Translating musculoskeletal bioengineering into tissue regeneration therapies

Musculoskeletal injuries and disorders are the leading cause of physical disability worldwide and a considerable socioeconomic burden. The lack of effective therapies has driven the development of novel bioengineering approaches that have recently started to gain clinical approvals. In this review, we first discuss the self-repair capacity of the musculoskeletal tissues and describe causes of musculoskeletal dysfunction. We then review the development of novel biomaterial, immunomodulatory, cellular, and gene therapies to treat musculoskeletal disorders. Last, we consider the recent regulatory changes and future areas of technological progress that can accelerate translation of these therapies to clinical practice. Description This Review discusses recent efforts in translating state-of-the-art bioengineering approaches to therapies for musculoskeletal regeneration.

• Publication year

  2022

• Venue

  Science Translational Medicine

• Publication date

  2022-10-12

• Fields of study

  Medicine, Engineering

• Identifiers
  DOI 10.1126/scitranslmed.abn9074PMID 36223445PMCID PMC7614064
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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