Emerging Mechanisms of Elastin Transcriptional Regulation.

Elastin provides recoil to tissues that stretch such as the lung, blood vessels and skin. It is deposited in a brief window starting in the prenatal period and extending to adolescence in vertebrates, and then slowly turns over. Elastin insufficiency causes conditions such as Williams-Beuren syndrome and elastin-related supravalvar aortic stenosis, which are associated with a range of vascular and connective tissue manifestations. Regulation of the elastin (ELN) gene occurs at multiple levels including promoter activation/inhibition, mRNA stability, interaction with microRNAs, and alternative splicing. However, these mechanisms are incompletely understood. Better understanding of the processes controlling ELN gene expression may improve medicine's ability to intervene in these rare conditions, as well as to replace age-associated losses by re-initiating elastin production. This review describes what is known about the ELN gene promoter structure, transcriptional regulation by cytokines and transcription factors, and post-transcriptional regulation via mRNA stability and micro-RNA and highlights new approaches that may influence regenerative medicine.

• Publication year

  2022

• Venue

  American Journal of Physiology - Cell Physiology

• Publication date

  2022-07-11

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1152/ajpcell.00228.2022PMID 35816641PMCID PMC9448287
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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