The earliest events in vesicular stomatitis virus infection of the murine olfactory neuroepithelium and entry of the central nervous system.

After intranasal instillation of mice with vesicular stomatitis virus (VSV), olfactory receptor neurons are infected. By 12 to 24 hr postinfection, VSV antigens are observed in adjoining supporting and basal cells and in other structures of the olfactory epithelium and lamina propria. Peripheral deafferentation of the olfactory epithelium with Triton X-100 or bilateral surgical bulbectomy does not prevent spread of VSV to the central nervous system (CNS); the route of spread differs considerably from the route taken when the olfactory nerve is intact. In contrast to rabies virus and HSV-1, VSV does not use the trigeminal nerve for entry into the brain, as the trigeminal ganglion remains virus-free following intranasal infection. These results indicate that VSV has a strong tropism for olfactory receptor cells, using them for entry into the CNS. Both retrograde and anterograde transneuronal and nonneuronal (ependymal cells and cerebrospinal fluid) pathways are utilized by VSV within the CNS.

• Publication year

  1995

• Venue

  Virology

• Publication date

  1995-05-10

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1006/VIRO.1995.1252PMID 7747478
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Immunohistochemical and behaviour pharmacological analysis of rats inoculated intranasally with vesicular stomatitis virus

  2003cited by this paper
• Propagation of pseudorabies virus in the nervous system of the mouse after intranasal inoculation.

  1994cited by this paper
• Distribution of vesicular stomatitis virus proteins in the brains of BALB/c mice following intranasal inoculation: an immunohistochemical analysis.

  1994cited by this paper
• Immunohistochemical identification of trigeminal ganglion neurons that innervate the mouse cornea: Relevance to intercellular spread of herpes simplex virus

  1993cited by this paper
• The olfactory nerve and not the trigeminal nerve is the major site of CNS entry for mouse hepatitis virus, strain JHM.

  1993cited by this paper
• Central neuropathogenesis of vesicular stomatitis virus infection of immunodeficient mice

  1993cited by this paper
• Two neurotropic viruses, herpes simplex virus type 1 and mouse hepatitis virus, spread along different neural pathways from the main olfactory bulb

  1993cited by this paper
• Kinetics of virus spread and changes in levels of several cytokine mRNAs in the brain after intranasal infection of rats with Borna disease virus

  1992cited by this paper
• Murine infection by vesicular stomatitis virus: initial characterization of the H-2d system

  1991cited by this paper
• Firefly luciferase as a marker for herpesvirus (pseudorabies virus) replication in vitro and in vivo.

  1991cited by this paper
• Spread of the CVS strain of rabies virus and of the avirulent mutant AvO1 along the olfactory pathways of the mouse after intranasal inoculation

  1991cited by this paper
• Viruses as transneuronal tracers.

  1990cited by this paper
• Neuroplasticity in the olfactory system: Differential effects of central and peripheral lesions of the primary olfactory pathway on the expression of B‐50/GAP43 and the olfactory marker protein

  1990cited by this paper
• Spread of a neurotropic murine coronavirus into the CNS via the trigeminal and olfactory nerves

  1989cited by this paper
• SELECTIVE INFECTIONS OF OLFACTORY AND RESPIRATORY EPITHELIUM BY VESICULAR STOMATITIS AND SENDAI VIRUSES

  1987cited by this paper
• Neuronal and transneuronal tracing in the trigeminal system of the rat using the herpes virus suis.

  1983cited by this paper
• Neuron to neuron transmission of herpes simplex virus. Transport of virus from skin to brainstem nuclei.

  1982cited by this paper
• Denervation in the primary olfactory pathway of mice. IV. Biochemical and morphological evidence for neuronal replacement following nerve section.

  1977cited by this paper
• INFLUENCE OF HOST FACTORS ON NEUROINVASIVENESS OF VESICULAR STOMATITIS VIRUS

  1938cited by this paper

• The cribriform plate: A dynamic central nervous system-immune hub.

  2026cites this paper
• Oncolytic Vesicular Stomatitis Virus: Optimisation Strategies for Anti-Cancer Therapies.

  2024cites this paper
• Zika virus leads to olfactory disorders in mice by targeting olfactory ensheathing cells

  2023cites this paper
• Phase I study of VSV-GP (BI 1831169) as monotherapy or combined with ezabenlimab in advanced and refractory solid tumors.

  2022cites this paper
• Contact-Dependent Transmission of Langat and Tick-Borne Encephalitis Virus in Type I Interferon Receptor 1-Deficient Mice

  2021cites this paper
• Anosmia in COVID-19: Underlying Mechanisms and Assessment of an Olfactory Route to Brain Infection (Russian translation)

  2021cites this paper
• Nanovaccine Delivery Approaches and Advanced Delivery Systems for the Prevention of Viral Infections: From Development to Clinical Application

  2021cites this paper
• Advances in viral oncolytics for treatment of multiple myeloma – a focused review

  2021cites this paper
• Potential Differences in Cleavage of the S Protein and Type 1 Interferon Together Control Human Coronavirus Infection, Propagation, and Neuropathology within the Central Nervous System

  2021cites this paper
• Innate Immune Sensing of Viruses and Its Consequences for the Central Nervous System

  2021cites this paper
• Limbic Encephalitis Brain Damage Induced by Cocal Virus in Adult Mice Is Reduced by Environmental Enrichment: Neuropathological and Behavioral Studies

  2020cites this paper
• Early and late neuropathological features of meningoencephalitis associated with Maraba virus infection

  2020cites this paper
• Anosmia in COVID-19: Underlying Mechanisms and Assessment of an Olfactory Route to Brain Infection

  2020cites this paper
• Viruses in connectomics: viral transneuronal tracers and genetically modified recombinants as neuroscience research tools.

  2020influential citation
• Can transsynaptic viral strategies be used to reveal functional aspects of neural circuitry?

  2020cites this paper
• Current Understanding of the Molecular Basis of Venezuelan Equine Encephalitis Virus Pathogenesis and Vaccine Development

  2019cites this paper
• Microglial and astroglial reaction in the olfactory bulb of mice after Triton X-100 application.

  2019cites this paper
• Ablation of nasal-associated lymphoid tissue does not affect focal ischemic brain injury in mice

  2018cites this paper
• Immunogenicity of propagation-restricted vesicular stomatitis virus encoding Ebola virus glycoprotein in guinea pigs

  2018cites this paper
• Recent advances in vesicular stomatitis virus-based oncolytic virotherapy: a 5-year update.

  2017cites this paper
• Immune Regulation of Antibody Access to Neuronal Tissues.

  2017cites this paper
• The Olfactory Bulb: An Immunosensory Effector Organ during Neurotropic Viral Infections.

  2016cites this paper
• Expression Kinetics of RANTES and MCP-1 in the Brain of Deer Mice (Peromyscus maniculatus) Infected with Vesicular Stomatitis New Jersey Virus.

  2016cites this paper
• Neuroanatomy goes viral!

  2015cites this paper
• Neuroinvasion by Chandipura virus.

  2014cites this paper
• Interferon-Induced Ifit Proteins: Their Role in Viral Pathogenesis

  2014cites this paper
• Burkholderia pseudomallei Penetrates the Brain via Destruction of the Olfactory and Trigeminal Nerves: Implications for the Pathogenesis of Neurological Melioidosis

  2014cites this paper
• Interferon-Induced Protein Ifit2 Protects Mice from Infection of the Peripheral Nervous System by Vesicular Stomatitis Virus

  2014cites this paper
• Pathogens Penetrating the Central Nervous System: Infection Pathways and the Cellular and Molecular Mechanisms of Invasion

  2014cites this paper
• Interferon Regulatory Factor-1 Protects from Fatal Neurotropic Infection with Vesicular Stomatitis Virus by Specific Inhibition of Viral Replication in Neurons

  2014cites this paper
• Invasionand Molecular Mechanisms of System: Infection Pathways and the Pathogens Penetrating the Central Nervous

  2014cites this paper
• Anti-bacterial properties of olfactory ensheathing cells and the primary olfactory pathway

  2014cites this paper
• In vitro inhibition of vesicular stomatitis virus replication by purified porcine Mx1 protein fused to HIV-1 Tat protein transduction domain (PTD).

  2013cites this paper
• Understanding and altering cell tropism of vesicular stomatitis virus.

  2013influential citation
• hsp70-Dependent Antiviral Immunity against Cytopathic Neuronal Infection by Vesicular Stomatitis Virus

  2013cites this paper
• hsp 70-Dependent Antiviral Immunity against Cytopathic Neuronal Infection by Vesicular Stomatitis Virus

  2013cites this paper
• Meningeal myeloma deposits adversely impact the therapeutic index of an oncolytic VSV

  2013cites this paper
• Myeloid-derived suppressor cells as a vehicle for tumor-specific oncolytic viral therapy.

  2013cites this paper
• mRNA Cap Methylation Influences Pathogenesis of Vesicular Stomatitis Virus In Vivo

  2013cites this paper
• Recombinant Vesicular Stomatitis Virus Vaccine Vectors Expressing Filovirus Glycoproteins Lack Neurovirulence in Nonhuman Primates

  2012cites this paper
• Vesicular stomatitis virus as a flexible platform for oncolytic virotherapy against cancer.

  2012cites this paper
• Acute Reactogenicity after Intramuscular Immunization with Recombinant Vesicular Stomatitis Virus Is Linked to Production of IL-1β

  2012cites this paper
• Interferon-Induced Ifit2/ISG54 Protects Mice from Lethal VSV Neuropathogenesis

  2012cites this paper
• Anterograde or retrograde transsynaptic labeling of CNS neurons with vesicular stomatitis virus vectors

  2011cites this paper
• Enforced viral replication activates adaptive immunity and is essential for the control of a cytopathic virus

  2011cites this paper
• Acute Pathogenesis of Recombinant Vesicular Stomatitis Virus Vaccine Vectors is Linked to Interleukin-1

  2011cites this paper
• Host strategies against virus entry via the olfactory system

  2011cites this paper
• Interferon-Induced Tetherin Restricts Vesicular Stomatitis Virus Release in Neurons

  2011cites this paper
• The rabies virus glycoprotein determines the distribution of different rabies virus strains in the brain

  2011cites this paper
• Interplay between Innate Immunity and Negative-Strand RNA Viruses: towards a Rational Model

  2011cites this paper
• Peripheral, but not central nervous system, type I interferon expression in mice in response to intranasal vesicular stomatitis virus infection

  2011cites this paper
• Nasal-associated lymphoid tissue and olfactory epithelium as portals of entry for Burkholderia pseudomallei in murine melioidosis.

  2009cites this paper
• Local Type I IFN Receptor Signaling Protects against Virus Spread within the Central Nervous System1

  2009cites this paper
• Cytokine-modified VSV is attenuated for neural pathology, but is both highly immunogenic and oncolytic.

  2009cites this paper
• Ependymal cells: biology and pathology

  2009cites this paper
• In vivo biodistribution of a highly attenuated recombinant vesicular stomatitis virus expressing HIV-1 Gag following intramuscular, intranasal, or intravenous inoculation

  2009cites this paper
• Peripheral dendritic cells are essential for both the innate and adaptive antiviral immune responses in the central nervous system.

  2009influential citation
• Recombinant Vectors as Influenza Vaccines

  2009cites this paper
• Antitumor and antimetastatic activities of vesicular stomatitis virus matrix protein in a murine model of breast cancer

  2009cites this paper
• Severe Acute Respiratory Syndrome Coronavirus Infection Causes Neuronal Death in the Absence of Encephalitis in Mice Transgenic for Human ACE2

  2008cites this paper
• Insect vector interactions with persistently transmitted viruses.

  2008cites this paper
• Disruption of IFN-γ–Mediated Antiviral Activity in Neurons: The Role of Cannabinoids

  2008cites this paper
• Disruption of IFN- (cid:2) –Mediated Antiviral Activity in Neurons: The Role of Cannabinoids

  2008cites this paper
• Early and Late Pathogenic Events of Newborn Mice Encephalitis Experimentally Induced by Itacaiunas and Curionópolis Bracorhabdoviruses Infection

  2008cites this paper
• La Crosse virus infectivity, pathogenesis, and immunogenicity in mice and monkeys

  2008cites this paper
• A neurotropic route for Maize mosaic virus (Rhabdoviridae) in its planthopper vector Peregrinus maidis.

  2008cites this paper
• Severe Acute Respiratory Syndrome Coronavirus Infection Causes Neuronal Death in the Absence of Encephalitis in Mice Transgenic for Human ACE2 (cid:1)

  2008cites this paper
• Modulation of microglia and CD8(+) T cell activation during the development of stress-induced herpes simplex virus type-1 encephalitis.

  2007cites this paper
• Vesicular Stomatitis Virus and RNA Viruses as Gene Therapy Vectors

  2007cites this paper
• Quantitative multiplex assay for simultaneous detection of the Indiana serotype of vesicular stomatitis virus and HIV gag.

  2007cites this paper
• Gene Expression Contributing to Recruitment of Circulating Cells in Response to Vesicular Stomatitis Virus Infection of the CNS

  2006cites this paper
• Recombinant vesicular stomatitis virus as an HIV-1 vaccine vector

  2006cites this paper
• MODULATION OF MICROGLIA AND CD8+ T LYMPHOCYTE ACTIVATION BY PSYCHOLOGICAL STRESS DURING THE DEVELOPMENT OF STRESS-INDUCED HERPES SIMPLEX VIRUS TYPE-1 ENCEPHALITIS

  2006cites this paper
• Neurovirulence properties of recombinant vesicular stomatitis virus vectors in non-human primates

  2006cites this paper
• Bioluminescence imaging of vaccinia virus: effects of interferon on viral replication and spread.

  2005cites this paper
• VSV-tumor selective replication and protein translation

  2005cites this paper
• Vector Competence of Culicoides sonorensis (Diptera: Ceratopogonidae) for Vesicular Stomatitis Virus

  2005cites this paper
• Expression of IL-12 Receptor by Neurons

  2004cites this paper
• Posttranscriptional Regulation of Neuronal Nitric Oxide Synthase Expression by IFN-γ

  2004cites this paper
• Vesicular Stomatitis Virus as an Oncolytic Vector

  2004cites this paper
• Interferon-γ-induced inhibition of neuronal vesicular stomatitis virus infection is STAT1 dependent

  2004influential citation
• Vesicular Stomatitis Virus Glycoprotein Is a Determinant of Pathogenesis in Swine, a Natural Host

  2003cites this paper
• Plant and animal rhabdovirus host range: a bug's view.

  2003cites this paper
• Vesicular Stomatitis Viruses with Rearranged Genomes Have Altered Invasiveness and Neuropathogenesis in Mice

  2003cites this paper
• PKR is not required for interferon-gamma inhibition of VSV replication in neurons.

  2003cites this paper
• Participação da glia nas alterações morfológicas do cérebro e na produção de beta-quimiocinas na encefalite experimental pelo vírus da estomatite vesicular em camundongos

  2003cites this paper
• PKR Is Not Required for Interferon-γ Inhibition of VSV Replication in Neurons

  2003cites this paper
• Vesicular Stomatitis Virus Infection and Neuropathogenesis in the Murine Model are Associated with Apoptosis

  2003cites this paper
• Vírus da estomatite vesicular (sorotipo indiana 2) como modelo experimental para o estudo de encefalite aguda – aspectos morfológicos

  2003cites this paper
• Pathology and Pathogenesis of Virus Infections

  2002cites this paper
• PKR Protection Against Intranasal Vesicular Stomatitis Virus Infection Is Mouse Strain Dependent

  2002cites this paper
• Matrix protein mutations contribute to inefficient induction of apoptosis leading to persistent infection of human neural cells by vesicular stomatitis virus.

  2002influential citation
• Selective inhibition of COX-2 is beneficial to mice infected intranasally with VSV.

  2002cites this paper
• The role of IFN-gamma in immune responses to viral infections of the central nervous system.

  2002cites this paper
• Innate Immunity in Viral Encephalitis: Role of C5

  2002cites this paper
• Innate immune responses in viral encephalitis.

  2002cites this paper
• A study of pathogenesis of West Nile virus encephalitis in the adult murine model

  2002cites this paper
• The role of IFN-γ in immune responses to viral infections of the central nervous system

  2002cites this paper
• Relative Neurotropism of a Recombinant Rhabdovirus Expressing a Green Fluorescent Envelope Glycoprotein

  2002cites this paper
• Blood—Brain Barrier

  2001cites this paper