The critical role of the Hippo signaling pathway in kidney diseases

The Hippo signaling pathway is involved in cell growth, proliferation, and apoptosis, and it plays a key role in regulating organ size, tissue regeneration, and tumor development. The Hippo signaling pathway also participates in the occurrence and development of various human diseases. Recently, many studies have shown that the Hippo pathway is closely related to renal diseases, including renal cancer, cystic kidney disease, diabetic nephropathy, and renal fibrosis, and it promotes the transformation of acute kidney disease to chronic kidney disease (CKD). The present paper summarizes and analyzes the research status of the Hippo signaling pathway in different kidney diseases, and it also summarizes the expression of Hippo signaling pathway components in pathological tissues of kidney diseases. In addition, the present paper discusses the positive therapeutic significance of traditional Chinese medicine (TCM) in regulating the Hippo signaling pathway for treating kidney diseases. This article introduces new targets and ideas for drug development, clinical diagnosis, and treatment of kidney diseases.

• Publication year

  2022

• Venue

  Frontiers in Pharmacology

• Publication date

  2022-11-22

• Fields of study

  Medicine

• Identifiers
  DOI 10.3389/fphar.2022.988175PMID 36483738PMCID 9723352
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The Hippo pathway in cancer: YAP/TAZ and TEAD as therapeutic targets in cancer

  2022cited by this paper
• METTL3 promotes colorectal carcinoma progression by regulating the m6A–CRB3–Hippo axis

  2022cited by this paper
• Claudin-2 inhibits renal clear cell carcinoma progression by inhibiting YAP-activation

  2021cited by this paper
• Expanding the Spectrum of FAT1 Nephropathies by Novel Mutations That Affect Hippo Signaling

  2021cited by this paper
• Targeting the Hippo pathway in cancer, fibrosis, wound healing and regenerative medicine

  2020cited by this paper
• SNX9 Inhibits Cell Proliferation and Cyst Development in Autosomal Dominant Polycystic Kidney Disease via Activation of the Hippo-YAP Signaling Pathway

  2020cited by this paper
• YAP mediates the interaction between the Hippo and PI3K/Akt pathways in mesangial cell proliferation in diabetic nephropathy

  2020cited by this paper
• SH3BGRL2 inhibits growth and metastasis in clear cell renal cell carcinoma via activating hippo/TEAD1-Twist1 pathway

  2020cited by this paper
• Fibrosis and cancer: shared features and mechanisms suggest common targeted therapeutic approaches.

  2020cited by this paper
• Targeting mammalian serine/threonine-protein kinase 4 through yes-associated protein/TEA domain transcription factor-mediated epithelial-mesenchymal transition ameliorates diabetic nephropathy orchestrated renal fibrosis.

  2020cited by this paper
• Dysregulation of Long Non-coding RNAs and mRNAs in Plasma of Clear Cell Renal Cell Carcinoma Patients Using Microarray and Bioinformatic Analysis

  2020influential reference
• TAZ/Wnt-β-catenin/c-MYC axis regulates cystogenesis in polycystic kidney disease

  2020cited by this paper
• Inhibition of Yes-Associated Protein by Verteporfin Ameliorates Unilateral Ureteral Obstruction-Induced Renal Tubulointerstitial Inflammation and Fibrosis

  2020cited by this paper
• YAP Activation in Renal Proximal Tubule Cells Drives Diabetic Renal Interstitial Fibrogenesis

  2020influential reference
• RacGAP1 ameliorates acute kidney injury by promoting proliferation and suppressing apoptosis of renal tubular cells.

  2020cited by this paper
• KLF4 initiates sustained YAP activation to promote renal fibrosis in mice after ischemia-reperfusion kidney injury

  2020cited by this paper
• The Hippo Pathway: Biology and Pathophysiology.

  2019influential reference
• Src‐mediated crosstalk between FXR and YAP protects against renal fibrosis

  2019cited by this paper
• The Hippo Pathway Effector TAZ Regulates Ferroptosis in Renal Cell Carcinoma.

  2019cited by this paper
• Quercetin inhibited mesangial cell proliferation of early diabetic nephropathy through the Hippo pathway.

  2019influential reference
• Activated YAP causes renal damage of type 2 diabetic nephropathy.

  2019cited by this paper
• The Metabolic Basis of Kidney Cancer.

  2019cited by this paper
• YAP/TAZ Inhibition Induces Metabolic and Signaling Rewiring Resulting in Targetable Vulnerabilities in NF2-Deficient Tumor Cells.

  2019cited by this paper
• Hippo signaling—a central player in cystic kidney disease?

  2019cited by this paper
• Exploring the mechanism of clear cell renal cell carcinoma metastasis and key genes based on multi-tool joint analysis.

  2019cited by this paper
• Autosomal dominant polycystic kidney disease

  2019cited by this paper
• Modulating NRF2 in Disease: Timing Is Everything.

  2019cited by this paper
• Podocyte GSK3 is an evolutionarily conserved critical regulator of kidney function

  2019cited by this paper
• Rac‐GTPase promotes fibrotic TGF‐β1 signaling and chronic kidney disease via EGFR, p53, and Hippo/YAP/TAZ pathways

  2019influential reference
• Four‐jointed knock‐out delays renal failure in an ADPKD model with kidney injury

  2019cited by this paper
• Therapeutic potential of quercetin as a cardiovascular agent.

  2018cited by this paper
• The signaling protein Wnt5a promotes TGFβ1-mediated macrophage polarization and kidney fibrosis by inducing the transcriptional regulators Yap/Taz

  2018cited by this paper
• The Role of KLF4 in Alzheimer’s Disease

  2018cited by this paper
• Nuclear YAP localization as a key regulator of podocyte function

  2018cited by this paper
• Long noncoding RNA TUG1 promotes cell proliferation and migration of renal cell carcinoma via regulation of YAP

  2018cited by this paper
• SOX2 recruits KLF4 to regulate nasopharyngeal carcinoma proliferation via PI3K/AKT signaling

  2018cited by this paper
• Update of pathophysiology and management of diabetic kidney disease.

  2018cited by this paper
• Krüppel-like factor 4 mediates cellular migration and invasion by altering RhoA activity

  2018cited by this paper
• YAP/TAZ Initiates Gastric Tumorigenesis via Upregulation of MYC.

  2018cited by this paper
• EGF Receptor-Dependent YAP Activation Is Important for Renal Recovery from AKI.

  2018cited by this paper
• Assembly and activation of the Hippo signalome by FAT1 tumor suppressor

  2018cited by this paper
• KLF4 functions as an oncogene in promoting cancer stem cell-like characteristics in osteosarcoma cells

  2018cited by this paper
• Comparative transcriptomics of shear stress treated Pkd1-/- cells and pre-cystic kidneys reveals pathways involved in early polycystic kidney disease.

  2018influential reference
• Polycystic kidney disease: a Hippo connection

  2018cited by this paper
• Leukemia Inhibitory Factor Receptor Suppresses the Metastasis of Clear Cell Renal Cell Carcinoma Through Negative Regulation of the Yes-Associated Protein

  2018cited by this paper
• A RhoA–YAP–c-Myc signaling axis promotes the development of polycystic kidney disease

  2018cited by this paper
• Role of Klf4 in the Regulation of Apoptosis and Cell Cycle in Rat Granulosa Cells during the Periovulatory Period

  2018cited by this paper
• REGγ deficiency suppresses tumor progression via stabilizing CK1ε in renal cell carcinoma

  2018cited by this paper
• Deregulation of Hippo–TAZ pathway during renal injury confers a fibrotic maladaptive phenotype

  2018cited by this paper
• Hippo–YAP/TAZ signalling in organ regeneration and regenerative medicine

  2018cited by this paper
• RNA-binding protein QKI regulates contact inhibition via Yes-associate protein in ccRCC

  2018cited by this paper
• Differential effect of quercetin on cisplatin-induced toxicity in kidney and tumor tissues.

  2017cited by this paper
• Polycystic kidney disease

  2017cited by this paper
• MiR‐30c protects diabetic nephropathy by suppressing epithelial‐to‐mesenchymal transition in db/db mice

  2017influential reference
• Lats1/2 Regulate Yap/Taz to Control Nephron Progenitor Epithelialization and Inhibit Myofibroblast Formation.

  2017cited by this paper
• Pals1 Haploinsufficiency Results in Proteinuria and Cyst Formation.

  2017cited by this paper
• Overexpression of the YAP1 oncogene in clear cell renal cell carcinoma is associated with poor outcome.

  2017cited by this paper
• Cytoresistance after acute kidney injury is limited to the recovery period of proximal tubule integrity and possibly involves Hippo‐YAP signaling

  2017cited by this paper
• Promoter methylation inhibits expression of tumor suppressor KIBRA in human clear cell renal cell carcinoma

  2017cited by this paper
• Partial Epithelial-to-Mesenchymal Transition and Other New Mechanisms of Kidney Fibrosis.

  2016influential reference
• Molecular analysis of aggressive renal cell carcinoma with unclassified histology reveals distinct subsets

  2016cited by this paper
• Hippo signaling in the kidney: the good and the bad.

  2016cited by this paper
• Acute Kidney Injury: Definition, Pathophysiology and Clinical Phenotypes.

  2016cited by this paper
• Interaction of the EGF Receptor and the Hippo Pathway in the Diabetic Kidney.

  2016cited by this paper
• Biallelic Alteration and Dysregulation of the Hippo Pathway in Mucinous Tubular and Spindle Cell Carcinoma of the Kidney.

  2016cited by this paper
• Mechanisms of Hippo pathway regulation

  2016influential reference
• The Hippo-Salvador signaling pathway regulates renal tubulointerstitial fibrosis

  2016cited by this paper
• Novel NEK8 Mutations Cause Severe Syndromic Renal Cystic Dysplasia through YAP Dysregulation

  2016cited by this paper
• Therapeutic Effects of Quercetin on Inflammation, Obesity, and Type 2 Diabetes

  2016cited by this paper
• Effectiveness of Periodic Treatment of Quercetin against Influenza A Virus H1N1 through Modulation of Protein Expression.

  2016cited by this paper
• YAP/TAZ Are Mechanoregulators of TGF-β-Smad Signaling and Renal Fibrogenesis.

  2016cited by this paper
• Multifunctional polymer-capped mesoporous silica nanoparticles for pH-responsive targeted drug delivery.

  2015cited by this paper
• Verteporfin without light stimulation inhibits YAP activation in trabecular meshwork cells: Implications for glaucoma treatment.

  2015cited by this paper
• Involvement of the Hippo pathway in regeneration and fibrogenesis after ischaemic acute kidney injury: YAP is the key effector

  2015cited by this paper
• Crosstalk between Hippo and TGFβ: Subcellular Localization of YAP/TAZ/Smad Complexes.

  2015cited by this paper
• Quercetin inhibits the mTORC1/p70S6K signaling-mediated renal tubular epithelial-mesenchymal transition and renal fibrosis in diabetic nephropathy.

  2015cited by this paper
• Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer.

  2015cited by this paper
• The contribution of epithelial-mesenchymal transition to renal fibrosis differs among kidney disease models.

  2015influential reference
• Role of Merlin/NF2 Inactivation in Tumor Biology

  2015cited by this paper
• FAT1 cadherin acts upstream of Hippo signalling through TAZ to regulate neuronal differentiation

  2015cited by this paper
• Alternative Wnt Signaling Activates YAP/TAZ.

  2015influential reference
• Methylation‑associated inactivation of LATS1 and its effect on demethylation or overexpression on YAP and cell biological function in human renal cell carcinoma.

  2014cited by this paper
• Quercetin prevents liver carcinogenesis by inducing cell cycle arrest, decreasing cell proliferation and enhancing apoptosis.

  2014cited by this paper
• HGF induces epithelial-to-mesenchymal transition by modulating the mammalian hippo/MST2 and ISG15 pathways.

  2014cited by this paper
• A dysregulated acetyl/SUMO switch of FXR promotes hepatic inflammation in obesity

  2014cited by this paper
• NADPH oxidases, reactive oxygen species, and the kidney: friend and foe.

  2013cited by this paper
• Regulation of Hippo signaling by EGFR-MAPK signaling through Ajuba family proteins.

  2013cited by this paper
• Regulation of Hippo pathway by mitogenic growth factors via phosphoinositide 3-kinase and phosphoinositide-dependent kinase-1

  2013cited by this paper
• Low nitric oxide bioavailability up-regulates renal heparin binding EGF-like growth factor expression

  2013cited by this paper
• Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP.

  2012cited by this paper
• Quercetin suppresses NF-κB and MCP-1 expression in a high glucose-induced human mesangial cell proliferation model.

  2012cited by this paper
• Threonine-120 Phosphorylation Regulated by Phosphoinositide-3-Kinase/Akt and Mammalian Target of Rapamycin Pathway Signaling Limits the Antitumor Activity of Mammalian Sterile 20-Like Kinase 1*

  2012cited by this paper
• Quercetin and Sesamin Protect Neuronal PC12 Cells from High-Glucose-Induced Oxidation, Nitrosative Stress, and Apoptosis

  2012cited by this paper
• Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR

  2012cited by this paper
• LIFR is a breast cancer metastasis suppressor upstream of the Hippo-YAP pathway and a prognostic marker

  2012cited by this paper
• Chronic kidney disease: a research and public health priority.

  2012cited by this paper
• Function and cancer genomics of FAT family genes

  2012cited by this paper
• The ciliopathy disease protein NPHP9 promotes nuclear delivery and activation of the oncogenic transcriptional regulator TAZ.

  2012cited by this paper
• EGFR signaling promotes TGFβ-dependent renal fibrosis.

  2012cited by this paper
• The reno-protective effect of a phosphoinositide 3-kinase inhibitor wortmannin on streptozotocin-induced proteinuric renal disease rats

  2011influential reference

• Macrophage Plasticity and Regulatory Networks During the Transition from Inflammation to Fibrosis in the Kidney

  2025cites this paper
• Proteomics reveals the key transcription-related factors mediating obstructive nephropathy in pediatric patients and mice

  2025cites this paper
• Is activated Yes-Associated Protein (YAP) associated with renal damage in type2 diabetic nephropathy?

  2025cites this paper
• The Hippo Pathway in Kidney Development

  2025cites this paper
• Alteration of chromatin states perturb the transcription regulation of gene during hydronephrosis

  2025cites this paper
• The critical role of the Hippo signaling pathway in renal fibrosis.

  2025cites this paper
• Ferulic acid lipid nano capsules versus its native form in alleviating diabetic nephropathy induced in rats through TGF-β1/Hippo pathway crosstalk modulation

  2025cites this paper
• Local C1q/TNF-related protein 1 attenuates kidney inflammation and fibrosis by regulating macrophage activation.

  2025cites this paper
• Decoding diabetic kidney disease: a comprehensive review of interconnected pathways, molecular mediators, and therapeutic insights

  2025influential citation
• Expression and diagnostic value evaluation of urinary exosomal miR-142-3p in diabetic nephropathy

  2025cites this paper
• Multi‐Target Modulation of Polyphenols in Diabetic Kidney Disease Therapeutics: A Comprehensive Review

  2025cites this paper
• Shared and Context-Specific Mechanisms of EMT and Cellular Plasticity in Cancer and Fibrotic Diseases

  2025cites this paper
• Neu-P11 Improves Type 2 Diabetes Mellitus Immune Function by Inhibiting the Hippo Signaling Pathway

  2025cites this paper
• Linagliptin Attenuates Kidney Cancer in Rats via AMPK Activation and Suppression of YAP/TAZ/HIF-1α Signaling.

  2025cites this paper
• Signaling Pathways in Clear Cell Renal Cell Carcinoma and Candidate Drugs Unveiled through Transcriptomic Network Analysis of Hub Genes

  2024cites this paper
• HIF‐1α induced FGF18 alleviates renal ischemia/reperfusion injury via YAP

  2024cites this paper
• Salvianolic acid B improves DEN/CCl4/C2H5OH-induced renal fibrosis by regulating YAP/TAZ and pSmad3C/pSmad3L

  2024cites this paper
• F2RL1 Inhibition Alleviates Lipotoxicity-Induced Kidney Injury Through the Hippo Pathway in Diabetic Kidney Disease

  2024cites this paper
• From Acute to Chronic: Unraveling the Pathophysiological Mechanisms of the Progression from Acute Kidney Injury to Acute Kidney Disease to Chronic Kidney Disease

  2024cites this paper
• Ameliorative effect of Metformin / alpha-lipoic acid combination on diabetic nephropathy via modulation of YAP/ miR-29a/PTEN/p-AKT axis.

  2024cites this paper
• Renal cancer: signaling pathways and advances in targeted therapies

  2024influential citation
• Wnt/β-Catenin Signaling Regulates Yap/Taz Activity during Embryonic Development in Zebrafish

  2024cites this paper
• Possible Future Avenues for Rheumatoid Arthritis Therapeutics: Hippo Pathway

  2023cites this paper
• Integrin β6 mediates epithelial-mesenchymal transition in diabetic kidney disease.

  2023cites this paper
• Isoliensinine Attenuates Renal Fibrosis and Inhibits TGF-β1/Smad2/3 Signaling Pathway in Spontaneously Hypertensive Rats

  2023cites this paper
• TPD52L2 as a potential prognostic and immunotherapy biomarker in clear cell renal cell carcinoma

  2023cites this paper
• Inflammatory Networks in Renal Cell Carcinoma

  2023cites this paper