Chemical approaches to understand the language of histone modifications.

No abstract is available for this paper.

• Publication year

  2011

• Venue

  ACS Chemical Biology

• Publication date

  2011-08-17

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1021/cb200142cPMID 21827195PMCID PMC7020651
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Spreading Chromatin into Chemical Biology

  2011cited by this paper
• Operating on chromatin, a colorful language where context matters.

  2011cited by this paper
• Quantum-dot-based FRET detection of histone acetyltransferase activity.

  2011cited by this paper
• Preparation of fully synthetic histone H3 reveals that acetyl-lysine 56 facilitates protein binding within nucleosomes.

  2011cited by this paper
• Chromodomain-mediated oligomerization of HP1 suggests a nucleosome-bridging mechanism for heterochromatin assembly.

  2011cited by this paper
• Recognition of a mononucleosomal histone modification pattern by BPTF via multivalent interactions.

  2011cited by this paper
• Human LSD2/KDM1b/AOF1 regulates gene transcription by modulating intragenic H3K4me2 methylation.

  2010cited by this paper
• Site-specific introduction of an acetyl-lysine mimic into peptides and proteins by cysteine alkylation.

  2010cited by this paper
• Histone H2B ubiquitylation disrupts local and higher order chromatin compaction

  2010cited by this paper
• Method for the synthesis of mono-ADP-ribose conjugated peptides.

  2010cited by this paper
• Dynamic changes in histone acetylation regulate origins of DNA replication

  2010cited by this paper
• Genetically directing ɛ-N, N-dimethyl-L-lysine in recombinant histones.

  2010cited by this paper
• A histone code for DNA repair

  2010cited by this paper
• Histidine phosphorylation in histones and in other mammalian proteins.

  2010cited by this paper
• Regulation of heterochromatic DNA replication by histone H3 lysine 27 methyltransferases

  2010cited by this paper
• N-methylcysteine-mediated total chemical synthesis of ubiquitin thioester.

  2010cited by this paper
• A Novel Proteomics Approach to Identify SUMOylated Proteins and Their Modification Sites in Human Cells*

  2010cited by this paper
• Adding new chemistries to the genetic code.

  2010cited by this paper
• Chromatin structure: does the 30-nm fibre exist in vivo?

  2010cited by this paper
• Chromatin methylation activity of Dnmt3a and Dnmt3a/3L is guided by interaction of the ADD domain with the histone H3 tail

  2010cited by this paper
• β-N-acetylglucosamine (O-GlcNAc) is part of the histone code

  2010cited by this paper
• The Dnmt3a PWWP Domain Reads Histone 3 Lysine 36 Trimethylation and Guides DNA Methylation*

  2010cited by this paper
• The effects of histone H4 tail acetylations on cation-induced chromatin folding and self-association

  2010cited by this paper
• A method to site-specifically introduce methyllysine into proteins in E. coli.

  2010cited by this paper
• A genetically encoded photocaged Nepsilon-methyl-L-lysine.

  2010cited by this paper
• Nucleosome Interactions and Stability in an Ordered Nucleosome Array Model System*

  2010cited by this paper
• Methyl‐H3K9‐binding protein MPP8 mediates E‐cadherin gene silencing and promotes tumour cell motility and invasion

  2010cited by this paper
• Development of stable phosphohistidine analogues.

  2010cited by this paper
• The language of histone crosstalk.

  2010cited by this paper
• Disulfide-directed histone ubiquitylation reveals plasticity in hDot1L activation.

  2010cited by this paper
• WDR5, a complexed protein

  2009cited by this paper
• Chemical modification of proteins at cysteine: opportunities in chemistry and biology.

  2009cited by this paper
• Identification and verification of lysine propionylation and butyrylation in yeast core histones using PTMap software.

  2009cited by this paper
• Genetically encoding N(epsilon)-methyl-L-lysine in recombinant histones.

  2009cited by this paper
• ING4 mediates crosstalk between histone H3 K4 trimethylation and H3 acetylation to attenuate cellular transformation.

  2009cited by this paper
• Cooperative binding of two acetylation marks on a histone tail by a single bromodomain

  2009cited by this paper
• Role of the polycomb protein EED in the propagation of repressive histone marks

  2009cited by this paper
• Acetylation of Histone H3 at the Nucleosome Dyad Alters DNA-Histone Binding*

  2009cited by this paper
• A Semisynthetic Strategy to Generate Phosphorylated and Acetylated Histone H2B

  2009cited by this paper
• CelluSpots: a reproducible means of making peptide arrays for the determination of SH2 domain binding specificity.

  2009cited by this paper
• Epigenome Microarray Platform for Proteome-Wide Dissection of Chromatin-Signaling Networks

  2009cited by this paper
• Understanding the words of chromatin regulation.

  2009cited by this paper
• RAD6-Mediated transcription-coupled H2B ubiquitylation directly stimulates H3K4 methylation in human cells.

  2009cited by this paper
• Histone H3 Lysine 36 Dimethylation (H3K36me2) Is Sufficient to Recruit the Rpd3s Histone Deacetylase Complex and to Repress Spurious Transcription*

  2009cited by this paper
• Structure-activity analysis of semisynthetic nucleosomes: mechanistic insights into the stimulation of Dot1L by ubiquitylated histone H2B.

  2009cited by this paper
• Combinatorial profiling of chromatin-binding modules reveals multi-site discrimination

  2009cited by this paper
• Analysis of the substrate specificity of the Dim-5 histone lysine methyltransferase using peptide arrays.

  2008cited by this paper
• An amalgamation of solid phase peptide synthesis and ribosomal peptide synthesis

  2008cited by this paper
• Structure of WDR5 Bound to Mixed Lineage Leukemia Protein-1 Peptide*

  2008cited by this paper
• Histone ubiquitination: triggering gene activity.

  2008cited by this paper
• Site-specific incorporation of methyl- and acetyl-lysine analogues into recombinant proteins.

  2008cited by this paper
• A combinatorial H4 tail library for exploring the histone code.

  2008cited by this paper
• Cathepsin L proteolytically processes histone H3 during mouse embryonic stem cell differentiation.

  2008cited by this paper
• Chemically ubiquitylated histone H2B stimulates hDot1L-mediated intranucleosomal methylation

  2008cited by this paper
• Cyclic peptide inhibitors of staphylococcal virulence prepared by Fmoc-based thiolactone peptide synthesis.

  2008cited by this paper
• WDR5 Interacts with Mixed Lineage Leukemia (MLL) Protein via the Histone H3-binding Pocket*

  2008cited by this paper
• An efficient Fmoc-SPPS approach for the generation of thioester peptide precursors for use in native chemical ligation.

  2008cited by this paper
• Genetically encoding N(epsilon)-acetyllysine in recombinant proteins.

  2008cited by this paper
• An easy assay for histone acetyltransferase activity using a PhosphorImager.

  2008cited by this paper
• Cross-talk between histone H3 tails produces cooperative nucleosome acetylation

  2008cited by this paper
• Chromatin modifications and their function.

  2007cited by this paper
• Free-radical-based, specific desulfurization of cysteine: a powerful advance in the synthesis of polypeptides and glycopolypeptides.

  2007cited by this paper
• The role of chromatin during transcription.

  2007cited by this paper
• RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination

  2007cited by this paper
• Histone Modifications Influence the Action of Snf2 Family Remodelling Enzymes by Different Mechanisms

  2007cited by this paper
• The site-specific installation of methyl-lysine analogs into recombinant histones.

  2007cited by this paper
• Methylation of lysine 4 on histone H3: intricacy of writing and reading a single epigenetic mark.

  2007cited by this paper
• Covalent modifications of histones during development and disease pathogenesis

  2007cited by this paper
• Auxiliary-mediated site-specific peptide ubiquitylation.

  2007cited by this paper
• Selective desulfurization of cysteine in the presence of Cys(Acm) in polypeptides obtained by native chemical ligation.

  2007cited by this paper
• Lysine Propionylation and Butyrylation Are Novel Post-translational Modifications in Histones*S

  2007cited by this paper
• Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF

  2006cited by this paper
• Histone H4-K16 Acetylation Controls Chromatin Structure and Protein Interactions

  2006cited by this paper
• Tudor, MBT and chromo domains gauge the degree of lysine methylation

  2006cited by this paper
• 3-thiopropionic acid as a highly versatile multidetachable thioester resin linker

  2006cited by this paper
• EM measurements define the dimensions of the "30-nm" chromatin fiber: evidence for a compact, interdigitated structure.

  2006cited by this paper
• Histone sumoylation is a negative regulator in Saccharomyces cerevisiae and shows dynamic interplay with positive-acting histone modifications.

  2006cited by this paper
• Proline isomerization of histone H3 regulates lysine methylation and gene expression.

  2006cited by this paper
• Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex

  2006cited by this paper
• Protein ligation: an enabling technology for the biophysical analysis of proteins

  2006cited by this paper
• Molecular recognition of histone H3 by the WD40 protein WDR5

  2006cited by this paper
• A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling

  2006cited by this paper
• Chromatin modifications by methylation and ubiquitination: implications in the regulation of gene expression.

  2006cited by this paper
• Ubiquitin-binding domains

  2005cited by this paper
• Assays for mechanistic investigations of protein/histone acetyltransferases.

  2005cited by this paper
• WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development.

  2005cited by this paper
• K4, K9 and K18 in human histone H3 are targets for biotinylation by biotinidase

  2005cited by this paper
• Mammalian histidine kinases.

  2005cited by this paper
• A one-pot total synthesis of crambin.

  2004cited by this paper
• Reconstitution of nucleosome core particles from recombinant histones and DNA.

  2004cited by this paper
• Nucleosome Arrays Reveal the Two-Start Organization of the Chromatin Fiber

  2004cited by this paper
• Histone deimination antagonizes arginine methylation.

  2004cited by this paper
• Human PAD4 Regulates Histone Arginine Methylation Levels via Demethylimination

  2004cited by this paper
• Facile synthesis of site-specifically acetylated and methylated histone proteins: Reagents for evaluation of the histone code hypothesis

  2003cited by this paper
• Histone sumoylation is associated with transcriptional repression

  2003cited by this paper
• Mass spectrometric quantification of acetylation at specific lysines within the amino-terminal tail of histone H4.

  2003cited by this paper
• A Native Peptide Ligation Strategy for Deciphering Nucleosomal Histone Modifications*

  2003cited by this paper
• The SPOT-synthesis technique. Synthetic peptide arrays on membrane supports--principles and applications.

  2002cited by this paper
• Deimination of arginine residues in nucleophosmin/B23 and histones in HL-60 granulocytes.

  2002cited by this paper
• Acetylation of the Yeast Histone H4 N Terminus Regulates Its Binding to Heterochromatin Protein SIR3*

  2002cited by this paper

• An improved version of the early histone HCl extraction protocol.

  2026cites this paper
• Rapid and Efficient Synthesis of Succinated Thiol Compounds via Maleic Anhydride Derivatization

  2025cites this paper
• Unveiling the guardians of the genome: The dynamic role of histones in DNA organization and disease.

  2025cites this paper
• Approaches to the Full and Partial Chemical Synthesis of Proteins.

  2024cites this paper
• The semisynthesis of site-specifically modified histones and histone-based probes of chromatin-modifying enzymes.

  2023cites this paper
• Total chemical synthesis of sumoylated histone H4 reveals negative biochemical crosstalk with histone ubiquitylation.

  2023cites this paper
• Advanced RAI-refractory thyroid cancer: an update on treatment perspectives.

  2022cites this paper
• Hydrophobic cavity-directed azide-acetyllysine photochemistry for profiling non-histone interacting partners of bromodomain protein 1

  2022cites this paper
• Creation of a Yeast Strain with Co-translationally Acylated Nucleosomes.

  2022cites this paper
• Photo-Cross-Linking To Delineate Epigenetic Interactome.

  2022cites this paper
• Cysteine‐Assisted Click‐Chemistry for Proximity‐Driven, Site‐Specific Acetylation of Histones

  2022cites this paper
• H2B Lys34 Ubiquitination Induces Nucleosome Distortion to Stimulate Dot1L Activity

  2022cites this paper
• Design, synthesis and biological evaluation of a novel spiro oxazolidinedione as potent p300/CBP HAT inhibitor for the treatment of ovarian cancer

  2021cites this paper
• Chemical methods for studying the crosstalk between histone H2B ubiquitylation and H3 methylation

  2021influential citation
• Nucleosome binding by the lysine specific demethylase 1 (LSD1) enzyme enables histone H3 demethylation.

  2020cites this paper
• Examining Several Strategies for the Chemical Synthesis of Phosphorylated Histone H3 Reveals the Effectiveness of the Convergent Approach

  2020cites this paper
• Tailored DNA nano-framework-enabled Medusa electrochemiluminescence immunosensor for quantitative detection of histone acetyltransferase

  2020cites this paper
• Endometriosis and ovarian cancer risk, an epigenetic connection

  2020cites this paper
• A clickable glutamine (CliQ) derivative for the traceless reversible modification of peptides and proteins.

  2019cites this paper
• Study of acetylated histone h3k9 – an active chromatin mark – in chromosomes from adult and fetal human lymphocytes

  2019cites this paper
• Synthetic post-translational modification of histones.

  2018cites this paper
• The Bump-and-Hole Tactic: Expanding the Scope of Chemical Genetics.

  2018cites this paper
• Chemistry-Driven Epigenetic Investigation of Histone and DNA Modifications.

  2018cites this paper
• Studies of biochemical crosstalk in chromatin with semisynthetic histones.

  2018cites this paper
• Chemical synthesis of histone H2A with methylation at Gln104

  2017cites this paper
• Mass Spectrometry-Based Methodology for Identification of Native Histone Variant Modifications From Mammalian Tissues and Solid Tumors.

  2017cites this paper
• Chemically Sumoylated Histone H4 Stimulates Intranucleosomal Demethylation by the LSD1-CoREST Complex.

  2017cites this paper
• Regulation of Nucleosome Stacking and Chromatin Compaction by the Histone H4 N-Terminal Tail-H2A Acidic Patch Interaction.

  2017cites this paper
• A Facile N-Mercaptoethoxyglycinamide (MEGA) Linker Approach to Peptide Thioesterification and Cyclization.

  2017cites this paper
• Rapid Semisynthesis of Acetylated and Sumoylated Histone Analogs.

  2016cites this paper
• Isoxazole‐Derived Amino Acids are Bromodomain‐Binding Acetyl‐Lysine Mimics: Incorporation into Histone H4 Peptides and Histone H3

  2016cites this paper
• Hybrid phase ligation for efficient synthesis of histone proteins.

  2016cites this paper
• Investigating the Effect of Histone H4 Sumoylation on Chromatin Structure and Function

  2016cites this paper
• Chemical Synthesis of Phosphorylated Histone H2A at Tyr57 Reveals Insight into the Inhibition Mode of the SAGA Deubiquitinating Module.

  2016cites this paper
• All about that Amide Bond: The Sixth Chemical Protein Synthesis (CPS) Meeting

  2015cites this paper
• Intramolecular long-distance nucleophilic reactions as a rapid fluorogenic switch applicable to the detection of enzymatic activity.

  2015cites this paper
• 2-Oxazoline formation for selective chemical labeling of 5-hydroxylysine.

  2015cites this paper
• Chemical and Genetic Approaches to Study Histone Modifications

  2015cites this paper
• Regulation of S-Adenosylhomocysteine Hydrolase by Lysine Acetylation*

  2014cites this paper
• Sumoylated Human Histone H4 Prevents Chromatin Compaction by Inhibiting Long-range Internucleosomal Interactions*

  2014cites this paper
• Chemical strategies to understand the language of ubiquitin signaling

  2014cites this paper
• Histone Modification Patterns and Their Responses to Environment

  2014cites this paper
• Histone modifications and a choice of variant: a language that helps the genome express itself

  2014cites this paper
• One-pot native chemical ligation of peptide hydrazides enables total synthesis of modified histones.

  2014cites this paper
• N‐Methylierung von Peptiden und Proteinen: ein wichtiges Element für die Regulation biologischer Funktionen

  2013cites this paper
• HMDO-promoted peptide and protein synthesis in ionic liquids.

  2013cites this paper
• N-methylation of peptides and proteins: an important element for modulating biological functions.

  2013cites this paper
• Histone deacetylation of NIS promoter underlies BRAF V600E-promoted NIS silencing in thyroid cancer

  2013influential citation
• Metabolic mechanisms of epigenetic regulation.

  2013cites this paper
• Current chemical biology approaches to interrogate protein methyltransferases.

  2012cites this paper
• Site-specific incorporation of ε-N-crotonyllysine into histones.

  2012cites this paper
• Genetically encoded alkenyl–pyrrolysine analogues for thiol–ene reaction mediated site-specific protein labeling

  2012cites this paper
• Novel gb(3) isoforms detected in urine of fabry disease patients: a metabolomic study.

  2012cites this paper
• Unraveling the complexity of ubiquitin signaling.

  2012cites this paper
• Conversion of cysteine into dehydroalanine enables access to synthetic histones bearing diverse post-translational modifications.

  2012cites this paper