Multidrug resistance in epilepsy: rats with drug-resistant seizures exhibit enhanced brain expression of P-glycoprotein compared with rats with drug-responsive seizures.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Brain : a journal of neurology

• Publication date

  2005-06-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1093/BRAIN/AWH437PMID 15716304
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• [Mechanisms of drug resistance in epilepsy].

  2006cited by this paper
• Blood-brain barrier active efflux transporters: ATP-binding cassette gene family

  2005cited by this paper
• Immunohistochemical Localization of P-glycoprotein in Rat Brain and Detection of Its Increased Expression by Seizures Are Sensitive to Fixation and Staining Variables

  2005cited by this paper
• Electroconvulsive seizures induce endothelial cell proliferation in adult rat hippocampus.

  2004cited by this paper
• Modulation of the blood-brain barrier in oncology: therapeutic opportunities for the treatment of brain tumours?

  2004cited by this paper
• ABC transporters and the blood-brain barrier.

  2004cited by this paper
• Striking Differences in Individual Anticonvulsant Response to Phenobarbital in Rats with Spontaneous Seizures after Status Epilepticus

  2004influential reference
• New horizons in the development of antiepileptic drugs: the search for new targets.

  2004cited by this paper
• The Consequences of Uncontrolled Epilepsy

  2004cited by this paper
• Modulation of Drug Transporters at the Blood-Brain Barrier

  2004cited by this paper
• Use of Verapamil as a Potential P-Glycoprotein Inhibitor in a Patient with Refractory Epilepsy

  2004cited by this paper
• A critical review of the different conceptual hypotheses framing human focal epilepsy.

  2004influential reference
• Clinical aspects of the MDR1 (ABCB1) gene polymorphism.

  2004cited by this paper
• Increased expression of the multidrug transporter P-glycoprotein in limbic brain regions after amygdala-kindled seizures in rats.

  2004influential reference
• Pharmacoresistance and expression of multidrug transporter P-glycoprotein in kindled rats

  2004influential reference
• Association of multidrug resistance in epilepsy with a polymorphism in the drug-transporter gene ABCB1.

  2003cited by this paper
• Vascular and parenchymal mechanisms in multiple drug resistance: a lesson from human epilepsy.

  2003influential reference
• A novel mechanism underlying drug resistance in chronic epilepsy

  2003cited by this paper
• Mechanisms of antiepileptic drug resistance

  2003influential reference
• Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview.

  2003cited by this paper
• Expression and cellular distribution of multidrug transporter proteins in two major causes of medically intractable epilepsy: focal cortical dysplasia and glioneuronal tumors.

  2003cited by this paper
• Epileptogenesis and neuropathology after different types of status epilepticus induced by prolonged electrical stimulation of the basolateral amygdala in rats.

  2003influential reference
• A comparison of extracellular levels of phenytoin in amygdala and hippocampus of kindled and non-kindled rats

  2002influential reference
• Reversal of multidrug resistance: lessons from clinical oncology.

  2002cited by this paper
• Limbic Seizures Induce P-Glycoprotein in Rodent Brain: Functional Implications for Pharmacoresistance

  2002influential reference
• P-Glycoprotein-mediated efflux of phenobarbital, lamotrigine, and felbamate at the blood-brain barrier: evidence from microdialysis experiments in rats.

  2002cited by this paper
• Drug transport to the brain: key roles for the efflux pump P-glycoprotein in the blood-brain barrier.

  2002cited by this paper
• Role of multidrug transporters in pharmacoresistance to antiepileptic drugs.

  2002cited by this paper
• ABC transporters and inhibitors: new targets, new agents.

  2002cited by this paper
• Is Refractory Epilepsy Preventable?

  2002cited by this paper
• Drug resistance in epilepsy: the role of the blood-brain barrier.

  2002cited by this paper
• Drug resistance in epilepsy: expression of drug resistance proteins in common causes of refractory epilepsy.

  2002cited by this paper
• Transient increase of P-glycoprotein expression in endothelium and parenchyma of limbic brain regions in the kainate model of temporal lobe epilepsy.

  2002cited by this paper
• Polymorphisms in the ABC drug transporter gene MDR1

  2001cited by this paper
• Neurotrophic and neuroprotective actions of estrogens and their therapeutic implications.

  2001cited by this paper
• Drug transporters in the central nervous system: brain barriers and brain parenchyma considerations.

  2001cited by this paper
• Early identification of refractory epilepsy.

  2000cited by this paper
• Status Epilepticus‐induced Neuronal Injury and Network Reorganization

  1999cited by this paper
• Blood-brain barrier biology and methodology.

  1999influential reference
• P-Glycoprotein, a gatekeeper in the blood-brain barrier.

  1999cited by this paper
• Quantitative Immunocytochemical Study of Blood-Brain Barrier Glucose Transporter (GLUT-1) in Four Regions of Mouse Brain

  1999cited by this paper
• Induction of P-glycoprotein expression in astrocytes following intracerebroventricular kainate injections

  1999cited by this paper
• Recent advances related to basic mechanisms of epileptogenesis.

  1996cited by this paper
• Basic mechanisms of seizure propagation: targets for rational drug design and rational polypharmacy.

  1996influential reference
• Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells.

  1996cited by this paper
• Recent advances related to basic mechanisms of epileptogenesis.

  1996cited by this paper
• Effects of conventional antiepileptic drugs in a model of spontaneous recurrent seizures in rats.

  1995cited by this paper
• New immunohistochemical "sandwich" staining method for mdr1 P-glycoprotein detection with JSB-1 monoclonal antibody in formalin-fixed, paraffin-embedded human tissues.

  1994cited by this paper
• Blood-brain barrier glucose transporter is asymmetrically distributed on brain capillary endothelial lumenal and ablumenal membranes: an electron microscopic immunogold study.

  1991cited by this paper
• Brain-type glucose transporter (GLUT-1) is selectively localized to the blood-brain barrier. Studies with quantitative western blotting and in situ hybridization.

  1990cited by this paper
• Comparison of the anticonvulsant efficacy of primidone and phenobarbital during chronic treatment of amygdala-kindled rats.

  1989cited by this paper
• Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle protein.

  1989cited by this paper
• Progression and Generalization of Seizure Discharge: Anatomical and Neurochemical Substrates

  1988cited by this paper
• The Rat Brain in Stereotaxic Coordinates

  1983influential reference
• Modification of seizure activity by electrical stimulation. II. Motor seizure.

  1972cited by this paper

• In‐vitro Assessment of BCRP‐Mediated Efflux of Antiseizure Medications in Human Blood‐Brain Barrier Cell Model

  2025cites this paper
• In vitro assessment of P-glycoprotein-mediated antiseizure medications efflux in a blood-brain barrier cell model.

  2025cites this paper
• The Role of Blood–Brain Barrier Disruption in Epilepsy: Mechanisms and Consequences

  2025cites this paper
• Erythropoietin for Seizures and Epilepsy: Neuroprotective Effects, Mechanisms, and Contradictory Risks.

  2025cites this paper
• An update on the novel methods for the discovery of antiseizure and antiepileptogenic medications: where are we in 2024?

  2024cites this paper
• The impact of ATP-binding cassette transporters in the diseased brain: Context matters

  2024cites this paper
• Tolerability of tariquidar - A third generation P-gp inhibitor as add-on medication to antiseizure medications in drug-resistant epilepsy.

  2024cites this paper
• miRNAs in epilepsy: A review from molecular signatures to therapeutic intervention.

  2024cites this paper
• The aging brain and late onset drug-refractory epilepsies.

  2024cites this paper
• Animal Models of Drug-Resistant Epilepsy as Tools for Deciphering the Cellular and Molecular Mechanisms of Pharmacoresistance and Discovering More Effective Treatments

  2023cites this paper
• Valproic acid-induced upregulation of multidrug efflux transporter ABCG2/BCRP via PPARα-dependent mechanism in human brain endothelial cells

  2022cites this paper
• Valproic acid-induced upregulation of multidrug efflux transporter ABCG2/BCRP via PPARα-dependent mechanism in human brain endothelial cells

  2022cites this paper
• A complex systems view on the current hypotheses of epilepsy pharmacoresistance

  2022cites this paper
• Effects of genetic polymorphism of drug-metabolizing enzymes on the plasma concentrations of antiepileptic drugs in Chinese population

  2022cites this paper
• Microvascular stabilization via blood-brain barrier regulation prevents seizure activity

  2022cites this paper
• P-glycoprotein: new insights into structure, physiological function, regulation and alterations in disease

  2022cites this paper
• The role of the efflux transporter, P‐glycoprotein, at the blood–brain barrier in drug discovery

  2022cites this paper
• Valproic acid-induced upregulation of multidrug efflux transporter ABCG2/BCRP via PPARα-dependent mechanism in human brain endothelial cells

  2022cites this paper
• Valproic Acid-Induced Upregulation of Multidrug Efflux Transporter ABCG2/BCRP via PPARα-Dependent Mechanism in Human Brain Endothelial Cells

  2022cites this paper
• First clinical assessment of [18F]MC225, a novel fluorine-18 labelled PET tracer for measuring functional P-glycoprotein at the blood–brain barrier

  2021cites this paper
• First-line management of canine status epilepticus at home and in hospital-opportunities and limitations of the various administration routes of benzodiazepines

  2021cites this paper
• Abnormal saccharides affecting cancer multi-drug resistance (MDR) and the reversal strategies.

  2021cites this paper
• Epileptische Anfälle bei Schlaganfall

  2021cites this paper
• ABC Transporters: Individual-Specific Considerations

  2021cites this paper
• Pergularia daemia hydro-ethanolic extract protects against pentylenetetrazole kindling-induced seizures, oxidative stress, and neuroinflammation in mice.

  2021cites this paper
• MicroRNAs in the development of resistance to antiseizure drugs and their potential as biomarkers in pharmacoresistant epilepsy

  2021cites this paper
• Reprint of: Nonclinical species sensitivity to convulsions: An IQ DruSafe consortium working group initiative.

  2020cites this paper
• The evolution of the pilocarpine animal model of status epilepticus

  2020cites this paper
• Automated synthesis, preclinical toxicity, and radiation dosimetry of [18F]MC225 for clinical use: a tracer for measuring P-glycoprotein function at the blood-brain barrier

  2020cites this paper
• P‐glycoprotein overactivity in epileptogenic developmental lesions measured in vivo using (R)‐[11C]verapamil PET

  2020cites this paper
• Drug Resistance in Epilepsy: Clinical Impact, Potential Mechanisms, and New Innovative Treatment Options

  2020cites this paper
• Nonclinical species sensitivity to convulsions: An IQ DruSafe consortium working group initiative.

  2020cites this paper
• Downregulation of peripheral PTGS2/COX-2 in response to valproate treatment in patients with epilepsy

  2020cites this paper
• ABC efflux transporters at blood-central nervous system barriers and their implications for treating spinal cord disorders

  2020cites this paper
• Possible interplay between the theories of pharmacoresistant epilepsy

  2020cites this paper
• Bypassing the Blood–Brain Barrier: Direct Intracranial Drug Delivery in Epilepsies

  2020cites this paper
• PET Imaging of ABC Transporters at the Blood-Brain Barrier

  2020cites this paper
• Activation of adenosine receptors modulates the efflux transporters in brain capillaries and restores the anticonvulsant effect of carbamazepine in carbamazepine resistant rats developed by window-pentylenetetrazole kindling.

  2020cites this paper
• ABC transporters in drug-resistant epilepsy: mechanisms of upregulation and therapeutic approaches.

  2019cites this paper
• Cyclooxygenase-2 (COX-2) inhibitors: future therapeutic strategies for epilepsy management

  2019cites this paper
• Inhibition of human microsomal PGE2 synthase‐1 reduces seizure‐induced increases of P‐glycoprotein expression and activity at the blood‐brain barrier

  2019cites this paper
• Imaging Mechanisms of Drug Resistance in Experimental Models of Epilepsy

  2019cites this paper
• Clinical reappraisal of the influence of drug-transporter polymorphisms in epilepsy

  2018cites this paper
• P‐glycoprotein protein expression versus functionality at the blood‐brain barrier using immunohistochemistry, microdialysis and mathematical modeling

  2018cites this paper
• [Status epilepticus: Recent advances].

  2018cites this paper
• PET imaging of P-glycoprotein at the blood-brain barrier with new 18F-tracers

  2018cites this paper
• Lamotrigine Lipid Nanoparticles for Effective Treatment of Epilepsy: a Focus on Brain Targeting via Nasal Route

  2018cites this paper
• Potentiation of antiseizure and neuroprotective efficacy of standard nerve agent treatment by addition of tariquidar

  2018cites this paper
• In vitro and in vivo experimental models employed in the discovery and development of antiepileptic drugs for pharmacoresistant epilepsy.

  2018cites this paper
• Delays in the treatment of status epilepticus - effect on outcome

  2018cites this paper
• Coadministration of antiepileptic drugs and P-glycoprotein inhibitors of flavonoid-type

  2018cites this paper
• Role of P‐glycoprotein inhibitors in children with drug‐resistant epilepsy

  2017cites this paper
• Drug-Resistant Epilepsy: Multiple Hypotheses, Few Answers

  2017cites this paper
• New model of pharmacoresistant seizures induced by 3-mercaptopropionic acid in mice.

  2017cites this paper
• Animal Models of Drug-Refractory Epilepsy

  2017cites this paper
• Nanotechnology as Potential Strategy for the Treatment of Pharmacoresistant Epilepsy and Comorbid Psychiatric Disorders.

  2017cites this paper
• The possible use of the L-type calcium channel antagonist verapamil in drug-resistant epilepsy

  2016cites this paper
• Knockout of P-glycoprotein does not alter antiepileptic drug efficacy in the intrahippocampal kainate model of mesial temporal lobe epilepsy in mice.

  2016cites this paper
• Intractable epilepsy and the P-glycoprotein hypothesis

  2016cites this paper
• Fit for purpose application of currently existing animal models in the discovery of novel epilepsy therapies.

  2016cites this paper
• Pluronic P85-coated poly(butylcyanoacrylate) nanoparticles overcome phenytoin resistance in P-glycoprotein overexpressing rats with lithium-pilocarpine-induced chronic temporal lobe epilepsy.

  2016cites this paper
• Importance of P-gp PET Imaging in Pharmacology.

  2016cites this paper
• ABC Transporters and Drug Resistance in Patients with Epilepsy.

  2016cites this paper
• Pathophysiology of status epilepticus.

  2016cites this paper
• The Use of Anti-inflammatory Drugs in Epilepsy

  2016cites this paper
• Phenytoin carried by silica core iron oxide nanoparticles reduces the expression of pharmacoresistant seizures in rats.

  2015cites this paper
• Mechanisms of Drug Resistance and Tolerance

  2015cites this paper
• Cross-species pharmacological characterization of the allylglycine seizure model in mice and larval zebrafish.

  2015cites this paper
• Genetics and Idiopathic Canine Epilepsy: Is Successful Treatment Out of Our Control?

  2014cites this paper
• (R)-[11C]PK11195 brain uptake as a biomarker of inflammation and antiepileptic drug resistance: evaluation in a rat epilepsy model.

  2014cites this paper
• Basic cellular and molecular mechanisms of refractory epilepsy: a review of current hypotheses

  2014cites this paper
• Unique Behavioral Characteristics and microRNA Signatures in a Drug Resistant Epilepsy Model

  2014cites this paper
• The Piriform Cortex and Human Focal Epilepsy

  2014cites this paper
• Efficacy of verapamil as an adjunctive treatment in children with drug-resistant epilepsy: a pilot study.

  2014cites this paper
• Role of blood-brain barrier in temporal lobe epilepsy and pharmacoresistance.

  2014cites this paper
• Pharmacoresistant epilepsy and nanotechnology.

  2014cites this paper
• Pathogenetic mechanisms of focal cortical dysplasia

  2014cites this paper
• The ABCB1-C3435T polymorphism likely acts as a risk factor for resistance to antiepileptic drugs.

  2014cites this paper
• CNS transporters and drug delivery in epilepsy.

  2014cites this paper
• NSAIDs Modulate Morphine Transport at the Blood-Brain Barrier: A Role for P-glycoprotein

  2013cites this paper
• Interaction between electrical modulation of the brain and pharmacotherapy to control pharmacoresistant epilepsy.

  2013cites this paper
• Carbamazepine, but not valproate, displays pharmacoresistance in lamotrigine-resistant amygdala kindled rats.

  2013cites this paper
• Impact of epilepsy and drug-responsiveness☆

  2013cites this paper
• Pharmacoresistance in Epilepsy

  2013cites this paper
• Role of Oxidative Stress in Refractory Epilepsy: Evidence in Patients and Experimental Models

  2013cites this paper
• Experimental Models to Study Pharmacoresistance in Epilepsy

  2013cites this paper
• Local MEG networks: The missing link between protein expression and epilepsy in glioma patients?

  2013cites this paper
• Targeted therapies for medulloblastoma: understanding the mechanisms of drug resistance and exploring new peptide-based therapeutics

  2013influential citation
• [11C]quinidine and [11C]laniquidar PET imaging in a chronic rodent epilepsy model: impact of epilepsy and drug-responsiveness.

  2013cites this paper
• Cerebral expression of drug transporters in epilepsy.

  2012cites this paper
• Targeting Anti-Epileptic Drug Therapy Without Collateral Damage: Nanocarrier-Based Drug Delivery

  2012cites this paper
• An overview on antiepileptic drugs.

  2012cites this paper
• Präklinische Positronen-Emissions-Tomographie-Studien in Epilepsiemodellen

  2012cites this paper
• Progress in Epileptic Disorders Workshop on AED trials

  2012cites this paper
• The transport of antiepileptic drugs by P-glycoprotein.

  2012cites this paper
• Animal models of drug-resistant epilepsy

  2012cites this paper
• Perspectives of zebrafish models of epilepsy: what, how and where next?

  2012cites this paper
• Disease progression and treatment response of idiopathic epilepsy in Australian Shepherd dogs.

  2012cites this paper
• MK-801 prevents overexpression of multidrug resistance protein 2 after status epilepticus

  2012cites this paper
• Association between ABCB1 genotype and seizure outcome in Collies with epilepsy.

  2012cites this paper