Stem cells: Aging and transcriptional fingerprints

Keyes and Fuchs discuss the decline in stem cell renewal and function with aging and the ensuing consequences on tissue homeostasis and regeneration.

• Publication year

  2018

• Venue

  Journal of Cell Biology

• Publication date

  2018-01-02

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1083/jcb.201708099PMID 29070608PMCID 5748991
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Rejuvenating Strategies for Stem Cell-Based Therapies in Aging.

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• Bone marrow adipocytes promote the regeneration of stem cells and hematopoiesis by secreting SCF

  2017cited by this paper
• Canonical Wnt Signaling Ameliorates Aging of Intestinal Stem Cells

  2017influential reference
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  2017influential reference
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  2017influential reference
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• Epigenetic stress responses induce muscle stem cell aging by Hoxa9 developmental signals

  2016influential reference
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  2016influential reference
• NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice

  2016cited by this paper
• Poor Repair of Skeletal Muscle in Aging Mice Reflects a Defect in Local, Interleukin-33-Dependent Accumulation of Regulatory T Cells.

  2016cited by this paper
• Gene expression signatures of human cell and tissue longevity

  2016cited by this paper
• Ageing, neurodegeneration and brain rejuvenation

  2016cited by this paper
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• RNA Splicing Modulation Selectively Impairs Leukemia Stem Cell Maintenance in Secondary Human AML.

  2016cited by this paper
• Foxc1 reinforces quiescence in self-renewing hair follicle stem cells

  2016cited by this paper
• FOXC1 maintains the hair follicle stem cell niche and governs stem cell quiescence to preserve long-term tissue-regenerating potential

  2016cited by this paper
• Adult Neurogenesis in the Hippocampus: From Stem Cells to Behavior.

  2016cited by this paper
• A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging

  2015cited by this paper
• Ascl2 acts as an R-spondin/Wnt-responsive switch to control stemness in intestinal crypts.

  2015cited by this paper
• Mest but Not MiR-335 Affects Skeletal Muscle Growth and Regeneration

  2015cited by this paper
• Variation in cancer risk among tissues can be explained by the number of stem cell divisions

  2015cited by this paper
• Ascl2 reinforces intestinal stem cell identity.

  2015cited by this paper
• SOCS2 Controls Proliferation and Stemness of Hematopoietic Cells under Stress Conditions and Its Deregulation Marks Unfavorable Acute Leukemias.

  2015cited by this paper
• Single-cell RNA-seq reveals changes in cell cycle and differentiation programs upon aging of hematopoietic stem cells

  2015cited by this paper
• Geriatric muscle stem cells switch reversible quiescence into senescence

  2014influential reference
• Inhibition of JAK/STAT signaling stimulates adult satellite cell function

  2014cited by this paper
• Restoring Systemic GDF11 Levels Reverses Age-Related Dysfunction in Mouse Skeletal Muscle

  2014influential reference
• In vivo transcriptional governance of hair follicle stem cells by canonical Wnt regulators

  2014cited by this paper
• Rejuvenation of the aged muscle stem cell population restores strength to injured aged muscles

  2014influential reference
• Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice

  2014cited by this paper
• Regenerative hair waves in aging mice and extra-follicular modulators Follistatin, Dkk1 and Sfrp4

  2014cited by this paper
• Quiescent hematopoietic stem cells accumulate DNA damage during aging that is repaired upon entry into cell cycle.

  2014influential reference
• Stem cell aging: mechanisms, regulators and therapeutic opportunities

  2014cited by this paper
• P38 MAPK signaling underlies a cell autonomous loss of stem cell self-renewal in aged skeletal muscle

  2014cited by this paper
• Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal.

  2014influential reference
• Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells

  2014cited by this paper
• Dynamics of hippocampal neurogenesis in adult humans.

  2013cited by this paper
• The hallmarks of aging.

  2013cited by this paper
• A canonical to non-canonical Wnt signalling switch in haematopoietic stem-cell ageing

  2013cited by this paper
• NFIB is a governor of epithelial–melanocyte stem cell behaviour in a shared niche

  2013cited by this paper
• Chromatin Modifications as Determinants of Muscle Stem Cell Quiescence and Chronological Aging

  2013influential reference
• Nfatc1 orchestrates aging in hair follicle stem cells

  2013influential reference
• Genome instability and aging.

  2013cited by this paper
• Oncogenic miRNAs and the perils of losing control of a stem cell's epigenetic identity.

  2013cited by this paper
• Mechanisms that regulate stem cell aging and life span.

  2013cited by this paper
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  2013cited by this paper
• Continuous clonal labeling reveals small numbers of functional stem cells in intestinal crypts and adenomas.

  2013cited by this paper
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  2013cited by this paper
• Foxp1 maintains hair follicle stem cell quiescence through regulation of Fgf18

  2013cited by this paper
• The aged niche disrupts muscle stem cell quiescence

  2012cited by this paper
• Stem cell recruitment after injury: lessons for regenerative medicine.

  2012cited by this paper
• Age-associated inflammation inhibits epidermal stem cell function.

  2012influential reference
• Tissue-specific stem cells: lessons from the skeletal muscle satellite cell.

  2012cited by this paper
• Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation.

  2012cited by this paper
• Clonal analysis reveals multiple functional defects of aged murine hematopoietic stem cells

  2011cited by this paper
• JAM-B regulates maintenance of hematopoietic stem cells in the bone marrow.

  2011cited by this paper
• The ageing systemic milieu negatively regulates neurogenesis and cognitive function

  2011cited by this paper
• The aging systemic milieu negatively regulates neurogenesis and cognitive function

  2011cited by this paper
• Coordinated activation of Wnt in epithelial and melanocyte stem cells initiates pigmented hair regeneration.

  2011cited by this paper
• Manifestations and mechanisms of stem cell aging

  2011cited by this paper
• Dynamics between stem cells, niche, and progeny in the hair follicle.

  2011influential reference
• Rate, molecular spectrum, and consequences of human mutation

  2010cited by this paper
• Role of Annexin A1 in mouse myoblast cell differentiation

  2010cited by this paper
• Tackling the widespread and critical impact of batch effects in high-throughput data

  2010cited by this paper
• Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion

  2010cited by this paper
• Bone marrow adipocytes as negative regulators of the hematopoietic microenvironment

  2009cited by this paper
• Genotoxic stress abrogates renewal of melanocyte stem cells by triggering their differentiation.

  2009cited by this paper
• A two-step mechanism for stem cell activation during hair regeneration.

  2009cited by this paper
• Neural Stem and Progenitor Cells Retain Their Potential for Proliferation and Differentiation into Functional Neurons Despite Lower Number in Aged Brain

  2009cited by this paper
• Stems cells and the pathways to aging and cancer.

  2008cited by this paper
• Origin of Stem Cells in Organogenesis

  2008cited by this paper
• Quantitative proliferation dynamics and random chromosome segregation of hair follicle stem cells

  2008cited by this paper
• A new mechanism for the aging of hematopoietic stem cells: aging changes the clonal composition of the stem cell compartment but not individual stem cells.

  2008cited by this paper
• Pbx1 regulates self-renewal of long-term hematopoietic stem cells by maintaining their quiescence.

  2008cited by this paper
• Stem cells and niches: mechanisms that promote stem cell maintenance throughout life.

  2008cited by this paper
• Increased Wnt Signaling During Aging Alters Muscle Stem Cell Fate and Increases Fibrosis

  2007cited by this paper
• Scratching the surface of skin development

  2007cited by this paper
• Ageing: from stem to stern.

  2007cited by this paper
• Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age

  2007cited by this paper
• Hematopoietic Stem Cell Quiescence Attenuates DNA Damage Response and Permits DNA Damage Accumulation During Aging

  2007cited by this paper
• Disruption of large-scale brain systems in advanced aging.

  2007cited by this paper
• Aging Hematopoietic Stem Cells Decline in Function and Exhibit Epigenetic Dysregulation

  2007influential reference
• How stem cells age and why this makes us grow old

  2007cited by this paper
• Bex1 knock out mice show altered skeletal muscle regeneration.

  2007cited by this paper
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  2007cited by this paper
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  2006cited by this paper
• Blackwell Publishing Ltd

  2006cited by this paper
• Cell intrinsic alterations underlie hematopoietic stem cell aging.

  2005influential reference
• Aging, Stem Cells and Tissue Regeneration: Lessons from Muscle

  2005cited by this paper
• Rejuvenation of aged progenitor cells by exposure to a young systemic environment

  2005influential reference
• Retrospective birth dating of cells in humans.

  2005cited by this paper
• Epidermal stem cells.

  2005cited by this paper
• Mechanisms of Hair Graying: Incomplete Melanocyte Stem Cell Maintenance in the Niche

  2005cited by this paper
• Defining the epithelial stem cell niche in skin.

  2004cited by this paper
• Neural Stem Cell Detection, Characterization, and Age-Related Changes in the Subventricular Zone of Mice

  2004influential reference
• Prevalence and outcomes of anemia in geriatrics: a systematic review of the literature.

  2004cited by this paper
• Age-related changes in lymphocyte development and function

  2004cited by this paper

• Hallmarks of stem cell aging.

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• Autophagy in adult stem cell homeostasis, aging, and disease therapy

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• Biomarkers of aging: from molecules and surrogates to physiology and function.

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  2023cites this paper
• Restoring bone marrow niche function rejuvenates aged hematopoietic stem cells by reactivating the DNA Damage Response

  2023cites this paper
• Regenerative medicine for male infertility: A focus on stem cell niche injury models

  2022cites this paper
• Novel roles for RNA binding proteins squid, hephaesteus, and Hrb27C in Drosophila oogenesis

  2022cites this paper
• Non-neutral clonal selection and its potential role in mammalian germline stem cell dysfunction with advancing age

  2022cites this paper
• Diverse geroprotectors differently affect a mechanism linking cellular aging to cellular quiescence in budding yeast

  2022cites this paper
• Promise and Perspective of Nanomaterials in Antisenescence Tissue Engineering Applications.

  2022cites this paper
• Atypically Shaped Cardiomyocytes (ACMs): The Identification, Characterization and New Insights into a Subpopulation of Cardiomyocytes

  2022cites this paper
• Anillin governs mitotic rounding during early epidermal development

  2022cites this paper
• Age‐related decrease in responsiveness of CD271‐positive skin stem cells to growth factors

  2022cites this paper
• Hallmarks of aging-based dual-purpose disease and age-associated targets predicted using PandaOmics AI-powered discovery engine

  2022cites this paper
• New developments in the biology of fibroblast growth factors.

  2022cites this paper
• A Long Journey before Cycling: Regulation of Quiescence Exit in Adult Muscle Satellite Cells

  2022cites this paper
• FOXO3 regulates a common genomic program in aging and glioblastoma stem cells

  2021cites this paper
• Aging and age‐related diseases: from mechanisms to therapeutic strategies

  2021cites this paper
• Stem cell quiescence: the challenging path to activation

  2021cites this paper
• Exploring Human Skin Aging at the Single-Cell Level.

  2021cites this paper
• Differentiation reveals latent features of aging and an energy barrier in murine myogenesis.

  2021cites this paper
• Stem cell aging and wound healing

  2021cites this paper
• Role of biological markers in stem cell aging and its implications in therapeutic processes

  2021cites this paper
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  2021cites this paper
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  2021cites this paper
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  2021cites this paper
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  2021cites this paper
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  2021cites this paper
• Investigating Adult Stem Cells Through Lineage analyses

  2021cites this paper
• Aging-associated stem/progenitor cell dysfunction in the salivary glands of mice.

  2021cites this paper
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  2021cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
• The aging skin microenvironment dictates stem cell behavior

  2020cites this paper
• APC/C-dependent control of gene expression and cell identity

  2020cites this paper
• Mesenchymal Stromal Cells as Critical Contributors to Tissue Regeneration

  2020cites this paper
• Gene regulatory programmes of tissue regeneration

  2020cites this paper
• Fate of Hematopoiesis During Aging. What Do We Really Know, and What are its Implications?

  2020cites this paper
• Biotechnology Applied to Cosmetics and Aesthetic Medicines

  2020cites this paper
• Senescence and Longevity of Sea Urchins

  2020cites this paper
• Tools and Concepts for Interrogating and Defining Cellular Identity.

  2020cites this paper
• Murine single-cell RNA-seq reveals cell-identity- and tissue-specific trajectories of aging

  2019cites this paper
• A murine aging cell atlas reveals cell identity and tissue-specific trajectories of aging

  2019cites this paper
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  2019cites this paper
• Nicotinamide Metabolism Modulates the Proliferation/Differentiation Balance and Senescence of Human Primary Keratinocytes.

  2019cites this paper
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  2019influential citation
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  2019cites this paper
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  2019cites this paper
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