Analysis of structural requirements for the absorption of drugs and macromolecules from the nasal cavity.

No abstract is available for this paper.

• Publication year

  1987

• Venue

  Journal of Pharmacy and Science

• Publication date

  1987-07-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1002/JPS.2600760709PMID 2889824
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Effects of DDAVP, a synthetic analogue of vasopressin, in patients with cranial diabetes insipidus.

  2009cited by this paper
• Plasma oxytocin concentrations in man after different routes of administration of synthetic oxytocin.

  2009cited by this paper
• Comparison of nonelectrolyte permeability patterns in several epithelia

  2005cited by this paper
• Intranasal delivery of nicardipine in the rat.

  1986cited by this paper
• Effects of intravenous, subcutaneous, and intranasal administration of growth hormone (GH)-releasing hormone-40 on serum GH concentrations in normal men.

  1985cited by this paper
• Nasal absorption of insulin: enhancement by hydrophobic bile salts.

  1985cited by this paper
• Effects of dose, pH, and osmolarity on nasal absorption of secretin in rats.

  1985cited by this paper
• Nasal delivery of polypeptides I: nasal absorption of enkephalins in rats.

  1985cited by this paper
• Intranasal drug delivery by spray and drops

  1985cited by this paper
• Peroral treatment of diabetes insipidus with a polypeptide hormone analog, desmopressin.

  1985cited by this paper
• Effect of subcutaneous and intranasal administration of ovine corticotropin-releasing hormone in man: comparison with intravenous administration.

  1985cited by this paper
• The nasal absorption of sodium cromoglycate in the albino rat

  1985cited by this paper
• Intranasal aerosolized insulin. Mixed-meal studies and long-term use in type I diabetes.

  1985cited by this paper
• Serum concentration patterns of an LHRH agonist, gonadotrophins and sex steroids after subcutaneous, vaginal, rectal and nasal administration of the agonist to pregnant rats.

  1984cited by this paper
• An immunospecific enzyme assay for horseradish peroxidase.

  1984cited by this paper
• Changes in plasma thyrotrophin-releasing hormone, thyrotrophin, prolactin and thyroid hormone levels after intravenous, intranasal or rectal administration of synthetic thyrotrophin-releasing hormone in man.

  1984cited by this paper
• Nasal drug delivery system of a quaternary ammonium compound: clofilium tosylate.

  1984cited by this paper
• Distribution and clearance of radioactive aerosol on the nasal mucosa.

  1984cited by this paper
• Absorption from the nasal mucous membrane. I. Nasal absorption of hydralazine in rats.

  1983cited by this paper
• in vitroとin vivoの薬物利用率を関連づける手段としての数字であらわしたコンボルューションとデコンボルューション

  1982cited by this paper
• Absorption of drugs from the nasal mucosa of rat

  1981cited by this paper
• Mechanisms for the enhancement of the nasal absorption of insulin by surfactants

  1981cited by this paper
• Nasal absorption of natural contraceptive steroids in rats-progesterone absorption.

  1981cited by this paper
• Nasal absorption of propranolol from different dosage forms by rats and dogs.

  1980cited by this paper
• Topical administration of progestational steroids in the eye and nose--a rapid absorption to the blood.

  1978cited by this paper
• Use of octadecasilyl-silica for the extraction and purification of peptides in biological samples. Application to the identification of circulating metabolites of corticotropin-(1-24)-tetracosapeptide and somatostatin in vivo.

  1977cited by this paper
• Distribution and removal of human serum albumin-technetium 99m instilled intranasally.

  1976cited by this paper
• Comparison of plasma levels of luteinizing hormone releasing hormone in men after intravenous or intranasal administration.

  1974cited by this paper
• TREATMENT OF DIABETES INSIPIDUS IN CHILDREN WITH DDAVP, A SYNTHETIC ANALOGUE OF VASOPRESSIN

  1973cited by this paper
• FRACTURE FACES OF ZONULAE OCCLUDENTES FROM "TIGHT" AND "LEAKY" EPITHELIA

  1973cited by this paper
• Intranasal application of luteinising-hormone releasing hormone.

  1973cited by this paper
• Hormonal responses to intranasal luteinizing hormone releasing hormone.

  1973cited by this paper
• Response to orally administered synthetic thyrotropin-releasing hormone in man.

  1972cited by this paper
• Synthetic lysine vasopressin nasal spray in the treatment of diabetes insipidus

  1964cited by this paper
• Permeability of Luminal Surface of Intestinal Mucosal Cells

  1962cited by this paper

• Intranasal Delivery of a Ghrelin Mimetic Engages the Brain Ghrelin Signaling System in Mice

  2025cites this paper
• Advanced intranasal peptide delivery systems for improved management of Alzheimer's disease.

  2025cites this paper
• Intranasal Absorption Enhancement of Antidiabetic Therapeuticals by the Functional Peptide Segment of Latroeggtoxin-VI.

  2025cites this paper
• Pharmacokinetics of intranasal levetiracetam in healthy dogs: a feasible route of administration.

  2025cites this paper
• Acute particulate matter exposure diminishes executive cognitive functioning after four hours regardless of inhalation pathway

  2025cites this paper
• Grueneberg Ganglion: An Unexplored Site for Intranasal Drug Delivery in Alzheimer's Disease.

  2025cites this paper
• An Overview on Protein and Peptide Drug Delivery System: Advancesand Strategies

  2024cites this paper
• Alternative Approaches for Addressing Acute Agitation in Schizophrenia and Bipolar Disorder.

  2024cites this paper
• Comprehensive evaluation of xylometazoline hydrochloride formulations: Ex-vivo and in-vitro studies.

  2024cites this paper
• Diazepam intranasal: una nueva estrategia para el tratamiento inmediato en la emergencia en pacientes con epilepsia

  2024cites this paper
• PLGA nanoparticles for nasal drug delivery

  2024cites this paper
• Nose-to-Brain delivery of donepezil hydrochloride following administration of an HPMC-Me-β-CD-PEG400 nasal film in mice

  2023cites this paper
• [Development of New Sublingual Formulation for Transmucosal Delivery of Peptides].

  2023cites this paper
• Transnasal-brain delivery of nanomedicines for neurodegenerative diseases

  2023cites this paper
• Intranasal transmucosal drug delivery: An alternative approach to the parenteral route for medical emergencies

  2023cites this paper
• Intranasal Fentanyl for Acute Pain Management in Children, Adults and Elderly Patients in the Prehospital Emergency Service and in the Emergency Department: A Systematic Review

  2023cites this paper
• Assessment of safety and intranasal neutralizing antibodies of HPMC-based human anti-SARS-CoV-2 IgG1 nasal spray in healthy volunteers

  2023cites this paper
• Utility of a Novel Micro-Spraying Device for Intranasal Administration of Drug Solutions to Mice

  2023cites this paper
• 鼻腔药物递送的影响因素和提高递送效率的设计策略

  2023cites this paper
• Applications of Polymeric Nanoparticle in Nose to Brain Drug Delivery

  2023cites this paper
• From Small Peptides to Large Proteins against Alzheimer’sDisease

  2022cites this paper
• Development of In Vitro Evaluation System for Assessing Drug Dissolution Considering Physiological Environment in Nasal Cavity

  2022cites this paper
• Unlocking the promise of mRNA therapeutics

  2022cites this paper
• Spanlastics as a Potential Platform for Enhancing the Brain Delivery of Flibanserin: In Vitro Response-Surface Optimization and In Vivo Pharmacokinetics Assessment

  2022cites this paper
• Advanced particulate carrier-mediated technologies for nasal drug delivery

  2022cites this paper
• The nose has it: Opportunities and challenges for intranasal drug administration for neurologic conditions including seizure clusters

  2022cites this paper
• Systemic and brain delivery of antidiabetic peptides through nasal administration using cell-penetrating peptides

  2022cites this paper
• Nasal Route: A Breakthrough for Drug Delivery

  2022cites this paper
• A randomized, placebo-controlled trial of a nasal spray solution containing broadly potent neutralizing antibodies against SARS-CoV-2 variants in healthy volunteers

  2022cites this paper
• First-line management of canine status epilepticus at home and in hospital-opportunities and limitations of the various administration routes of benzodiazepines

  2021cites this paper
• A REVIEW ON NOSE TO BRAIN DRUG DELIVERY SYSTEM

  2021cites this paper
• Microemulsion as a promising carrier for nose to brain delivery: journey since last decade

  2021cites this paper
• Evaluation of the Pharmacokinetics of Intranasal Drug Delivery for Targeting Cervical Lymph Nodes in Rats

  2021cites this paper
• Physicochemical, biopharmaceutical, and practical considerations for efficient nose-to-brain drug delivery

  2021cites this paper
• Therapeutic nanoparticles in the brain: a review of types, physicochemical properties and challenges.

  2021cites this paper
• Hemagglutinin Nanoparticulate Vaccine with Controlled Photochemical Immunomodulation for Pathogenic Influenza‐Specific Immunity

  2021cites this paper
• Improvement of Intranasal Drug Delivery with Intravail® Alkylsaccharide Excipient as a Mucosal Absorption Enhancer Aiding in the Treatment of Conditions of the Central Nervous System

  2021cites this paper
• Applications of direct nose-to-brain drug delivery in biomedicine, biotechnology, tissue engineering, and immunology

  2021cites this paper
• An overview of anatomical and physiological aspects of the nose and the brain

  2021cites this paper
• The importance of pre-formulation studies and of 3D-printed nasal casts in the success of a pharmaceutical product intended for nose-to-brain delivery.

  2021cites this paper
• Generation of KS-133 as a Novel Bicyclic Peptide with a Potent and Selective VIPR2 Antagonist Activity that Counteracts Cognitive Decline in a Mouse Model of Psychiatric Disorders

  2021influential citation
• A Comprehensive Review of Intranasal Insulin and Its Effect on the Cognitive Function of Diabetics

  2021cites this paper
• Investigating Secreted Amyloid Precursor Protein-alpha and its Functional Domains in Stimulating Hippocampal Protein Synthesis

  2020cites this paper
• Advances in nasal drug delivery systems

  2020cites this paper
• Nose‐to‐brain delivery of sumatriptan‐loaded nanostructured lipid carriers: preparation, optimization, characterization and pharmacokinetic evaluation

  2020cites this paper
• Albumin-bound nanodiscs as delivery vehicle candidates: Development and characterization.

  2019cites this paper
• Inhalation Drug Therapy: Emerging Trends in Nasal and Pulmonary Drug Delivery

  2019cites this paper
• The impact of frying aerosol on human brain activity.

  2019cites this paper
• How to characterize a nasal product. The state of the art of in vitro and ex vivo specific methods

  2019cites this paper
• Advanced Approaches of Bioactive Peptide Molecules and Protein Drug Delivery Systems.

  2019cites this paper
• Glucagon-Like Peptide-1 Receptor Agonists and Strategies To Improve Their Efficiency.

  2019cites this paper
• Enhancement Effect of Poly-L-ornithine on the Nasal Absorption of Water-Soluble Macromolecules in Rats.

  2019cites this paper
• Combustion and friction-derived nanoparticles and industrial-sourced nanoparticles: The culprit of Alzheimer and Parkinson's diseases.

  2019cites this paper
• Vía intranasal: una alternativa para la administración de fármacos de acción central en equinos

  2019cites this paper
• Modification of translationally controlled tumor protein-derived protein transduction domain for improved intranasal delivery of insulin

  2018cites this paper
• Nose‐to‐brain delivery of insulin enhanced by a nanogel carrier

  2018cites this paper
• Overview of intranasally delivered peptides: key considerations for pharmaceutical development

  2018influential citation
• Mechanism of intranasal drug delivery directly to the brain

  2018cites this paper
• Anti-Allergic Inflammatory Activity of Interleukin-37 Is Mediated by Novel Signaling Cascades in Human Eosinophils

  2018cites this paper
• Development & characterization and in vivo assessment of insulin loaded thermo sensitive in situ nano gel for nasal delivery

  2018cites this paper
• Factorial Design Methodology for Development of Pediatric Nasal Spray: Study on Xylometazoline Nasal Solution Used For Treatment of Nasal Congestion

  2018cites this paper
• PEDIATRIC NASAL SPRAY SOLUTION: FACTORIAL DESIGN DEVELOPMENT AND EVALUATION

  2018cites this paper
• [Optimization of Nasal Drug Absorption from Powder Formulations: The Feasibility of Controlling Drug Absorption by the Use of Pharmaceutical Excipients].

  2018cites this paper
• Saliva oxytocin measures do not reflect peripheral plasma concentrations after intranasal oxytocin administration in men

  2018cites this paper
• Improved Intranasal Retentivity and Transnasal Absorption Enhancement by PEGylated Poly-l-ornithine

  2018cites this paper
• The use of fatty acids as absorption enhancer for pulmonary drug delivery.

  2018cites this paper
• Do Glucose and Caffeine Nasal Sprays Influence Exercise or Cognitive Performance?

  2017cites this paper
• Nasal Physiology and Drug Transport

  2017cites this paper
• Current status and promising future of nasal drug delivery.

  2017cites this paper
• Preparation and Evaluation of PEGylated Poly-L-ornithine Complex as a Novel Absorption Enhancer.

  2017cites this paper
• Modulating nasal mucosal permeation using metabolic saturation and enzyme inhibition techniques

  2017cites this paper
• Development of Binary Composite Solid Microparticles for Improved Intranasal Absorption of Low Permeation Drug Molecules

  2017cites this paper
• Intranasal Medication Administration Using a Squeeze Bottle Atomizer Results in Overdosing if Deployed in Supine Patients

  2017cites this paper
• Dabigatran ameliorates post-haemorrhagic hydrocephalus development after germinal matrix haemorrhage in neonatal rat pups

  2017cites this paper
• Lipid Nanoparticles for Nasal/Intranasal Drug Delivery.

  2017cites this paper
• INTRANASAL ROUTE FOR CNS DELIVERY: OVERVIEW AND RECENT ADVANCEMENTS

  2017cites this paper
• TRANSFERSOMES: NOVEL APPROACH FOR INTRANASAL DELIVERY

  2017cites this paper
• Intranasal Delivery of Microspheres Loaded with 20 (R)-ginsenoside Rg3 Enhances Anti-Fatigue Effect in Mice.

  2017cites this paper
• Intranasal delivery of antipsychotic drugs.

  2017cites this paper
• Lipophilic peptide character - What oral barriers fear the most.

  2017cites this paper
• From Natural Peptides to Market

  2017cites this paper
• Nasal Drug Delivery-A Pre Hospital Therapy in Status Epilepsy-Review

  2016cites this paper
• Preparation, characterization, and potential application of chitosan, chitosan derivatives, and chitosan metal nanoparticles in pharmaceutical drug delivery

  2016cites this paper
• The Enhancement of Nasal Drug Absorption From Powder Formulations by the Addition of Sodium Carboxymethyl Cellulose

  2016cites this paper
• Aqueous Nasal Dosage Forms

  2016cites this paper
• Aerosol Delivery of Curcumin Reduced Amyloid-β Deposition and Improved Cognitive Performance in a Transgenic Model of Alzheimer’s Disease

  2016cites this paper
• The Enhancement of Nasal Drug Absorption From Powder Formulations by the Addition of Sodium Carboxymethyl Cellulose.

  2016cites this paper
• Review Article Emerging Trends in Novel Drug Delivery System: Intra Nasal Drug Delivery

  2016cites this paper
• Preparation, characterization, and potential application of chitosan, chitosan derivatives, and chitosan metal nanoparticles in pharmaceutical drug delivery

  2016cites this paper
• Delivery of Therapeutic Proteins: Challenges and Strategies.

  2016cites this paper
• INTRANASAL ROUTE: A PROMISING TECHNIQUE FOR BRAIN TARGETING

  2016cites this paper
• Emerging Insights for Translational Pharmacokinetic and Pharmacokinetic-Pharmacodynamic Studies: Towards Prediction of Nose-to-Brain Transport in Humans

  2015cites this paper
• Development of a Novel Drug Delivery System to Enhance the Oral Bioavailability of Lactoferrin

  2015cites this paper
• Emerging Trends in Delivery of Novel Vaccine Formulations

  2015cites this paper
• Safety and efficacy of intranasally administered medications in the emergency department and prehospital settings.

  2015cites this paper
• The Olfactory System as a Route of Delivery for Agents to the Brain and Circulation

  2015cites this paper
• Targeted Drug Delivery Systems Mediated Through Nasal Delivery for Improved Absorption: an Update

  2015cites this paper
• Carbohydrate Polymers: Colon-Targeted Drug Delivery

  2015cites this paper
• Improving brain drug targeting through exploitation of the nose-to-brain route: a physiological and pharmacokinetic perspective.

  2014cites this paper
• Absorption Enhancing Excipients in Systemic Nasal Drug Delivery

  2014cites this paper