Activation of the proto-oncogene p60c-src by point mutations in the SH2 domain

No abstract is available for this paper.

• Publication year

  1990

• Venue

  Molecular and Cellular Biology

• Publication date

  1990-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/mcb.10.6.2855-2862.1990PMID 2111444PMCID PMC360647
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases

  1990cited by this paper
• Characterization of partially activated p60c-src in chicken embryo fibroblasts

  1989cited by this paper
• A mutation in v-src that removes a single conserved residue in the SH-2 domain of pp60v-src restricts transformation in a host-dependent manner

  1989cited by this paper
• Deletions within the amino-terminal half of the c-src gene product that alter the functional activity of the protein

  1989cited by this paper
• Purified maturation promoting factor phosphorylates pp60c-src at the sites phosphorylated during fibroblast mitosis.

  1989cited by this paper
• Studies of inositol phospholipid-specific phospholipase C.

  1989cited by this paper
• Mitosis-specific phosphorylation of p60c-src by p34cdc2-associated protein kinase.

  1989cited by this paper
• Biological and biochemical properties of the c-src+ gene product overexpressed in chicken embryo fibroblasts

  1989cited by this paper
• Phosphatidylinositol kinase type I activity associates with various oncogene products.

  1989cited by this paper
• Deletions and insertions within an amino-terminal domain of pp60v-src inactivate transformation and modulate membrane stability

  1989cited by this paper
• Transformation-specific tyrosine phosphorylation of a novel cellular protein in chicken cells expressing oncogenic variants of the avian cellular src gene

  1989cited by this paper
• Phosphatidylinositol kinase activity associates with viral p60src protein

  1989cited by this paper
• Linker insertion-deletion mutagenesis of the v-src gene: isolation of host- and temperature-dependent mutants

  1989cited by this paper
• Src homology 2 domain deletion mutants of p60v-src do not phosphorylate cellular proteins of 120-150 kDa.

  1989cited by this paper
• In vivo phosphorylation states and kinase activities of transforming p60c-src mutants.

  1989cited by this paper
• The common src homology region 2 domain of cytoplasmic signaling proteins is a positive effector of v-fps tyrosine kinase function

  1989cited by this paper
• Stable association of activated pp60src with two tyrosine-phosphorylated cellular proteins

  1989cited by this paper
• A novel viral oncogene with structural similarity to phospholipase C

  1988cited by this paper
• Cloning of bovine GAP and its interaction with oncogenic ras p21

  1988cited by this paper
• Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate

  1988cited by this paper
• Sequence similarity of phospholipase C with the non-catalytic region of src

  1988cited by this paper
• The first seven amino acids encoded by the v-src oncogene act as a myristylation signal: lysine 7 is a critical determinant

  1988cited by this paper
• Identification of multiple novel polypeptide substrates of the v-src, v-yes, v-fps, v-ros, and v-erb-B oncogenic tyrosine protein kinases utilizing antisera against phosphotyrosine.

  1988cited by this paper
• Activation of pp60c-src transforming potential by mutations altering the structure of an amino terminal domain containing residues 90-95.

  1988cited by this paper
• Immunological characterization of proteins detected by phosphotyrosine antibodies in cells transformed by Rous sarcoma virus

  1988cited by this paper
• Platelet-derived growth factor induces multisite phosphorylation of pp60c-src and increases its protein-tyrosine kinase activity

  1988cited by this paper
• Non-catalytic domains of cytoplasmic protein-tyrosine kinases: regulatory elements in signal transduction.

  1988cited by this paper
• Altered phosphorylation and activation of pp60c-src during fibroblast mitosis.

  1988cited by this paper
• Identification of an amino terminal domain required for the transforming activity of the Rous sarcoma virus src protein.

  1987cited by this paper
• An 81 kd protein complexed with middle T antigen and pp60c-src: a possible phosphatidylinositol kinase.

  1987cited by this paper
• A conserved domain regulates interactions of the v-fps protein-tyrosine kinase with the host cell.

  1987cited by this paper
• Neuronal pp60c-src contains a six-amino acid insertion relative to its non-neuronal counterpart.

  1987cited by this paper
• The structurally distinct form of pp60c-src detected in neuronal cells is encoded by a unique c-src mRNA

  1987cited by this paper
• Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity.

  1987cited by this paper
• A tail of two src's: mutatis mutandis.

  1987cited by this paper
• Cell transformation by the viral src oncogene.

  1987cited by this paper
• Enzymatically inactive p60c-src mutant with altered ATP-binding site is fully phosphorylated in its carboxy-terminal regulatory region.

  1987cited by this paper
• Rapid and efficient site-specific mutagenesis without phenotypic selection.

  1987cited by this paper
• Activation of the c-src Gene

  1986cited by this paper
• A noncatalytic domain conserved among cytoplasmic protein-tyrosine kinases modifies the kinase function and transforming activity of Fujinami sarcoma virus P130gag-fps

  1986cited by this paper
• Activation of the transforming potential of p60c-src by a single amino acid change.

  1986cited by this paper
• Amino acid substitutions sufficient to convert the nontransforming p60c-src protein to a transforming protein

  1986cited by this paper
• Genetic analysis of p60v-src domains involved in the induction of different cell transformation parameters

  1986cited by this paper
• Isolation of antibodies for phosphotyrosine by immunization with a v-abl oncogene-encoded protein

  1985cited by this paper
• Rapid and efficient site-specific mutagenesis without phenotypic selection.

  1985cited by this paper
• N-terminal deletions in Rous sarcoma virus p60src: effects on tyrosine kinase and biological activities and on recombination in tissue culture with the cellular src gene

  1985cited by this paper
• Expression of v-src and chicken c-src in rat cells demonstrates qualitative differences between pp60v-src and pp60c-src.

  1984cited by this paper
• Rous sarcoma virus variants that carry the cellular src gene instead of the viral src gene cannot transform chicken embryo fibroblasts.

  1984cited by this paper
• Overexpression of the c-src protein does not induce transformation of NIH 3T3 cells.

  1984cited by this paper
• Analysis of the catalytic domain of phosphotransferase activity of two avian sarcoma virus-transforming proteins.

  1984cited by this paper
• Structure and sequence of the cellular gene homologous to the RSV src gene and the mechanism for generating the transforming virus.

  1983cited by this paper
• Small deletion in src of Rous sarcoma virus modifying transformation phenotypes: identification of 207-nucleotide deletion and its smaller product with protein kinase activity

  1983cited by this paper
• Local mutagenesis of Rous sarcoma virus: the major sites of tyrosine and serine phosphorylation of pp60src are dispensable for transformation.

  1983cited by this paper
• Nucleotide sequence of Abelson murine leukemia virus genome: structural similarity of its transforming gene product to other onc gene products with tyrosine-specific kinase activity.

  1983cited by this paper
• Isolation of monoclonal antibodies that recognize the transforming proteins of avian sarcoma viruses

  1983cited by this paper
• Site-directed mutagenesis of the src gene of Rous sarcoma virus: construction and characterization of a deletion mutant temperature sensitive for transformation

  1982cited by this paper
• Nucleotide sequence of Fujinami sarcoma virus: evolutionary relationship of its transforming gene with transforming genes of other sarcoma viruses.

  1982cited by this paper
• Structural and functional domains of the Rous sarcoma virus transforming protein (pp60src).

  1981cited by this paper
• Molecular cloning and characterization of avian sarcoma virus circular DNA molecules

  1980influential reference
• The reverse turn as a polypeptide conformation in globular proteins.

  1973influential reference
• Rapid transformation of cells by Rous sarcoma virus.

  1969cited by this paper

• Phosphoinositide 3-kinases-a historical perspective.

  2012cites this paper
• SH 2 mutants of csrc that are host dependent for transformation are trans-dominant inhibitors of mouse cell transformation by activated csrc

  2007cites this paper
• SH2 Domain Structures

  2007cites this paper
• Human Melanocytes and Melanoma Cells Exhibits Elevated Specific Activity and Reduced Tyrosine 530 Phosphorylation Compared to Human Fibroblast

  2005cites this paper
• Binding of a High Affinity Phosphotyrosyl Peptide to the Src SH 2 Domain : Crystal Structures of the Complexed and Peptide

  2004cites this paper
• Philadelphia chromosome-positive human the BCR / ABL tyrosine kinase oncogene of BCR first exon sequences specifically activate

  2003cites this paper
• Specificity in signaling by c-Yes.

  2003cites this paper
• Abl: mechanisms of regulation and activation.

  2002cites this paper
• The kinase-deficient Src acts as a suppressor of the Abl kinase for Cbl phosphorylation.

  2000cites this paper
• Constitutive Activation of STAT5 by a Point Mutation in the SH2 Domain*

  2000cites this paper
• Phosphorylation of c-Crk II on the Negative Regulatory Tyr222 Mediates Nerve Growth Factor-induced Cell Spreading and Morphogenesis*

  2000cites this paper
• The C-terminal domain of the regulatory protein NOVH is sufficient to promote interaction with fibulin 1C: a clue for a role of NOVH in cell-adhesion signaling.

  1999cites this paper
• Acute retroviruses and oncogenesis.

  1999cites this paper
• Fisp12/Mouse Connective Tissue Growth Factor Mediates Endothelial Cell Adhesion and Migration through Integrin αvβ3, Promotes Endothelial Cell Survival, and Induces Angiogenesis In Vivo

  1999cites this paper
• CYR61, a product of a growth factor-inducible immediate early gene, promotes angiogenesis and tumor growth.

  1998cites this paper
• Identification of rCop-1, a New Member of the CCN Protein Family, as a Negative Regulator for Cell Transformation

  1998cites this paper
• Interactions between SH2 and SH3 domains.

  1998cites this paper
• The Human c-Src Proto-oncogene Promoter Contains Multiple Targets for Triplex-Forming Oligonucleotides

  1998cites this paper
• Specific stimulation of c-Fgr kinase by tyrosine-phosphorylated (poly)peptides--possible implication in the sequential mode of protein phosphorylation.

  1997cites this paper
• Src regulated by C-terminal phosphorylation is monomeric.

  1997cites this paper
• Identification of a family of low-affinity insulin-like growth factor binding proteins (IGFBPs): characterization of connective tissue growth factor as a member of the IGFBP superfamily.

  1997cites this paper
• pp60v-src transformation of rat cells but not chicken cells strongly correlates with low-affinity phosphopeptide binding by the SH2 domain.

  1997cites this paper
• Regulation, substrates and functions of src.

  1996cites this paper
• Protein phosphorylation and dephosphorylation in physiologic and oncologic processes.

  1996cites this paper
• A New Monoclonal Antibody Which Selectively Recognizes the Active Form of Src Tyrosine Kinase (*)

  1996cites this paper
• Cyr61, a product of a growth factor-inducible immediate-early gene, promotes cell proliferation, migration, and adhesion

  1996cites this paper
• Transformation of mouse cells by wild-type mouse c-Src.

  1995cites this paper
• Activation of Bruton's tyrosine kinase (BTK) by a point mutation in its pleckstrin homology (PH) domain.

  1995cites this paper
• Mutations in the non-catalytic domains of Fyn and Fgr tyrosine kinases reveal differences in mechanisms of their regulation.

  1995cites this paper
• The catalytic activity of Src‐family tyrosine kinase is required for B cell antigen receptor signaling

  1995cites this paper
• Signalling by the p60c-src family of protein-tyrosine kinases.

  1995cites this paper
• SH2 domain structure and function.

  1995cites this paper
• Association of p62, a multifunctional SH2- and SH3-domain-binding protein, with src family tyrosine kinases, Grb2, and phospholipase C gamma-1

  1995cites this paper
• A Bcl‐2‐related gene is activated in avian cells transformed by the Rous sarcoma virus.

  1995cites this paper
• The molecular basis of X-linked agammaglobulinemia

  1995cites this paper
• Regulation of the Src protein tyrosine kinase

  1995cites this paper
• Csk suppression of Src involves movement of Csk to sites of Src activity

  1994cites this paper
• Physical and functional interactions between SH2 and SH3 domains of the Src family protein tyrosine kinase p59fyn

  1994cites this paper
• Biochemistry of the Src protein-tyrosine kinase: regulation by SH2 and SH3 domains.

  1994cites this paper
• Focal adhesion as a signal transduction organelle

  1994cites this paper
• An RNA-binding protein associated with Src through its SH2 and SH3 domains in mitosis

  1994cites this paper
• Analysis of Ig‐alpha‐tyrosine kinase interaction reveals two levels of binding specificity and tyrosine phosphorylated Ig‐alpha stimulation of Fyn activity.

  1994cites this paper
• Activation of the Src family of tyrosine kinases in mammary tumorigenesis.

  1994cites this paper
• Rapid andefficient purification ofSrchomology 2domain-containin g proteins: Fyn, Cskandphosphatidylinos

  1994cites this paper
• Synthesis and biochemical evaluation of a series of aminoflavones as potential inhibitors of protein-tyrosine kinases p56lck, EGFr, and p60v-src.

  1994cites this paper
• Comparative study of three protein-tyrosine phosphatases. Chicken protein-tyrosine phosphatase lambda dephosphorylates c-Src tyrosine 527.

  1994cites this paper
• The role of tyrosine kinases and phosphotyrosine‐containing recognition motifs in regulation of the T cell‐antigen receptor‐mediated signal transduction pathway

  1994cites this paper
• Structure, regulation and function of phosphoinositide 3-kinases.

  1994cites this paper
• Autophosphorylation is required for high kinase activity and efficient transformation ability of proteins encoded by host range alleles of v-src

  1994cites this paper
• Highly conserved amino acids in the SH2 and catalytic domains of v-src are altered in naturally occurring, transformation-defective alleles.

  1994cites this paper
• Physical and functional interactions between SH2 and SH3 domains of the Src family protein tyrosine kinase p59fyn.

  1994cites this paper
• Rapid and efficient purification of Src homology 2 domain-containing proteins: Fyn, Csk and phosphatidylinositol 3-kinase p85.

  1994cites this paper
• Activation of phosphatidylinositol-3' kinase by Src-family kinase SH3 binding to the p85 subunit.

  1994cites this paper
• Thermodynamic studies of tyrosyl-phosphopeptide binding to the SH2 domain of p56lck.

  1994cites this paper
• New insights into protein‐tyrosine kinase receptor signaling complexes

  1993cites this paper
• En bloc substitution of the Src homology region 2 domain activates the transforming potential of the c-Abl protein tyrosine kinase.

  1993cites this paper
• Csk inhibition of c‐Src activity requires both the SH2 and SH3 domains of Src.

  1993cites this paper
• The Src family of protein tyrosine kinases: regulation and functions.

  1993cites this paper
• Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides

  1993cites this paper
• Regulation of c-Src tyrosine kinase activity by the Src SH2 domain.

  1993cites this paper
• CD19 of B cells as a surrogate kinase insert region to bind phosphatidylinositol 3-kinase.

  1993cites this paper
• Evidence for autoinhibitory regulation of the c-src gene product. A possible interaction between the src homology 2 domain and autophosphorylation site.

  1993cites this paper
• Root development in Arabidopsis: four mutants with dramatically altered root morphogenesis.

  1993cites this paper
• SH2 domains exhibit high-affinity binding to tyrosine-phosphorylated peptides yet also exhibit rapid dissociation and exchange

  1993cites this paper
• SH2 domains of the protein-tyrosine kinases Blk, Lyn, and Fyn(T) bind distinct sets of phosphoproteins from B lymphocytes.

  1993cites this paper
• The SH3 domain of p56lck is involved in binding to phosphatidylinositol 3'-kinase from T lymphocytes

  1993cites this paper
• Signalling through SH2 and SH3 domains.

  1993cites this paper
• Direct analysis of the binding of the abl Src homology 2 domain to the activated epidermal growth factor receptor.

  1993cites this paper
• The lethality of p60v-src in Saccharomyces cerevisiae and the activation of p34CDC28 kinase are dependent on the integrity of the SH2 domain.

  1993cites this paper
• Binding of the Src SH2 domain to phosphopeptides is determined by residues in both the SH2 domain and the phosphopeptides

  1993cites this paper
• Deletion of the SH3 domain of Src interferes with regulation by the phosphorylated carboxyl-terminal tyrosine.

  1993cites this paper
• The cell cycle and c-Src.

  1993cites this paper
• CD45 specifically modulates binding of Lck to a phosphopeptide encompassing the negative regulatory tyrosine of Lck.

  1993cites this paper
• Single point mutations in the SH2 domain impair the transforming potential of vav and fail to activate proto-vav.

  1993cites this paper
• Tyrosine phosphorylation and dephosphorylation in T lymphocyte activation.

  1993cites this paper
• Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: crystal structures of the complexed and peptide-free forms.

  1993cites this paper
• Kinetics of p56lck and p60src Src homology 2 domain binding to tyrosine-phosphorylated peptides determined by a competition assay or surface plasmon resonance.

  1993cites this paper
• Regulation and Functions of Src-Family Kinases: An Update

  1993cites this paper
• Three-dimensional solution structure of the src homology 2 domain of c-abl.

  1992cites this paper
• Identification of distinct populations of PI-3 kinase activity following T-cell activation.

  1992cites this paper
• Characterization of protein tyrosine kinases from human breast cancer: involvement of the c-src oncogene product.

  1992cites this paper
• Proteins with SH2 domains: transducers in the tyrosine kinase signaling pathway.

  1992cites this paper
• The pp60c-src in retinal pigment epithelium and its modulation by vasoactive intestinal peptide.

  1992cites this paper
• SH2 and SH3 domains

  1992cites this paper
• Membrane and Signal Transduction Targets

  1992cites this paper
• Tyrosine kinases and their interactions with signalling proteins.

  1992cites this paper
• Three-dimensional solution structure of the src homology 2 domain of c-abl.

  1992cites this paper
• Phosphorylation and regulatory effects of the carboxy terminus of a Drosophila src homolog.

  1992cites this paper
• Point mutations in the abl SH2 domain coordinately impair phosphotyrosine binding in vitro and transforming activity in vivo

  1992cites this paper
• The src family of tyrosine protein kinases in hemopoietic signal transduction

  1992cites this paper
• Regulation of the enzymatic function of the lymphocyte-specific tyrosine protein kinase p56lck by the non-catalytic SH2 and SH3 domains.

  1992cites this paper
• pp60c-src in human melanocytes and melanoma cells exhibits elevated specific activity and reduced tyrosine 530 phosphorylation compared to human fibroblast pp60c-src.

  1992cites this paper
• Effects of SH2 and SH3 deletions on the functional activities of wild-type and transforming variants of c-Src

  1992cites this paper
• Functional analysis of the SH2 and SH3 domains of the lck tyrosine protein kinase.

  1992cites this paper
• Deletions in the SH2 domain of p60v-src prevent association with the detergent-insoluble cellular matrix

  1991cites this paper
• A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region.

  1991cites this paper
• BCR first exon sequences specifically activate the BCR/ABL tyrosine kinase oncogene of Philadelphia chromosome-positive human leukemias

  1991cites this paper
• SH2 domains: elements that control protein interactions during signal transduction.

  1991cites this paper
• The noncatalytic src homology region 2 segment of abl tyrosine kinase binds to tyrosine-phosphorylated cellular proteins with high affinity.

  1991cites this paper
• SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins.

  1991cites this paper