Matricellular Protein CCN1 Promotes Regression of Liver Fibrosis through Induction of Cellular Senescence in Hepatic Myofibroblasts

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Molecular and Cellular Biology

• Publication date

  2013-03-18

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/MCB.00049-13PMID 23508104PMCID PMC3647960
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Wound Repair and Regeneration

  2012cited by this paper
• Deactivation of hepatic stellate cells during liver fibrosis resolution in mice.

  2012cited by this paper
• Liver fibrosis and hepatocyte apoptosis are attenuated by GKT137831, a novel NOX4/NOX1 inhibitor in vivo.

  2012cited by this paper
• Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis

  2012cited by this paper
• Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent

  2012cited by this paper
• Regulation of hepatic stellate cells by connective tissue growth factor.

  2012cited by this paper
• What's new in liver fibrosis? The origin of myofibroblasts in liver fibrosis

  2012cited by this paper
• NOX1/nicotinamide adenine dinucleotide phosphate, reduced form (NADPH) oxidase promotes proliferation of stellate cells and aggravates liver fibrosis induced by bile duct ligation

  2011cited by this paper
• Current status of novel antifibrotic therapies in patients with chronic liver disease

  2011cited by this paper
• CCN1/CYR61: the very model of a modern matricellular protein

  2011cited by this paper
• Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets

  2011influential reference
• Pathogenesis of liver fibrosis.

  2011cited by this paper
• Four faces of cellular senescence

  2011cited by this paper
• The nicotinamide adenine dinucleotide phosphate oxidase (NOX) homologues NOX1 and NOX2/gp91phox mediate hepatic fibrosis in mice

  2011cited by this paper
• The opposing effects of CCN2 and CCN5 on the development of cardiac hypertrophy and fibrosis.

  2010cited by this paper
• Hepatocytes do not undergo epithelial‐mesenchymal transition in liver fibrosis in mice

  2010cited by this paper
• Cellular senescence controls fibrosis in wound healing

  2010cited by this paper
• The Matricellular Protein CCN1/CYR61 Induces Fibroblast Senescence and Restricts Fibrosis in Cutaneous Wound Healing

  2010cited by this paper
• The senescence-associated secretory phenotype: the dark side of tumor suppression.

  2010cited by this paper
• Epithelial‐to‐mesenchymal transitions in the liver

  2009cited by this paper
• Fibrogenic Potential of Human Multipotent Mesenchymal Stromal Cells in Injured Liver

  2009cited by this paper
• Connective tissue growth factor (CCN2, CTGF) and organ fibrosis: lessons from transgenic animals

  2009cited by this paper
• Reversal of Liver Fibrosis

  2009cited by this paper
• Protocols to detect senescence-associated beta-galactosidase (SA-βgal) activity, a biomarker of senescent cells in culture and in vivo

  2009cited by this paper
• Assessing the Metabolic Competence of Sandwich-Cultured Mouse Primary Hepatocytes

  2009cited by this paper
• Negligible contribution of bone marrow-derived cells to collagen production during hepatic fibrogenesis in mice.

  2009cited by this paper
• Fas-Mediated Apoptosis Is Regulated by the Extracellular Matrix Protein CCN1 (CYR61) In Vitro and In Vivo

  2009cited by this paper
• Connective tissue growth factor: a fibrogenic master switch in fibrotic liver diseases

  2008cited by this paper
• Oxidative stress in alcoholic liver disease: Role of NADPH oxidase complex

  2008cited by this paper
• NOX enzymes as novel targets for drug development

  2008cited by this paper
• A reproducible and well-tolerated method for 2/3 partial hepatectomy in mice

  2008cited by this paper
• Resolution of liver cirrhosis using vitamin A–coupled liposomes to deliver siRNA against a collagen-specific chaperone

  2008cited by this paper
• Senescence of activated stellate cells limits liver fibrosis.

  2008influential reference
• Cellular senescence in cancer and aging.

  2007cited by this paper
• Regulation of Nox and Duox enzymatic activity and expression.

  2007cited by this paper
• Vascular Endothelial Growth Factor (VEGF)-induced Up-regulation of CCN1 in Osteoblasts Mediates Proangiogenic Activities in Endothelial Cells and Promotes Fracture Healing*

  2007cited by this paper
• Cytotoxicity of TNFα is regulated by integrin‐mediated matrix signaling

  2007cited by this paper
• Cellular senescence: when bad things happen to good cells

  2007cited by this paper
• Transforming growth factor‐β and substrate stiffness regulate portal fibroblast activation in culture

  2007cited by this paper
• The Matricellular Protein CCN1 Is Essential for Cardiac Development

  2006cited by this paper
• Nox1-dependent Reactive Oxygen Generation Is Regulated by Rac1*

  2006cited by this paper
• Liver fibrosis.

  2005cited by this paper
• Isolation and culture of hepatic stellate cells.

  2005cited by this paper
• Modeling liver fibrosis in rodents.

  2005cited by this paper
• The role and regulation of hepatic stellate cell apoptosis in reversal of liver fibrosis

  2005cited by this paper
• Targeted Mutagenesis of the Angiogenic Protein CCN1 (CYR61)

  2004cited by this paper
• Liver fibrosis

  2004cited by this paper
• Identification of a Novel Integrin α6β1 Binding Site in the Angiogenic Inducer CCN1 (CYR61)*

  2003cited by this paper
• Identification of a novel integrin alpha 6 beta 1 binding site in the angiogenic inducer CCN1 (CYR61).

  2003cited by this paper
• CYR61 (CCN1) Is Essential for Placental Development and Vascular Integrity

  2002cited by this paper
• The Angiogenic Factor Cyr61 Activates a Genetic Program for Wound Healing in Human Skin Fibroblasts*

  2001cited by this paper
• The Angiogenic Factors Cyr61 and Connective Tissue Growth Factor Induce Adhesive Signaling in Primary Human Skin Fibroblasts*

  2001cited by this paper
• Adhesion of human skin fibroblasts to Cyr61 is mediated through integrin alpha 6beta 1 and cell surface heparan sulfate proteoglycans.

  2000cited by this paper
• DNA excision in liver by an albumin‐Cre transgene occurs progressively with age

  2000cited by this paper
• Adhesion of Human Skin Fibroblasts to Cyr61 Is Mediated through Integrin α6β1 and Cell Surface Heparan Sulfate Proteoglycans*

  2000cited by this paper
• Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA

  1999cited by this paper
• Dual Roles for Glucokinase in Glucose Homeostasis as Determined by Liver and Pancreatic β Cell-specific Gene Knock-outs Using Cre Recombinase*

  1999cited by this paper
• Pathogenesis of liver fibrosis.

  1997influential reference
• Cyr61, a product of a growth factor-inducible immediate-early gene, promotes cell proliferation, migration, and adhesion

  1996cited by this paper
• Wound repair and regeneration

  1994cited by this paper
• Prolonged bile duct obstruction: a new experimental model for cirrhosis in the rat.

  1984cited by this paper
• Modified assay for determination of hydroxyproline in a tissue hydrolyzate.

  1980cited by this paper

• The relationship between CXC chemokines and cellular senescence: from mechanisms to therapy

  2026cites this paper
• CCN1: a SASPy protein that plays multifaceted roles in fibrogenesis.

  2025cites this paper
• Injured tubular epithelia-derived CCN1 promotes the mobilization of fibroblasts toward injury sites after kidney injury

  2025cites this paper
• Lesion-remote astrocytes govern microglia-mediated white matter repair

  2025cites this paper
• Revealed the regulatory role of CCN1 to microglia distribution through region-specific cellular interactions

  2025cites this paper
• The multifunctional protein CCN1/CYR61: Bridging physiology and disease.

  2025cites this paper
• Exploring the double-edged role of cellular senescence in chronic liver disease for new treatment approaches.

  2025cites this paper
• Astrocyte CCN1 stabilizes neural circuits in the adult brain

  2025cites this paper
• Liver aging: underlying mechanisms and therapeutic strategies.

  2025cites this paper
• The context-dependent effect of cellular senescence: from embryogenesis and wound healing to aging.

  2025cites this paper
• CYR61 as a Potential Biomarker and Target in Cancer Prognosis and Therapies

  2025cites this paper
• Influence of a Zombie-like State of the Liver on Drugs and Its Medico-Legal Implications: A Scoping Review

  2025cites this paper
• Injured tubule derived CCN1 exacerbates renal congestion-mediated acute kidney injury and fibrosis

  2025cites this paper
• Dynamic crosstalk between HSCs and liver microenvironment: multicellular interactions in the regulation of liver fibrosis

  2025cites this paper
• Hallmarks of the Aging Skin Microenvironment: Components and Mechanisms

  2025influential citation
• Can Nutraceuticals Support the Treatment of MASLD/MASH, and thus Affect the Process of Liver Fibrosis?

  2024cites this paper
• The p21+ Perinecrotic Hepatocytes Produce the Chemokine CXCL14 After a Severe Acetaminophen Overdose Promoting Hepatocyte Injury and Delaying Regeneration.

  2024cites this paper
• Inhibition of endogenous hydrogen sulfide production reduces activation of hepatic stellate cells via the induction of cellular senescence

  2024cites this paper
• Selective induction of senescence in cancer cells through near‐infrared light treatment via mitochondrial modulation

  2024cites this paper
• Navigating the complex role of senescence in liver disease

  2024cites this paper
• Upregulation of CYR61 by TGF-β and YAP signaling exerts a counter-suppression of hepatocellular carcinoma

  2024cites this paper
• Aging, senescence, and cutaneous wound healing—a complex relationship

  2024cites this paper
• Involvement of Matricellular Proteins in Cellular Senescence: Potential Therapeutic Targets for Age-Related Diseases

  2024cites this paper
• Cysteine‐rich 61 inhibition attenuates hepatic insulin resistance and improves lipid metabolism in high‐fat diet fed mice and HepG2 cells

  2024cites this paper
• Recent progress on the role of cellular communication network factors (CCN) 3, 4 and 6 in regulating adiposity, liver fibrosis and pancreatic islets

  2023cites this paper
• Senescence-associated alterations in the extracellular matrix: Deciphering their role in the regulation of cellular function.

  2023cites this paper
• Administration of AG490 decreases the senescence of umbilical cord-mesenchymal stem cells and promotes the cytotherapeutic effect in liver fibrosis

  2023cites this paper
• The Janus-Faced Role of Lipid Droplets in Aging: Insights from the Cellular Perspective

  2023cites this paper
• Senescent Subtypes Transition Model

  2023cites this paper
• Hepatocyte CYR61 polarizes profibrotic macrophages to orchestrate NASH fibrosis

  2023cites this paper
• Significance of CCNs in liver regeneration

  2023cites this paper
• Flip a coin: cell senescence at the maternal–fetal interface

  2023cites this paper
• Unlocking the potential of Mesenchymal stem cells in liver Fibrosis: Insights into the impact of autophagy and aging.

  2023cites this paper
• TGF-β as A Master Regulator of Aging-Associated Tissue Fibrosis

  2023cites this paper
• The ageing immune system as a potential target of senolytics

  2023cites this paper
• Atomic Force Microscopy-Based Measurements of Retinal Microvessel Stiffness in Mice with Endothelial-Specific Deletion of CCN1.

  2023cites this paper
• Embryonic stem cell-derived extracellular vesicles rejuvenate senescent cells and antagonize aging in mice

  2023cites this paper
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  2023cites this paper
• Expression and biological function of the cellular communication network factor 5 (CCN5) in primary liver cells

  2023influential citation
• Analysis of CCN Functions in Liver Regeneration After Partial Hepatectomy.

  2023cites this paper
• Role of the Hippo pathway in liver regeneration and repair: recent advances

  2022cites this paper
• Cellular senescence and cardiovascular diseases: moving to the "heart" of the problem.

  2022cites this paper
• CCN1/Integrin α5β1 Instigates Free Fatty Acid-Induced Hepatocyte Lipid Accumulation and Pyroptosis through NLRP3 Inflammasome Activation

  2022cites this paper
• Matrix-bound Cyr61/CCN1 is required to retain the properties of the bone marrow mesenchymal stem cell niche but is depleted with aging

  2022cites this paper
• Role of Mesenchymal Stem Cells and Extracellular Vesicles in Idiopathic Pulmonary Fibrosis

  2022cites this paper
• Cellular communication network factor 1‐stimulated liver macrophage efferocytosis drives hepatic stellate cell activation and liver fibrosis

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  2022cites this paper
• Targeting CCN2 protects against progressive non-alcoholic steatohepatitis in a preclinical model induced by high-fat feeding and type 2 diabetes

  2022cites this paper
• Gadd45 in Senescence.

  2022cites this paper
• CCN1 interacts with integrins to regulate intestinal stem cell proliferation and differentiation

  2022cites this paper
• Cellular senescence and acute kidney injury

  2022cites this paper
• Senescence as a therapeutic target

  2022cites this paper
• Sheng-ji Hua-yu ointment ameliorates cutaneous wound healing in diabetes via up-regulating CCN1.

  2022cites this paper
• Senescent hepatic stellate cells promote liver regeneration through IL-6 and ligands of CXCR2

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  2022cites this paper
• The role of p53 in liver fibrosis

  2022cites this paper
• Senescence under appraisal: hopes and challenges revisited

  2021cites this paper
• Autophagy, tissue repair, and fibrosis: a delicate balance.

  2021cites this paper
• A dietary ketone ester mitigates histological outcomes of NAFLD and markers of fibrosis in high-fat diet fed mice.

  2021cites this paper
• CCN1 coordinately regulates intestinal stem cell proliferation and differentiation through integrins αvβ3/αvβ5

  2021cites this paper
• Cellular and Molecular Mechanisms Underlying Liver Fibrosis Regression

  2021cites this paper
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  2021cites this paper
• Cellular senescence in lymphoid organs and immunosenescence

  2021cites this paper
• CYR61, regulated by miR-22-3p and MALAT1, promotes autophagy in HK-2 cell inflammatory model

  2021cites this paper
• Beneficial Effects of Exogenous Ketogenic Supplements on Aging Processes and Age-Related Neurodegenerative Diseases

  2021cites this paper
• Impact of Senescent Cell Subtypes on Tissue Dysfunction and Repair: Importance and Research Questions.

  2021cites this paper
• Cellular senescence in liver fibrosis: Implications for age-related chronic liver diseases

  2021cites this paper
• Senotherapeutics: Experimental therapy of cellular senescence

  2021cites this paper
• Hepatic Wnt1 Inducible Signaling Pathway Protein 1 (WISP-1/CCN4) Associates with Markers of Liver Fibrosis in Severe Obesity

  2021cites this paper
• Myofibroblast fate plasticity in tissue repair and fibrosis: Deactivation, apoptosis, senescence and reprogramming

  2021cites this paper
• Cellular Senescence in Liver Disease and Regeneration

  2021cites this paper
• Macrophages in Chronic Liver Failure: Diversity, Plasticity and Therapeutic Targeting

  2021cites this paper
• The Role of Ageing and Parenchymal Senescence on Macrophage Function and Fibrosis

  2021cites this paper
• The role of cellular senescence in tissue repair and regeneration.

  2021cites this paper
• Cellular senescence in ageing: from mechanisms to therapeutic opportunities

  2020cites this paper
• CCN1 promotes hepatic steatosis and inflammation in non-alcoholic steatohepatitis

  2020cites this paper
• Emerging role of CCN family proteins in fibrosis

  2020influential citation
• The ECM path of senescence in aging: components and modifiers

  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
• Proteomic landscape of TGF-β1-induced fibrogenesis in renal fibroblasts

  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
• Stochastic non-enzymatic modification of long-lived macromolecules - a missing hallmark of aging.

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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
• Classical and Nonclassical Intercellular Communication in Senescence and Ageing.

  2020cites this paper
• The potential role of senescence in limiting fibrosis caused by aging

  2020cites this paper
• Regulation of cellular senescence by extracellular matrix during chronic fibrotic diseases

  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper