Bone Morphogenetic Protein-Induced Msx1 and Msx2 Inhibit Myocardin-Dependent Smooth Muscle Gene Transcription

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Molecular and Cellular Biology

• Publication date

  2006-10-09

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/MCB.00759-06PMID 17030628PMCID PMC1698541
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Modification of Msx1 by SUMO-1.

  2006cited by this paper
• Smooth muscle of the dorsal aorta shares a common clonal origin with skeletal muscle of the myotome

  2006cited by this paper
• SMAD 8 binding to mice Msx1 basal promoter is required for transcriptional activation.

  2006cited by this paper
• The myocardin family of transcriptional coactivators: versatile regulators of cell growth, migration, and myogenesis.

  2006cited by this paper
• Molecular mechanisms of vascular calcification: lessons learned from the aorta.

  2006cited by this paper
• Cartilage formation in growth plate and arteries: from physiology to pathology

  2005cited by this paper
• Myocardin Enhances Smad3-Mediated Transforming Growth Factor-β1 Signaling in a CArG Box-Independent Manner: Smad-Binding Element Is an Important cis Element for SM22α Transcription In Vivo

  2005cited by this paper
• Msx2 promotes cardiovascular calcification by activating paracrine Wnt signals.

  2005cited by this paper
• Kruppel-like Factor 4 Abrogates Myocardin-induced Activation of Smooth Muscle Gene Expression*

  2005influential reference
• 5' CArG degeneracy in smooth muscle alpha-actin is required for injury-induced gene suppression in vivo.

  2005cited by this paper
• Recruitment of the Androgen Receptor via Serum Response Factor Facilitates Expression of a Myogenic Gene*

  2005cited by this paper
• Bone Morphogenetic Proteins in Vascular Calcification

  2005influential reference
• HERP1 Inhibits Myocardin-Induced Vascular Smooth Muscle Cell Differentiation by Interfering With SRF Binding to CArG Box

  2005influential reference
• Phenotypic modulation of smooth muscle cells through interaction of Foxo4 and myocardin.

  2005influential reference
• Necdin Interacts with the Msx2 Homeodomain Protein via MAGE-D1 to Promote Myogenic Differentiation of C2C12 Cells*

  2004cited by this paper
• Msx2 and Necdin Combined Activities Are Required for Smooth Muscle Differentiation in Mesoangioblast Stem Cells

  2004influential reference
• Myocardin and ternary complex factors compete for SRF to control smooth muscle gene expression

  2004cited by this paper
• Expressional regulation of smooth muscle cell-specific genes in association with phenotypic modulation

  2004cited by this paper
• Msx1 Cooperates with Histone H1b for Inhibition of Transcription and Myogenesis

  2004cited by this paper
• Msx2 Promotes Osteogenesis and Suppresses Adipogenic Differentiation of Multipotent Mesenchymal Progenitors*

  2003cited by this paper
• Osteo/Chondrocytic Transcription Factors and Their Target Genes Exhibit Distinct Patterns of Expression in Human Arterial Calcification

  2003cited by this paper
• Epiregulin as a Major Autocrine/Paracrine Factor Released From ERK- and p38MAPK-Activated Vascular Smooth Muscle Cells

  2003cited by this paper
• Actin dynamics control SRF activity by regulation of its coactivator MAL.

  2003influential reference
• Krüppel-like Factor 4 (KLF4/GKLF) Is a Target of Bone Morphogenetic Proteins and Transforming Growth Factor β1 in the Regulation of Vascular Smooth Muscle Cell Phenotype*

  2003cited by this paper
• Myocardin is a master regulator of smooth muscle gene expression

  2003cited by this paper
• Msx homeobox gene family and craniofacial development

  2003cited by this paper
• Bone morphogenetic protein‐2 enhances osterix gene expression in chondrocytes

  2003cited by this paper
• Cysteine-rich LIM-only proteins CRP1 and CRP2 are potent smooth muscle differentiation cofactors.

  2003influential reference
• Smad4 and β-Catenin Co-activators Functionally Interact with Lymphoid-enhancing Factor to Regulate Graded Expression of Msx2*

  2003cited by this paper
• Epiregulin as a major autocrine/paracrine factor released from the ERK- and p38MAPK-activated vascular smooth muscle cells

  2003cited by this paper
• A Triad of Serum Response Factor and the GATA and NK Families Governs the Transcription of Smooth and Cardiac Muscle Genes*

  2002cited by this paper
• Myocardin: a component of a molecular switch for smooth muscle differentiation.

  2002cited by this paper
• Msx2 is an immediate downstream effector of Pax3 in the development of the murine cardiac neural crest.

  2002cited by this paper
• Regulation of expression of plasminogen activator inhibitor‐1 in cultured rat osteoblastic cells by osteogenic protein‐1 (BMP‐7)

  2001cited by this paper
• Msx homeobox genes inhibit differentiation through upregulation of cyclin D1.

  2001cited by this paper
• Differential Expression of Bone Matrix Regulatory Proteins in Human Atherosclerotic Plaques

  2001cited by this paper
• Phenotypic Modulation of Vascular Smooth Muscle Cells Induced by Unsaturated Lysophosphatidic Acids

  2001influential reference
• Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor.

  2001cited by this paper
• Msx2 deficiency in mice causes pleiotropic defects in bone growth and ectodermal organ formation

  2000cited by this paper
• The homeobox gene Msx1 is expressed in a subset of somites, and in muscle progenitor cells migrating into the forelimb.

  1999cited by this paper
• Msx1 antagonizes the myogenic activity of Pax3 in migrating limb muscle precursors.

  1999cited by this paper
• Changes in the Balance of Phosphoinositide 3-Kinase/Protein Kinase B (Akt) and the Mitogen-activated Protein Kinases (ERK/p38MAPK) Determine a Phenotype of Visceral and Vascular Smooth Muscle Cells

  1999cited by this paper
• Differentiated Phenotype of Smooth Muscle Cells Depends on Signaling Pathways through Insulin-like Growth Factors and Phosphatidylinositol 3-Kinase*

  1998cited by this paper
• Protein complex formation between Msx1 and Lhx2 homeoproteins is incompatible with DNA binding activity.

  1998cited by this paper
• Functional involvement of serum response factor in the transcriptional regulation of caldesmon gene.

  1998cited by this paper
• Evidence for serum response factor-mediated regulatory networks governing SM22alpha transcription in smooth, skeletal, and cardiac muscle cells.

  1997cited by this paper
• Heterodimerization of Msx and Dlx homeoproteins results in functional antagonism

  1997cited by this paper
• Immunolocalization of BMP-6, a novel TGF-beta-related cytokine, in normal and atherosclerotic smooth muscle cells.

  1995cited by this paper
• Transcriptional Regulation of the Chicken Caldesmon Gene

  1995influential reference
• Regulation of differentiation of vascular smooth muscle cells.

  1995cited by this paper
• Transcriptional repression by Msx-1 does not require homeodomain DNA-binding sites

  1995cited by this paper
• Msx1 deficient mice exhibit cleft palate and abnormalities of craniofacial and tooth development

  1994cited by this paper
• Bone morphogenetic protein expression in human atherosclerotic lesions.

  1993cited by this paper
• In vitro squelching of activated transcription by serum response factor: evidence for a common coactivator used by multiple transcriptional activators.

  1992cited by this paper
• Myogenin resides in the nucleus and acquires high affinity for a conserved enhancer element on heterodimerization.

  1990cited by this paper
• Isolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response element.

  1988cited by this paper
• Mesenchymal derivatives of the neural crest: analysis of chimaeric quail and chick embryos.

  1975cited by this paper

• Loss-of-function G6PD variant moderated high-fat diet-induced obesity, adipocyte hypertrophy, and fatty liver in male rats

  2024cites this paper
• Stress, Vascular Smooth Muscle Cell Phenotype and Atherosclerosis: Novel Insight into Smooth Muscle Cell Phenotypic Transition in Atherosclerosis

  2024cites this paper
• Transcription factors: key regulatory targets of vascular smooth muscle cell in atherosclerosis

  2023cites this paper
• Role of CRP2-MRTF interaction in functions of myofibroblasts

  2023cites this paper
• Transmural pressure signals through retinoic acid to regulate lung branching.

  2022influential citation
• MGP Regulates Perivascular Adipose-Derived Stem Cells Differentiation Toward Smooth Muscle Cells Via BMP2/SMAD Pathway Enhancing Neointimal Formation

  2022cites this paper
• Molecular Mechanisms of Vascular Health: Insights From Vascular Aging and Calcification

  2022cites this paper
• Glucose-6-phosphate dehydrogenase and MEG3 controls hypoxia-induced expression of serum response factor (SRF) and SRF-dependent genes in pulmonary smooth muscle cell

  2022cites this paper
• Osteomodulin Gene Expression Is Associated With Plaque Calcification, Stability, and Fewer Cardiovascular Events in the CPIP Cohort

  2022cites this paper
• BMP4 and WNT signaling interact to promote mouse tracheal mesenchyme morphogenesis.

  2021cites this paper
• G6PD activity contributes to the regulation of histone acetylation and gene expression in smooth muscle cells and to the pathogenesis of vascular diseases.

  2021cites this paper
• Molecular crosstalk in tracheal development and its recurrence in adult tissue regeneration

  2021influential citation
• The Cell Origin and Role of Osteoclastogenesis and Osteoblastogenesis in Vascular Calcification

  2021cites this paper
• Overexpression of Msx1 in Mouse Lung Leads to Loss of Pulmonary Vessels Following Vascular Hypoxic Injury

  2021cites this paper
• Regulation of MDM2 E3 ligase-dependent vascular calcification by MSX1/2

  2021cites this paper
• MicroRNAs are critical in regulating smooth muscle cell mineralization and apoptosis during vascular calcification

  2020cites this paper
• Arterial Stiffness

  2020cites this paper
• The role of bone morphogenetic protein signaling in vascular calcification.

  2020cites this paper
• Epicardial Adipose Tissue in the Progression and Calcification of the Coronary Artery Disease

  2020cites this paper
• del sistema RANK / RANKL / OPG sobre la desmineralización ósea y la calcificación vascular en la enfermedad renal crónica

  2019cites this paper
• Bone morphogenetic protein signaling in inflammation

  2019cites this paper
• Wnt signaling in orofacial clefts: crosstalk, pathogenesis and models

  2019cites this paper
• BMP‐2 induces human mononuclear cell chemotaxis and adhesion and modulates monocyte‐to‐macrophage differentiation

  2018cites this paper
• Teniposide regulates the phenotype switching of vascular smooth muscle cells in a miR-21-dependent manner.

  2018cites this paper
• Conditioned medium from bone marrow-derived mesenchymal stem cells inhibits vascular calcification through blockade of the BMP2–Smad1/5/8 signaling pathway

  2018cites this paper
• Smooth muscle differentiation from human umbilical cord derived mesenchymal stem cells : miRNA-involved mechanism and potential application for vascular tissue engineering

  2017influential citation
• Possible Muscle Repair in the Human Cardiovascular System

  2017cites this paper
• Myocardin: A novel player in atherosclerosis.

  2017cites this paper
• Distinguishing the Role of the c-myb Proto-Oncogene in Mouse Models of Cardiovascular Disease

  2016cites this paper
• Noncoding RNAs in smooth muscle cell homeostasis: implications in phenotypic switch and vascular disorders

  2016cites this paper
• Effect of RANK / RANKL / OPG pathway on bone demineralization and vascular calcification in chronic kidney disease

  2016cites this paper
• Porphyromonas gingivalis‐derived outer membrane vesicles promote calcification of vascular smooth muscle cells through ERK1/2‐RUNX2

  2016cites this paper
• Vitamin K2 regression aortic calcification induced by warfarin via Gas6/Axl survival pathway in rats.

  2016cites this paper
• Increased plasma BMP-2 levels are associated with atherosclerosis burden and coronary calcification in type 2 diabetic patients

  2015cites this paper
• Ectopic expression of Msx2 in mammalian myotubes recapitulates aspects of amphibian muscle dedifferentiation.

  2015cites this paper
• Endodermal Wnt signaling is required for tracheal cartilage formation.

  2015cites this paper
• The role of astrocytic RFX4_v3 in demyelination

  2015cites this paper
• Regulators and effectors of bone morphogenetic protein signalling in the cardiovascular system

  2015cites this paper
• A novel inhibitory mechanism of MRTF-A/B on the ICAM-1 gene expression in vascular endothelial cells

  2015cites this paper
• Endothelial Msx1 transduces hemodynamic changes into an arteriogenic remodeling response

  2015cites this paper
• Arp5 is a key regulator of myocardin in smooth muscle cells

  2014cites this paper
• RPEL Proteins Are the Molecular Targets for CCG-1423, an Inhibitor of Rho Signaling

  2014cites this paper
• TGF-β Prevents Phosphate-Induced Osteogenesis through Inhibition of BMP and Wnt/β-Catenin Pathways

  2014influential citation
• The Role of Type-2 Cannabinoid Receptors in Calcification of Atherosclerotic Lesions

  2014cites this paper
• Myocardin and smooth muscle differentiation.

  2014cites this paper
• BMP-2 and -4 produced by vascular smooth muscle cells from atherosclerotic lesions induce monocyte chemotaxis through direct BMPRII activation.

  2014cites this paper
• TGF-b Prevents Phosphate-Induced Osteogenesis through Inhibition of BMP and Wnt / b-Catenin Pathways

  2014influential citation
• Importance of dimer formation of myocardin family members in the regulation of their nuclear export.

  2013cites this paper
• Differences in the Nuclear Export Mechanism between Myocardin and Myocardin-related Transcription Factor A*

  2013cites this paper
• Role of KLF4 in regulation of myocardin induced SMC differentiation in human smooth muscle stem progenitor cells (hSMSPC)

  2013cites this paper
• The R ole of Type-2 Cannabinoid Receptors in Calcific ation of Atherosclerotic Lesions.

  2013cites this paper
• Myocardin-related Transcription Factor A Mechanism between Myocardin and Differences in the Nuclear Export Cell

  2013cites this paper
• SOX9 and myocardin counteract each other in regulating vascular smooth muscle cell differentiation.

  2012cites this paper
• Characterization of the Arterial Adventitia as a Sonic Hedgehog Responsive Niche

  2012cites this paper
• Palmitate Promotes the Paracrine Effects of Macrophages on Vascular Smooth Muscle Cells: The Role of Bone Morphogenetic Proteins

  2012cites this paper
• BMP signaling in vascular diseases

  2012cites this paper
• TGFβ Signaling and Cardiovascular Diseases

  2012influential citation
• Myocardin is differentially required for the development of smooth muscle cells and cardiomyocytes.

  2011cites this paper
• Signalling pathways and vascular calcification.

  2011cites this paper
• Runx2-Upregulated Receptor Activator of Nuclear Factor &kgr;B Ligand in Calcifying Smooth Muscle Cells Promotes Migration and Osteoclastic Differentiation of Macrophages

  2011cites this paper
• Vascular smooth muscle progenitor cells: building and repairing blood vessels.

  2011cites this paper
• ATVB in Focus Vascular Cell Lineage Determination and Differentiation

  2011cites this paper
• Expression profiling identifies Klf15 as a glucocorticoid target that regulates airway hyperresponsiveness.

  2011cites this paper
• Notch Signaling Pathway Enhances Bone Morphogenetic Protein 2 (BMP2) Responsiveness of Msx2 Gene to Induce Osteogenic Differentiation and Mineralization of Vascular Smooth Muscle Cells*

  2011cites this paper
• Six1 and Eya1 are critical regulators of peri-cloacal mesenchymal progenitors during genitourinary tract development.

  2011cites this paper
• Msx1 and Msx2 promote meiosis initiation

  2011cites this paper
• Signaling mechanisms that regulate smooth muscle cell differentiation.

  2011cites this paper
• Divergent activities of osteogenic BMP2, and tenogenic BMP12 and BMP13 independent of receptor binding affinities

  2011cites this paper
• Myocardin functions as an effective inducer of growth arrest and differentiation in human uterine leiomyosarcoma cells.

  2010cites this paper
• Downregulation of msh-like 2 (msx2) and neurotrophic tyrosine kinase receptor type 2 (ntrk2) in the developmental gut of KIT mutant mice.

  2010cites this paper
• Regulation of adventitia-resident progenitor cells

  2010cites this paper
• Linking actin dynamics and gene transcription to drive cellular motile functions

  2010cites this paper
• Caldesmon, an actin-linked regulatory protein, comes across glucocorticoids

  2010cites this paper
• Runx2/Cbfa1, but not loss of myocardin, is required for smooth muscle cell lineage reprogramming toward osteochondrogenesis

  2010cites this paper
• Nuclear Import Mechanism for Myocardin Family Members and Their Correlation with Vascular Smooth Muscle Cell Phenotype*

  2010cites this paper
• RANKL Increases Vascular Smooth Muscle Cell Calcification Through a RANK-BMP4–Dependent Pathway

  2009cites this paper
• Myocardin-dependent Activation of the CArG Box-rich Smooth Muscle γ-Actin Gene

  2009cites this paper
• Detrimental effects of glucocorticoids on neuronal migration during brain development

  2009cites this paper
• Transcriptional regulation of SM22alpha by Wnt3a: convergence with TGFbeta(1)/Smad signaling at a novel regulatory element.

  2009cites this paper
• Autoregulatory loop of Msx1 expression involving its antisense transcripts

  2009cites this paper
• The expression and crucial roles of BMP signaling in development of smooth muscle progenitor cells in the mouse embryonic gut.

  2009cites this paper
• Mecanismos de calcificación vascular asociados a la uremia y al tratamiento con Calcitriol.

  2009cites this paper
• Sonic Hedgehog mediator Gli2 regulates bladder mesenchymal patterning.

  2008cites this paper
• Rho/Rho-associated Kinase Signal Regulates Myogenic Differentiation via Myocardin-related Transcription Factor-A/Smad-dependent Transcription of the Id3 Gene*

  2008cites this paper
• A sonic hedgehog signaling domain in the arterial adventitia supports resident Sca1+ smooth muscle progenitor cells

  2008cites this paper
• Msx1 Expression Regulation by Its Own Antisense RNA: Consequence on Tooth Development and Bone Regeneration

  2008cites this paper
• Oxidative Stress Induces Vascular Calcification through Modulation of the Osteogenic Transcription Factor Runx2 by AKT Signaling*

  2008cites this paper
• Reorganization of the actin cytoskeleton via transcriptional regulation of cytoskeletal/focal adhesion genes by myocardin-related transcription factors (MRTFs/MAL/MKLs).

  2007cites this paper
• Formation de la condensation dermique chez l'embryon de poulet : études in vivo, in vitro et in silico

  2007cites this paper
• Runx2 Represses Myocardin-Mediated Differentiation and Facilitates Osteogenic Conversion of Vascular Smooth Muscle Cells

  2007cites this paper
• Control of Phenotypic Plasticity of Smooth Muscle Cells by Bone Morphogenetic Protein Signaling through the Myocardin-related Transcription Factors*

  2007cites this paper
• Functional interactions between the Forkhead transcription factor FOXK1 and the MADS-box protein SRF

  2007cites this paper