Co-localization of nephrin, podocin, and the actin cytoskeleton: evidence for a role in podocyte foot process formation.

No abstract is available for this paper.

• Publication year

  2002

• Venue

  American Journal of Pathology

• Publication date

  2002-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S0002-9440(10)64421-5PMID 12368218PMCID PMC1867300
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A conditionally immortalized human podocyte cell line demonstrating nephrin and podocin expression.

  2002cited by this paper
• N-linked glycosylation is critical for the plasma membrane localization of nephrin.

  2002cited by this paper
• The murine nephrin gene is specifically expressed in kidney, brain and pancreas: inactivation of the gene leads to massive proteinuria and neonatal death.

  2001cited by this paper
• Stomatin, flotillin-1, and flotillin-2 are major integral proteins of erythrocyte lipid rafts.

  2001cited by this paper
• Podocin, a raft-associated component of the glomerular slit diaphragm, interacts with CD2AP and nephrin.

  2001cited by this paper
• Interaction with Podocin Facilitates Nephrin Signaling*

  2001cited by this paper
• Role of nephrin in cell junction formation in human nephrogenesis.

  2000cited by this paper
• The glomerular slit diaphragm is a modified adherens junction.

  2000cited by this paper
• Glomerular function and morphology in puromycin aminonucleoside nephropathy in rats.

  2000cited by this paper
• NPHS2, encoding the glomerular protein podocin, is mutated in autosomal recessive steroid-resistant nephrotic syndrome

  2000cited by this paper
• Congenital nephrotic syndrome (NPHS1): features resulting from different mutations in Finnish patients.

  2000cited by this paper
• Cloning of rat nephrin: expression in developing glomeruli and in proteinuric states.

  2000cited by this paper
• Nephrin localizes to the slit pore of the glomerular epithelial cell.

  1999cited by this paper
• Nephrin is specifically located at the slit diaphragm of glomerular podocytes.

  1999cited by this paper
• Nephrin localizes at the podocyte filtration slit area and is characteristically spliced in the human kidney.

  1999cited by this paper
• Congenital nephrotic syndrome in mice lacking CD2-associated protein.

  1999cited by this paper
• Positionally cloned gene for a novel glomerular protein--nephrin--is mutated in congenital nephrotic syndrome.

  1998cited by this paper
• Regulation of podocyte structure during the development of nephrotic syndrome

  1998cited by this paper
• A novel adaptor protein orchestrates receptor patterning and cytoskeletal polarity in T-cell contacts.

  1998cited by this paper
• Rearrangements of the cytoskeleton and cell contacts induce process formation during differentiation of conditionally immortalized mouse podocyte cell lines.

  1997cited by this paper
• Synaptopodin: An Actin-associated Protein in Telencephalic Dendrites and Renal Podocytes

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• Structure and function of podocytes: an update

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• Nuclear localization of the protein encoded by the Wilms' tumor gene WT1 in embryonic and adult tissues.

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• Effects of the aminonucleoside of puromycin on glomerular epithelial cells in vitro.

  1985cited by this paper
• CONTACTS

  1967cited by this paper

• Mapping of PTP1B, TCPTP, SHP2, and Putative Substrates Reveals Novel Networks in Glomerular Podocytes

  2026cites this paper
• Pathogenic podocin variants exhibit distinct defects in trafficking, membrane organization, and degradation pathways.

  2025cites this paper
• High mobility group box 1 (HMGB1) mediates nicotine-induced podocyte injury

  2025cites this paper
• The PM2.5 component, benzo[b]fluoranthene, may contribute to the pathogenesis of membranous nephropathy by activating phosphoinositide 3-kinase/protein kinase B pathway and causing podocyte pyroptosis.

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• Structural and functional insights of the podocyte slit diaphragm complex.

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• Targeting TRPC6 in podocytopathies: Why clinical translation remains a challenge?

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  2023cites this paper
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  2020cites this paper
• Crk1/2 and CrkL play critical roles in maintaining podocyte morphology and function.

  2020cites this paper
• Glomerular endothelial derived vesicles mediate podocyte dysfunction: A potential role for miRNA

  2020influential citation
• Cell‐Derived Extracellular Matrix‐Rich Biomimetic Substrate Supports Podocyte Proliferation, Differentiation, and Maintenance of Native Phenotype

  2020cites this paper
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  2020cites this paper
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  2020cites this paper
• Challenges in primary focal segmental glomerulosclerosis diagnosis: from the diagnostic algorithm to novel biomarkers

  2020cites this paper
• Mitochondrial biogenesis induced by the β2-adrenergic receptor agonist formoterol accelerates podocyte recovery from glomerular injury.

  2019cites this paper
• The Use of High-Throughput Transcriptomics to Identify Pathways with Therapeutic Significance in Podocytes

  2019cites this paper
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  2019cites this paper
• Signal regulatory protein a protects podocytes through promotion of autophagic activity

  2019cites this paper
• Intrarenal Renin–Angiotensin System Involvement in the Pathogenesis of Chronic Progressive Nephropathy—Bridging the Informational Gap Between Disciplines

  2019cites this paper
• Tyrosine Phosphorylation of CD2AP Affects Stability of the Slit Diaphragm Complex.

  2019cites this paper
• Cell Biology International

  2019cites this paper
• The motor protein Myo1c regulates transforming growth factor-β-signaling and fibrosis in podocytes.

  2019cites this paper
• Signal regulatory protein α protects podocytes through promoting autophagic activity.

  2019cites this paper
• Glucagon‑like peptide‑1 protects mouse podocytes against high glucose‑induced apoptosis, and suppresses reactive oxygen species production and proinflammatory cytokine secretion, through sirtuin 1 activation in vitro.

  2018cites this paper
• Genetic and acquired abnormalities in C3 glomerulopathy and primary immune complex-mediated MPGN

  2018cites this paper
• Proteinuric Kidney Diseases: A Podocyte's Slit Diaphragm and Cytoskeleton Approach

  2018cites this paper
• Induction of B 7-1 in podocytes is associated with nephrotic syndrome

  2018cites this paper
• Gremlin Regulates Podocyte Apoptosis via Transforming Growth Factor-β (TGF-β) Pathway in Diabetic Nephropathy

  2018influential citation
• Blocking peptides and molecular mimicry as treatment for kidney disease.

  2017cites this paper
• Visualisation studies and glomerular filtration in early diabetic rats.

  2017cites this paper
• C1-Ten is a PTPase of nephrin, regulating podocyte hypertrophy through mTORC1 activation

  2017cites this paper
• Truncation of C-mip (Tc-mip), a new proximal signaling protein, induces c-maf Th2 transcription factor and cytoskeleton reorganization

  2017cites this paper
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  2017cites this paper
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  2017cites this paper
• Fragility of foot process morphology in kidney podocytes arises from chaotic spatial propagation of cytoskeletal instability

  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
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  2014cites this paper
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  2014cites this paper
• Running Title: Kinin receptors in glomerulosclerosis.

  2014cites this paper
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  2013cites this paper
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  2013cites this paper
• B7-1 expression regulates the hypoxia-driven cytoskeleton rearrangement in glomerular podocytes.

  2013cites this paper
• A Compendium of Urinary Biomarkers Indicative of Glomerular Podocytopathy

  2013influential citation
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• Sirolimus reduces vasculopathy but exacerbates proteinuria in association with inhibition of VEGF and VEGFR in a rat kidney model of chronic allograft dysfunction.

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• Hydrogen peroxide induces dimerization of protein kinase G type Iα subunits and increases albumin permeability in cultured rat podocytes

  2012cites this paper
• Podocyte culture: Tricks of the trade

  2012cites this paper
• [Pathogenesis and treatment of idiopathic nephrotic syndrome in adults].

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• Solution Structure Analysis of Cytoplasmic Domain of Podocyte Protein Neph1 Using Small/Wide Angle X-ray Scattering (SWAXS)*

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  2011cites this paper
• Bradykinin receptor 1 activation exacerbates experimental focal and segmental glomerulosclerosis.

  2011cites this paper
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  2011cites this paper
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  2011cites this paper
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  2010cites this paper
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  2010cites this paper
• Identification and characterization of novel glomerulus-associated genes and proteins

  2010cites this paper
• Ameliorating Effects of l-Carnitine on Diabetic Podocyte Injury

  2010cites this paper
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  2010cites this paper
• Loss of collagen-receptor DDR1 delays renal fibrosis in hereditary type IV collagen disease.

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