Metal-dependent Deacetylases: Cancer and Epigenetic Regulators.

No abstract is available for this paper.

• Publication year

  2016

• Venue

  ACS Chemical Biology

• Publication date

  2016-02-24

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1021/acschembio.5b01067PMID 26907466PMCID PMC5590829
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• General Base-General Acid Catalysis in Human Histone Deacetylase 8.

  2016cited by this paper
• Regulation of Histone Deacetylase 6 Activity via S-Nitrosylation.

  2015cited by this paper
• Selective inhibition of HDAC8 decreases neuroblastoma growth in vitro and in vivo and enhances retinoic acid-mediated differentiation

  2015cited by this paper
• Histone deacetylase inhibitors prevent activation-induced cell death and promote anti-tumor immunity

  2015cited by this paper
• Histone deacetylase 6 inhibition enhances oncolytic viral replication in glioma.

  2015cited by this paper
• Histone Modifications, Modifiers and Readers in Melanoma Resistance to Targeted and Immune Therapy

  2015cited by this paper
• Histone Deacetylase Inhibitors in Clinical Studies as Templates for New Anticancer Agents

  2015cited by this paper
• FDA approves new agent for multiple myeloma.

  2015cited by this paper
• Histone deacetylase 3 promotes pancreatic cancer cell proliferation, invasion and increases drug-resistance through histone modification of P27, P53 and Bax.

  2014cited by this paper
• HDAC inhibition imparts beneficial transgenerational effects in Huntington's disease mice via altered DNA and histone methylation

  2014cited by this paper
• Silencing histone deacetylase 2 using small hairpin RNA induces regression of fibrotic plaque in a rat model of Peyronie's disease

  2014cited by this paper
• An Unbiased Approach To Identify Endogenous Substrates of “Histone” Deacetylase 8

  2014cited by this paper
• 50 years of protein acetylation: from gene regulation to epigenetics, metabolism and beyond

  2014cited by this paper
• Histone Deacetylases

  2014cited by this paper
• Cancer Immunology at the Crossroads : Experimental Immunotherapies Oncolytic Viruses and Their Application to Cancer Immunotherapy

  2014cited by this paper
• Belinostat: First Global Approval

  2014cited by this paper
• A dual role for Hdac1: oncosuppressor in tumorigenesis, oncogene in tumor maintenance.

  2013cited by this paper
• Deacetylase-independent function of HDAC3 in transcription and metabolism requires nuclear receptor corepressor.

  2013cited by this paper
• Histone deacetylase 11 is an epigenetic regulator of cytotoxic T-lymphocyte effector function and memory formation (P1404)

  2013cited by this paper
• Histone deacetylase (HDAC) 1 and 2 are essential for normal T cell development and genomic stability in mice

  2013cited by this paper
• HDAC11 is a novel drug target in carcinomas

  2013cited by this paper
• HDAC7 Is a Repressor of Myeloid Genes Whose Downregulation Is Required for Transdifferentiation of Pre-B Cells into Macrophages

  2013cited by this paper
• Inhibition of histone deacetylase 2 mitigates profibrotic TGF-β1 responses in fibroblasts derived from Peyronie's plaque.

  2013cited by this paper
• Dosage-dependent tumor suppression by histone deacetylases 1 and 2 through regulation of c-Myc collaborating genes and p53 function.

  2013cited by this paper
• Injury-induced HDAC5 nuclear export is essential for axon regeneration.

  2013cited by this paper
• Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis

  2013cited by this paper
• Reducing HDAC6 ameliorates cognitive deficits in a mouse model for Alzheimer's disease

  2012cited by this paper
• Endogenous modulators and pharmacological inhibitors of histone deacetylases in cancer therapy

  2012cited by this paper
• HDAC5 is required for maintenance of pericentric heterochromatin, and controls cell-cycle progression and survival of human cancer cells

  2012cited by this paper
• Combination therapy for hepatocellular carcinoma: additive preclinical efficacy of the HDAC inhibitor panobinostat with sorafenib.

  2012cited by this paper
• miR-155 targets histone deacetylase 4 (HDAC4) and impairs transcriptional activity of B-cell lymphoma 6 (BCL6) in the Eµ-miR-155 transgenic mouse model

  2012cited by this paper
• HDAC8 mutations in Cornelia de Lange Syndrome affect the cohesin acetylation cycle

  2012cited by this paper
• Preclinical activity, pharmacodynamic, and pharmacokinetic properties of a selective HDAC6 inhibitor, ACY-1215, in combination with bortezomib in multiple myeloma.

  2012cited by this paper
• Loss of HDAC5 Impairs Memory Function: Implications for Alzheimer's Disease

  2012cited by this paper
• HDAC5 is a novel injury‐regulated tubulin deacetylase controlling axon regeneration

  2012cited by this paper
• Histone deacetylase 5 limits cocaine reward through cAMP-induced nuclear import.

  2012cited by this paper
• HDAC2 overexpression confers oncogenic potential to human lung cancer cells by deregulating expression of apoptosis and cell cycle proteins

  2012cited by this paper
• HDAC4-regulated STAT1 activation mediates platinum resistance in ovarian cancer.

  2011cited by this paper
• Frequent mutation of histone modifying genes in non-Hodgkin lymphoma

  2011cited by this paper
• HDAC4 Protein Regulates HIF1α Protein Lysine Acetylation and Cancer Cell Response to Hypoxia*

  2011cited by this paper
• HDAC6 α-tubulin deacetylase: a potential therapeutic target in neurodegenerative diseases.

  2011cited by this paper
• Inhibition of Histone Deacetylases 1 and 6 Enhances Cytarabine-Induced Apoptosis in Pediatric Acute Myeloid Leukemia Cells

  2011cited by this paper
• Proteome-wide post-translational modification statistics: frequency analysis and curation of the swiss-prot database

  2011cited by this paper
• A Self-Propagating Matrix Metalloprotease-9 (MMP-9) Dependent Cycle of Chronic Neutrophilic Inflammation

  2011cited by this paper
• Expression of histone deacetylase 1 correlates with a poor prognosis in patients with adenocarcinoma of the lung.

  2011cited by this paper
• Histone deacetylase inhibitors demonstrate significant preclinical activity as single agents, and in combination with bortezomib in Waldenström's macroglobulinemia.

  2011cited by this paper
• HDAC5 and HDAC9 in Medulloblastoma: Novel Markers for Risk Stratification and Role in Tumor Cell Growth

  2010cited by this paper
• Crucial function of histone deacetylase 1 for differentiation of teratomas in mice and humans

  2010cited by this paper
• Histone Deacetylase 9 (HDAC9) Regulates the Functions of the ATDC (TRIM29) Protein*

  2010cited by this paper
• Chromatin unfolding by Cdt1 regulates MCM loading via opposing functions of HBO1 and HDAC11-geminin

  2010cited by this paper
• Inhibition of histone deacetylase 10 induces thioredoxin-interacting protein and causes accumulation of reactive oxygen species in SNU-620 human gastric cancer cells

  2010cited by this paper
• Epigenetic regulation of androgen receptor signaling in prostate cancer

  2010cited by this paper
• INHIBITION OF ANDROGEN RECEPTOR ACTIVITY BY HISTONE DEACETYLASE 4 THROUGH RECEPTOR SUMOYLATION

  2010cited by this paper
• Class I histone deacetylases 1, 2 and 3 are highly expressed in classical Hodgkin's lymphoma

  2010cited by this paper
• Structures of metal-substituted human histone deacetylase 8 provide mechanistic inferences on biological function .

  2010cited by this paper
• microRNA-22, downregulated in hepatocellular carcinoma and correlated with prognosis, suppresses cell proliferation and tumourigenicity

  2010cited by this paper
• Regulatory signal transduction pathways for class IIa histone deacetylases.

  2010cited by this paper
• Activation and Inhibition of Histone Deacetylase 8 by Monovalent Cations*

  2009cited by this paper
• The many roles of histone deacetylases in development and physiology: implications for disease and therapy

  2009cited by this paper
• Mechanism of chemoresistance mediated by miR-140 in human osteosarcoma and colon cancer cells

  2009cited by this paper
• Histone Deacetylase 8 in Neuroblastoma Tumorigenesis

  2009cited by this paper
• HDAC4 represses p21WAF1/Cip1 expression in human cancer cells through a Sp1-dependent, p53-independent mechanism

  2009cited by this paper
• Chemical mechanisms of histone lysine and arginine modifications.

  2009cited by this paper
• The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune tolerance

  2009cited by this paper
• Histone Deacetylase 7 and FoxA1 in Estrogen-Mediated Repression of RPRM

  2009cited by this paper
• HDAC4 Represses Vascular Endothelial Growth Factor Expression in Chondrosarcoma by Modulating RUNX2 Activity*

  2009cited by this paper
• Acetylation/Deacetylation Modulates the Stability of DNA Replication Licensing Factor Cdt1*

  2009cited by this paper
• The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men

  2008cited by this paper
• Histone Deacetylase 7 Promotes PML Sumoylation and Is Essential for PML Nuclear Body Formation

  2008cited by this paper
• TBX3 is overexpressed in breast cancer and represses p14 ARF by interacting with histone deacetylases.

  2008cited by this paper
• HDAC4 promotes growth of colon cancer cells via repression of p21.

  2008cited by this paper
• Methylation mediated silencing of MicroRNA-1 gene and its role in hepatocellular carcinogenesis.

  2008cited by this paper
• Interferon-α is able to maintain complete molecular remission induced by imatinib after its discontinuation

  2008cited by this paper
• Class I histone deacetylases 1, 2 and 3 are highly expressed in renal cell cancer

  2008cited by this paper
• Developmental expression of histone deacetylase 11 in the murine brain

  2008cited by this paper
• Reduced body size and decreased intestinal tumor rates in HDAC2-mutant mice.

  2007cited by this paper
• Genome-wide loss of heterozygosity and copy number analysis in melanoma using high-density single-nucleotide polymorphism arrays.

  2007cited by this paper
• Inhibition of Histone Deacetylase Activity Promotes Invasion of Human Cancer Cells through Activation of Urokinase Plasminogen Activator*

  2007cited by this paper
• Histone Deacetylase 7 Functions as a Key Regulator of Genes Involved in both Positive and Negative Selection of Thymocytes

  2007cited by this paper
• Role for Histone Deacetylase 1 in Human Tumor Cell Proliferation

  2007cited by this paper
• Substrate binding to histone deacetylases as shown by the crystal structure of the HDAC8–substrate complex

  2007cited by this paper
• Control of MEF2 Transcriptional Activity by Coordinated Phosphorylation and Sumoylation*

  2006cited by this paper
• A truncating mutation of HDAC2 in human cancers confers resistance to histone deacetylase inhibition

  2006cited by this paper
• Inhibition of histone deacetylase class I but not class II is critical for the sensitization of leukemic cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis.

  2006cited by this paper
• Histone Deacetylase 3 (HDAC3) and Other Class I HDACs Regulate Colon Cell Maturation and p21 Expression and Are Deregulated in Human Colon Cancer*

  2006cited by this paper
• Catalytic activity and inhibition of human histone deacetylase 8 is dependent on the identity of the active site metal ion.

  2006cited by this paper
• Histone deacetylase 3 (HDAC3) is recruited to target promoters by PML-RARalpha as a component of the N-CoR co-repressor complex to repress transcription in vivo.

  2006cited by this paper
• Positive and Negative Regulation of the Innate Antiviral Response and Beta Interferon Gene Expression by Deacetylation

  2006cited by this paper
• Aberrant expression of histone deacetylase 6 in oral squamous cell carcinoma.

  2006cited by this paper
• Histone deacetylase-1 and -3 protein expression in human breast cancer: a tissue microarray analysis

  2005cited by this paper
• Regulatory cross‐talk between lysine acetylation and ubiquitination: role in the control of protein stability

  2005cited by this paper
• Acetylation and deacetylation of non-histone proteins.

  2005cited by this paper
• Regulation of MEF2 by Histone Deacetylase 4- and SIRT1 Deacetylase-Mediated Lysine Modifications

  2005cited by this paper
• Histone deacetylase HDAC8 associates with smooth muscle α‐actin and is essential for smooth muscle cell contractility

  2005cited by this paper
• Mechanism of recruitment of class II histone deacetylases by myocyte enhancer factor-2.

  2004cited by this paper
• Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor.

  2004cited by this paper
• Upregulation and Nuclear Recruitment of HDAC1 in Hormone Refractory Prostate Cancer

  2004cited by this paper
• HDAC6 Expression Is Correlated with Better Survival in Breast Cancer

  2004cited by this paper
• An epigenetically altered tumor cell vaccine

  2004cited by this paper
• The Metastasis-associated Proteins 1 and 2 Form Distinct Protein Complexes with Histone Deacetylase Activity*

  2003cited by this paper

• Mechanism-Based Inhibition of Histone Deacetylase 6 by a Selenocyanate is Subject to Redox Modulation

  2025cites this paper
• Cardioprotective role of SIRT1 activation on mitochondrial function in insulin-resistant H9c2 cells

  2025cites this paper
• Mechanism-Based Inhibition of Histone Deacetylase 6 by a Selenocyanate Is Subject to Redox Modulation.

  2025cites this paper
• MD Simulations for Rational Design of High-Affinity HDAC4 Inhibitors - Analysis of Non-Bonding Interaction Energies for Building New Compounds.

  2024cites this paper
• Design, Synthesis, and Structural Evaluation of Acetylated Phenylthioketone Inhibitors of HDAC10.

  2024cites this paper
• Role of protein Post-translational modifications in enterovirus infection

  2024cites this paper
• Molecular Dynamics Simulations of HDAC-Ligand Complexes Towards the Design of New Anticancer Compounds±.

  2023cites this paper
• The HDAC2/YY1/c‐Myc signaling axis regulates lung cancer cell migration and proliferation

  2023cites this paper
• Methyl Esters of (E)-Cinnamic Acid: Activity against the Plant-Parasitic Nematode Meloidogyne incognita and In Silico Interaction with Histone Deacetylase.

  2022cites this paper
• HDAC5 Loss Impairs RB Repression of Pro-Oncogenic Genes and Confers CDK4/6 Inhibitor Resistance in Cancer

  2021cites this paper
• Non-bonding energy directed designing of HDAC2 inhibitors through molecular dynamics simulation

  2021cites this paper
• Investigation of HDAC8-ligands’ intermolecular forces through molecular dynamics simulations: profiling of non-bonding energies to design potential compounds as new anti-cancer agents

  2020cites this paper
• Structural determinants of affinity and selectivity in the binding of inhibitors to histone deacetylase 6.

  2020cites this paper
• In silico design of novel benzohydroxamate-based compounds as inhibitors of histone deacetylase 6 based on 3D-QSAR, molecular docking, and molecular dynamics simulations

  2020cites this paper
• Binding of inhibitors to active-site mutants of CD1, the enigmatic catalytic domain of histone deacetylase 6.

  2020cites this paper
• Structure-Based Inhibitor Discovery of Class I Histone Deacetylases (HDACs)

  2020cites this paper
• Structural Basis of Catalysis and Inhibition of HDAC6 CD1, the Enigmatic Catalytic Domain of Histone Deacetylase 6.

  2019cites this paper
• Medicinal chemistry of metal chelating fragments in metalloenzyme active sites: A perspective.

  2019cites this paper
• Methods for the expression, purification, and crystallization of histone deacetylase 6-inhibitor complexes.

  2019cites this paper
• Research on Information Security Situation Awareness System Based on Big Data and Artificial Intelligence Technology

  2019cites this paper
• Recent advances in class IIa histone deacetylases research.

  2019cites this paper
• Exploring Structural Determinants of Inhibitor Affinity and Selectivity in Complexes with Histone Deacetylase 6.

  2019cites this paper
• Molecular Basis for the Selective Inhibition of Histone Deacetylase 6 by a Mercaptoacetamide Inhibitor.

  2018cites this paper
• Histone Deacetylase 6-Selective Inhibitors and the Influence of Capping Groups on Hydroxamate-Zinc Denticity.

  2018cites this paper
• Chelatable trace zinc causes low, irreproducible KDAC8 activity.

  2018cites this paper
• Lysine-14 acetylation of histone H3 in chromatin confers resistance to the deacetylase and demethylase activities of an epigenetic silencing complex

  2018influential citation
• Molecular Imaging of Hydrolytic Enzymes Using PET and SPECT

  2017influential citation
• Lysine Deacetylases Exhibit Distinct Changes in Activity Profiles Due to Fluorophore Conjugation of Substrates.

  2017cites this paper
• Identification of the host histone deacetylase 1 and 2 as novel anti-influenza A virus factors

  2017cites this paper
• Hydroxyl Ketone-Based Histone Deacetylase Inhibitors To Gain Insight into Class I HDAC Selectivity versus That of HDAC6

  2017cites this paper
• Design, synthesis, and preliminary bioactivity evaluation of N1‐hydroxyterephthalamide derivatives with indole cap as novel histone deacetylase inhibitors

  2017cites this paper
• Novel Class IIa-Selective Histone Deacetylase Inhibitors Discovered Using an in Silico Virtual Screening Approach

  2017cites this paper
• The interplay between histone deacetylases and rho kinases is important for cancer and neurodegeneration.

  2017influential citation
• Unusual zinc-binding mode of HDAC6-selective hydroxamate inhibitors

  2017cites this paper
• A direct alkylation route to branched derivatives of suberoylanilide hydroxamic acid (SAHA), a potent non-selective inhibitor of histone deacetylases

  2016cites this paper
• Bone Density and Dental External Apical Root Resorption

  2016cites this paper