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Multifaceted role of synbiotics as nutraceuticals, therapeutics and carrier for drug delivery.

R. Khursheed,M. Gulati,Sheetu Wadhwa,Sukriti Vishwas,D. Sharma,L. Corrie,Aftab Alam,S. Alnasser,Faris F. Aba Alkhayl,Z. Parveen,S. Nammi,D. Chellappan,G. Gupta,Flavia C. Zacconi,A. Steel,J. Adams,N. Jha,K. Dua,S. Singh

Published 2022 in Chemico-Biological Interactions

ABSTRACT

Synbiotics, are a combination of probiotics and prebiotics. They play an important role in metabolizing different nutritional substrates and thus helps in the maintenance of human health. Any disbalance in the gut microflora, known as dysbiosis, is known to lead to a number of diseased conditions. It can be reverted by the administration of synbiotics. Present review highlights various mechanistic pathways through which synbiotics act as therapeutics. The dual role of synbiotics as nutraceutical and excipient in developing oral formulations are entailed with case studies. The findings entailed that there exist numerous studies on prebiotics as well as probiotics have been carried out to show their effects in several diseases. However, the concept of combining together them for prevention and treatment of various pathological conditions accruing from dysbiosis is relatively new. Synbiotics, however, face challenge of low stability during their sojourn in the GIT, which is generally overcome by various encapsulation techniques. Various studies also showed potential role of synbiotics in drug delivery. However, it is an emerging area and lacks clinical correlation. It is important to focus on clinical trials of formulations wherein synbiotics have been used as therapeutic moiety as well as pharmaceutical carrier for treating various diseases.

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