Senescence of activated stellate cells limits liver fibrosis.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Cell

• Publication date

  2008-08-22

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.cell.2008.06.049PMID 18724938PMCID PMC3073300
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Tissue-specific and reversible RNA interference in transgenic mice

  2007cited by this paper
• microRNAs join the p53 network — another piece in the tumour-suppression puzzle

  2007cited by this paper
• Lymphocyte–hepatic stellate cell proximity suggests a direct interaction

  2007cited by this paper
• Regulation of Hepatic Stellate Cell Differentiation by the Neurotrophin Receptor p75NTR

  2007influential reference
• The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence.

  2007cited by this paper
• Cellular senescence in cancer and aging.

  2007influential reference
• Cellular senescence: when bad things happen to good cells

  2007cited by this paper
• Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

  2007influential reference
• Female hepatology: favorable role of estrogen in chronic liver disease with hepatitis B virus infection.

  2007cited by this paper
• A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formation.

  2006cited by this paper
• Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

  2006cited by this paper
• Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication

  2006cited by this paper
• Self-tolerance of natural killer cells

  2006influential reference
• Natural killer cells ameliorate liver fibrosis by killing activated stellate cells in NKG2D-dependent and tumor necrosis factor-related apoptosis-inducing ligand-dependent manners.

  2006cited by this paper
• Liver fibrosis.

  2005cited by this paper
• Tumour biology: Senescence in premalignant tumours

  2005cited by this paper
• BRAFE600-associated senescence-like cell cycle arrest of human naevi

  2005cited by this paper
• The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor

  2005cited by this paper
• National Center for Health Statistics (NCHS)

  2005cited by this paper
• Oncogene-induced senescence as an initial barrier in lymphoma development

  2005cited by this paper
• Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

  2005cited by this paper
• Immunology of hepatitis B virus and hepatitis C virus infection

  2005cited by this paper
• Liver fibrosis

  2004influential reference
• Inducible production of interferon-γ in the developing brain causes cerebellar dysplasia with activation of the Sonic hedgehog pathway

  2004cited by this paper
• Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence.

  2003influential reference
• Replicative senescence of activated human hepatic stellate cells is accompanied by a pronounced inflammatory but less fibrogenic phenotype

  2003cited by this paper
• A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy.

  2002cited by this paper
• Hepatocyte telomere shortening and senescence are general markers of human liver cirrhosis.

  2002influential reference
• hGFAP‐cre transgenic mice for manipulation of glial and neuronal function in vivo

  2001cited by this paper
• Senescent fibroblasts promote epithelial cell growth and tumorigenesis: A link between cancer and aging

  2001cited by this paper
• HCV-related fibrosis progression following liver transplantation: increase in recent years.

  2000cited by this paper
• Malignant hematopoietic cell lines: in vitro models for the study of natural killer cell leukemia–lymphoma

  2000cited by this paper
• Tumor surveillance via the ARF-p53 pathway.

  1998cited by this paper
• Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling.

  1998cited by this paper
• Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a.

  1997influential reference
• The serial cultivation of human diploid cell strains.

  1961cited by this paper

• IGF-1 as a mediator in the association between body mass index and risk of liver cancer: A prospective analysis of 432,203 participants from the UK biobank.

  2026cites this paper
• Senescent hepatic stellate cells drive inflammation and disease progression in MASH (Review)

  2026influential citation
• Hepatocyte–hepatic stellate cell interactions in liver fibrosis: Mechanisms and therapeutic implications

  2026cites this paper
• Fibroblasts as regulators of lung immunity, repair and fibrosis.

  2026cites this paper
• The Role of Cellular Senescence in Oral Health and Disease

  2026cites this paper
• Natural killer cell-based senotherapy: a promising strategy for healthy aging

  2026cites this paper
• Myocardial Aging: Cellular Mechanisms and Therapeutic Perspectives

  2026cites this paper
• Cellular senescence in human liver under normal aging and cancer

  2026cites this paper
• Biological aging across the metabolic dysfunction-associated steatotic liver disease spectrum: A systematic review.

  2026cites this paper
• Targeting Cellular Senescence: A New Therapeutic Axis in Chronic Liver Disease

  2026cites this paper
• Beyond hepatic stellate cell heterogeneity: Resolving fibrosis, restoring regeneration (Review)

  2026cites this paper
• p16Ink4a-Positive Hepatocytes Drive Liver Fibrosis Through Activation of LIFR Family Pathway.

  2026cites this paper
• Harnessing the NKG2D immune surveillance pathway using engineered T-cells for the treatment of human disease

  2026cites this paper
• Atrial myocyte senescence as a driver of atrial fibrillation: mechanisms and therapeutic implications

  2026cites this paper
• Proliferation of activated hepatic stellate cells requires REST

  2026cites this paper
• Supramolecular delivery of senolytics enables targeted anti-senescence therapy and accelerated fracture healing.

  2026cites this paper
• Monitoring senescent cell dynamics in wound healing using a p16-tdtomato mouse model.

  2026cites this paper
• Exploring senescence markers as potential drivers of osteoarthritis pain in aging adults.

  2025cites this paper
• γδ17 T cell-stromal networks modulate matrix composition and vascularity in foreign body response

  2025cites this paper
• Cancer and Aging Biomarkers: Classification, Early Detection Technologies and Emerging Research Trends

  2025cites this paper
• The senescence-like activity of BMS-470539 is associated with anti-fibrotic actions in models of dermal fibrosis

  2025cites this paper
• Cellular Senescence in Liver Diseases: From Molecular Drivers to Therapeutic Targeting.

  2025cites this paper
• Aging increases susceptibility to liver fibrosis through enhanced NAT10-mediated ac4C modification of TGFβ1 mRNA

  2025cites this paper
• Hybrid Platinum(IV)-Naproxen Nanostructured Drugs Reprogram Melanoma Cells and Overpower Cisplatin

  2025cites this paper
• Senolytic-Resistant Senescent Cells Have a Distinct SASP Profile and Functional Impact: The Path to Developing Senosensitizers

  2025cites this paper
• Dissecting the mechanisms of MASLD fibrosis in the era of single-cell and spatial omics

  2025cites this paper
• Deciphering the Role of Oroxylin A in Liver Fibrosis

  2025cites this paper
• Heterogeneity of Cellular Senescence, Senotyping, and Targeting by Senolytics and Senomorphics in Lung Diseases

  2025cites this paper
• Targeting cellular senescence for cancer therapy.

  2025cites this paper
• The drug discovery and therapeutic nano-strategies targeting cellular senescence

  2025cites this paper
• Targeting immunosenesence promotes clearance of senescent cells

  2025influential citation
• Mechanisms of aging in the cardiovascular system: challenges and opportunities

  2025cites this paper
• Aging and Aging-Related Senescence in Liver

  2025cites this paper
• Senescence, aging and disease throughout the gastrointestinal system.

  2025cites this paper
• Characterizing primary and secondary senescence in vivo

  2025cites this paper
• Bioinformatics-Guided Experimental Validation Identifies NQO1 as a Senescence-Ferroptosis Hub in Liver Fibrosis

  2025cites this paper
• Exploring the double-edged role of cellular senescence in chronic liver disease for new treatment approaches.

  2025cites this paper
• The context-dependent effect of cellular senescence: from embryogenesis and wound healing to aging.

  2025cites this paper
• Quasi-spatial single-cell transcriptome based on physical tissue properties defines early aging associated niche in liver

  2025cites this paper
• ADSCs attenuate Liver fibrosis via inducing HSC senescence: validation in dual-etiology models

  2025cites this paper
• Hepatic stellate cell heterogeneity: Functional aspects and therapeutic implications.

  2025cites this paper
• Advancing T-cell immunotherapy for cellular senescence and disease: Mechanisms, challenges, and clinical prospects.

  2025cites this paper
• Gly-βMCA modulates bile acid metabolism to reduce hepatobiliary injury in Mdr2 KO mice.

  2025cites this paper
• Photoactivatable Exosenolytics Activate Natural Killer Cells for Delaying Osteoarthritis.

  2025cites this paper
• The Role of Sirtuins in Cellular Senescence and the Development of Age-Associated Diseases

  2025cites this paper
• Cardiolipin-mimic lipid nanoparticles without antibody modification delivered senolytic in vivo CAR-T therapy for inflamm-aging

  2025cites this paper
• Disturbance of cytoskeleton induced by ligustilide promotes hepatic stellate cell senescence and ameliorates liver fibrosis

  2025cites this paper
• Immune surveillance of senescent cells in aging and disease

  2025cites this paper
• All-trans Retinoic Acid regulates cellular senescence of Mouse Embryonic Palatal Mesenchyme (MEPM) cells in developing cleft palates.

  2025cites this paper
• Fangchinoline attenuates hepatic fibrosis by regulating taurine metabolism and oxidative stress

  2025cites this paper
• Redefining senescence through hepatocyte fate changes in liver diseases.

  2025cites this paper
• Liver aging: underlying mechanisms and therapeutic strategies.

  2025cites this paper
• The Immune System and Cellular Senescence: A Complex Interplay in Aging and Disease

  2025cites this paper
• Roles and potential mechanisms of hepatic stellate cells activation mediated by epigenetics through insulin like growth factor 1 and receptor: A review.

  2025cites this paper
• Aging: the wound that never starts healing

  2025cites this paper
• Reprogramming cellular senescence and aging clocks for advanced cancer immunotherapy

  2025cites this paper
• Immunoregulatory mechanisms in the aging microenvironment: Targeting the senescence-associated secretory phenotype for cancer immunotherapy

  2025cites this paper
• CD4 T cells acquire Eomesodermin to modulate cellular senescence and aging

  2025cites this paper
• Liver fibrosis as a major prognostic factor in chronic liver diseases and a key target for pharmacotherapy

  2025cites this paper
• P21-positive senescent stromal cells promote prostate cancer immune suppression and progression that can be reversed by senolytic therapy.

  2025cites this paper
• Balancing senescence and apoptosis: therapeutic insights into aging and cancer

  2025cites this paper
• Senescent cells promote viral infection-associated inflammation and tissue damage through a robust NF-κB pathway

  2025cites this paper
• Dual Roles of SIRT7 Inhibition by Oroxylin A Reprogram HSCs Fate: PRMT5 Succinylation-Driven Senescence and Ecto-Calreticulin-Dependent NK Cell Immune Clearance in Liver Fibrosis

  2025cites this paper
• The influence of cell source on the senescence of human mesenchymal stem/stromal cells

  2025cites this paper
• Diverse potential of chimeric antigen receptor‐engineered cell therapy: Beyond cancer

  2025cites this paper
• Antifibrotic therapies for metabolic dysfunction-associated steatotic liver disease

  2025cites this paper
• Recent Advances in Aging and Immunosenescence: Mechanisms and Therapeutic Strategies

  2025cites this paper
• Reactivation of CTLA4-expressing T cells accelerates resolution of lung fibrosis in a humanized mouse model

  2025cites this paper
• Airway basal stem cell-derived extracellular vesicles modulate proliferation, migration and collagen deposition of fibroblasts

  2025cites this paper
• Regulation of Hepatic Stellate Cell Phenotypes in MASH.

  2025cites this paper
• Targeting senescent hepatocytes for treatment of metabolic dysfunction-associated steatotic liver disease and multi-organ dysfunction

  2025cites this paper
• A Novel Mechanism of the p53 Isoform Δ40p53α in Regulating Collagen III Expression in TGFβ1‐Induced LX‐2 Human Hepatic Stellate Cells

  2025cites this paper
• NUMB endocytic adaptor protein (NUMB) mediates the anti-hepatic fibrosis effect of artesunate (ART) by inducing senescence in hepatic stellate cells (HSCs).

  2025cites this paper
• Melatonin-mediated cGAS-STING signal in senescent macrophages promote TNBC chemotherapy resistance and drive the SASP.

  2025cites this paper
• Cells of all trades: On the importance of spatial positioning of senescent cells in development, healing and aging

  2025cites this paper
• Circadian clock regulation of myofibroblast fate.

  2025cites this paper
• Cellular senescence as a source of chronic microinflammation that promotes the aging process

  2025cites this paper
• Is Senolytic Therapy in Cardiovascular Diseases Ready for Translation to Clinics?

  2025cites this paper
• Reactive Oxygen Species and Antioxidants in Wound Healing: Mechanisms and Therapeutic Potential

  2025cites this paper
• Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

  2025cites this paper
• Trilocked Photodynamic Senolytic Inducer Potentiating Immunogenic Senescent Cell Removal for Liver Fibrosis Resolution.

  2025cites this paper
• Aging and metabolic dysfunction-associated steatotic liver disease: a bidirectional relationship

  2025cites this paper
• The rise of RAS: how gradual oncogene activation shapes the OIS spectrum

  2025cites this paper
• CCN2 Activates Cellular Senescence Leading to Kidney Fibrosis in Folic Acid-Induced Experimental Nephropathy

  2025cites this paper
• Alcohol-Associated Hepatocarcinogenesis

  2025cites this paper
• How aging causes osteoarthritis: an evolutionary physiology perspective

  2025cites this paper
• New Insights into the Role of Cellular Senescence and Its Therapeutic Implications in Ocular Diseases

  2025cites this paper
• Crosstalk between Hepatic Stellate Cells and Hepatic Macrophages in Metabolic Dysfunction-Associated Steatohepatitis.

  2025cites this paper
• A transcriptome-based human universal senescence index (hUSI) robustly predicts cellular senescence under various conditions

  2025cites this paper
• Future Perspectives in Senescence-Based Therapies for Head and Neck Cancer

  2025cites this paper
• Fibroblast activation and heterogeneity in fibrotic disease

  2025cites this paper
• Molecular Regulation of SASP in Cellular Senescence: Therapeutic Implications and Translational Challenges

  2025cites this paper
• CD47-mediated regulation of glucose and lipid metabolism: implications for the pathogenesis of MASLD

  2025cites this paper
• An overview of contemporary theories of ageing

  2025cites this paper
• Persistent accumulation of therapy-induced senescent cells: an obstacle to long-term cancer treatment efficacy

  2025cites this paper
• Stromal senescence contributes to age-related increases in cancer

  2025cites this paper
• The Role of Senescence, its Therapeutic Relevance and Clinical Implications in the Tumor Microenvironment

  2025cites this paper
• Oxy210 Inhibits Hepatic Expression of Senescence-Associated, Pro-Fibrotic, and Pro-Inflammatory Genes in Mice During Development of MASH and in Hepatocytes In Vitro

  2025cites this paper
• Inhibiting CXCR6 promotes senescence of activated hepatic stellate cells with limited proinflammatory SASP to attenuate hepatic fibrosis

  2025cites this paper
• Antioxidant Senotherapy by Natural Compounds: A Beneficial Partner in Cancer Treatment

  2025cites this paper