Glycine: a new anti-inflammatory immunonutrient

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Cellular and Molecular Life Sciences (CMLS)

• Publication date

  1999-11-30

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s000180050030PMID 11212343PMCID PMC11147092
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A pharmacological study of the depression of spinal neurones by glycine and related amino acids

  2004cited by this paper
• The hyperpolarization of spinal motoneurones by glycine and related amino acids

  2004cited by this paper
• Dietary glycine inhibits the growth of B16 melanoma tumors in mice.

  1999cited by this paper
• Production of superoxide and TNF-α from alveolar macrophages is blunted by glycine.

  1999cited by this paper
• Intravenous glycine improves survival in rat liver transplantation.

  1999cited by this paper
• Immunomodulatory effects of glycine on LPS‐treated monocytes: reduced TNF‐α production and accelerated IL‐10 expression

  1999cited by this paper
• Glycine and uridine prevent d‐galactosamine hepatotoxicity in the rat: Role of kupffer cells

  1999cited by this paper
• Glycine Accelerates Recovery from Alcohol-Induced Liver Injury

  1998cited by this paper
• Cyclosporin A increases hypoxia and free radical production in rat kidneys: prevention by dietary glycine.

  1998cited by this paper
• Cell Activation Mediated by Glycosylphosphatidylinositol-Anchored or Transmembrane Forms of CD14

  1998cited by this paper
• Glycine accelerates recovery from alcohol-induced liver injury.

  1998cited by this paper
• Gentle in situ liver manipulation during organ harvest decreases survival after rat liver transplantation: role of Kupffer cells.

  1998cited by this paper
• Taurine blunts LPS‐induced increases in intracellular calcium and TNF‐α production by Kupffer cells

  1998cited by this paper
• Dietary glycine prevents increases in hepatocyte proliferation caused by the peroxisome proliferator WY-14,643.

  1997cited by this paper
• The glycine receptor.

  1997cited by this paper
• Kupffer cells are causally responsible for the mitogenic effect of peroxisome proliferators.

  1997cited by this paper
• Prevention of cyclosporine-induced nephrotoxicity with dietary glycine.

  1997cited by this paper
• CD14-dependent and CD14-independent signaling pathways in murine macrophages from normal and CD14 knockout mice stimulated with lipopolysaccharide or taxol.

  1997cited by this paper
• Kupffer cells contain a glycine-gated chloride channel.

  1997cited by this paper
• Cytoprotection of kidney epithelial cells by compounds that target amino acid gated chloride channels.

  1996cited by this paper
• Glycine minimizes reperfusion injury in a low-flow, reflow liver perfusion model in the rat.

  1996cited by this paper
• The human glycine receptor beta subunit: primary structure, functional characterisation and chromosomal localisation of the human and murine genes.

  1996cited by this paper
• Glycine prevents alcohol-induced liver injury by decreasing alcohol in the rat stomach.

  1996cited by this paper
• A diet containing glycine improves survival in endotoxin shock in the rat.

  1996cited by this paper
• Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin.

  1995cited by this paper
• Calcium signaling.

  1995cited by this paper
• Mutation of an arginine residue in the human glycine receptor transforms beta-alanine and taurine from agonists into competitive antagonists.

  1995cited by this paper
• A missense mutation in the gene encoding the α1 subunit of the inhibitory glycine receptor in the spasmodic mouse

  1994cited by this paper
• Glycine receptor β–subunit gene mutation in spastic mouse associated with LINE–1 element insertion

  1994cited by this paper
• Strychnine and glycine protect renal proximal tubules from various nephrotoxicants and act in the late phase of necrotic cell injury.

  1994cited by this paper
• Point mutation of glycine receptor alpha 1 subunit in the spasmodic mouse affects agonist responses.

  1994cited by this paper
• A missense mutation in the gene encoding the alpha 1 subunit of the inhibitory glycine receptor in the spasmodic mouse.

  1994cited by this paper
• Structural analysis of mouse glycine receptor alpha subunit genes. Identification and chromosomal localization of a novel variant.

  1994cited by this paper
• Excitement about calcium signaling in inexcitable cells.

  1993cited by this paper
• Conservation of structure in ATP-depleted proximal tubules: role of calcium, polyphosphoinositides, and glycine.

  1993cited by this paper
• Macrophage activation and leukocyte adhesion after liver transplantation.

  1993cited by this paper
• Kupffer cells contain voltage-dependent calcium channels

  1993cited by this paper
• Heterogeneity of rat liver and spleen macrophages in gadolinium chloride–induced elimination and repopulation

  1992cited by this paper
• The atypical M2 segment of the beta subunit confers picrotoxinin resistance to inhibitory glycine receptor channels.

  1992cited by this paper
• Kupffer cells contain voltage-dependent calcium channels.

  1992cited by this paper
• Structure and expression of inhibitory glycine receptors.

  1991cited by this paper
• Identification and functional expression of a novel ligand binding subunit of the inhibitory glycine receptor.

  1990cited by this paper
• Prevention of early graft failure by the calcium channel blocker nisoldipine: involvement of Kupffer cells.

  1990cited by this paper
• Alpha subunit variants of the human glycine receptor: primary structures, functional expression and chromosomal localization of the corresponding genes.

  1990cited by this paper
• INCREASE IN SURVIVAL TIME OF LIVER TRANSPLANTS BY PROTEASE INHIBITORS AND A CALCIUM CHANNEL BLOCKER, NISOLDIPINE

  1990cited by this paper
• How do inositol phosphates regulate calcium signaling?

  1989cited by this paper
• Functional chloride channels by mammalian cell expression of rat glycine receptor subunit.

  1989cited by this paper
• Glycine-gated chloride current in acutely isolated rat hypothalamic neurons.

  1989cited by this paper
• Benzodiazepine Enhancement of γ‐Aminobutyric Acid‐Mediated Chloride Ion Flux in Rat Brain Synaptoneurosomes

  1988cited by this paper
• Heterogeneity of glycine receptors and their messenger RNAs in rat brain and spinal cord.

  1988cited by this paper
• Glycine receptor heterogeneity in rat spinal cord during postnatal development.

  1988cited by this paper
• Relationship of hepatic peroxisome proliferation and replicative DNA synthesis to the hepatocarcinogenicity of the peroxisome proliferators di(2-ethylhexyl)phthalate and [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic acid (Wy-14,643) in rats.

  1988cited by this paper
• Properties of glycine-activated conductances in rat brain neurones.

  1988cited by this paper
• Peroxisome proliferation and hepatocarcinogenesis.

  1987cited by this paper
• Peroxisome proliferation and hepatocarcinogenesis.

  1987cited by this paper
• Peroxisome proliferation and lipid peroxidation in rat liver.

  1986cited by this paper
• Properties of human brain glycine receptors expressed in Xenopus oocytes

  1984cited by this paper
• Inositol trisphosphate and diacylglycerol as second messengers.

  1984cited by this paper
• Monoclonal antibodies and peptide mapping reveal structural similarities between the subunits of the glycine receptor of rat spinal cord.

  1984cited by this paper
• Monoclonal antibodies and peptide mapping reveal structural homologies between the subunits of the glycine receptor of rat spinal cord

  1984cited by this paper
• Purification by affinity chromatography of the glycine receptor of rat spinal cord.

  1982cited by this paper
• Solubilization of the glycine receptor from rat spinal cord.

  1981cited by this paper
• Strychnine binding associated with glycine receptors of the central nervous system.

  1973cited by this paper
• Light and electron microscopic autoradiography on spinal cord slices after incubation with labeled glycine.

  1971cited by this paper
• Inhibitory of glycine on spinal neurons in the cat.

  1968cited by this paper
• CHANGES IN AMINO ACID CONCENTRATIONS ASSOCIATED WITH LOSS OF SPINAL INTERNEURONS *

  1967cited by this paper
• Inhibition of motoneurones by iontophoresis of glycine.

  1967cited by this paper
• The distribution of glycine in cat spinal cord and roots.

  1965cited by this paper
• The depression of spinal inhibition by electrophoretically administered strychnine

  1962cited by this paper
• Anion permeability of the synaptic and non‐synaptic motoneurone membrane

  1961cited by this paper

• Gelsemium elegans extract powder alleviates high stocking density-related adverse effects in broilers via immune-intestinal microbiota synergistic mechanisms

  2026cites this paper
• Plasma supplemented with glycine is superior to standard plasma in reducing vascular permeability and organ injury via reduction of inflammation in an experimental traumatic shock model

  2026cites this paper
• Glicina y sus efectos sobre el metabolismo muscular: posibles mecanismos para el desarrollo de potencia e hipertrofia.

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• Acetylcarnitine in cerebrospinal fluid and blood as a protective factor for neuromyelitis optica spectrum disorders: a mendelian randomization study

  2025cites this paper
• Therapeutic inhibition of HBsAg and HBV cccDNA through a novel phased combination treatment: glycine and interferon-α

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• A review on quinolines: New green synthetic methods and bioactive potential.

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• Association of 91 Inflammatory Factors and 1400 Metabolites with Sepsis: A Mendelian Randomization Analysis

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• Cold storage of human precision-cut lung slices in TiProtec preserves cellular composition and transcriptional responses and enables on-demand mechanistic studies

  2025cites this paper
• Aqueous Solubility of Sodium and Chloride Salts of Glycine─"Uncommon" Common-Ion Effects of Self-Titrating Solids.

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• Investigation of functional, antioxidant, anti-inflammatory, and antidiabetic properties of legume seed protein hydrolysates

  2024cites this paper
• In ovo sodium butyrate administration differentially impacts growth performance, intestinal barrier function, immune response, and gut microbiota characteristics in low and high hatch-weight broilers

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• Glycine by enteral route does not improve major clinical outcomes in severe COVID-19: a randomized clinical pilot trial

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• Single and Joined Behaviour of Circulating Biomarkers and Metabolic Parameters in High-Fit and Low-Fit Healthy Females

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• Collagen-Derived Dipeptides and Amino Acids Have Immunomodulatory Effects in M1-Differentiated RAW264.7 Cells and PBMC

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• Metabolomics Analysis of Mesenchymal Stem Cell (MSC) Therapy in a Phase I Clinical Trial of Septic Shock: An Exploratory Study

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• Amino Acids in New Organic Fertilizer AnchoisFert

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• Potential therapeutic effects of Ivermectin in COVID-19

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• Nutraceutical Prevention of Diabetic Complications—Focus on Dicarbonyl and Oxidative Stress

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• Dietary glycine supplementation prevents heat stress-induced impairment of antioxidant status and intestinal barrier function in broilers

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• Identification of Urine Metabolic Biomarkers for Vogt-Koyanagi-Harada Disease

  2021cites this paper
• Molecular Modeling and Simulation of glycine functionalized B12N12 and B16N16 nanoclusters as potential inhibitors of proinflammatory cytokines

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• Glycinergic Signaling in Macrophages and Its Application in Macrophage-Associated Diseases

  2021cites this paper
• Melatonin and Glycine Reduce Uterus Ischemia/Reperfusion Injury in a Rat Model of Warm Ischemia

  2021cites this paper
• Role of fish collagen hydrolysate in attenuating inflammation-An in vitro study.

  2021cites this paper
• Glycine Attenuates Citrobacter rodentium-Induced Colitis by Regulating ATF6-Mediated Endoplasmic Reticulum Stress in Mice.

  2021cites this paper
• Anti-inflammatory activity of ivermectin in late-stage COVID-19 may reflect activation of systemic glycine receptors

  2021cites this paper
• The Effects of Dietary Protein Supplementation on Exercise-Induced Inflammation and Oxidative Stress: A Systematic Review of Human Trials

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• Glycine Ameliorates Endoplasmic Reticulum Stress Induced by Thapsigargin in Porcine Oocytes

  2021cites this paper
• Obesity increases hepatic glycine dehydrogenase and aminomethyltransferase expression while dietary glycine supplementation reduces white adipose tissue in Zucker diabetic fatty rats

  2020cites this paper
• l-theanine alleviates liver and kidney dysfunction in septic rats induced by cecal ligation and puncture.

  2020cites this paper
• Glycine Attenuates Lipopolysaccharide-Induced Acute Lung Injury by Regulating NLRP3 Inflammasome and NRF2 Signaling

  2020cites this paper
• Identifying metabolomic profiles of inflammatory diets in postmenopausal women.

  2020cites this paper
• Glycine and Selenium (Separately and in Combination) Reduced Bromate-Mediated Oxidative Stress and Inflammatory Response in U937 Cells

  2020cites this paper
• Plasma amino acid levels in individuals with bacterial pneumonia and healthy controls.

  2020cites this paper
• Serum free amino acid levels in rheumatoid arthritis according to therapy and physical disability

  2019cites this paper
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  2019cites this paper
• Potential anti-inflammatory and lipase inhibitory peptides generated by in vitro gastrointestinal hydrolysis of heat treated millet grains

  2019cites this paper
• Glycine Metabolism and Its Alterations in Obesity and Metabolic Diseases

  2019cites this paper
• Glycine protects partial liver grafts from Kupffer cell-dependent ischemia–reperfusion injury without negative effect on regeneration

  2019cites this paper
• Glycine supplementation extends lifespan of male and female mice

  2019cites this paper
• Activated glycine receptors may decrease endosomal NADPH oxidase activity by opposing ClC-3-mediated efflux of chloride from endosomes.

  2019cites this paper
• Dietary Glycine Is Rate-Limiting for Glutathione Synthesis and May Have Broad Potential for Health Protection.

  2018cites this paper
• Mitochondria protection as a mechanism underlying the hepatoprotective effects of glycine in cholestatic mice.

  2018cites this paper
• Participation of the IKK-α/β complex in the inhibition of the TNF-α/NF-κB pathway by glycine: Possible involvement of a membrane receptor specific to adipocytes.

  2018cites this paper
• Glycine enhances expression of adiponectin and IL-10 in 3T3-L1 adipocytes without affecting adipogenesis and lipolysis

  2018cites this paper
• Polyethyleneglycol nanoparticles adsorbed to glycine as a bioengineered neomaterial for application in inflammatory processes

  2018cites this paper
• Glycine Induces Migration of Microglial BV-2 Cells via SNAT-Mediated Cell Swelling

  2018cites this paper
• Glycine Protects the Liver from Reperfusion Injury following Pneumoperitoneum

  2018cites this paper
• Comparative effect of selenium and glycine on hydrogen peroxide-induced cell death and activation of macrophage U937 cells

  2017cites this paper
• Inflammation, vitamin B6 and related pathways.

  2017cites this paper
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• Impaired “Glycine”-mia in Type 2 Diabetes and Potential Mechanisms Contributing to Glucose Homeostasis

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• Effect of oral glycine on the clinical, spirometric and inflammatory status in subjects with cystic fibrosis: a pilot randomized trial

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• Amelioration by glycine of brain damage in neonatal rat brain following hypoxia–ischemia

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• Nutrition and Liver Health

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• Use of l -Arginine and Glycine Supplementation to Reduce Radiotherapy Damage

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• Frontiers in Skeletal Muscle Wasting, Regeneration and Stem Cells

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• Green Tea and Glycine Modulate the Activity of Metalloproteinases and Collagen in the Tendinitis of the Myotendinous Junction of the Achilles Tendon

  2016cites this paper
• Glycine Regulates Expression and Distribution of Claudin-7 and ZO-3 Proteins in Intestinal Porcine Epithelial Cells.

  2016cites this paper
• Effect of N-acetyl cysteine and glycine supplementation on growth performance, glutathione synthesis, anti-oxidative and immune ability of Nile tilapia, Oreochromis niloticus.

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• Comparative Effectiveness of Cysteine, Lysine and Glycine to Fend Off Paracetamol-Induced Hepatic Insult

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• The role of glycine in regulated cell death

  2016cites this paper
• CONTRAINDICATIONS, PRECAUTIONS, ADVERSE REACTIONS CONTRA INDICA TlONS

  2016cites this paper
• Untersuchungen zum Einfluss von Glycin auf die Schädigung des Dünndarms der Ratte durch absolute mesenteriale Ischämie und Reperfusion

  2016cites this paper
• Glycine inhibits angiogenesis in colorectal cancer: role of endothelial cells

  2016influential citation
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• PHYSIOLOGICAL AND BIOCHEMICAL RESPONSES OF RAT STRESS MODELS TO NEUROTRANSMITTERS PRETREATMENT

  2015cites this paper
• Hydrolyzed tilapia fish collagen modulates the biological behavior of macrophages under inflammatory conditions

  2015cites this paper
• Green tea and glycine aid in the recovery of tendinitis of the Achilles tendon of rats

  2015cites this paper
• Plasma Glycine and Risk of Acute Myocardial Infarction in Patients With Suspected Stable Angina Pectoris

  2015cites this paper
• Preclinical Studies Suggest Complex Nutraceutical Strategies May Have Potential for Preventing and Managing Sepsis.

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• Glycine Improves Biochemical and Biomechanical Properties Following Inflammation of the Achilles Tendon

  2015cites this paper
• The investigation of anti-inflammatory activity of volatile oil of Angelica sinensis by plasma metabolomics approach.

  2015cites this paper
• Biomarker discovery of liver diseases using mass spectrometry-based metabolomics.

  2014cites this paper
• A metabolic link to skeletal muscle wasting and regeneration

  2014cites this paper
• Prediction of Postoperative Mortality in Liver Transplantation in the Era of MELD-Based Liver Allocation: A Multivariate Analysis

  2014cites this paper
• Glycine modulates membrane potential, cell volume, and phagocytosis in murine microglia

  2014cites this paper
• Glycine inhibits angiogenic signaling in human hepatocellular carcinoma cells

  2014cites this paper
• Metabolomic analysis of the effects of chronic arsenic exposure in a mouse model of diet-induced Fatty liver disease.

  2014cites this paper
• Glycine aggravates ischemia reperfusion-induced acute kidney injury through N-Methyl-D-Aspartate receptor activation in rats

  2014cites this paper
• Effect of Glycine on Protein Oxidation and Advanced Glycation End Products Formation

  2013cites this paper
• Amino acid and dipeptide combination strongly attenuates endotoxemic cytokine production in human whole-blood monocytes

  2013cites this paper
• Glycine reduces platelet aggregation

  2013cites this paper
• UNIVERSITÀ DEGLI STUDI DI MILANO

  2013cites this paper
• Potential Immune Modularly Role of Glycine in Oral Gingival Inflammation

  2013cites this paper
• Glycine metabolism in animals and humans: implications for nutrition and health

  2013cites this paper
• Cysteine, histidine and glycine exhibit anti‐inflammatory effects in human coronary arterial endothelial cells

  2012cites this paper
• Radiation protection following nuclear power accidents: a survey of putative mechanisms involved in the radioprotective actions of taurine during and after radiation exposure

  2012cites this paper
• HTK-N, a modified HTK solution, decreases preservation injury in a model of microsteatotic rat liver transplantation

  2012cites this paper
• Glycine suppresses TNF-α-induced activation of NF-κB in differentiated 3T3-L1 adipocytes.

  2012cites this paper
• Glycine, a simple physiological compound protecting by yet puzzling mechanism(s) against ischaemia–reperfusion injury: current knowledge

  2012influential citation
• Cu(II), Co(II), and Ni(II)–Antioxidative Phenolate–Glycine Peptide Systems: An Insight into Its Equilibrium Solution Study

  2012cites this paper
• Protection from Glycine at Low Doses in Ischemia-Reperfusion Injury of the Rat Small Intestine

  2011cites this paper
• Molecular characterisation of glycine–N–acyltransferase from two primates : the vervet monkey and the chacma baboon

  2011cites this paper
• Prophylactic Glycine Administration Attenuates Pancreatic Damage and Inflammation in Experimental Acute Pancreatitis

  2011cites this paper