The Role of Early Life Microbiota Composition in the Development of Allergic Diseases

Allergic diseases are becoming a major healthcare issue in many developed nations, where living environment and lifestyle are most predominantly distinct. Such differences include urbanized, industrialized living environments, overused hygiene products, antibiotics, stationary lifestyle, and fast-food-based diets, which tend to reduce microbial diversity and lead to impaired immune protection, which further increase the development of allergic diseases. At the same time, studies have also shown that modulating a microbiocidal community can ameliorate allergic symptoms. Therefore, in this paper, we aimed to review recent findings on the potential role of human microbiota in the gastrointestinal tract, surface of skin, and respiratory tract in the development of allergic diseases. Furthermore, we addressed a potential therapeutic or even preventive strategy for such allergic diseases by modulating human microbial composition.

• Publication year

  2022

• Venue

  Microorganisms

• Publication date

  2022-06-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.3390/microorganisms10061190PMID 35744708PMCID 9227185
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2020influential reference
• Factors affecting early-life intestinal microbiota development.

  2020cited by this paper
• Association of Infant Antibiotic Exposure With Childhood Health Outcomes.

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  2019cited by this paper
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  2019cited by this paper
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  2019cited by this paper
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  2019cited by this paper
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  2019cited by this paper
• Is preterm birth associated with asthma among children from birth to 17 years old? -A study based on 2011-2012 US National Survey of Children’s Health

  2018cited by this paper
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  2018cited by this paper
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  2018cited by this paper
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  2018cited by this paper
• Microbiota and Food Allergy

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• Prenatal antibiotic exposure and childhood asthma: a population-based study

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• Immunologic, microbial, and epithelial interactions in atopic dermatitis.

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• Prenatal and early‐life antibiotic use and risk of childhood asthma: A retrospective cohort study

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• Pregnancy diet and offspring asthma risk over a 10-year period: the Lifeways Cross Generation Cohort Study, Ireland

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  2018cited by this paper
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  2017cited by this paper
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• The microbiome in allergic disease: Current understanding and future opportunities—2017 PRACTALL document of the American Academy of Allergy, Asthma & Immunology and the European Academy of Allergy and Clinical Immunology

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