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Sheng-ji Hua-yu ointment ameliorates cutaneous wound healing in diabetes via up-regulating CCN1.

Dan-Zhou Yang,Yilun Tan,Ying Zhang,Jiankun Song,Yue Luo,Ying Luo,Xiao-ya Fei,Y. Ru,Bin Li,Jing-Si Jiang,L. Kuai

Published 2022 in Journal of Ethnopharmacology

ABSTRACT

ETHNOPHARMACOLOGICAL RELEVANCE Diabetic ulcers (DUs) are one of the most severe complications of diabetes, and efficacious therapeutic means are currently lacking. Sheng-ji Hua-yu (SJHY) ointment is a classical Chinese traditional prescription that can significantly attenuate DU defects, but the specific mechanism remains to be fully elucidated. AIM OF THE STUDY In order to verify the underlying mechanism of SJHY ointment in accelerating the closure of DUs. MATERIALS AND METHODS Modular pharmacology and molecular docking were utilized to predict the therapeutic targets of SJHY ointment against DUs. Male db/db diabetic mice and HaCaT cell models induced by methylglyoxal were used to validate the findings. RESULTS CCN1 was proven to be the core target of SJHY ointment involved in DUs treatment. CCN1 up-regulated by SJHY treatment (0.5 g/cm2/day) at the mRNA and protein levels were detected on Day 9 after wounding. When CCN1 knockdown, accelerated cell proliferation, migration, and anti-inflammatory effect of SJHY treatment (10 mg/L) were reversed. CONCLUSIONS SJHY ointment ameliorates cutaneous wound healing by up-regulating CCN1.

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