this paper
• Drug and single-cell gene expression integration identifies sensitive and resistant glioblastoma cell populations

  2026cites this paper
• Cobalt mitigates zinc-starvation effects in Pseudomonas aeruginosa.

  2025cites this paper
• Parkinson's Disease and Cancer: Mechanistic Insights and Therapeutic Opportunities From Cancer Neuroscience

  2025cites this paper
• Aberrant neural activity in the peritumoral cortex underlies the progression of tumor-associated seizures

  2025cites this paper
• Transcriptomic analysis identifies a potential target for bevacizumab resistant glioblastoma

  2025cites this paper
• TET CpG sequence context specific DNA demethylation shapes progression of IDH-mutant gliomas

  2025cites this paper
• TyCHE enables time-resolved lineage tracing of heterogeneously-evolving populations

  2025cites this paper
• Primary central nervous system tumors: future directions in systemic treatment

  2025cites this paper
• Glioblastoma’s Effect on Brain Circuitry

  2025cites this paper
• Immunopathology of Glioblastoma.

  2025cites this paper
• Region-specific human brain organoids reveal synaptic and cell state drivers of glioblastoma invasion

  2025cites this paper
• Gliomas phenocopy an inborn error of metabolism to drive neuronal activity and tumor growth

  2025cites this paper
• Wnt inhibition alleviates resistance to anti-PD1 therapy and improves antitumor immunity in glioblastoma

  2025cites this paper
• A Human Neuronal Co-Culture System Reveals Early Tumor-Neuron Communication and Targetable Pathways in Glioblastoma

  2025cites this paper
• Endothelin Signaling via EDNRB receptor Reduces Proliferation and Promotes Proneural-to-Mesenchymal Transition in Gliomas

  2025cites this paper
• Pericytes orchestrate a tumor-restraining microenvironment in glioblastoma

  2025influential citation
• Baseline MRI habitat imaging for predicting treatment response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer

  2025cites this paper
• Repurposing the anthelmintic drug mebendazole in combination with radiation therapy in an isocitrate dehydrogenase mutant glioma model

  2025cites this paper
• Cellular heterogeneity and therapeutic response profiling of human IDH+ glioma stem cell cultures

  2025cites this paper
• Deciphering neuron-tumor networks with rabies virus-based retrograde tracing

  2025cites this paper
• A spatiotemporal cancer cell trajectory underlies glioblastoma heterogeneity

  2025cites this paper
• Forecasting oncogene amplification and tumour suppressor deletion

  2025influential citation
• A Toolkit for Single-Nucleus Characterization of Glioblastoma.

  2025cites this paper
• Proneural–mesenchymal hybrid glioblastoma cells are resistant to therapy and dependent on nuclear import

  2025cites this paper
• BRD2 bromodomain-mediated regulation of cell state plasticity modulates therapy response in glioblastoma

  2025cites this paper
• Fibroblast activation protein expression in the tumor microenvironment is crucial in survival prediction and differentiation of recurrent gliomas: a head-to-head comparison of 68Ga-FAPI-04 and 18F-FET in PET/CT imaging

  2025cites this paper
• Protein-based classification reveals an immune-hot subtype in IDH mutant astrocytoma with worse prognosis.

  2025cites this paper
• Case Report: Metabolic alterations and cholesterol esterification in a low-grade diffuse astrocytoma patient who progressed to glioblastoma at recurrence

  2025cites this paper
• Pilot research on predicting the sub-volume with high risk of tumor recurrence inside peritumoral edema using the ratio-maxiADC/meanADC from the advanced MRI

  2025cites this paper
• Nanobiotechnology‐Based Approaches for Targeted Glioma Therapy

  2025cites this paper
• The immunology of brain tumors.

  2025cites this paper
• IGF2 supports glioblastoma growth and immune evasion through a combination of tumor cell-intrinsic and -extrinsic mechanisms

  2025cites this paper
• COL22A1 expression identifies aggressive glioma and independently predicts survival through integrated multiomics and clinical validation

  2025cites this paper
• Integrative multi-modal analysis reveals the contribution of noncoding RNAs to post-treatment progression of IDH-mutant astrocytomas

  2025influential citation
• Integrative multi-omics combined with functional pharmacological profiling in patient-derived organoids identifies personalized therapeutic vulnerabilities of adult high-grade gliomas

  2025cites this paper
• Targeting the MDK/c‐Myc complex to overcome temozolomide resistance in glioma

  2025cites this paper
• PD-L1 Clones and Their Relevance in Glioblastoma, IDH-Wildtype: A Comparative Analysis

  2025cites this paper
• Exploring Neural Stem Cell Therapies as Innovative Treatments for Glioblastoma

  2025cites this paper
• Single Cell Spatial Profiling Identifies Region-Specific Extracellular Matrix Adhesion and Signaling Networks in Glioblastoma

  2025cites this paper
• Development of a highly differentiated rat brain organoid model for exploring glioblastoma invasion dynamics and therapy.

  2025cites this paper
• SKP2 protein as a prognostic biomarker for glioma and promotes tumor progression by regulating the cell cycle

  2025cites this paper
• The multilayered transcriptional architecture of glioblastoma ecosystems

  2025influential citation
• Dissecting the immune landscape in pediatric high-grade glioma reveals cell state changes under therapeutic pressure

  2025cites this paper
• Deciphering the longitudinal trajectories of glioblastoma ecosystems by integrative single-cell genomics

  2025influential citation
• Enhancer RNA–mediated transcriptional regulatory programs reveal the malignant progression of glioma

  2025cites this paper
• Cross-species comparison reveals therapeutic vulnerabilities halting glioblastoma progression

  2025cites this paper
• Integrating Multiplex Immunohistochemistry and Machine Learning for Glioma Subtyping and Prognosis Prediction

  2025cites this paper
• Spatial synaptic connectivity underlies oligodendroglioma evolution and recurrence

  2025cites this paper
• IDH status dictates oHSV mediated metabolic reprogramming affecting anti-tumor immunity

  2025cites this paper
• Molecular biology of the deadliest cancer – glioblastoma: what do we know?

  2025cites this paper
• Identification of drug candidates against glioblastoma with machine learning and high-throughput screening of heterogeneous cellular models

  2025cites this paper
• Cutting-Edge Technologies Illuminate the Neural Landscape of Cancer: Insights into Tumor Development.

  2025cites this paper
• Aging and senescence: Key players in brain tumor progression and drug resistance.

  2025cites this paper
• Development of a fully human glioblastoma-in-brain-spheroid model for accelerated translational research

  2025cites this paper
• Regulatory T Cell Mimicry by a Subset of Mesenchymal GBM Stem Cells Suppresses CD4 and CD8 Cells

  2025cites this paper
• Precancerous Cells Initiate Glioblastoma Evolution and Contribute to Intratumoral Heterogeneity.

  2025cites this paper
• Longitudinal profiling of IDH-mutant astrocytomas reveals acquired RAS-MAPK pathway mutations associated with inferior survival

  2025cites this paper
• Multipronged SMAD pathway targeting by lipophilic poly(β-amino ester) miR-590-3p nanomiRs inhibits mesenchymal glioblastoma growth and prolongs survival

  2025cites this paper
• Charting the single-cell and spatial landscape of IDH-wild-type glioblastoma with GBmap

  2025cites this paper
• Targeting Glioma Stem Cells: Therapeutic Opportunities and Challenges

  2025cites this paper
• Deciphering the Dialogue between Brain Tumors, Neurons, and Astrocytes

  2025cites this paper
• Targeting mesenchymal monocyte-derived macrophages to enhance the sensitivity of glioblastoma to temozolomide by inhibiting TNF/CELSR2/p65/Kla-HDAC1/EPAS1 axis

  2025cites this paper
• Targeting the glioblastoma resection margin with locoregional nanotechnologies

  2025cites this paper
• Neurodevelopmental hijacking of oligodendrocyte lineage programs drives glioblastoma infiltration.

  2025cites this paper
• Dissecting PTPN7‐driven aggressiveness in IDH‐wildtype astrocytomas: multi‐omics, clinical validation, and spatial transcriptomics for prognostic insights

  2025cites this paper
• Machine learning and multi-omics analysis reveal key regulators of proneural–mesenchymal transition in glioblastoma

  2025cites this paper
• Palmitoylation-driven immune dysregulation and prognostic signature in low-grade glioma: a multi-omics and functional validation study

  2025cites this paper
• Glioportal: a comprehensive transcriptomic resource unveiling ligand-mediated mesenchymal transition in glioblastoma

  2025influential citation
• Mechanisms and Therapeutic Implications of Glioma-Neuron Interactions.

  2025cites this paper
• Persistent chromatin alterations and gene expression reprogramming follow widespread DNA damage in glioblastoma

  2025cites this paper
• Malignant Transformation of Glioblastoma: One Step at a Time.

  2025cites this paper
• Contribution of Prostaglandin E2‐Induced Neuronal Excitation to Drug Resistance in Glioblastoma Countered by a Novel Blood–Brain Barrier Crossing Celecoxib Derivative

  2025cites this paper
• Spatial-in-Spatial: The Utility of Combining Fluorescence-Guided Multiple Sampling with Spatial-Omics in Human Glioblastoma.

  2025cites this paper
• Tumor-initiating genetics and therapy drive divergent molecular evolution in IDH-mutant gliomas

  2025cites this paper
• Glioblastoma in Adults: A Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) Consensus Review on Current Management and Future Directions.

  2025cites this paper
• Spatial profiling of longitudinal glioblastoma reveals consistent changes in cellular architecture, post-treatment.

  2025cites this paper
• What makes the human brain special - from cellular function to clinical translation.

  2025cites this paper
• Restraint of cancer cell plasticity by spatial homotypic clustering.

  2025cites this paper
• IL-6 underlies microenvironment immunosuppression and resistance to therapy in glioblastoma

  2025cites this paper