H2B Lys34 Ubiquitination Induces Nucleosome Distortion to Stimulate Dot1L Activity

No abstract is available for this paper.

• Publication year

  2022

• Venue

  Nature Chemical Biology

• Publication date

  2022-06-23

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1038/s41589-022-01067-7PMID 35739357
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mechanisms of BRCA1–BARD1 nucleosome recognition and ubiquitylation

  2021cited by this paper
• Regulation of the Dot1 histone H3K79 methyltransferase by histone H4K16 acetylation

  2021cited by this paper
• Structural insight into BRCA1-BARD1 complex recruitment to damaged chromatin.

  2021cited by this paper
• Structural basis of the crosstalk between histone H2B monoubiquitination and H3 lysine 79 methylation on nucleosome

  2019cited by this paper
• Structural basis for COMPASS recognition of an H2B-ubiquitinated nucleosome

  2019cited by this paper
• Mechanism of Cross-talk between H2B Ubiquitination and H3 Methylation by Dot1L.

  2019cited by this paper
• Structural Basis of H2B Ubiquitination-Dependent H3K4 Methylation by COMPASS

  2019cited by this paper
• Structural basis of nucleosome recognition and modification by MLL methyltransferases

  2019cited by this paper
• Ubiquitylation: How Nucleosomes Use Histones to Evict Histones.

  2019cited by this paper
• Structural Basis of Dot1L Stimulation by Histone H2B Lysine 120 Ubiquitination.

  2019cited by this paper
• Semisynthesis of ubiquitinated histone H2B with a native or nonhydrolyzable linkage.

  2019cited by this paper
• Structural basis of recognition and destabilization of the histone H2B ubiquitinated nucleosome by the DOT1L histone H3 Lys79 methyltransferase

  2019cited by this paper
• Cysteine-Aminoethylation-Assisted Chemical Ubiquitination of Recombinant Histones.

  2019cited by this paper
• Structural Basis for Recognition of Ubiquitylated Nucleosome by Dot1L Methyltransferase

  2019cited by this paper
• Examination of the Deubiquitylation Site Selectivity of USP51 by Using Chemically Synthesized Ubiquitylated Histones

  2018cited by this paper
• Chemical chromatin ubiquitylation.

  2018cited by this paper
• Effects of DNA Superhelical Stress on the Stability of H2B-Ubiquitylated Nucleosomes.

  2018cited by this paper
• Effects of histone H2B ubiquitylation on the nucleosome structure and dynamics

  2018cited by this paper
• MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

  2017cited by this paper
• CRL4DCAF8 Ubiquitin Ligase Targets Histone H3K79 and Promotes H3K9 Methylation in the Liver.

  2017cited by this paper
• Chemical Synthesis of K34‐Ubiquitylated H2B for Nucleosome Reconstitution and Single‐Particle Cryo‐Electron Microscopy Structural Analysis

  2017cited by this paper
• Assessing the Current State of Amber Force Field Modifications for DNA

  2016cited by this paper
• Evidence that ubiquitylated H2B corrals hDot1L on the nucleosomal surface to induce H3K79 methylation

  2016cited by this paper
• S-adenosyl methionine is necessary for inhibition of the methyltransferase G9a by the lysine 9 to methionine mutation on histone H3

  2016cited by this paper
• Gctf: Real-time CTF determination and correction

  2015cited by this paper
• Targeting DOT1L and HOX gene expression in MLL-rearranged leukemia and beyond.

  2015cited by this paper
• GROMACS: High performance molecular simulations through multi-level parallelism from laptops to supercomputers

  2015cited by this paper
• ff14SB: Improving the Accuracy of Protein Side Chain and Backbone Parameters from ff99SB.

  2015cited by this paper
• H2B ubiquitylation promotes RNA Pol II processivity via PAF1 and pTEFb.

  2014cited by this paper
• Generation of nonhydrolyzable ubiquitin-histone mimics.

  2014cited by this paper
• Histone H2B ubiquitin ligase RNF20 is required for MLL-rearranged leukemia

  2013cited by this paper
• Readout of epigenetic modifications.

  2013cited by this paper
• Linker Histone H1.2 cooperates with Cul4A and PAF1 to drive H4K31 ubiquitylation-mediated transactivation.

  2013cited by this paper
• The RING finger protein MSL2 in the MOF complex is an E3 ubiquitin ligase for H2B K34 and is involved in crosstalk with H3 K4 and K79 methylation.

  2011cited by this paper
• MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L.

  2011cited by this paper
• Protein chemical synthesis by ligation of peptide hydrazides.

  2011cited by this paper
• Chemical approaches to understand the language of histone modifications.

  2011cited by this paper
• Dot1 and histone H3K79 methylation in natural telomeric and HM silencing.

  2011cited by this paper
• Crosstalk among Histone Modifications.

  2008cited by this paper
• Chemically ubiquitylated histone H2B stimulates hDot1L-mediated intranucleosomal methylation

  2008cited by this paper
• H3K79 methylation profiles define murine and human MLL-AF4 leukemias.

  2008cited by this paper
• Chromatin modifications and their function.

  2007cited by this paper
• The DNA Damage Checkpoint Response Requires Histone H2B Ubiquitination by Rad6-Bre1 and H3 Methylation by Dot1*

  2005cited by this paper
• Automated acquisition of cryo-electron micrographs for single particle reconstruction on an FEI Tecnai electron microscope.

  2005cited by this paper
• Histone modifications defining active genes persist after transcriptional and mitotic inactivation

  2005cited by this paper
• Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation.

  2005cited by this paper
• Coot: model-building tools for molecular graphics.

  2004cited by this paper
• Histone and chromatin cross-talk.

  2003cited by this paper
• Ubiquitination of Histone H2B by Rad6 Is Required for Efficient Dot1-mediated Methylation of Histone H3 Lysine 79*

  2002cited by this paper
• Dot1p modulates silencing in yeast by methylation of the nucleosome core.

  2002cited by this paper
• Trans-tail histone modifications: wedge or bridge?

  2002cited by this paper
• Gene silencing: Trans-histone regulatory pathway in chromatin

  2002cited by this paper
• Methylation of H3-lysine 79 is mediated by a new family of HMTases without a SET domain.

  2002cited by this paper
• Crystal structure of the nucleosome core particle at 2.8 Å resolution

  1997cited by this paper
• Chromatin Modifications and Their Function

  year unknowncited by this paper

• Allosteric activation of RNF20/RNF40-RAD6A-mediated H2BK120 monoubiquitylation by H2BS112 GlcNAcylation.

  2026cites this paper
• Acetohydroxamic acid-assisted peptide hydrazide ligation for chemical protein synthesis.

  2026cites this paper
• Development of Substrate-Directed Activity-Based Probes via Disulfide-Trapping for Site-Specific Interrogation of Nucleosomal Deubiquitination.

  2026cites this paper
• Chemical Protein Synthesis via Direction-Switching One-Pot Peptide Ligation Enabled by Orthogonal Cysteinyl Protection.

  2026cites this paper
• Discovery of novel tumor-targeting peptide-oncolytic peptide based conjugates (PPCs): A new paradigm for targeted oncolytic-immunotherapy

  2026cites this paper
• Unique gluing effect of ASXL1 K351 monoubiquitination stimulates the PR-DUB activity.

  2026cites this paper
• Chemical strategies for trapping fleeting enzymatic complexes in nucleosome ubiquitylation.

  2026cites this paper
• Synthesis of an E2-Ub-nucleosome conjugate to capture the E3 ligase PHF7-catalyzed H3K14 ubiquitination intermediate

  2025cites this paper
• Development of Semisynthesis to Achieve Sulfonium Proteins with Diverse Modifications.

  2025cites this paper
• Design and Semisynthesis of Ubiquitin Extension Probes for Structural Analysis of Cullin1-Mediated Substrate Polyubiquitination.

  2025cites this paper
• Enhancing cyclic peptide functionality with hydrophilic diamino acids for improved APC-Asef interaction inhibition.

  2025cites this paper
• Mechanistic insights into the stimulation of the histone H3K9 methyltransferase Clr4 by proximal H3K14 ubiquitination

  2025cites this paper
• Expression and purification of functional recombinant Cullin1-Rbx1/2 in E. coli.

  2025cites this paper
• Parasite nucleosomes: Chromatin dynamics rewired

  2025influential citation
• A histone H2A and H2B point mutant library defines essential in vivo functions in Drosophila.

  2025cites this paper
• Glyco-based building blocks for the chemical synthesis of glycoproteins.

  2025cites this paper
• Strategies for the Generation of Bispecific Antibodies

  2025cites this paper
• The Emerging Role of the Histone H2AK13/15 Ubiquitination: Mechanisms of Writing, Reading, and Erasing in DNA Damage Repair and Disease

  2025cites this paper
• Efficient chemical synthesis of mirror-image DNA polymerase Dpo4 assisted by one-pot multi-segment condensation.

  2025cites this paper
• Semi-synthesis of functionalized cell-permeable ubiquitin probes via SrtA-mediated ligation.

  2025cites this paper
• Superfast Protein Desulfurization Triggered by Low-Energy Visible Light.

  2025cites this paper
• Efficient Synthesis of Cleavable Cell‐Penetrating Peptide–Cargo Conjugate via Low‐Equivalent of Cell‐Penetrating Peptide Activated by 2,2′‐Dithiodipyridine

  2025cites this paper
• Advances in the chemical synthesis of human proteoforms

  2025cites this paper
• Cryo‐EM Structures of Native Chromatin Units From Human Cells

  2025cites this paper
• Two Step Synthesis of Octreotide-doxorubicin Conjugates Based on Disulfide Bond Linker

  2025cites this paper
• Trypanosome histone variants H3.V and H4.V promote nucleosome plasticity in repressed chromatin

  2025cites this paper
• Effect of glycosylation on protein folding: From biological roles to chemical protein synthesis

  2025cites this paper
• The structure and composition of native human nucleosomes

  2025cites this paper
• Histone probes for reader and eraser investigations

  2025cites this paper
• SpyTag/SpyCatcher-mediated protein ubiquitination to investigate 20S and 26S proteasomal degradation

  2025cites this paper
• Chemical Synthesis of the Mirror-Image Fast-PETase by the Enzyme-Cleavable Solubilizing-Tag Strategy.

  2025cites this paper
• Chemical crosslinking extends and complements UV crosslinking in analysis of RNA/DNA nucleic acid–protein interaction sites by mass spectrometry

  2025cites this paper
• Chemically synthesized phosphorylated ubiquitin unlocks parkin for activation-controlled PROTAC platforms

  2025cites this paper
• One-step solid-phase synthesis of activated cell-penetrating peptides for cytosolic delivery of protein

  2024cites this paper
• Generation of antibody-drug conjugates by proximity-driven acyl transfer and sortase-mediated ligation.

  2024cites this paper
• Facile semisynthesis of histone H3 enables nucleosome probes for investigation of histone H3K79 modifications

  2024cites this paper
• L-Glycosidase-Cleavable Natural Glycans Facilitate the Chemical Synthesis of Correctly Folded Disulfide-Bonded D-Proteins.

  2024cites this paper
• Decoding chromatin ubiquitylation: a chemical biology perspective.

  2024cites this paper
• Three Rounds of Stability-Guided Optimization and Systematical Evaluation of Oncolytic Peptide LTX-315.

  2024cites this paper
• An Enzyme-Cleavable Solubilizing-Tag Facilitates the Chemical Synthesis of Mirror-Image Proteins.

  2024cites this paper
• Encouraging Solution to the Problem of Synthesizing Protein α‐Thioester

  2024cites this paper
• Sequential release of interacting proteins and Ub-modifying enzymes by disulfide heterotypic ubiquitin reagents.

  2024cites this paper
• Structure-guided engineering enables E3 ligase-free and versatile protein ubiquitination via UBE2E1

  2024cites this paper
• Substrate and Functional Diversity of Protein Lysine Post-translational Modifications

  2024cites this paper
• d-type peptides based fluorescent probes for "turn on" sensing of heparin.

  2024cites this paper
• Synthesis of Asp-based lactam cyclic peptides using an amide-bonded diaminodiacid to prevent aspartimide formation.

  2024cites this paper
• To Ub or not to Ub: The epic dilemma of histones that regulate gene expression and epigenetic cross-talk.

  2024cites this paper
• Synthesis and structural optimization of oncolytic peptide LTX-315.

  2024cites this paper
• Histone ubiquitination: Role in genome integrity and chromatin organization.

  2024cites this paper
• Efficient Chemical Synthesis and Folding of Mirror‐Image Tropomyosin Receptor Kinase A Using the Strategy of Removable Glycosylation Modification†

  2024cites this paper
• Thioproline-Based Oxidation Strategy for Direct Preparation of N-Terminal Thiazolidine-Containing Peptide Thioesters from Peptide Hydrazides.

  2024cites this paper
• Rapid reconstitution of ubiquitinated nucleosome using a non-denatured histone octamer ubiquitylation approach

  2024cites this paper
• Structural and mechanistic basis for nucleosomal H2AK119 deubiquitination by single-subunit deubiquitinase USP16

  2024cites this paper
• Efficient Chemical Synthesis of Multi-Monoubiquitylated and Diubiquitylated Histones by the α-Halogen Ketone-Mediated Strategy.

  2024cites this paper
• Chemical Synthesis of Human Proteoforms and Application in Biomedicine

  2024cites this paper
• Promotion of RNF168-Mediated Nucleosomal H2A Ubiquitylation by Structurally-defined K63-Polyubiquitylated Linker Histone H1

  2024cites this paper
• Design and synthesis of TH19P01-Camptothecin based hybrid peptides inducing effective anticancer responses on sortilin positive cancer cells.

  2024cites this paper
• The molecular basis of lamin-specific chromatin interactions

  2024cites this paper
• Molecular dynamics simulations of nucleosomes are coming of age

  2024cites this paper
• Chemical crosslinking extends and complements UV crosslinking in analysis of RNA/DNA nucleic acid–protein interaction sites by mass spectrometry

  2024cites this paper
• Thiazolidine Deprotection Using an Organic Solvent Extractable Aldehyde Scavenger for One-Pot Four-Segment Ligation.

  2024cites this paper
• Testis-specific H2B.W1 disrupts nucleosome integrity by reducing DNA–histone interactions

  2024cites this paper
• Biomimetic Folding Strategies for Chemical Synthesis of Disulfide‐Bonded Peptides and Proteins

  2024cites this paper
• Mechanism of nucleosomal H2A K13/15 monoubiquitination and adjacent dual monoubiquitination by RNF168

  2024cites this paper
• A review on the promising antibacterial agents in bone cement–From past to current insights

  2024cites this paper
• Development and applications of enzymatic peptide and protein ligation

  2024cites this paper
• The N-terminal region of DNMT3A engages the nucleosome surface to aid chromatin recruitment

  2024influential citation
• The Effects of Histone H2B ubiquitylations and H3K79me3 on Transcription Elongation

  2023cites this paper
• Chemical synthesis of a 28 kDa full-length PET degrading enzyme ICCG by the removable backbone modification strategy.

  2023cites this paper
• Peptide Oxo-Esters for Ligation of Peptide Hydrazide at Gln and Asn Sites

  2023cites this paper
• Efficient synthesis of lactylated histone peptides enabled by a pre-prepared protected lactylated-lysine

  2023cites this paper
• Interrogating epigenetic mechanisms with chemically customized chromatin

  2023cites this paper
• Mesenchymal stem cells under epigenetic control – the role of epigenetic machinery in fate decision and functional properties

  2023cites this paper
• Synthesis of disulfide-rich C-terminal Cys-containing peptide acids through a photocleavable side-chain anchoring strategy.

  2023cites this paper
• Interactions of Nucleosomes with Acidic Patch-Binding Peptides: A Combined Structural Bioinformatics, Molecular Modeling, Fluorescence Polarization, and Single-Molecule FRET Study

  2023cites this paper
• Cell-Permeable Stimuli-Responsive Ubiquitin Probe for Time-Resolved Monitoring of Substrate Ubiquitination in Live Cells

  2023cites this paper
• Synthesis of ubiquitinated proteins for biochemical and functional analysis

  2023cites this paper
• Synthesis of A11Cys-B11Cys Disulfide Surrogates of H2 Relaxin through an Intermolecular Native Chemical Ligation-Assisted Diaminodiacid Strategy.

  2023cites this paper
• Chemical Synthesis of On Demand-Activated SUMO-Based Probe by a Photocaged Glycine-Assisted Strategy.

  2023cites this paper
• Mechanistic insights into nucleosomal H2B monoubiquitylation mediated by yeast Bre1-Rad6 and its human homolog RNF20/RNF40-hRAD6A.

  2023cites this paper
• Structural basis of telomeric nucleosome recognition by shelterin factor TRF1

  2023cites this paper
• Methods of the enzymatic production of Ub-based tools

  2023cites this paper
• The ubiquitin codes in cellular stress responses

  2023cites this paper
• Synovial sarcoma X breakpoint 1 protein uses a cryptic groove to selectively recognize H2AK119Ub nucleosomes

  2023cites this paper
• Diverse modes of regulating methyltransferase activity by histone ubiquitination.

  2023cites this paper
• Histone divergence in trypanosomes results in unique alterations to nucleosome structure

  2023cites this paper
• The expedient, CAET-assisted synthesis of dual-monoubiquitinated histone H3 enables evaluation of its interaction with DNMT1

  2023cites this paper
• Histone divergence in Trypanosoma brucei results in unique alterations to nucleosome structure

  2023cites this paper
• BRCA1–BARD1 combines multiple chromatin recognition modules to bridge nascent nucleosomes

  2023cites this paper
• Effects of Histone H2B Ubiquitylations and H3K79me3 on Transcription Elongation.

  2023cites this paper
• Chemical Synthesis of Post-Translationally Modified H2AX Reveals Redundancy in Interplay between Histone Phosphorylation, Ubiquitination, and Methylation on the Binding of 53BP1 with Nucleosomes.

  2022cites this paper