Chromatin-specific regulation of LEF-1-beta-catenin transcription activation and inhibition in vitro.

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Genes & Development

• Publication date

  2001-12-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1101/GAD.946501PMID 11751639PMCID PMC312851
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The nonsteroidal anti-inflammatory drugs aspirin and indomethacin attenuate beta-catenin/TCF-4 signaling.

  2001cited by this paper
• β-catenin–sensitive isoforms of lymphoid enhancer factor-1 are selectively expressed in colon cancer

  2001influential reference
• New aspects of Wnt signaling pathways in higher vertebrates.

  2001cited by this paper
• The chromatin remodelling factor Brg‐1 interacts with β‐catenin to promote target gene activation

  2001cited by this paper
• Inhibition of Tcf3 Binding by I-mfa Domain Proteins

  2001influential reference
• Tcf3 and Lef1 regulate lineage differentiation of multipotent stem cells in skin.

  2001cited by this paper
• Rescue of a Wnt mutation by an activated form of LEF-1: Regulation of maintenance but not initiation of Brachyury expression

  2001cited by this paper
• The nonsteroidal anti-inflammatory drugs aspirin and indomethacin attenuate β-catenin/TCF-4 signaling

  2001cited by this paper
• Inhibition of Wnt signaling by ICAT, a novel β-catenin-interacting protein

  2000influential reference
• HFR1 encodes an atypical bHLH protein that acts in phytochrome A signal transduction.

  2000cited by this paper
• Repressor activity of Headless/Tcf3 is essential for vertebrate head formation

  2000cited by this paper
• The p300/CBP acetyltransferases function as transcriptional coactivators of β‐catenin in vertebrates

  2000influential reference
• Linking colorectal cancer to Wnt signaling.

  2000cited by this paper
• Recognition of distorted DNA structures by HMG domains.

  2000cited by this paper
• Differential Mechanisms of LEF/TCF Family-Dependent Transcriptional Activation by β-Catenin and Plakoglobin

  2000cited by this paper
• Curbing the nuclear activities of β‐catenin

  2000cited by this paper
• Wnt signaling and cancer.

  2000cited by this paper
• The transcriptional coactivator CBP interacts with beta-catenin to activate gene expression.

  2000cited by this paper
• Regulation of beta -catenin transformation by the p300 transcriptional coactivator.

  2000influential reference
• Regulation of Lef-mediated Transcription and p53-dependent Pathway by Associating β-Catenin with CBP/p300*

  2000cited by this paper
• Functional selectivity of recombinant mammalian SWI/SNF subunits.

  2000cited by this paper
• Inhibition of Wnt signaling by ICAT, a novel beta-catenin-interacting protein.

  2000influential reference
• Curbing the nuclear activities of beta-catenin. Control over Wnt target gene expression.

  2000cited by this paper
• gamma-catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of beta-catenin.

  2000cited by this paper
• Crystal structure of a beta-catenin/Tcf complex.

  2000cited by this paper
• Osa-containing Brahma chromatin remodeling complexes are required for the repression of wingless target genes.

  2000cited by this paper
• Regulation of β-catenin transformation by the p300 transcriptional coactivator

  2000influential reference
• γ-Catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of β-catenin

  2000cited by this paper
• Neoplastic Transformation of RK3E by Mutant β-Catenin Requires Deregulation of Tcf/Lef Transcription but Not Activation of c-myc Expression

  1999cited by this paper
• Evaluation of 5-aminosalicylic acid (5-ASA) for cancer chemoprevention: lack of efficacy against nascent adenomatous polyps in the Apc(Min) mouse.

  1999cited by this paper
• The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway.

  1999cited by this paper
• Colorectal cancer: molecules and populations.

  1999cited by this paper
• A functional interaction between the histone deacetylase Rpd3 and the corepressor groucho in Drosophila development.

  1999cited by this paper
• PPAR d Is an APC-Regulated Target of Nonsteroidal Anti-Inflammatory Drugs

  1999cited by this paper
• Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells.

  1999cited by this paper
• Biochemical Analysis of Distinct Activation Functions in p300 That Enhance Transcription Initiation with Chromatin Templates

  1999cited by this paper
• Functional Characterization of Multiple Transactivating Elements in β-Catenin, Some of Which Interact with the TATA-binding Proteinin Vitro *

  1999influential reference
• Regulation of LEF-1/TCF transcription factors by Wnt and other signals.

  1999cited by this paper
• Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1.

  1999cited by this paper
• Nuclear endpoint of Wnt signaling: neoplastic transformation induced by transactivating lymphoid-enhancing factor 1.

  1999cited by this paper
• WNT targets. Repression and activation.

  1999cited by this paper
• PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs.

  1999cited by this paper
• Promoter Structure and Transcriptional Activation with Chromatin Templates Assembled In Vitro

  1998cited by this paper
• Modulation of Transcriptional Regulation by LEF-1 in Response to Wnt-1 Signaling and Association with β-Catenin

  1998influential reference
• Pontin52, an interaction partner of beta-catenin, binds to the TATA box binding protein.

  1998cited by this paper
• The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-β

  1998cited by this paper
• A SWI/SNF-related chromatin remodeling complex, E-RC1, is required for tissue-specific transcriptional regulation by EKLF in vitro.

  1998cited by this paper
• De Novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in skin.

  1998cited by this paper
• The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta.

  1998cited by this paper
• De Novo Hair Follicle Morphogenesis and Hair Tumors in Mice Expressing a Truncated β-Catenin in Skin

  1998cited by this paper
• Drosophila Tcf and Groucho interact to repress Wingless signalling activity

  1998cited by this paper
• The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors

  1998cited by this paper
• Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors.

  1998influential reference
• Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC−/− Colon Carcinoma

  1997cited by this paper
• Distinct roles for P-CREB and LEF-1 in TCR alpha enhancer assembly and activation on chromatin templates in vitro.

  1997cited by this paper
• pangolinencodes a Lef-1 homologue that acts downstream of Armadillo to transduce the Wingless signal in Drosophila

  1997cited by this paper
• Histone acetyltransferases regulate HIV-1 enhancer activity in vitro.

  1997cited by this paper
• Three-Dimensional Structure of the Armadillo Repeat Region of β-Catenin

  1997cited by this paper
• Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF.

  1997cited by this paper
• Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC

  1997cited by this paper
• Three-dimensional structure of the armadillo repeat region of beta-catenin.

  1997cited by this paper
• Cyclooxygenase-2 overexpression and tumor formation are blocked by sulindac in a murine model of familial adenomatous polyposis.

  1996cited by this paper
• Functional interaction of beta-catenin with the transcription factor LEF-1.

  1996cited by this paper
• XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos.

  1996cited by this paper
• Functional interaction of β-catenin with the transcription factor LEF-1

  1996cited by this paper
• Activation of the HIV-1 enhancer by the LEF-1 HMG protein on nucleosome-assembled DNA in vitro.

  1995cited by this paper
• Crystal Structure of a b -Catenin/Tcf Complex

  year unknowncited by this paper

• Dual-Proximity Labeling Strategy Identifies TrxR1 as a Cuproprotein that Regulates Apoptosis via Caspase-3 S-Nitrosylation.

  2026cites this paper
• Exposure to Brominated Flame Retardants During Pregnancy and Lactation Increases the Prevalence of Breast Lesions and Cancer-Associated Pathways in Sprague-Dawley Rats.

  2025cites this paper
• Research progress on NUSAP1 and its role in digestive system neoplasms

  2025cites this paper
• Why Is Wnt/β-Catenin Not Yet Targeted in Routine Cancer Care?

  2024cites this paper
• LEF1 enhances β-catenin transactivation through IDR-dependent liquid–liquid phase separation

  2023cites this paper
• Hepatocyte nuclear factor 1β suppresses canonical Wnt signaling through transcriptional repression of lymphoid enhancer-binding factor 1.

  2020cites this paper
• CTNNBIP1 modulates keratinocyte proliferation through promoting the transcription of β‐catenin/TCF complex downstream genes

  2020cites this paper
• CTNNBIP1 modulates keratinocyte differentiation through promoting the transcription of β-catenin/TCF-complex downstream genes

  2019influential citation
• Interaction of LEF1 with TAZ is necessary for the osteoblastogenic activity of Wnt3a

  2018cites this paper
• Ubiquitin C-terminal hydrolase37 regulates Tcf7 DNA binding for the activation of Wnt signalling

  2017cites this paper
• Opposing roles of ICAT and Wnt/β-catenin signaling in NSC67657-induced monocytic differentiation

  2017cites this paper
• HL-60细胞中ICAT基因沉默对Wnt信号通路及NSC67657诱导细胞分化的影响

  2017cites this paper
• Βeta-catenin N-terminal domain: An enigmatic region prone to cancer causing mutations.

  2017cites this paper
• A Simple Method to Assess Abundance of the β-Catenin Signaling Pool in Cells.

  2016cites this paper
• Wnt‐induced deubiquitination FoxM1 ensures nucleus β‐catenin transactivation

  2016cites this paper
• Frequent inactivation of MCC/CTNNBIP1 and overexpression of phospho-beta-catenin(Y654) are associated with breast carcinoma: Clinical and prognostic significance.

  2016cites this paper
• Positive regulation of β-catenin–PROX1 signaling axis by DBC1 in colon cancer progression

  2016cites this paper
• The WNT‐less wonder: WNT‐independent β‐catenin signaling

  2016cites this paper
• FoxM 1 , USP 5 , and ICAT in Wnt / b-catenin signaling

  2016cites this paper
• SMADs and YAP compete to control elongation of β-catenin:LEF-1-recruited RNAPII during hESC differentiation.

  2015cites this paper
• Cell Fate Determination by Notch

  2015cites this paper
• A conserved phosphorylation switch controls the interaction between cadherin and β-catenin in vitro and in vivo.

  2015cites this paper
• A Conserved Phosphorylation Switch Controls the Interaction between Cadherin and b-Catenin In Vitro and In Vivo Highlights

  2015cites this paper
• β-catenin inhibitor ICAT modulates the invasive motility of melanoma cells.

  2014cites this paper
• Regulation of target gene transcription by Wnt/β-catenin signaling

  2014cites this paper
• Wnt/β-catenin Pathway Functions by Inactivation of Tcf7l1 Protein

  2014influential citation
• Rôle de ICAT (inhibitor of β-catenin and TCF4) dans le développement normal et pathologique des mélanocytes

  2014cites this paper
• β-Catenin Inactivation Is a Pre-Requisite for Chick Retina Regeneration

  2014cites this paper
• Chromatin Dynamics During in vitro Differentiation of Human Urothelium

  2013cites this paper
• Regulation of Tcf7l1 DNA binding and protein stability as principal mechanisms of Wnt/β-catenin signaling.

  2013cites this paper
• Androgen Action, Wnt Signaling, and Prostate Tumorigenesis

  2013cites this paper
• Androgen-Responsive Genes in Prostate Cancer

  2013cites this paper
• Intrinsic properties of Tcf1 and Tcf4 splice variants determine cell-type-specific Wnt/β-catenin target gene expression

  2012cites this paper
• Pathophysiology of CKD-MBD

  2012cites this paper
• β-catenin is O-GlcNAc modified at Serine 23: Implications for β-catenin’s Subcellular Distribution and Transcriptional Activity

  2012cites this paper
• Prostaglandin E2 promotes the nuclear accumulation of lymphoid enhancer factor-1 in poorly differentiated breast cancer cells.

  2012cites this paper
• The importance of WNT pathways for bone metabolism and their regulation by implant topography.

  2012cites this paper
• Mecanismo molecular de la activación del enhancer del locus de la cadena alfa del receptor de linfocitos T (Tcra)

  2011cites this paper
• The beta-catenin binding protein ICAT modulates androgen receptor activity.

  2011influential citation
• FoxOs, Wnts and oxidative stress-induced bone loss: new players in the periodontitis arena?

  2011cites this paper
• Prostate Cancer Progression to Androgen Independent Disease: The Role of the Wnt/β-Catenin Pathway

  2011cites this paper
• Biochemical and structural characterization of β-catenin interactions with nonphosphorylated and CK2-phosphorylated Lef-1.

  2011cites this paper
• The -Catenin Binding Protein ICAT Modulates Androgen Receptor Activity

  2011influential citation
• Phosphorylation of TCF Proteins by Homeodomain-interacting Protein Kinase 2*

  2011cites this paper
• Histone H4 Lys 20 monomethylation by histone methylase SET8 mediates Wnt target gene activation

  2011cites this paper
• Non-cell-autonomous stimulation of stem cell proliferation following ablation of Tcf3.

  2010cites this paper
• beta-Catenin primes organizer gene expression by recruiting a histone H3 arginine 8 methyltransferase, Prmt2.

  2010cites this paper
• A lymphoid enhancer binding factor (Lef) 1 isoform regulates osteoblast maturation.

  2010cites this paper
• Osteocytes and WNT: the Mechanical Control of Bone Formation

  2010cites this paper
• LEF1/β-Catenin Complex Regulates Transcription of the Cav3.1 Calcium Channel Gene (Cacna1g) in Thalamic Neurons of the Adult Brain

  2010cites this paper
• Dysregulation of TNFα-induced necroptotic signaling in chronic lymphocytic leukemia: suppression of CYLD gene by LEF1

  2010cites this paper
• Analysis of chromatin modification and remodeling in the transcriptional regulation of the Wnt/Wg pathway

  2010influential citation
• Target gene selection in the wingless signaling pathway

  2009cites this paper
• B-catenin expression and associated signalling in moderately differentiated human oesophageal squamous carcinoma cell lines

  2009cites this paper
• β-Catenin hits chromatin: regulation of Wnt target gene activation

  2009cites this paper
• LoopingRegulates Transcription through Gene Lymphoid Enhancer Binding Factor 1

  2009cites this paper
• Alternative splicing of Tcf7l2 transcripts generates protein variants with differential promoter-binding and transcriptional activation properties at Wnt/β-catenin targets

  2009cites this paper
• The transcriptional activity of Pygopus is enhanced by its interaction with cAMP-response-element-binding protein (CREB)-binding protein.

  2009cites this paper
• Dissociation of E‐cadherin and β‐catenin in a mouse model of total parenteral nutrition: a mechanism for the loss of epithelial cell proliferation and villus atrophy

  2009cites this paper
• Lymphoid Enhancer Binding Factor 1 Regulates Transcription through Gene Looping1

  2009cites this paper
• Epigenetic background of neuronal fate determination.

  2009cites this paper
• Runx2 and bone morphogenic protein 2 regulate the expression of an alternative Lef1 transcript during osteoblast maturation

  2009cites this paper
• Lef‐1 isoforms regulate different target genes and reduce cellular adhesion

  2009cites this paper
• CHD8, a novel ATP-dependent chromatin remodeling enzyme

  2009cites this paper
• Transcriptional poising prior to the midblastula transition underlies dorsal cell fate specification by the Wnt/beta-catenin pathway

  2009cites this paper
• Chapter 22 – Notch

  2009cites this paper
• An oncogenic hub: beta-catenin as a molecular target for cancer therapeutics.

  2008cites this paper
• CHD8 Is an ATP-Dependent Chromatin Remodeling Factor That Regulates β-Catenin Target Genes

  2008cites this paper
• Wnt/β-catenin-mediated transcriptional regulation

  2007cites this paper
• Expression of motility-related protein MRP1/CD9, N-cadherin, E-cadherin, alpha-catenin and beta-catenin in retinoblastoma.

  2007cites this paper
• Necdin mediates skeletal muscle regeneration by promoting myoblast survival and differentiation

  2007cites this paper
• Stem cells and TCF proteins: a role for beta-catenin--independent functions.

  2007cites this paper
• Stem Cells and TCF Proteins: A Role for β-Catenin—Independent Functions

  2007cites this paper
• Wingless Signaling Induces Widespread Chromatin Remodeling of Target Loci

  2007cites this paper
• β-Catenin binds to the downstream region and regulates the expression C-reactive protein gene

  2007cites this paper
• Mammalian Nemo-like kinase enhances β-catenin-TCF transcription activity in human osteosarcoma and neuroblastoma cells

  2007cites this paper
• Molecular plasticity of β‐catenin: New insights from single‐molecule measurements and MD simulation

  2007cites this paper
• Expression of motility-related protein MRP1/CD9, N-cadherin, E-cadherin, α-catenin and β-catenin in retinoblastoma

  2007cites this paper
• No exit strategy? No problem: APC inhibits beta-catenin inside the nucleus.

  2006cites this paper
• Diversity of LEF/TCF action in development and disease

  2006cites this paper
• The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes.

  2006influential citation
• The Wnt/β-catenin pathway regulates Gli-mediated Myf5 expression during somitogenesis

  2006cites this paper
• Wnt signaling: is the party in the nucleus?

  2006cites this paper
• Molecular bases of the regulation of bone remodeling by the canonical Wnt signaling pathway.

  2006cites this paper
• Transcription under the Control of Nuclear Arm/β-Catenin

  2006cites this paper
• The Wnt/ (cid:2) -catenin pathway regulates Gli-mediated Myf5 expression during somitogenesis

  2006cites this paper
• CK2 controls the recruitment of Wnt regulators to target genes in vivo.

  2006cites this paper
• Wnt Activation and Alternative Promoter Repression of LEF1 in Colon Cancer

  2006cites this paper
• Parafibromin/Hyrax activates Wnt/Wg target gene transcription by direct association with beta-catenin/Armadillo.

  2006cites this paper
• Kotake nucleus-catenin inside the β No exit strategy ? No problem : APC inhibits

  2006cites this paper
• No exit strategy? No problem: APC inhibits (cid:1) -catenin inside the nucleus

  2006cites this paper
• Transcription under the control of nuclear Arm/beta-catenin.

  2006cites this paper
• A vertebrate homolog of the cell cycle regulator Dbf4 is an inhibitor of Wnt signaling required for heart development.

  2005cites this paper
• Wnt signaling in lymphopoiesis.

  2005cites this paper
• A role for MSX2 and necdin in smooth muscle differentiation of mesoangioblasts and other mesoderm progenitor cells.

  2005cites this paper
• β-catenin directly displaces Groucho/TLE repressors from Tcf/Lef in Wnt-mediated transcription activation

  2005cites this paper
• Wnt Signaling Networks and Embryonic Patterning

  2005cites this paper
• Distinct molecular forms of β-catenin are targeted to adhesive or transcriptional complexes

  2004cites this paper
• LDL receptor-related proteins 5 and 6 in Wnt/β-catenin signaling: Arrows point the way

  2004cites this paper
• A Nuclear Function for Armadillo/β-Catenin

  2004cites this paper