Novel human monoclonal antibodies to insulin-like growth factor (IGF)-II that potently inhibit the IGF receptor type I signal transduction function

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Molecular Cancer Therapeutics

• Publication date

  2006-01-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1158/1535-7163.MCT-05-0252PMID 16432169
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The role of the growth hormone/insulin-like growth factor axis in tumor growth and progression: Lessons from animal models.

  2005cited by this paper
• Blockade of Paracrine Supply of Insulin-Like Growth Factors Using Neutralizing Antibodies Suppresses the Liver Metastasis of Human Colorectal Cancers

  2005influential reference
• Insulin-like growth factor-I and breast cancer therapy.

  2005cited by this paper
• The therapeutic potential of agents targeting the type I insulin-like growth factor receptor

  2004cited by this paper
• Growth Inhibition of Human Prostate Cancer Cells in Human Adult Bone Implanted into Nonobese Diabetic/Severe Combined Immunodeficient Mice by a Ligand-Specific Antibody to Human Insulin-Like Growth Factors

  2004influential reference
• Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors.

  2004cited by this paper
• The new kid on the block(ade) of the IGF-1 receptor.

  2004cited by this paper
• A Dominant Negative Type I Insulin-like Growth Factor Receptor Inhibits Metastasis of Human Cancer Cells*

  2004cited by this paper
• In vivo antitumor activity of NVP-AEW541-A novel, potent, and selective inhibitor of the IGF-IR kinase.

  2004cited by this paper
• An anti-insulin-like growth factor I receptor antibody that is a potent inhibitor of cancer cell proliferation.

  2003cited by this paper
• A fully human monoclonal antibody to the insulin-like growth factor I receptor blocks ligand-dependent signaling and inhibits human tumor growth in vivo.

  2003cited by this paper
• A chimeric humanized single-chain antibody against the type I insulin-like growth factor (IGF) receptor renders breast cancer cells refractory to the mitogenic effects of IGF-I.

  2003cited by this paper
• The insulin-like growth factor system and cancer.

  2003cited by this paper
• Insulin-like growth factor receptor-1 as an anti-cancer target: blocking transformation and inducing apoptosis.

  2002cited by this paper
• Neutralizing anti-insulin-like growth factor receptor 1 antibodies inhibit receptor function and induce receptor degradation in tumor cells.

  2002cited by this paper
• Phage Display: A Laboratory Manual

  2001cited by this paper
• The molecular and cellular biology of HER2/neu gene amplification/overexpression and the clinical development of herceptin (trastuzumab) therapy for breast cancer.

  2000cited by this paper
• The contradictions of the insulin-like growth factor 1 receptor

  2000cited by this paper
• Insulin-like growth factor receptors and binding proteins.

  1996cited by this paper
• Effects of insulin-like growth factors (IGFs) and IGF receptor antibodies on the proliferation of human breast cancer cells.

  1992cited by this paper
• Blockade of the type I somatomedin receptor inhibits growth of human breast cancer cells in athymic mice.

  1989cited by this paper
• Growth inhibition of human breast cancer cells in vitro with an antibody against the type I somatomedin receptor.

  1989cited by this paper
• Identification and Characterization of a New Cross-Reactive Human Immunodeficiency Virus Type 1-Neutralizing Human Monoclonal Antibody

  year unknowncited by this paper

• Paraneoplastic hypoglycemia: An overview for optimal clinical guidance

  2024cites this paper
• Hypoglycemia in Children: Major Endocrine-Metabolic Causes and Novel Therapeutic Perspectives

  2023cites this paper
• IGFBP-7 secreted by adipose-derived stem cells inhibits keloid formation via the BRAF/MEK/ERK signaling pathway.

  2023cites this paper
• Steviol glycosides affect functional properties and macromolecular expression of breast cancer cells

  2022cites this paper
• IGF family effects on development, stability, and treatment of hematological malignancies

  2020cites this paper
• Advances in insulin-like growth factor biology and -directed cancer therapeutics.

  2020cites this paper
• The IGF-II–Insulin Receptor Isoform-A Autocrine Signal in Cancer: Actionable Perspectives

  2020cites this paper
• The role of insulin-like growth factors in the development of prostate cancer

  2020cites this paper
• Non-islet Cell Hypoglycemia: Case Series and Review of the Literature

  2019cites this paper
• A novel epitope-presenting thermostable scaffold for the development of highly specific insulin-like growth factor-1/2 antibodies

  2019cites this paper
• Bladder urothelial carcinoma producing insulin‐like growth factor II: A case report

  2018cites this paper
• Non Islet Cell Hypoglycemia

  2018cites this paper
• A dual-specific IGF-I/II human engineered antibody domain inhibits IGF signaling in breast cancer cells

  2018cites this paper
• Clinical studies in humans targeting the various components of the IGF system show lack of efficacy in the treatment of cancer.

  2017cites this paper
• High affinity FRβ-specific CAR T cells eradicate AML and normal yeloid lineage without HSC toxicity

  2016cites this paper
• Human IGF1 pro-forms induce breast cancer cell proliferation via the IGF1 receptor

  2016cites this paper
• Classical and non-classical proangiogenic factors as a target of antiangiogenic therapy in tumor microenvironment.

  2016cites this paper
• A computational model for investigating the effects of changes in bioavailability of insulin-like growth factor-1 on the homeostasis of the intervertebral disc

  2016cites this paper
• Differential killing of CD56-expressing cells by drug-conjugated human antibodies targeting membrane-distal and membrane-proximal non-overlapping epitopes

  2016cites this paper
• Type I insulin-like growth factor receptor signaling in hematological malignancies

  2016cites this paper
• Frβ-directed car T cells for immunotherapy of cancer

  2015cites this paper
• A dual‐specific anti‐IGF‐1/IGF‐2 human monoclonal antibody alone and in combination with temsirolimus for therapy of neuroblastoma

  2015cites this paper
• Globalni proteomski profil ekspresije i uloga proteina IGF2/IGF2R u patogenezi prekanceroznih lezija usne šupljine

  2015cites this paper
• A new bispecific antibody targeting non-overlapping epitopes on IGF2: design, in vitro characterization and pharmacokinetics in macaques.

  2014cites this paper
• Discovery of novel candidate therapeutics and diagnostics based on engineered human antibody domains.

  2014cites this paper
• The insulin-like growth factor 1 axis in prognosis and treatment of breast cancer

  2014cites this paper
• Engineered Antibody Domains as Candidate Therapeutics

  2014cites this paper
• IGF2 and cancer.

  2013cites this paper
• Targeting Non-Small Cell Lung Cancer Cells by Dual Inhibition of the Insulin Receptor and the Insulin-Like Growth Factor-1 Receptor

  2013cites this paper
• Circulating insulin-like growth factors may contribute substantially to insulin receptor isoform A and insulin receptor isoform B signalling.

  2013cites this paper
• Tumors, IGF-2, and hypoglycemia: insights from the clinic, the laboratory, and the historical archive.

  2013cites this paper
• Something old, something new and something borrowed: emerging paradigm of insulin-like growth factor type 1 receptor (IGF-1R) signaling regulation

  2013influential citation
• Exceptionally Potent and Broadly Cross-Reactive, Bispecific Multivalent HIV-1 Inhibitors Based on Single Human CD4 and Antibody Domains

  2013cites this paper
• Preclinical Development Potent Inhibition of Angiogenesis by the IGF-1 Receptor-Targeting Antibody SCH 717454 Is Reversed by IGF2

  2012cites this paper
• 'Big'-insulin-like growth factor-II signaling is an autocrine survival pathway in gastrointestinal stromal tumors.

  2012cites this paper
• The role of mTOR inhibitors in the inhibition of growth and cortisol secretion in human adrenocortical carcinoma cells.

  2012cites this paper
• The IGF-I Axis in Prostate Cancer: The Role of Rapid Steroid Actions

  2012cites this paper
• Targeting the Insulin-Like Growth Factor (IGF) System Is Not as Simple as Just Targeting the Type 1 IGF Receptor.

  2012cites this paper
• Targeting insulin-like growth factor in breast cancer therapeutics.

  2012cites this paper
• Human Monoclonal Antibodies Targeting Nonoverlapping Epitopes on Insulin-like Growth Factor II as a Novel Type of Candidate Cancer Therapeutics

  2012influential citation
• Antibody-based therapeutics against components of the IGF system

  2012cites this paper
• A folate receptor beta-specific human monoclonal antibody recognizes activated macrophage of rheumatoid patients and mediates antibody-dependent cell-mediated cytotoxicity

  2011cites this paper
• IGF-I and Insulin Receptor Families in Cancer

  2011cites this paper
• Endocrine-Related Cancer ( 2011 ) 18 R 125 – R 147 Insulin receptor and cancer

  2011cites this paper
• Insulin Resistance and Cancer: Epidemiology, Cellular and Molecular Mechanisms and Clinical Implications

  2011cites this paper
• Targeting IGF-I, IGFBPs and IGF-I receptor system in cancer: the current and future in breast cancer therapy.

  2011cites this paper
• The Insulin Receptor: A New Target for Cancer Therapy

  2011cites this paper
• Plasma and tissue insulin-like growth factor-I receptor (IGF-IR) as a prognostic marker for prostate cancer and anti-IGF-IR agents as novel therapeutic strategy for refractory cases: a review.

  2011cites this paper
• Engineered Single Human CD4 Domains as Potent HIV-1 Inhibitors and Components of Vaccine Immunogens

  2011cites this paper
• Human Monoclonal Antibody Fragments Binding to Insulin-like Growth Factors I and II with Picomolar Affinity

  2011cites this paper
• Insulin receptor and cancer.

  2011cites this paper
• The Molecular Basis of Sarcoma

  2011cites this paper
• Potent Inhibition of Angiogenesis by the IGF-1 Receptor-Targeting Antibody SCH717454 Is Reversed by IGF-2

  2011cites this paper
• Malaguarnera : IR and cancer Studies linking insulin resistance , circulating insulin , and cancer

  2011cites this paper
• Targeting of Bone-Derived Insulin-Like Growth Factor-II by a Human Neutralizing Antibody Suppresses the Growth of Prostate Cancer Cells in a Human Bone Environment

  2010cites this paper
• Targeting Angiogenesis in Childhood Sarcomas

  2010influential citation
• Identification and characterization of a novel agonistic anti-DR4 human monoclonal antibody

  2010cites this paper
• Expression of IGF1R in normal breast tissue and subsequent risk of breast cancer

  2010cites this paper
• Targeting the type I insulin-like growth factor system for breast cancer therapy.

  2010cites this paper
• Dalotuzumab, a recombinant humanized mAb targeted against IGFR1 for the treatment of cancer.

  2010cites this paper
• A Human Monoclonal Antibody against Insulin-Like Growth Factor-II Blocks the Growth of Human Hepatocellular Carcinoma Cell Lines In vitro and In vivo

  2010cites this paper
• Hepatic cancer stem cells and drug resistance: Relevance in targeted therapies for hepatocellular carcinoma.

  2010cites this paper
• Ligand-Specific Antibodies to Insulin-Like Growth Factors Suppress Intestinal Polyp Formation in Apc+/− Mice

  2010cites this paper
• Molecular Therapy for Rhabdomyosarcoma

  2010cites this paper
• Implications of insulin‐like growth factor‐I for prostate cancer therapies

  2009cites this paper
• Characterization of a chimeric monoclonal antibody against the insulin-like growth factor-I receptor

  2009cites this paper
• Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease.

  2009cites this paper
• Molecular mechanisms involved in activity of h7C10, a humanized monoclonal antibody, to IGF‐1 receptor

  2009cites this paper
• A novel human monoclonal antibody that binds with high affinity to mesothelin-expressing cells and kills them by antibody-dependent cell-mediated cytotoxicity

  2009cites this paper
• The role of IGF-1R in pediatric malignancies.

  2009cites this paper
• Construction of a large naïve human phage-displayed Fab library through one-step cloning.

  2009cites this paper
• Reversibility and recurrence of IGF-IR-induced mammary tumors

  2009cites this paper
• Molecularly targeted therapy for hepatocellular carcinoma

  2009cites this paper
• Molecular markers in epithelial ovarian cancer: paving the way to innovative therapies

  2009cites this paper
• Sensitivity of breast cancer cell lines to the novel insulin-like growth factor-1 receptor (IGF-1R) inhibitor NVP-AEW541 is dependent on the level of IRS-1 expression.

  2009cites this paper
• The Role of IGF-1 R in Pediatric Malignancies

  2009cites this paper
• Growth Factors, Cytokines, Cell Cycle Molecules Neuraminidase-1, a Subunit of the Cell Surface Elastin Receptor, Desialylates and Functionally Inactivates Adjacent Receptors Interacting with the Mitogenic Growth Factors PDGF-BB and IGF-2

  2008cites this paper
• Early drug development of inhibitors of the insulin-like growth factor-I receptor pathway: Lessons from the first clinical trials

  2008cites this paper
• Monoclonal antibodies against components of the IGF system for cancer treatment.

  2008cites this paper
• Cross-Talk Between the ErbB/HER Family and the Type I Insulin-Like Growth Factor Receptor Signaling Pathway in Breast Cancer

  2008cites this paper
• Regulation of Breast Cancer Metastasis by IGF Signaling

  2008cites this paper
• Reactivation of the insulin-like growth factor-II signaling pathway in human hepatocellular carcinoma.

  2008cites this paper
• Design and characterization of a plasmid vector system capable of rapid generation of antibodies of multiple isotypes and specificities

  2008cites this paper
• Growth factor receptors and related signalling pathways as targets for novel treatment strategies of hepatocellular cancer.

  2008cites this paper
• IGF and Insulin Receptor Signaling in Breast Cancer

  2008cites this paper
• IGF signaling pathway as a selective target of familial breast cancer therapy.

  2008cites this paper
• Treatment of gastrointestinal neuroendocrine tumors with inhibitors of growth factor receptors and their signaling pathways: recent advances and future perspectives.

  2008cites this paper
• Targeted medical therapy of biliary tract cancer: recent advances and future perspectives.

  2008cites this paper
• Biological & physiological aspects of action of insulin-like growth factor peptide family.

  2007cites this paper
• The insulin-like growth factor 1 receptor in cancer: old focus, new future.

  2007cites this paper
• Activated coagulation factors in human malignant effusions and their contribution to cancer cell metastasis and therapy

  2007cites this paper
• Novel human monoclonal antibodies to insulin-like growth factor (IGF)-II that potently inhibit the IGF receptor type I signal transduction functionFeng Y, Zhu Z, Xiao X, et al (NIH, Frederick, Md; NIH, Bethesda, Md) Mol Cancer Ther 5:114–120, 2006§

  2007cites this paper
• Emerging therapies for colorectal cancer

  2007cites this paper
• Functional evaluation of novel soluble insulin-like growth factor (IGF)-II–specific ligand traps based on modified domain 11 of the human IGF2 receptor

  2007cites this paper
• Molekulare RNAinterference-Analysen zur Funktion des insulin-like growth factor (IGF)-II Signalweges in der humanen Hepatokarzinogenese

  2006cites this paper
• Novel therapies in colon cancer

  2006cites this paper
• Insulin-Like Growth Factor and Lung Cancer (Pathway of the Month)

  2006cites this paper
• Inhibitors of Insulin-like Growth Factor Signaling: A Therapeutic Approach for Breast Cancer

  2006cites this paper
• IGF-I mediated survival pathways in normal and malignant cells.

  2006cites this paper
• Insulin-like growth factor and lung cancer.

  2006cites this paper